BR0213583A - Processo para preparar um composto de insulina, e, composto de insulina - Google Patents

Processo para preparar um composto de insulina, e, composto de insulina

Info

Publication number
BR0213583A
BR0213583A BR0213583-3A BR0213583A BR0213583A BR 0213583 A BR0213583 A BR 0213583A BR 0213583 A BR0213583 A BR 0213583A BR 0213583 A BR0213583 A BR 0213583A
Authority
BR
Brazil
Prior art keywords
insulin compound
insulin
preparing
compound
ester
Prior art date
Application number
BR0213583-3A
Other languages
English (en)
Inventor
Are Bogsnes
Ingun Christiansen
Per Balschmidt
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of BR0213583A publication Critical patent/BR0213583A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA PREPARAR UM COMPOSTO DE INSULINA, E, COMPOSTO DE INSULINA". Um caminho preferido de converter precursores de insulina em compostos de insulina é realizar uma clivagem de peptídeo enzimática em um meio aquoso e, depois disso, sem remoção do produto intermediário formado, adicionar um éster de aminoácido ou um éster de peptídeo e um solvente orgânico para que a ligação desejada ocorra.
BR0213583-3A 2001-11-19 2002-11-15 Processo para preparar um composto de insulina, e, composto de insulina BR0213583A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101716 2001-11-19
PCT/DK2002/000765 WO2003044210A2 (en) 2001-11-19 2002-11-15 Process for preparing insulin compounds

Publications (1)

Publication Number Publication Date
BR0213583A true BR0213583A (pt) 2004-08-24

Family

ID=8160841

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213583-3A BR0213583A (pt) 2001-11-19 2002-11-15 Processo para preparar um composto de insulina, e, composto de insulina

Country Status (15)

Country Link
EP (1) EP1448786B1 (pt)
JP (1) JP4404631B2 (pt)
KR (1) KR100925381B1 (pt)
CN (1) CN100424179C (pt)
AT (1) ATE464390T1 (pt)
AU (1) AU2002342597A1 (pt)
BR (1) BR0213583A (pt)
CA (1) CA2464616C (pt)
DE (1) DE60236014D1 (pt)
ES (1) ES2344448T3 (pt)
HU (1) HU228934B1 (pt)
IL (2) IL161358A0 (pt)
PL (1) PL210437B1 (pt)
RU (1) RU2376379C2 (pt)
WO (1) WO2003044210A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP3228320B1 (de) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Kombination von einem insulin und einem glp-1-agonisten
CN102471368A (zh) * 2009-08-11 2012-05-23 拜康有限公司 色谱方法及其纯化的化合物
AR080669A1 (es) 2009-11-13 2012-05-02 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina
UY33025A (es) 2009-11-13 2011-06-30 Sanofi Aventis Deustschland Gmbh Composicion farmaceutica que comprende un agonista de glp-1 metionina
MX339614B (es) 2010-08-30 2016-06-02 Sanofi - Aventis Deutschland GmbH Uso de ave0010 para la fabricacion de un medicamento para el tratamiento de la diabetes mellitus tipo 2.
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
RU2650616C2 (ru) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN102703552B (zh) * 2012-05-15 2014-10-29 山东阿华生物药业有限公司 重组人胰岛素的制备方法及其产品
CN102816819B (zh) * 2012-08-13 2014-10-29 山东阿华生物药业有限公司 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
CN103305581B (zh) * 2013-07-04 2015-05-27 珠海联邦制药股份有限公司 一种重组人胰岛素的制备方法
US10611813B2 (en) * 2013-12-23 2020-04-07 Biocon Research Limited Method of production of human insulin methyl ester
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
TW201726702A (zh) * 2015-09-24 2017-08-01 韓美藥品股份有限公司 生產胰島素之方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
JPS58501208A (ja) 1981-08-10 1983-07-28 ノルデイスク　インシユリンラボラトリユ−ム インシユリン誘導体の製造法
DK149824C (da) 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
WO1983002772A1 (en) 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
IT1189353B (it) 1982-06-07 1988-02-04 Nordisk Insulinlab Procedimento per la preparazione di insulina umana e suoi esteri
DK347086D0 (da) 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
IL84110A (en) * 1986-10-14 1992-11-15 Lilly Co Eli Process for transforming a human insulin precursor to a human insulin
DE10075034I1 (de) 1987-02-25 2001-05-23 Novo Nordisk As Insulinderivate
PL178466B1 (pl) 1993-09-17 2000-05-31 Novo Nordisk As Pochodna insuliny i kompozycja farmaceutyczna do leczenia cukrzycy
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
DE60039074D1 (de) 1999-12-29 2008-07-10 Novo Nordisk As Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern
RU2002120513A (ru) 1999-12-29 2004-03-27 Ново Нордиск А/С (DK) Способ производства предшественников инсулина и аналогов предшественников инсулина с повышенным выходом ферментации у дрожжей
ATE381573T1 (de) 2000-04-14 2008-01-15 Univ Maryland Biotech Inst Verbesserte thermostabilität und temperaturresistenz von proteinen
WO2002079254A1 (en) 2001-03-29 2002-10-10 Janoff Edward N Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

Also Published As

Publication number Publication date
JP2005509687A (ja) 2005-04-14
CN1589328A (zh) 2005-03-02
PL210437B1 (pl) 2012-01-31
HU228934B1 (hu) 2013-06-28
KR100925381B1 (ko) 2009-11-09
IL161358A (en) 2011-05-31
HUP0500037A2 (hu) 2005-03-29
HUP0500037A3 (en) 2010-01-28
PL369447A1 (en) 2005-04-18
RU2376379C2 (ru) 2009-12-20
AU2002342597A1 (en) 2003-06-10
EP1448786B1 (en) 2010-04-14
RU2004118503A (ru) 2005-06-10
CA2464616A1 (en) 2003-05-30
EP1448786A2 (en) 2004-08-25
ES2344448T3 (es) 2010-08-27
IL161358A0 (en) 2004-09-27
JP4404631B2 (ja) 2010-01-27
WO2003044210A3 (en) 2004-03-25
WO2003044210A2 (en) 2003-05-30
DE60236014D1 (de) 2010-05-27
KR20050044855A (ko) 2005-05-13
AU2002342597A8 (en) 2003-06-10
CA2464616C (en) 2012-07-24
CN100424179C (zh) 2008-10-08
ATE464390T1 (de) 2010-04-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C12P 21/02

Ipc: C12P 21/02 (2006.01), C07K 14/62 (2006.01), A61K 3

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B10A Cessation: cessation confirmed

Free format text: HOMOLOGADA A DESISTENCIA DO PEDIDO SOLICITADA ATRAVES DA PETICAO NO 870180149807 DE 09/11/2018.