ATE464390T1 - Verfahren zur herstellung von insulinverbindungen - Google Patents
Verfahren zur herstellung von insulinverbindungenInfo
- Publication number
- ATE464390T1 ATE464390T1 AT02779247T AT02779247T ATE464390T1 AT E464390 T1 ATE464390 T1 AT E464390T1 AT 02779247 T AT02779247 T AT 02779247T AT 02779247 T AT02779247 T AT 02779247T AT E464390 T1 ATE464390 T1 AT E464390T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin compounds
- producing insulin
- compounds
- insulin
- ester
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- -1 amino acid ester Chemical class 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000007030 peptide scission Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101716 | 2001-11-19 | ||
| PCT/DK2002/000765 WO2003044210A2 (en) | 2001-11-19 | 2002-11-15 | Process for preparing insulin compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE464390T1 true ATE464390T1 (de) | 2010-04-15 |
Family
ID=8160841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02779247T ATE464390T1 (de) | 2001-11-19 | 2002-11-15 | Verfahren zur herstellung von insulinverbindungen |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1448786B1 (de) |
| JP (1) | JP4404631B2 (de) |
| KR (1) | KR100925381B1 (de) |
| CN (1) | CN100424179C (de) |
| AT (1) | ATE464390T1 (de) |
| AU (1) | AU2002342597A1 (de) |
| BR (1) | BR0213583A (de) |
| CA (1) | CA2464616C (de) |
| DE (1) | DE60236014D1 (de) |
| ES (1) | ES2344448T3 (de) |
| HU (1) | HU228934B1 (de) |
| IL (2) | IL161358A0 (de) |
| PL (1) | PL210437B1 (de) |
| RU (1) | RU2376379C2 (de) |
| WO (1) | WO2003044210A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006031962A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| DE102006031955A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| EP3228320B1 (de) | 2008-10-17 | 2019-12-18 | Sanofi-Aventis Deutschland GmbH | Kombination von einem insulin und einem glp-1-agonisten |
| EP3202394A1 (de) | 2009-07-06 | 2017-08-09 | Sanofi-Aventis Deutschland GmbH | Wässrige insulinzubereitungen enthaltend methionin |
| PL2464655T3 (pl) * | 2009-08-11 | 2017-08-31 | Biocon Limited | Procesy chromatograficzne |
| PT2554183T (pt) | 2009-11-13 | 2018-07-09 | Sanofi Aventis Deutschland | Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina |
| PE20121316A1 (es) | 2009-11-13 | 2012-10-05 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1 y metionina |
| US20140148384A1 (en) | 2010-08-30 | 2014-05-29 | Sanofi-Aventis Deutschland Gmbh | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| CN108079281A (zh) | 2011-08-29 | 2018-05-29 | 赛诺菲-安万特德国有限公司 | 用于2型糖尿病患者中的血糖控制的药物组合 |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| CN102703552B (zh) * | 2012-05-15 | 2014-10-29 | 山东阿华生物药业有限公司 | 重组人胰岛素的制备方法及其产品 |
| CN102816819B (zh) * | 2012-08-13 | 2014-10-29 | 山东阿华生物药业有限公司 | 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法 |
| CN103305581B (zh) * | 2013-07-04 | 2015-05-27 | 珠海联邦制药股份有限公司 | 一种重组人胰岛素的制备方法 |
| EP3087192B1 (de) * | 2013-12-23 | 2020-08-12 | Biocon Biologics India Limited | Verfahren zur herstellung von humaninsulinmethylester |
| TWI758239B (zh) | 2014-12-12 | 2022-03-21 | 德商賽諾菲阿凡提斯德意志有限公司 | 甘精胰島素/利司那肽固定比率配製劑 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| WO2017052305A1 (en) * | 2015-09-24 | 2017-03-30 | Hanmi Pharm. Co., Ltd. | Method of insulin production |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4343898A (en) * | 1980-02-11 | 1982-08-10 | Novo Industri A/S | Process for preparing esters of human insulin |
| EP0085083B1 (de) | 1981-08-10 | 1985-01-23 | Nordisk Insulinlaboratorium | Verfahren zur enzymatischen Herstellung von Humaninsulin |
| AU551174B2 (en) | 1981-09-15 | 1986-04-17 | Nordisk Insulinlaboratorium | Enzymatic preparation of human insulin or b-30 esters thereof |
| DK149824C (da) | 1982-01-22 | 1987-03-16 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner |
| EP0087238A1 (de) | 1982-02-08 | 1983-08-31 | Biogen N.V. | Methode zur Herstellung von menschlichem Insulin aus nichtmenschlichem Insulin- |
| DK347086D0 (da) | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| ZA877505B (en) * | 1986-10-14 | 1989-05-30 | Lilly Co Eli | Process for transforming a human insulin precursor to human insulin |
| WO1988006599A1 (en) | 1987-02-25 | 1988-09-07 | Novo Industri A/S | Novel insulin derivatives |
| US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| SI0792290T1 (en) | 1993-09-17 | 2001-12-31 | Novo Nordisk As | Acylated insulin |
| RU2141531C1 (ru) * | 1999-05-26 | 1999-11-20 | Российское акционерное общество открытого типа "Биопрепарат" | Способ получения рекомбинантного инсулина человека |
| KR20030004315A (ko) | 1999-12-29 | 2003-01-14 | 노보 노르디스크 에이/에스 | 효모에서 개선된 발효 수율을 갖는 인슐린 선구물질 및인슐린 선구물질 유사체의 제조 방법 |
| HUP0203475A3 (en) | 1999-12-29 | 2005-11-28 | Novo Nordisk As | Method for making insulin precursors and insulin precursor analogs |
| WO2001079250A1 (en) | 2000-04-14 | 2001-10-25 | University Of Maryland Biotechnology Institute | Enhanced protein thermostability and temperature resistance |
| WO2002079254A1 (en) | 2001-03-29 | 2002-10-10 | Janoff Edward N | Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae |
-
2002
- 2002-11-15 AT AT02779247T patent/ATE464390T1/de not_active IP Right Cessation
- 2002-11-15 JP JP2003545831A patent/JP4404631B2/ja not_active Expired - Lifetime
- 2002-11-15 HU HU0500037A patent/HU228934B1/hu not_active IP Right Cessation
- 2002-11-15 WO PCT/DK2002/000765 patent/WO2003044210A2/en not_active Ceased
- 2002-11-15 AU AU2002342597A patent/AU2002342597A1/en not_active Abandoned
- 2002-11-15 CA CA2464616A patent/CA2464616C/en not_active Expired - Fee Related
- 2002-11-15 PL PL369447A patent/PL210437B1/pl unknown
- 2002-11-15 KR KR1020047007129A patent/KR100925381B1/ko not_active Expired - Fee Related
- 2002-11-15 BR BR0213583-3A patent/BR0213583A/pt not_active Application Discontinuation
- 2002-11-15 ES ES02779247T patent/ES2344448T3/es not_active Expired - Lifetime
- 2002-11-15 IL IL16135802A patent/IL161358A0/xx unknown
- 2002-11-15 EP EP02779247A patent/EP1448786B1/de not_active Expired - Lifetime
- 2002-11-15 CN CNB028229622A patent/CN100424179C/zh not_active Expired - Lifetime
- 2002-11-15 RU RU2004118503/13A patent/RU2376379C2/ru not_active IP Right Cessation
- 2002-11-15 DE DE60236014T patent/DE60236014D1/de not_active Expired - Lifetime
-
2004
- 2004-04-14 IL IL161358A patent/IL161358A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2464616A1 (en) | 2003-05-30 |
| HU228934B1 (hu) | 2013-06-28 |
| KR100925381B1 (ko) | 2009-11-09 |
| RU2376379C2 (ru) | 2009-12-20 |
| WO2003044210A2 (en) | 2003-05-30 |
| AU2002342597A8 (en) | 2003-06-10 |
| WO2003044210A3 (en) | 2004-03-25 |
| RU2004118503A (ru) | 2005-06-10 |
| KR20050044855A (ko) | 2005-05-13 |
| DE60236014D1 (de) | 2010-05-27 |
| JP2005509687A (ja) | 2005-04-14 |
| EP1448786A2 (de) | 2004-08-25 |
| BR0213583A (pt) | 2004-08-24 |
| ES2344448T3 (es) | 2010-08-27 |
| HUP0500037A2 (hu) | 2005-03-29 |
| CN1589328A (zh) | 2005-03-02 |
| IL161358A (en) | 2011-05-31 |
| CA2464616C (en) | 2012-07-24 |
| PL369447A1 (en) | 2005-04-18 |
| HUP0500037A3 (en) | 2010-01-28 |
| IL161358A0 (en) | 2004-09-27 |
| AU2002342597A1 (en) | 2003-06-10 |
| PL210437B1 (pl) | 2012-01-31 |
| EP1448786B1 (de) | 2010-04-14 |
| JP4404631B2 (ja) | 2010-01-27 |
| CN100424179C (zh) | 2008-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |