ATE464390T1 - Verfahren zur herstellung von insulinverbindungen - Google Patents
Verfahren zur herstellung von insulinverbindungenInfo
- Publication number
- ATE464390T1 ATE464390T1 AT02779247T AT02779247T ATE464390T1 AT E464390 T1 ATE464390 T1 AT E464390T1 AT 02779247 T AT02779247 T AT 02779247T AT 02779247 T AT02779247 T AT 02779247T AT E464390 T1 ATE464390 T1 AT E464390T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin compounds
- producing insulin
- compounds
- insulin
- ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101716 | 2001-11-19 | ||
| PCT/DK2002/000765 WO2003044210A2 (en) | 2001-11-19 | 2002-11-15 | Process for preparing insulin compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE464390T1 true ATE464390T1 (de) | 2010-04-15 |
Family
ID=8160841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02779247T ATE464390T1 (de) | 2001-11-19 | 2002-11-15 | Verfahren zur herstellung von insulinverbindungen |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1448786B1 (de) |
| JP (1) | JP4404631B2 (de) |
| KR (1) | KR100925381B1 (de) |
| CN (1) | CN100424179C (de) |
| AT (1) | ATE464390T1 (de) |
| AU (1) | AU2002342597A1 (de) |
| BR (1) | BR0213583A (de) |
| CA (1) | CA2464616C (de) |
| DE (1) | DE60236014D1 (de) |
| ES (1) | ES2344448T3 (de) |
| HU (1) | HU228934B1 (de) |
| IL (2) | IL161358A0 (de) |
| PL (1) | PL210437B1 (de) |
| RU (1) | RU2376379C2 (de) |
| WO (1) | WO2003044210A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006031955A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| DE102006031962A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| KR101820024B1 (ko) | 2008-10-17 | 2018-01-18 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린과 ｇｌｐ－1 효능제의 병용물 |
| CN102471368A (zh) * | 2009-08-11 | 2012-05-23 | 拜康有限公司 | 色谱方法及其纯化的化合物 |
| HUE037735T2 (hu) | 2009-11-13 | 2018-09-28 | Sanofi Aventis Deutschland | DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény |
| ES2534191T3 (es) | 2009-11-13 | 2015-04-20 | Sanofi-Aventis Deutschland Gmbh | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
| BR112013004756B1 (pt) | 2010-08-30 | 2020-04-28 | Sanofi Aventis Deutschland | uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| RU2650616C2 (ru) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| CN102703552B (zh) * | 2012-05-15 | 2014-10-29 | 山东阿华生物药业有限公司 | 重组人胰岛素的制备方法及其产品 |
| CN102816819B (zh) * | 2012-08-13 | 2014-10-29 | 山东阿华生物药业有限公司 | 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法 |
| CN103305581B (zh) * | 2013-07-04 | 2015-05-27 | 珠海联邦制药股份有限公司 | 一种重组人胰岛素的制备方法 |
| EP3087192B1 (de) * | 2013-12-23 | 2020-08-12 | Biocon Biologics India Limited | Verfahren zur herstellung von humaninsulinmethylester |
| JP6970615B2 (ja) | 2014-12-12 | 2021-11-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリングラルギン／リキシセナチド固定比処方 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| EP3341405A4 (de) * | 2015-09-24 | 2019-05-01 | Hanmi Pharm. Co., Ltd. | Verfahren zur insulinproduktion |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE50892B1 (en) | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
| WO1983000504A1 (en) | 1981-08-10 | 1983-02-17 | Andresen, Finn, Hede | Enzymatic preparation of human insulin |
| JPS58501455A (ja) | 1981-09-15 | 1983-09-01 | ノルデイスク インシユリンラボラトリユ−ム | 人インシユリンまたはそのｂ−３０エステルの製造法 |
| DK149824C (da) | 1982-01-22 | 1987-03-16 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner |
| WO1983002772A1 (en) | 1982-02-08 | 1983-08-18 | Robin Ewart Offord | An improved method for preparing human insulin from non-human insulin |
| DK347086D0 (da) | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| CA1339955C (en) | 1986-10-14 | 1998-07-14 | Richard Eugene Heiney | Process for transforming a human insulin precursor to human insulin |
| NZ223630A (en) | 1987-02-25 | 1989-11-28 | Novo Industri As | Insulin derivative and pharmaceutical compositions |
| US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| WO1995007931A1 (en) | 1993-09-17 | 1995-03-23 | Novo Nordisk A/S | Acylated insulin |
| WO2001049742A1 (en) | 1999-12-29 | 2001-07-12 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
| CN1415019A (zh) | 1999-12-29 | 2003-04-30 | 诺沃挪第克公司 | 用于生产在酵母中具有改进发酵产量的胰岛素前体和胰岛素前体类似物的方法 |
| WO2001079250A1 (en) | 2000-04-14 | 2001-10-25 | University Of Maryland Biotechnology Institute | Enhanced protein thermostability and temperature resistance |
| WO2002079254A1 (en) | 2001-03-29 | 2002-10-10 | Janoff Edward N | Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae |
-
2002
- 2002-11-15 AT AT02779247T patent/ATE464390T1/de not_active IP Right Cessation
- 2002-11-15 EP EP02779247A patent/EP1448786B1/de not_active Expired - Lifetime
- 2002-11-15 KR KR1020047007129A patent/KR100925381B1/ko active IP Right Grant
- 2002-11-15 RU RU2004118503/13A patent/RU2376379C2/ru not_active IP Right Cessation
- 2002-11-15 CN CNB028229622A patent/CN100424179C/zh not_active Expired - Lifetime
- 2002-11-15 HU HU0500037A patent/HU228934B1/hu not_active IP Right Cessation
- 2002-11-15 PL PL369447A patent/PL210437B1/pl unknown
- 2002-11-15 CA CA2464616A patent/CA2464616C/en not_active Expired - Fee Related
- 2002-11-15 WO PCT/DK2002/000765 patent/WO2003044210A2/en active Application Filing
- 2002-11-15 BR BR0213583-3A patent/BR0213583A/pt not_active Application Discontinuation
- 2002-11-15 AU AU2002342597A patent/AU2002342597A1/en not_active Abandoned
- 2002-11-15 JP JP2003545831A patent/JP4404631B2/ja not_active Expired - Lifetime
- 2002-11-15 ES ES02779247T patent/ES2344448T3/es not_active Expired - Lifetime
- 2002-11-15 DE DE60236014T patent/DE60236014D1/de not_active Expired - Lifetime
- 2002-11-15 IL IL16135802A patent/IL161358A0/xx unknown
-
2004
- 2004-04-14 IL IL161358A patent/IL161358A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002342597A1 (en) | 2003-06-10 |
| JP4404631B2 (ja) | 2010-01-27 |
| HUP0500037A3 (en) | 2010-01-28 |
| BR0213583A (pt) | 2004-08-24 |
| HUP0500037A2 (hu) | 2005-03-29 |
| PL210437B1 (pl) | 2012-01-31 |
| IL161358A0 (en) | 2004-09-27 |
| CN100424179C (zh) | 2008-10-08 |
| PL369447A1 (en) | 2005-04-18 |
| CA2464616A1 (en) | 2003-05-30 |
| KR20050044855A (ko) | 2005-05-13 |
| WO2003044210A3 (en) | 2004-03-25 |
| ES2344448T3 (es) | 2010-08-27 |
| DE60236014D1 (de) | 2010-05-27 |
| AU2002342597A8 (en) | 2003-06-10 |
| CN1589328A (zh) | 2005-03-02 |
| RU2004118503A (ru) | 2005-06-10 |
| JP2005509687A (ja) | 2005-04-14 |
| WO2003044210A2 (en) | 2003-05-30 |
| KR100925381B1 (ko) | 2009-11-09 |
| EP1448786A2 (de) | 2004-08-25 |
| HU228934B1 (hu) | 2013-06-28 |
| EP1448786B1 (de) | 2010-04-14 |
| RU2376379C2 (ru) | 2009-12-20 |
| IL161358A (en) | 2011-05-31 |
| CA2464616C (en) | 2012-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |