KR850001897A - α-6-데옥시-데트라 싸이클린의 제조방법 - Google Patents

α-6-데옥시-데트라 싸이클린의 제조방법 Download PDF

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Publication number
KR850001897A
KR850001897A KR1019840004933A KR840004933A KR850001897A KR 850001897 A KR850001897 A KR 850001897A KR 1019840004933 A KR1019840004933 A KR 1019840004933A KR 840004933 A KR840004933 A KR 840004933A KR 850001897 A KR850001897 A KR 850001897A
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Prior art keywords
reaction
rhodium
rhcl
sio
deoxy
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KR1019840004933A
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KR870001142B1 (ko
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로날드 페이지 필립
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이. 발더
호비온 인터 리미리드
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Priority claimed from PT77210A external-priority patent/PT77210A/pt
Priority claimed from PT7833484A external-priority patent/PT78334A/pt
Application filed by 이. 발더, 호비온 인터 리미리드 filed Critical 이. 발더
Publication of KR850001897A publication Critical patent/KR850001897A/ko
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Publication of KR870001142B1 publication Critical patent/KR870001142B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

내용 없음

Description

－6－데옥시－테트라 싸이클린의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 로듐염 촉매를 사용하여 러시아리포스핀 존재하에서 6－데메틸－6－데옥시－6－메틸렌－테트라싸이클린이나 이것의 산부가염을 입체선택성 불균일 수소화반응시키거나 또는 터시아리 포스핀 존재하에서 11 a－할로－6－데메틸－6－데옥시－6－메틸렌－테트라싸이클린이나 이것의 산부가염을 동시적으로 할로겐이탈 반응과 입체선택성 수소화 반응시킴을 특징으로 하는－6－데옥시－테트라싸이클린의 제조방법(여기에서 로듐은 아미노 폴리실옥산에 결합되어 로듐의 회수를 용이하게 한다).
  2. 제1항에 있어서, 생성물은 P－톨루엔설포네이트 염으로 반응혼합물로부터 직접 얻어진다는 것.
  3. 제1항에 있어서, 터시아리 포스핀은 다음과 같은 구조식을 갖는다는 것.
    여기에서, R1과 R2는 페닐, 치환된 페닐이나 디메틸 아미노기이고 R3는 페닐, 치환된 페닐, 알킬, 아르알킬, 벤질 또는 디메틸아미노기이다.
  4. 제3항에 있어서, 터시아리포스핀은 트리페닐포스핀이라는 것.
  5. 제1항에 있어서, 완전한 반응을 위해 필요한 로듐은 6－메틸렌기질의 몰당 0.1내지 5m㏖ 사이라는 것.
  6. 제1항에 있어서, 로듐염 촉매들은 질소를 포함하는 기를 통하여 폴리실을산과 결합된 것으로 다음의 구조식을 갖는다는 것.
    RhCl3[N {(CH2)3SiO3/2}3]10, RhCl3[N{(CH2)3SiO3/2}3]12, RhCl3[N{(CH2)3SiO3/2}3]15, RhCl3[HN{(CH2)3SiO3/2}2]4, RhCl3[HN{(CH2)3SiO3/2}2]8
  7. 제1,2,3,4,5,6항중 어느한항에 있어서 수소화반응은 0.1㎏/㎠ 내지 20㎏/㎠사이의 압력과 50℃ 내지 100℃사이의 반응온도에서 행하며, 반응매질은 수소화반응과정에 불리한 영향을 미치지 않는 용매로 메탄올과 같은 저급알콜이 바람직하다는 것.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840004933A 1983-08-17 1984-08-16 α-6-데옥시-테트라싸이클린의 제조방법 KR870001142B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PT77210 1983-08-17
PT77210A PT77210A (fr) 1983-08-17 1983-08-17 Nouveau procede pour preparation de alpha-6-deoxy-tetracyclines
PT7833484A PT78334A (en) 1984-03-29 1984-03-29 Preparation of the alpha-6-deoxy-tetracyclines new process
PT78334 1984-03-29

Publications (2)

Publication Number Publication Date
KR850001897A true KR850001897A (ko) 1985-04-10
KR870001142B1 KR870001142B1 (ko) 1987-06-11

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840004933A KR870001142B1 (ko) 1983-08-17 1984-08-16 α-6-데옥시-테트라싸이클린의 제조방법

Country Status (11)

Country Link
US (1) US4597904A (ko)
EP (1) EP0137661B1 (ko)
KR (1) KR870001142B1 (ko)
AU (1) AU548771B2 (ko)
CA (1) CA1242704A (ko)
DE (1) DE3480339D1 (ko)
DK (1) DK386784A (ko)
ES (1) ES8600734A1 (ko)
FR (1) FR2550788B1 (ko)
HK (1) HK70090A (ko)
NZ (1) NZ209262A (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190067186A (ko) * 2016-10-27 2019-06-14 바나디스 다이아그노스틱스 회전환 증폭 생성물을 처리하는 방법

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743699A (en) * 1982-01-19 1988-05-10 Plurichemie Anstalt Homogeneous catalytic system and a process for the preparation of same
HU198173B (en) * 1987-09-18 1989-08-28 Chinoin Gyogyszer Es Vegyeszet Process for producing doxycycline
US4902447A (en) * 1988-10-28 1990-02-20 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines and hydrogenation catalyst useful therein
EP0391005B1 (en) * 1989-04-03 1991-10-16 Ranbaxy Laboratories, Ltd. Process for the production of alpha-6-deoxytetracyclines
US4987242A (en) * 1988-10-28 1991-01-22 Jagmohan Khanna Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines
JP2665395B2 (ja) * 1989-01-04 1997-10-22 フーバ，インコーポレーテッド α―６―デオキシテトラサイクリン類の製造法
US5049683A (en) * 1989-01-04 1991-09-17 Houba, Inc. Process for the production of alpha-6-deoxytetracyclines
CN103040773A (zh) * 2003-07-25 2013-04-17 沃纳奇尔科特有限责任公司 多西环素金属络合物固体剂型
KR101171408B1 (ko) 2004-05-21 2012-08-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 테트라사이클린 및 이의 유사체의 합성
ES2588584T3 (es) * 2005-01-21 2016-11-03 Warner Chilcott Company, Llc Un complejo metálico de tetraciclina en una forma de dosificación sólida
JP5335664B2 (ja) * 2006-04-07 2013-11-06 プレジデント アンド フェロウズ オブ ハーバード カレッジ テトラサイクリンおよびその類似体の合成
EP2487160B1 (en) 2006-10-11 2016-02-03 President and Fellows of Harvard College Synthesis of Enone Intermediate
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
CN107056641B (zh) * 2017-04-10 2019-05-17 河南师范大学 一种强力霉素的制备方法
CN107098825B (zh) * 2017-04-10 2019-05-31 广东中农联生物制药有限公司 一种强力霉素的高效制备方法
CN113248397B (zh) * 2021-07-01 2021-11-05 山东国邦药业有限公司 一种盐酸多西环素的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA668581A (en) * 1963-08-13 R. D. Mccormick Jerry Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
FR1430859A (ko) * 1960-05-23 1966-05-25
US3484483A (en) * 1966-10-31 1969-12-16 Pfizer & Co C Process for producing alpha-6-deoxytetracyclines
US3444198A (en) * 1967-02-13 1969-05-13 Pfizer & Co C Process for producing alpha-6-deoxytetracyclines
US3397231A (en) * 1967-04-12 1968-08-13 Pfizer & Co C Refining of alpha-6-deoxy-5-oxytetracycline
US3442943A (en) * 1967-08-16 1969-05-06 American Cyanamid Co Process for preparing 6-deoxytetracyclines
AU2940371A (en) * 1970-06-12 1972-11-30 Societa Farmaceutici Italia 6-deoxy-5-oxytetracycline-5-esters
CA942743A (en) * 1970-07-03 1974-02-26 Ivan Villax Process for producing 6-methylenetetracyclines and 6-deoxytetracyclines
US4061676A (en) * 1970-07-03 1977-12-06 Ivan Villax Recovery of doxycycline and products thereof
US3795707A (en) * 1970-12-28 1974-03-05 Rachelle Labor Italia Spa Manufacture of alpha-6-deoxytetracyclines
US4207258A (en) * 1972-02-24 1980-06-10 Ankerfarm S.P.A. Process for the preparatin of α-6-deoxytetracyclines
SE435619C (sv) * 1973-02-01 1985-11-18 Pfizer Forfarande for framstellning av en 6alfa-deoxitetracyklin
US3954862A (en) * 1973-04-20 1976-05-04 Pfizer Inc. Process for producing α-6-deoxytetracyclines
HU167250B (ko) * 1973-06-08 1975-09-27
GB1459861A (en) * 1973-06-21 1976-12-31 Pfizer Process for 11a-dehalogenation of 11a-halotetracyclines
DK501574A (ko) * 1973-09-28 1975-05-26 Ankerfarm Spa
US3907890A (en) * 1974-05-28 1975-09-23 Pfizer Preparation of alpha-6-deoxy-5-hydroxytetracycline
AR208347A1 (es) * 1974-12-19 1976-12-20 Pfizer Mejora en la produccion de alfa-6-deoxitetraciclinas
US4001321A (en) * 1975-06-26 1977-01-04 Pfizer Inc. Preparation of α-6-deoxytetracyclines
US3962131A (en) * 1975-01-28 1976-06-08 Pfizer Inc. Rhodium containing catalyst and use thereof in preparation of 6-deoxy-5-oxytetracycline
GB1593927A (en) * 1978-05-15 1981-07-22 Pliva Pharm & Chem Works T-butyl derivatives of 5-hydroxy-tetracycline and a process for preparing the same
IT1198342B (it) * 1980-07-10 1988-12-21 Carbo Biochimica Srl Processo per la produzione di alfa-6-desossi-tetracicline
DE3131954C2 (de) * 1981-08-13 1984-10-31 Degussa Ag, 6000 Frankfurt Metallkomplexe von polymeren, gegebenenfalls vernetzten Organosiloxanaminen, Verfahren zu ihrer Herstellung und Verwendung
US4500458A (en) * 1982-01-19 1985-02-19 Plurichemie Anstalt Process for the preparation of α-6-deoxytetracyclines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190067186A (ko) * 2016-10-27 2019-06-14 바나디스 다이아그노스틱스 회전환 증폭 생성물을 처리하는 방법

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EP0137661A2 (en) 1985-04-17
ES535223A0 (es) 1985-11-01
ES8600734A1 (es) 1985-11-01
EP0137661B1 (en) 1989-11-02
FR2550788B1 (fr) 1989-11-17
CA1242704A (en) 1988-10-04
KR870001142B1 (ko) 1987-06-11
HK70090A (en) 1990-09-14
DK386784D0 (da) 1984-08-10
DE3480339D1 (en) 1989-12-07
NZ209262A (en) 1987-07-31
FR2550788A1 (fr) 1985-02-22
US4597904A (en) 1986-07-01
DK386784A (da) 1985-02-18
AU548771B2 (en) 1986-01-02
EP0137661A3 (en) 1987-08-19
AU3197984A (en) 1985-02-21

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