IL161358A0 - Process for preparing insulin compounds - Google Patents

Process for preparing insulin compounds

Info

Publication number
IL161358A0
IL161358A0 IL16135802A IL16135802A IL161358A0 IL 161358 A0 IL161358 A0 IL 161358A0 IL 16135802 A IL16135802 A IL 16135802A IL 16135802 A IL16135802 A IL 16135802A IL 161358 A0 IL161358 A0 IL 161358A0
Authority
IL
Israel
Prior art keywords
insulin compounds
preparing insulin
compounds
insulin
ester
Prior art date
Application number
IL16135802A
Other languages
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL161358A0 publication Critical patent/IL161358A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL16135802A 2001-11-19 2002-11-15 Process for preparing insulin compounds IL161358A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101716 2001-11-19
PCT/DK2002/000765 WO2003044210A2 (en) 2001-11-19 2002-11-15 Process for preparing insulin compounds

Publications (1)

Publication Number Publication Date
IL161358A0 true IL161358A0 (en) 2004-09-27

Family

ID=8160841

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16135802A IL161358A0 (en) 2001-11-19 2002-11-15 Process for preparing insulin compounds
IL161358A IL161358A (en) 2001-11-19 2004-04-14 Process for preparing insulin compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL161358A IL161358A (en) 2001-11-19 2004-04-14 Process for preparing insulin compounds

Country Status (15)

Country Link
EP (1) EP1448786B1 (de)
JP (1) JP4404631B2 (de)
KR (1) KR100925381B1 (de)
CN (1) CN100424179C (de)
AT (1) ATE464390T1 (de)
AU (1) AU2002342597A1 (de)
BR (1) BR0213583A (de)
CA (1) CA2464616C (de)
DE (1) DE60236014D1 (de)
ES (1) ES2344448T3 (de)
HU (1) HU228934B1 (de)
IL (2) IL161358A0 (de)
PL (1) PL210437B1 (de)
RU (1) RU2376379C2 (de)
WO (1) WO2003044210A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
KR101820024B1 (ko) 2008-10-17 2018-01-18 사노피-아벤티스 도이칠란트 게엠베하 인슐린과 ｇｌｐ－1 효능제의 병용물
CN102471368A (zh) * 2009-08-11 2012-05-23 拜康有限公司 色谱方法及其纯化的化合物
HUE037735T2 (hu) 2009-11-13 2018-09-28 Sanofi Aventis Deutschland DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény
ES2534191T3 (es) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
BR112013004756B1 (pt) 2010-08-30 2020-04-28 Sanofi Aventis Deutschland uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
RU2650616C2 (ru) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN102703552B (zh) * 2012-05-15 2014-10-29 山东阿华生物药业有限公司 重组人胰岛素的制备方法及其产品
CN102816819B (zh) * 2012-08-13 2014-10-29 山东阿华生物药业有限公司 提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
CN103305581B (zh) * 2013-07-04 2015-05-27 珠海联邦制药股份有限公司 一种重组人胰岛素的制备方法
EP3087192B1 (de) * 2013-12-23 2020-08-12 Biocon Biologics India Limited Verfahren zur herstellung von humaninsulinmethylester
JP6970615B2 (ja) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリングラルギン／リキシセナチド固定比処方
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
EP3341405A4 (de) * 2015-09-24 2019-05-01 Hanmi Pharm. Co., Ltd. Verfahren zur insulinproduktion

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
WO1983000504A1 (en) 1981-08-10 1983-02-17 Andresen, Finn, Hede Enzymatic preparation of human insulin
JPS58501455A (ja) 1981-09-15 1983-09-01 ノルデイスク　インシユリンラボラトリユ−ム 人インシユリンまたはそのｂ−３０エステルの製造法
DK149824C (da) 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
WO1983002772A1 (en) 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
DK347086D0 (da) 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
CA1339955C (en) 1986-10-14 1998-07-14 Richard Eugene Heiney Process for transforming a human insulin precursor to human insulin
NZ223630A (en) 1987-02-25 1989-11-28 Novo Industri As Insulin derivative and pharmaceutical compositions
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
WO1995007931A1 (en) 1993-09-17 1995-03-23 Novo Nordisk A/S Acylated insulin
WO2001049742A1 (en) 1999-12-29 2001-07-12 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
CN1415019A (zh) 1999-12-29 2003-04-30 诺沃挪第克公司 用于生产在酵母中具有改进发酵产量的胰岛素前体和胰岛素前体类似物的方法
WO2001079250A1 (en) 2000-04-14 2001-10-25 University Of Maryland Biotechnology Institute Enhanced protein thermostability and temperature resistance
WO2002079254A1 (en) 2001-03-29 2002-10-10 Janoff Edward N Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

Also Published As

Publication number Publication date
AU2002342597A1 (en) 2003-06-10
JP4404631B2 (ja) 2010-01-27
HUP0500037A3 (en) 2010-01-28
BR0213583A (pt) 2004-08-24
HUP0500037A2 (hu) 2005-03-29
PL210437B1 (pl) 2012-01-31
CN100424179C (zh) 2008-10-08
PL369447A1 (en) 2005-04-18
CA2464616A1 (en) 2003-05-30
KR20050044855A (ko) 2005-05-13
WO2003044210A3 (en) 2004-03-25
ES2344448T3 (es) 2010-08-27
ATE464390T1 (de) 2010-04-15
DE60236014D1 (de) 2010-05-27
AU2002342597A8 (en) 2003-06-10
CN1589328A (zh) 2005-03-02
RU2004118503A (ru) 2005-06-10
JP2005509687A (ja) 2005-04-14
WO2003044210A2 (en) 2003-05-30
KR100925381B1 (ko) 2009-11-09
EP1448786A2 (de) 2004-08-25
HU228934B1 (hu) 2013-06-28
EP1448786B1 (de) 2010-04-14
RU2376379C2 (ru) 2009-12-20
IL161358A (en) 2011-05-31
CA2464616C (en) 2012-07-24

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