KR840008651A - 퓨로-(3,4-c)-피리딘 유도체의 제조방법 - Google Patents

퓨로-(3,4-c)-피리딘 유도체의 제조방법 Download PDF

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Publication number
KR840008651A
KR840008651A KR1019840001772A KR840001772A KR840008651A KR 840008651 A KR840008651 A KR 840008651A KR 1019840001772 A KR1019840001772 A KR 1019840001772A KR 840001772 A KR840001772 A KR 840001772A KR 840008651 A KR840008651 A KR 840008651A
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South Korea
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group
carbon atoms
alkoxy
alkyl
methyl
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KR1019840001772A
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English (en)
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KR900005518B1 (ko
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에사뉘(외 1) 앙드레
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제라트 보푸
쏘시에떼 드 꽁세이 드 르셰르셰 에 다쁠리까시옹 시앙띠휘끄
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Priority claimed from GB838327815A external-priority patent/GB8327815D0/en
Application filed by 제라트 보푸, 쏘시에떼 드 꽁세이 드 르셰르셰 에 다쁠리까시옹 시앙띠휘끄 filed Critical 제라트 보푸
Publication of KR840008651A publication Critical patent/KR840008651A/ko
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Publication of KR900005518B1 publication Critical patent/KR900005518B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

퓨로-(3,4-C)-피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 이차 알코올 α4,3-0-이소프로필리덴-1-메틸-5-(1-하이드록시-1-A₁)-메틸을 통상적인 방법으로 산화하여 케론을 생성하고 이 결과물을 끓이면서 디에틸 에테르내의 마그네슘 존재하에 XA₂(여기서 X는 Br 또는 I이고 A₂는 후술되는 바와 같다)와 반응시킨후 결과의 삼차 알코올을 이소프로필리덴 환과 3,4-환화작용을 깨기위해 산성제로 처리하는 것으로 성상된, 다음 일반식(1)의 1,3-디하이드로-6-메틸-7-하이드록시-퓨로-(3,4-C)-피리딘 유도체의 제조방법.
    여기서, A₁및 A₂는 각각 독립적으로 1-5개 탄소원자의 직쇄 포화 또는 불포화 탄화수소그룹, 6개까지의 환(環) 원자를 가지는 헤테로사이클 그륨, 카보모노사이클 그룹, 페닐알킬그룹 또는 페닐알케닐 그룹을 나타내며, A₁및 A₂로 표시되는 각각의 그룹은 비치환된 상태로 있거나 한개 이상의 염소 또는 불소원자,트리플루오로메틸 그룹, 1-5개 탄소원자의 알킬그룹, 1-5개 탄소원자의 알콕시그룹, 1-5개 탄소원자의 알킬 티오그룹, 디알킬 아미노 그룹(여기서 각각의 알킬그룹은 1-6개 탄소원자를 가짐), 디알킬아미노 알콕시그룹(여기서 두개 알킬그룹 및 알콕시 그룹 각각은 1-5개 탄소원자를 가짐) 또는 α-또는 β-알콕시-N-피롤리디닐 그룹(여기서 알콕시 그룹은 1-5개의 탄소원자를 가짐)으로 치환되어 있다.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019840001772A 1983-04-05 1984-04-04 퓨로-(3,4-c)-피리딘 유도체의 제조방법 KR900005518B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8309165 1983-04-05
GB8309165 1983-04-05
GB8327815 1983-10-18
GB838327815A GB8327815D0 (en) 1983-10-18 1983-10-18 Furo-(3 4-c)-pyridine derivatives

Publications (2)

Publication Number Publication Date
KR840008651A true KR840008651A (ko) 1984-12-17
KR900005518B1 KR900005518B1 (ko) 1990-07-30

Family

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KR1019840001772A KR900005518B1 (ko) 1983-04-05 1984-04-04 퓨로-(3,4-c)-피리딘 유도체의 제조방법

Country Status (29)

Country Link
US (1) US4581363A (ko)
JP (1) JPS59193888A (ko)
KR (1) KR900005518B1 (ko)
AU (1) AU582113B2 (ko)
CA (1) CA1257269A (ko)
CH (1) CH660191A5 (ko)
DE (1) DE3412885C2 (ko)
DK (1) DK157931C (ko)
DZ (1) DZ629A1 (ko)
EG (1) EG18150A (ko)
ES (1) ES531285A0 (ko)
FI (1) FI76804C (ko)
FR (2) FR2543956B1 (ko)
GR (1) GR79577B (ko)
HK (1) HK11187A (ko)
IE (1) IE57424B1 (ko)
IL (1) IL71243A (ko)
IN (1) IN160104B (ko)
IT (1) IT1173770B (ko)
LU (1) LU85262A1 (ko)
MA (1) MA20084A1 (ko)
MX (1) MX167397B (ko)
MY (1) MY8600664A (ko)
NL (1) NL190328C (ko)
NO (1) NO161802C (ko)
NZ (1) NZ207552A (ko)
OA (1) OA07699A (ko)
PT (1) PT78361B (ko)
SE (1) SE458362B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735950A (en) * 1983-04-05 1988-04-05 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S) Furo-(3,4-C)-pyridine derivatives and therapeutic composition containing the same
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
DE3990349T1 (de) * 1988-04-06 1990-04-26 Scras Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
GB8917168D0 (en) * 1989-07-27 1989-09-13 Scras Asymmetric synthesis of furo(3,4-c)pyridine derivatives
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
AU763464B2 (en) 1999-03-08 2003-07-24 Medicure Inc. Pyridoxal analogues for vitamin B-6 disorders
CA2376029A1 (en) * 1999-07-13 2001-01-18 Medicure Inc. Use of pyridoxin derivatives for the treatment of diabetes and related complications
CA2383252A1 (en) 1999-08-24 2001-03-01 Medicure International Inc. Treatment of cardiovascular related pathologies
JP2003525303A (ja) 2000-02-29 2003-08-26 メディキュア インターナショナル インコーポレイテッド 心臓保護ホスホン酸塩およびマロン酸塩
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
JP2003528146A (ja) 2000-03-28 2003-09-24 メディキュア インターナショナル インコーポレイテッド 脳血管疾患の治療
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
WO2002004421A2 (en) 2000-07-07 2002-01-17 Medicure International Inc. Pyridoxine and pyridoxal analogues: cardiovascular therapeutics
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
WO2006002549A1 (en) * 2004-07-07 2006-01-12 Medicure International Inc. Combination therapies employing platelet aggregation drugs
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
AU2005304220A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
CA2632090A1 (en) * 2005-11-28 2007-05-31 Medicure International Inc. Selected dosage for the treatment of cardiovascular and related pathologies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2008582B (en) * 1977-11-25 1982-04-28 Scras Pyridine derivative
ZA786269B (en) * 1977-11-25 1979-10-31 Scras New pyridine derivative,its preparation and use
IN156817B (ko) * 1981-02-10 1985-11-09 Scras

Also Published As

Publication number Publication date
FR2543829B1 (fr) 1986-11-21
DK178084D0 (da) 1984-04-04
HK11187A (en) 1987-02-13
KR900005518B1 (ko) 1990-07-30
NO841322L (no) 1984-10-08
EG18150A (en) 1992-08-30
NO161802C (no) 1989-09-27
IT8420396A0 (it) 1984-04-05
AU2640184A (en) 1984-10-11
PT78361B (en) 1986-05-28
AU582113B2 (en) 1989-03-16
OA07699A (fr) 1985-08-30
IE840826L (en) 1984-10-05
US4581363A (en) 1986-04-08
GR79577B (ko) 1984-10-30
SE8401841L (sv) 1984-10-06
SE458362B (sv) 1989-03-20
ES8601998A1 (es) 1985-11-01
NL8401013A (nl) 1984-11-01
PT78361A (en) 1984-05-01
MY8600664A (en) 1986-12-31
CH660191A5 (fr) 1987-03-31
IL71243A (en) 1987-12-20
JPH0556353B2 (ko) 1993-08-19
IE57424B1 (en) 1992-09-09
FI841273A0 (fi) 1984-03-30
DK157931B (da) 1990-03-05
NL190328C (nl) 1994-01-17
DE3412885A1 (de) 1984-10-11
LU85262A1 (fr) 1984-10-24
MA20084A1 (fr) 1984-12-31
NL190328B (nl) 1993-08-16
SE8401841D0 (sv) 1984-04-03
CA1257269A (en) 1989-07-11
JPS59193888A (ja) 1984-11-02
MX167397B (es) 1993-03-22
DE3412885C2 (de) 1990-10-04
DZ629A1 (fr) 2004-09-13
FR2543956A1 (fr) 1984-10-12
FR2543829A1 (fr) 1984-10-12
FI76804B (fi) 1988-08-31
IL71243A0 (en) 1984-06-29
ES531285A0 (es) 1985-11-01
FI841273A (fi) 1984-10-06
FI76804C (fi) 1988-12-12
NO161802B (no) 1989-06-19
IN160104B (ko) 1987-06-27
IT1173770B (it) 1987-06-24
DK157931C (da) 1990-08-27
FR2543956B1 (fr) 1986-07-04
NZ207552A (en) 1986-05-09
DK178084A (da) 1984-10-06

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