AU2002215360A1 - Production of alpha-hydroxy-carboxylic acids using a coupled enzyme system - Google Patents

Production of alpha-hydroxy-carboxylic acids using a coupled enzyme system

Info

Publication number
AU2002215360A1
AU2002215360A1 AU2002215360A AU1536002A AU2002215360A1 AU 2002215360 A1 AU2002215360 A1 AU 2002215360A1 AU 2002215360 A AU2002215360 A AU 2002215360A AU 1536002 A AU1536002 A AU 1536002A AU 2002215360 A1 AU2002215360 A1 AU 2002215360A1
Authority
AU
Australia
Prior art keywords
alpha
carboxylic acids
hydroxy
salts
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002215360A
Inventor
David P. Pantaleone
Richard F. Senkpeil
Paul P Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PCBU Services Inc
Original Assignee
PCBU Services Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PCBU Services Inc filed Critical PCBU Services Inc
Publication of AU2002215360A1 publication Critical patent/AU2002215360A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

An economical and expedient method is disclosed for the preparation of alpha-hydroxy-carboxylic acids or salts thereof in very high enantiomeric purity which comprises oxidizing a corresponding alpha-amino-carboxylic acid or salt thereof using an amino acid deaminase followed by reducing the corresponding alpha-keto-carboxylic acid or salt produced using a D- or L-lactate dehydrogenase in the combination with an electron donor and an enzyme/substrate system for recycling the electron donor. The resulting alpha-hydroxy-carboxylic acids, hydrates, and salts thereof are valuable components and intermediates in the preparation of chiral compounds, especially pharmaceuticals. This invention also relates to the use of alpha-amino-carboxylic acids, hydrates, and salts thereof and a coupled enzyme system in the production of alpha-hydroxy-carboxylic acids, hydrates, and salts thereof.
AU2002215360A 2000-10-17 2001-10-17 Production of alpha-hydroxy-carboxylic acids using a coupled enzyme system Abandoned AU2002215360A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24117700P 2000-10-17 2000-10-17
US60/241,177 2000-10-17
PCT/US2001/032243 WO2002033110A2 (en) 2000-10-17 2001-10-17 PRODUCTION OF α-HYDROXY-CARBOXYLIC ACIDS USING A COUPLED ENZYME SYSTEM

Publications (1)

Publication Number Publication Date
AU2002215360A1 true AU2002215360A1 (en) 2002-04-29

Family

ID=22909567

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002215360A Abandoned AU2002215360A1 (en) 2000-10-17 2001-10-17 Production of alpha-hydroxy-carboxylic acids using a coupled enzyme system

Country Status (8)

Country Link
US (1) US20040053382A1 (en)
EP (1) EP1326993B1 (en)
JP (1) JP2004511249A (en)
AT (1) ATE362992T1 (en)
AU (1) AU2002215360A1 (en)
CA (1) CA2426594A1 (en)
DE (1) DE60128581T2 (en)
WO (1) WO2002033110A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006016517A1 (en) * 2004-08-13 2008-05-01 株式会社カネカ Process for producing optically active 2-substituted oxy-3- (4-substituted oxyphenyl) propionic acid derivative
US7754454B2 (en) 2004-09-17 2010-07-13 Sumitomo Chemical Co., Ltd. Process for producing sulfur-containing hydroxycarboxylic acid
US20080090274A1 (en) * 2004-12-16 2008-04-17 Moore Jeffrey C Process For The Synthesis Of (S)-1-(3,5-Bis (Trifluoromethyl)-Phenyl-Ethan-1-Ol
US8067398B2 (en) 2005-06-01 2011-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Biodegradable polymers having a pre-determined chirality
JP4962016B2 (en) * 2006-09-25 2012-06-27 住友化学株式会社 Method for producing sulfur-containing hydroxycarboxylic acid
AU2007293373A1 (en) * 2006-09-01 2008-03-13 Merck Sharp & Dohme Corp. Inhibitors of 5 -lipoxygenase activating protein (FLAP)
ES2356271T3 (en) * 2006-09-25 2011-04-06 Sumitomo Chemical Company, Limited PROCESS FOR THE PREPARATION OF 2-HYDROXICARBOXYLIC ACIDS USING BACTERIA OF THE PSEUDONOMAS, RHODOCOCCUS OR BACILLUS GENDERS.
US8404465B2 (en) 2009-03-11 2013-03-26 Celexion, Llc Biological synthesis of 6-aminocaproic acid from carbohydrate feedstocks
CN103041380B (en) * 2012-12-28 2014-08-06 中国医学科学院输血研究所 Stabilizer in dry heat treatment process of human antithrombase preparation
CN103789247B (en) * 2014-02-14 2015-06-24 江南大学 Method for producing alpha-ketoisocaproate by whole-cell transformation
CN104830815B (en) * 2015-06-02 2018-02-23 江南大学 A kind of method that α phenylpyruvic acids are efficiently produced using resting cell
CN105603007B (en) * 2016-02-15 2019-07-23 江南大学 A kind of method of microorganism conversion
CN105603010B (en) * 2016-02-15 2019-07-23 江南大学 A kind of method of microorganism conversion
CN108624576B (en) * 2018-04-25 2020-11-03 江南大学 Mutant of L-amino acid deaminase and preparation method and application thereof
CN109136205B (en) * 2018-08-10 2021-08-27 浙江正硕生物科技有限公司 L-amino acid deaminase mutant with improved heat resistance and preparation method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2930087A1 (en) * 1979-07-25 1981-02-26 Biotechnolog Forschung Gmbh METHOD FOR THE CONTINUOUS ENCYMATIC CONVERSION OF WATER-SOLUBLE ALPHA KETOCARBONIC ACIDS INTO THE CORRESPONDING ALPHA HYDROXYCARBONIC ACIDS
ES2059817T3 (en) * 1988-06-06 1994-11-16 Ciba Geigy Ag PROCEDURE FOR THE PREPARATION OF HYDROXIACIDES.
CA2096637A1 (en) * 1990-12-26 1992-06-27 Harry J. Klee Control of fruit ripening and senescence in plants
US5397700A (en) * 1991-10-31 1995-03-14 University Of Toledo Method of producing products with a bilayer pellet containing a coimmobilized enzyme system that maintains a ph difference
DE69231314T2 (en) * 1991-12-23 2001-05-17 Genzyme Ltd SYNTHESIS OF HOMOCHIRAL 2-HYDROXIC ACIDS
CA2121972A1 (en) * 1993-05-06 1994-11-07 Konrad Lerch Substituted valeric acid
GB9413710D0 (en) * 1994-07-07 1994-08-24 Genzyme Ltd Chiral synthesis

Also Published As

Publication number Publication date
WO2002033110A2 (en) 2002-04-25
ATE362992T1 (en) 2007-06-15
JP2004511249A (en) 2004-04-15
EP1326993B1 (en) 2007-05-23
EP1326993A2 (en) 2003-07-16
US20040053382A1 (en) 2004-03-18
WO2002033110A3 (en) 2003-02-13
DE60128581T2 (en) 2008-02-14
DE60128581D1 (en) 2007-07-05
CA2426594A1 (en) 2002-04-25

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