ES8601998A1 - Procedimiento de preparacion de derivados de 1,3-dihidro-6-metil-7-hidroxi-furo-(3,4-c)-piridina - Google Patents

Procedimiento de preparacion de derivados de 1,3-dihidro-6-metil-7-hidroxi-furo-(3,4-c)-piridina

Info

Publication number
ES8601998A1
ES8601998A1 ES531285A ES531285A ES8601998A1 ES 8601998 A1 ES8601998 A1 ES 8601998A1 ES 531285 A ES531285 A ES 531285A ES 531285 A ES531285 A ES 531285A ES 8601998 A1 ES8601998 A1 ES 8601998A1
Authority
ES
Spain
Prior art keywords
methyl
furo
compositions containing
same
pyridine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531285A
Other languages
English (en)
Other versions
ES531285A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838327815A external-priority patent/GB8327815D0/en
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES531285A0 publication Critical patent/ES531285A0/es
Publication of ES8601998A1 publication Critical patent/ES8601998A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 1,3-DIHIDRO-6-METIL-7-HIDROXI-FURO(3,4-C)-PIRIDINA, DE FORMULA GENERAL (I). COMPRENDE OXIDAR EL ALCOHOL SECUNDARIO A4,3-O-ISOPROPILIDEN-1-METIL-(1-HIDROXI-1-A1)-METILPIRIDINA POR CUALQUIER TECNICA USUAL, HACER REACCIONAR LA CETONA RESULTANTE CON UN COMPUESTO DE FORMULA GENERAL XA2, DONDE X REPRESENTA BR O I, EN PRESENCIA DE MAGNESIO EN ETER DIETILICO, A EBULLICION, Y TRATAR EL ALCOHOL TERCIARIO RESULTANTE CON UN AGENTE ACIDO, PARA PROVOCAR LA ROTURA DEL ANILLO DE ISOPROPILIDENO Y LA CICLACION EN 3,4.
ES531285A 1983-04-05 1984-04-04 Procedimiento de preparacion de derivados de 1,3-dihidro-6-metil-7-hidroxi-furo-(3,4-c)-piridina Expired ES8601998A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8309165 1983-04-05
GB838327815A GB8327815D0 (en) 1983-10-18 1983-10-18 Furo-(3 4-c)-pyridine derivatives

Publications (2)

Publication Number Publication Date
ES531285A0 ES531285A0 (es) 1985-11-01
ES8601998A1 true ES8601998A1 (es) 1985-11-01

Family

ID=26285725

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531285A Expired ES8601998A1 (es) 1983-04-05 1984-04-04 Procedimiento de preparacion de derivados de 1,3-dihidro-6-metil-7-hidroxi-furo-(3,4-c)-piridina

Country Status (29)

Country Link
US (1) US4581363A (es)
JP (1) JPS59193888A (es)
KR (1) KR900005518B1 (es)
AU (1) AU582113B2 (es)
CA (1) CA1257269A (es)
CH (1) CH660191A5 (es)
DE (1) DE3412885C2 (es)
DK (1) DK157931C (es)
DZ (1) DZ629A1 (es)
EG (1) EG18150A (es)
ES (1) ES8601998A1 (es)
FI (1) FI76804C (es)
FR (2) FR2543956B1 (es)
GR (1) GR79577B (es)
HK (1) HK11187A (es)
IE (1) IE57424B1 (es)
IL (1) IL71243A (es)
IN (1) IN160104B (es)
IT (1) IT1173770B (es)
LU (1) LU85262A1 (es)
MA (1) MA20084A1 (es)
MX (1) MX167397B (es)
MY (1) MY8600664A (es)
NL (1) NL190328C (es)
NO (1) NO161802C (es)
NZ (1) NZ207552A (es)
OA (1) OA07699A (es)
PT (1) PT78361B (es)
SE (1) SE458362B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735950A (en) * 1983-04-05 1988-04-05 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S) Furo-(3,4-C)-pyridine derivatives and therapeutic composition containing the same
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
DE3990349T1 (de) * 1988-04-06 1990-04-26 Scras Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen
GB8917168D0 (en) * 1989-07-27 1989-09-13 Scras Asymmetric synthesis of furo(3,4-c)pyridine derivatives
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
ES2250112T3 (es) 1999-03-08 2006-04-16 Medicure Inc. Analogos de piridoxal para el tratamiento de trastornos causados por carencia de vitamina b6.
CA2376029A1 (en) 1999-07-13 2001-01-18 Medicure Inc. Use of pyridoxin derivatives for the treatment of diabetes and related complications
WO2001013900A2 (en) * 1999-08-24 2001-03-01 Medicure International Inc. Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
ATE293119T1 (de) 2000-02-29 2005-04-15 Medicure Int Inc Cardioprotektive phosphonate
AU784840B2 (en) 2000-03-28 2006-07-06 Medicure International Inc. Treatment of cerebrovascular disease
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
EP1299358B1 (en) 2000-07-07 2007-06-13 Medicure International Inc. Pyridoxine and pyridoxal analogues as cardiovascular therapeutics
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
AU2005259735A1 (en) * 2004-07-07 2006-01-12 Medicure International Inc. Combination therapies employing platelet aggregation drugs
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
AU2005304220A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
AU2006317440A1 (en) * 2005-11-28 2007-05-31 Medicure International Inc. Selected dosage for the treatment of cardiovascular and related pathologies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2008582B (en) * 1977-11-25 1982-04-28 Scras Pyridine derivative
ZA786269B (en) * 1977-11-25 1979-10-31 Scras New pyridine derivative,its preparation and use
IN156817B (es) * 1981-02-10 1985-11-09 Scras

Also Published As

Publication number Publication date
FI76804B (fi) 1988-08-31
PT78361A (en) 1984-05-01
FR2543829B1 (fr) 1986-11-21
NO161802C (no) 1989-09-27
HK11187A (en) 1987-02-13
SE458362B (sv) 1989-03-20
OA07699A (fr) 1985-08-30
CA1257269A (en) 1989-07-11
MA20084A1 (fr) 1984-12-31
IE840826L (en) 1984-10-05
DZ629A1 (fr) 2004-09-13
NL190328C (nl) 1994-01-17
KR900005518B1 (ko) 1990-07-30
NZ207552A (en) 1986-05-09
GR79577B (es) 1984-10-30
DK178084A (da) 1984-10-06
DK178084D0 (da) 1984-04-04
SE8401841D0 (sv) 1984-04-03
IL71243A (en) 1987-12-20
FI841273A (fi) 1984-10-06
MX167397B (es) 1993-03-22
EG18150A (en) 1992-08-30
IT8420396A0 (it) 1984-04-05
FI841273A0 (fi) 1984-03-30
FR2543956A1 (fr) 1984-10-12
IL71243A0 (en) 1984-06-29
PT78361B (en) 1986-05-28
IE57424B1 (en) 1992-09-09
SE8401841L (sv) 1984-10-06
NO841322L (no) 1984-10-08
DE3412885A1 (de) 1984-10-11
JPH0556353B2 (es) 1993-08-19
MY8600664A (en) 1986-12-31
IT1173770B (it) 1987-06-24
KR840008651A (ko) 1984-12-17
NL190328B (nl) 1993-08-16
ES531285A0 (es) 1985-11-01
NO161802B (no) 1989-06-19
FI76804C (fi) 1988-12-12
DK157931B (da) 1990-03-05
FR2543956B1 (fr) 1986-07-04
LU85262A1 (fr) 1984-10-24
US4581363A (en) 1986-04-08
JPS59193888A (ja) 1984-11-02
NL8401013A (nl) 1984-11-01
DK157931C (da) 1990-08-27
AU2640184A (en) 1984-10-11
FR2543829A1 (fr) 1984-10-12
IN160104B (es) 1987-06-27
CH660191A5 (fr) 1987-03-31
DE3412885C2 (de) 1990-10-04
AU582113B2 (en) 1989-03-16

Similar Documents

Publication Publication Date Title
ES8601998A1 (es) Procedimiento de preparacion de derivados de 1,3-dihidro-6-metil-7-hidroxi-furo-(3,4-c)-piridina
PT78751A (en) Preparation process of 2-pyrimidinyl-1-piperazine derivatives and medicines containing them
PT77125A (en) Process for preparing triphenylimidazolyloxy-alkanoic acids and their derivatives and of pharmaceutical compositions containing these compounds
SE8405754L (sv) 7-karboximetoxi-furo-(3,4-c)-pyridinderivat, framstellning derav och terapeutiska kompositioner innehallande dem
IL112622A (en) Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them
ES8506705A1 (es) Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles
PT77370A (en) Process for preparing new pyrazolo <3,4-b> piridine derivatives and pharmaceutical preparations containing the same
ES8401960A1 (es) Procedimiento para la preparacion de imidazolilfenil-tetrahidropiridazinas.
ES8403910A1 (es) Procedimiento para la preparacion de nitratos de amino-deso-xi-1.4;3.6-dianhidro-hexito,asi como de sus sales de adicionacida farmacologicamente inocuas
IE781013L (en) Pyrido-indole tranquilisers
ES8609319A1 (es) Procedimiento de preparacion de nuevas fenil-naftiridinas.
ES8307249A1 (es) Procedimiento de preparacion de nuevos derivados del adamantano.
ES8104222A1 (es) Un procedimiento para la preparacion de derivados del acido 7-oxo-1-aza-biciclo (3,2,0) hept-2-en-2-carboxilico
ES8601209A1 (es) Procedimiento para preparar derivados de 5h-(1)-benzopirano-(2,3-d)pirimidina
ES8403911A1 (es) Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0
IE811626L (en) Anthracycline glycosides
JPS53116321A (en) Purification of organocyano compounds
ES8303299A1 (es) Procedimiento de preparacion de un nuevo derivado de acido benzamido-alquil-hidroxamico.
DE3065093D1 (en) Therapeutic composition based on imidazoles, especially for the treatment of thromboses; imidazoles and process for their preparation
ES8203087A1 (es) Procedimiento para la obtencion de imidazolil-indeno-tiofe- nos
DE3275465D1 (en) Thiolactime ethers of delta-1-pyrrolidine, and their preparation
JPS5646811A (en) Antibacterial containing 1,8-naphthylidine derivative as the effective component
ATE43586T1 (de) Arphameninderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000601