IT1189353B - Procedimento per la preparazione di insulina umana e suoi esteri - Google Patents

Procedimento per la preparazione di insulina umana e suoi esteri

Info

Publication number
IT1189353B
IT1189353B IT8249114A IT4911482A IT1189353B IT 1189353 B IT1189353 B IT 1189353B IT 8249114 A IT8249114 A IT 8249114A IT 4911482 A IT4911482 A IT 4911482A IT 1189353 B IT1189353 B IT 1189353B
Authority
IT
Italy
Prior art keywords
esters
procedure
preparation
human insulin
insulin
Prior art date
Application number
IT8249114A
Other languages
English (en)
Other versions
IT8249114A0 (it
Inventor
Finn Hede Andresen
Per Balschmidt
Kim Ry Hejnaes
Hans Kofod
Original Assignee
Nordisk Insulinlab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlab filed Critical Nordisk Insulinlab
Publication of IT8249114A0 publication Critical patent/IT8249114A0/it
Application granted granted Critical
Publication of IT1189353B publication Critical patent/IT1189353B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
IT8249114A 1982-06-07 1982-09-14 Procedimento per la preparazione di insulina umana e suoi esteri IT1189353B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK254582 1982-06-07
DK254682 1982-06-07

Publications (2)

Publication Number Publication Date
IT8249114A0 IT8249114A0 (it) 1982-09-14
IT1189353B true IT1189353B (it) 1988-02-04

Family

ID=26066590

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8249114A IT1189353B (it) 1982-06-07 1982-09-14 Procedimento per la preparazione di insulina umana e suoi esteri

Country Status (11)

Country Link
US (1) US4601979A (it)
EP (1) EP0088117B1 (it)
JP (1) JPS58501455A (it)
AU (1) AU551174B2 (it)
CA (1) CA1174623A (it)
DK (1) DK149457C (it)
ES (1) ES8400772A1 (it)
FI (1) FI78119C (it)
IT (1) IT1189353B (it)
NO (1) NO156052C (it)
WO (1) WO1983001074A1 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3381980D1 (de) * 1982-04-23 1990-12-13 Wako Pure Chem Ind Ltd Verfahren zur halbsynthese von menschlichem insulin und dazu zu verwendende alkalische protease.
EP0294851A3 (de) * 1987-06-12 1990-05-09 Berlin-Chemie Ag Verfahren zur Herstellung von Humaninsulin und seinen Derivaten
US5130236A (en) * 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
JP2001521006A (ja) 1997-10-24 2001-11-06 イーライ・リリー・アンド・カンパニー 不溶性インシュリン組成物
US6531448B1 (en) * 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
ATE464390T1 (de) 2001-11-19 2010-04-15 Novo Nordisk As Verfahren zur herstellung von insulinverbindungen
US7396903B2 (en) * 2001-11-19 2008-07-08 Novo Nordisk A/S Process for preparing insulin compounds
US7589233B2 (en) * 2003-07-29 2009-09-15 Signature R&D Holdings, Llc L-Threonine derivatives of high therapeutic index
US8173840B2 (en) * 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
EP3087192B1 (en) * 2013-12-23 2020-08-12 Biocon Biologics India Limited Method of production of human insulin methyl ester

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
BR8008024A (pt) * 1979-04-06 1981-03-31 Forenede Bryggerier As Processo para a producao enzimatica de peptideos
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
JPS55138392A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"

Also Published As

Publication number Publication date
JPS58501455A (ja) 1983-09-01
EP0088117A1 (en) 1983-09-14
CA1174623A (en) 1984-09-18
ES515713A0 (es) 1983-11-01
DK213983D0 (da) 1983-05-13
FI78119C (fi) 1989-06-12
FI78119B (fi) 1989-02-28
DK149457C (da) 1991-11-25
DK149457B (da) 1986-06-16
DK213983A (da) 1983-05-13
FI831157L (fi) 1983-04-06
AU551174B2 (en) 1986-04-17
FI831157A0 (fi) 1983-04-06
ES8400772A1 (es) 1983-11-01
EP0088117B1 (en) 1986-09-24
IT8249114A0 (it) 1982-09-14
US4601979A (en) 1986-07-22
AU8953982A (en) 1983-04-08
NO831730L (no) 1983-05-13
NO156052C (no) 1987-07-15
WO1983001074A1 (en) 1983-03-31
NO156052B (no) 1987-04-06
JPH0526469B2 (it) 1993-04-16

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Effective date: 19960925