KR830001187A - 펜에탄올 아민류, 동몰질을 포함하는 조성물 및 효과적인 체중조절법 - Google Patents

펜에탄올 아민류, 동몰질을 포함하는 조성물 및 효과적인 체중조절법 Download PDF

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Publication number
KR830001187A
KR830001187A KR1019820000619A KR820000619A KR830001187A KR 830001187 A KR830001187 A KR 830001187A KR 1019820000619 A KR1019820000619 A KR 1019820000619A KR 820000619 A KR820000619 A KR 820000619A KR 830001187 A KR830001187 A KR 830001187A
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South Korea
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formula
penethanol
homomolar
amines
composition
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KR1019820000619A
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KR880002310B1 (ko
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밀즈 잭
커트 슈미겔 클라우스
노만 쇼 월터
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아더 알. 웨일
일라이 릴리 앤드 캄파니
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Publication of KR830001187A publication Critical patent/KR830001187A/ko
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Publication of KR880002310B1 publication Critical patent/KR880002310B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/06—Preparation of carboxylic acid nitriles from N-formylated amino compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Dairy Products (AREA)

Abstract

내용 없음

Description

펜에탄올 아민류, 동몰질을 포함하는 조성물 및 효과적인 체중조절법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식(III)의 화합물을 환원시키고 R3가 벤질인 경우에는 벤질기를 가수소분해하여 R3가 하이드록실인 일반식(I) 화합물을 수득하고 R, S-에난티오머만을 얻기 위해 생성된 일반식(I)의 R, S-및 S, S-에난티오머 혼합물을 분리시킴을 특징으로 하여 일반식(I)의 광학적 활성화합물 및 그 염을 제조하는 방법.
    상기식에서
    R1은 수소 또는 불소이고
    R2는 메틸 또는 에틸이며
    R3는 하이드록시, 탄소수 1 내지 4의 알카노일옥시, 아미노카보닐, 메틸아미노카보닐, 또는 탄소수 1내지 2의 알콕시카보닐이며,
    C*는 R 절대 입체 화학적 배위를 가진 비대칭 탄소원자이며,
    는 S 절대 입체 화학적 배위를 가진 비대칭탄소원자를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8200619A 1978-07-03 1982-02-12 펜에탄올 아민류의 제조방법 KR880002310B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92167078A 1978-07-03 1978-07-03
US921670 1978-07-03

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR7902195A Division KR820002065B1 (ko) 1979-07-03 1979-07-03 펜에탄올 아민류의 제조방법

Publications (2)

Publication Number Publication Date
KR830001187A true KR830001187A (ko) 1983-04-29
KR880002310B1 KR880002310B1 (ko) 1988-10-22

Family

ID=25445792

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8200619A KR880002310B1 (ko) 1978-07-03 1982-02-12 펜에탄올 아민류의 제조방법

Country Status (31)

Country Link
EP (3) EP0048037A1 (ko)
JP (2) JPS559097A (ko)
KR (1) KR880002310B1 (ko)
AR (4) AR225744A1 (ko)
AT (2) AT367025B (ko)
AU (2) AU523720B2 (ko)
BE (2) BE877393A (ko)
BG (4) BG31646A3 (ko)
CA (2) CA1142954A (ko)
CH (2) CH643529A5 (ko)
CS (4) CS208662B2 (ko)
DD (2) DD144761A5 (ko)
DE (2) DE2964604D1 (ko)
DK (2) DK160936C (ko)
EG (1) EG14238A (ko)
ES (4) ES482155A1 (ko)
FI (2) FI792082A (ko)
FR (3) FR2430410B1 (ko)
GB (3) GB2028799B (ko)
GR (2) GR72940B (ko)
HU (2) HU179172B (ko)
IE (2) IE48769B1 (ko)
IL (2) IL57671A (ko)
LU (2) LU81457A1 (ko)
NZ (2) NZ190861A (ko)
PH (2) PH14522A (ko)
PL (4) PL121297B1 (ko)
PT (2) PT69843A (ko)
RO (4) RO83052B (ko)
SU (4) SU849997A3 (ko)
ZA (2) ZA793297B (ko)

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DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
EP0028105B1 (en) * 1979-10-25 1983-01-19 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
EP0029320B1 (en) * 1979-11-15 1985-07-10 Beecham Group Plc Secondary ethanol amines, their preparation and their use in pharmaceutical compositions
DE3161165D1 (en) * 1980-05-08 1983-11-17 Beecham Group Plc Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions
DE3264364D1 (en) * 1981-03-06 1985-08-01 Beecham Group Plc Arylethanol amine derivatives, their preparation and use in pharmaceutical compositions
DE3260490D1 (en) * 1981-03-31 1984-09-06 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
EP0070133B1 (en) * 1981-07-11 1986-05-14 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
EP0089154A3 (en) * 1982-03-12 1984-08-08 Beecham Group Plc Ethanolamine derivatives, their preparation and use in pharmaceutical compositions
CA1219865A (en) * 1982-05-14 1987-03-31 Leo Alig Aziridine phenethanolamine derivatives
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
JPS5980640A (ja) * 1982-09-27 1984-05-10 イーライ・リリー・アンド・カンパニー ２−ヒドロキシ−２−フエニルエチルアミン類の製造方法
PL144053B1 (en) * 1983-01-31 1988-04-30 Lilly Co Eli Method of stimulating growth of domesticated animals,improving effectivness of food utilization ba domesticated animals and improving leanness of domesticated animals and fodder pre-mixture
CA1262729A (en) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
US5166218A (en) * 1983-10-19 1992-11-24 Hoffmann-La Roche Inc. Phenoxypropanolamines and pharmaceutical compositions thereof
US4602044A (en) * 1983-12-19 1986-07-22 Eli Lilly And Company β-phenethanolamine antiobesity agents
EP0151513A1 (en) * 1984-01-12 1985-08-14 Eli Lilly And Company Inotropic agent
GB8505284D0 (en) * 1985-03-01 1985-04-03 Beecham Group Plc Growth promoters
PT82120B (en) * 1985-03-01 1988-06-16 Beecham Group Plc Process for preparing veterinary formulations containing ethanolamine derivatives
IT1204416B (it) * 1986-06-27 1989-03-01 Midy Spa Medicamenti a base di analoghi di feniletanolammine per il trattamento di disturbi gastro-intestinali ed uterini
JP2837408B2 (ja) * 1987-05-30 1998-12-16 鐘紡株式会社 アクリル系繊維の処理方法
US5135955A (en) * 1988-04-25 1992-08-04 Eli Lilly And Company Propanamine derivatives
FI892341A (fi) * 1988-06-10 1989-12-11 Hoffmann La Roche Propanolaminderivat.
US5191112A (en) * 1989-10-17 1993-03-02 Nissan Chemical Industries, Ltd. Process for optical resolution of (±)-2-(3-benzoyl)-phenylpropionic acid
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
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US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
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US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
KR100251995B1 (ko) * 1991-08-23 2000-06-01 젠센 제임스 유. 칼슘 수용체 활성 분자
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US5321036A (en) * 1993-02-10 1994-06-14 Bristol-Myers Squibb Company Thiazole and oxazole-based β3 adrenergic receptor agonists
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
CN1312116C (zh) 1994-10-21 2007-04-25 Nps药物有限公司 钙受体活性化合物
DE69722934T2 (de) 1996-05-01 2004-05-27 NPS Pharmaceuticals, Inc., Salt Lake City Verbindungen , die auf anorganische ionen-rezeptoren wirken
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof

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NL56308C (ko) * 1941-03-15
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GB1301134A (en) 1970-07-18 1972-12-29 Pfizer Ltd SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
BE788850A (fr) * 1972-09-15 1973-03-15 Hoffmann La Roche Derives d'acide benzoique
IE39247B1 (en) * 1973-05-07 1978-08-30 Allen & Hanburys Ltd Substituted benzamides
US4000192A (en) * 1973-05-07 1976-12-28 Allen & Hanburys Limited Pharmacologically active compounds
NZ190854A (en) * 1978-06-28 1984-10-19 Beecham Group Ltd 2-hydroxy-2-phenyl ethylamine derivatives;pharmaceutical compositions
CA1145766A (en) * 1978-07-03 1983-05-03 Jack Mills Optically active phenethanolamines and method for increasing cardiac contractility

Also Published As

Publication number Publication date
AU4848779A (en) 1980-01-10
FI792081A (fi) 1980-01-04
ATA463579A (de) 1983-04-15
AU4848979A (en) 1980-01-10
IE791228L (en) 1980-01-03
SU1007554A3 (ru) 1983-03-23
NZ190863A (en) 1982-05-25
GB2028799A (en) 1980-03-12
HU179172B (en) 1982-08-28
GB2028799B (en) 1982-09-08
BE877393A (fr) 1980-01-02
AU523721B2 (en) 1982-08-12
ZA793296B (en) 1981-02-25
RO83051B (ro) 1984-02-28
SU957761A3 (ru) 1982-09-07
AT367025B (de) 1982-05-25
BG31645A3 (en) 1982-02-15
SU849997A3 (ru) 1981-07-23
AR229080A1 (es) 1983-06-15
DE2964091D1 (en) 1982-12-30
FR2450806B1 (fr) 1985-07-12
ES490215A0 (es) 1981-04-16
ES490214A0 (es) 1981-04-16
ES482155A1 (es) 1980-08-16
BG31375A3 (en) 1981-12-15
FR2430410A1 (fr) 1980-02-01
RO77732A (ro) 1981-11-24
RO83051A (ro) 1984-02-21
IL57672A (en) 1983-03-31
GB2101582A (en) 1983-01-19
IE48586B1 (en) 1985-03-20
FR2430411B1 (ko) 1983-08-19
PL117551B1 (en) 1981-08-31
ZA793297B (en) 1981-02-25
CH642618A5 (fr) 1984-04-30
CS208663B2 (en) 1981-09-15
ES8104189A1 (es) 1981-04-16
EP0007204A1 (en) 1980-01-23
CS209815B2 (en) 1981-12-31
EG14238A (en) 1983-12-31
EP0006766A1 (en) 1980-01-09
KR880002310B1 (ko) 1988-10-22
JPS6254095B2 (ko) 1987-11-13
PH15275A (en) 1982-11-02
AR231434A1 (es) 1984-11-30
DE2964604D1 (en) 1983-03-03
BE877394A (fr) 1980-01-02
RO83052B (ro) 1984-02-28
RO83052A (ro) 1984-02-21
PL121297B1 (en) 1982-04-30
ATA463679A (de) 1981-10-15
PT69843A (en) 1979-07-01
ES8104190A1 (es) 1981-04-16
DD144761A5 (de) 1980-11-05
JPS559097A (en) 1980-01-22
PL117997B1 (en) 1981-09-30
LU81458A1 (fr) 1979-10-30
GR74524B (ko) 1984-06-29
FI792082A (fi) 1980-01-04
IL57671A (en) 1982-11-30
CS208664B2 (en) 1981-09-15
PT69839A (en) 1979-07-01
DD144762A5 (de) 1980-11-05
CA1142954A (en) 1983-03-15
IE791227L (en) 1980-01-03
EP0006766B1 (en) 1983-01-26
GB2101582B (en) 1983-06-08
AR225744A1 (es) 1982-04-30
BG31646A3 (en) 1982-02-15
CH643529A5 (fr) 1984-06-15
AU523720B2 (en) 1982-08-12
AT372937B (de) 1983-11-25
LU81457A1 (fr) 1979-10-30
DK160936C (da) 1991-10-21
FR2450806A1 (fr) 1980-10-03
DK268779A (da) 1980-01-04
GB2028802B (en) 1983-03-30
CS208662B2 (en) 1981-09-15
EP0048037A1 (en) 1982-03-24
DK160936B (da) 1991-05-06
BG31647A3 (en) 1982-02-15
ES482156A1 (es) 1980-08-16
RO77728A (ro) 1981-11-24
AR227165A1 (es) 1982-09-30
IE48769B1 (en) 1985-05-15
GR72940B (ko) 1984-01-16
PL117996B1 (en) 1981-09-30
DK268679A (da) 1980-01-04
FR2430410B1 (fr) 1986-03-21
FR2430411A1 (fr) 1980-02-01
PL216814A1 (ko) 1980-03-24
JPS559096A (en) 1980-01-22
NZ190861A (en) 1981-12-15
IL57671A0 (en) 1979-10-31
IL57672A0 (en) 1979-10-31
HU179171B (en) 1982-08-28
CA1145767A (en) 1983-05-03
PH14522A (en) 1981-08-26
EP0007204B1 (en) 1982-11-24
GB2028802A (en) 1980-03-12
PL216811A1 (ko) 1980-08-25
SU965350A3 (ru) 1982-10-07

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