KR20240045379A - 재조합 알칼리성 포스파타제를 이용한 발작 치료 - Google Patents
재조합 알칼리성 포스파타제를 이용한 발작 치료 Download PDFInfo
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- KR20240045379A KR20240045379A KR1020247010346A KR20247010346A KR20240045379A KR 20240045379 A KR20240045379 A KR 20240045379A KR 1020247010346 A KR1020247010346 A KR 1020247010346A KR 20247010346 A KR20247010346 A KR 20247010346A KR 20240045379 A KR20240045379 A KR 20240045379A
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Landscapes
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| US201562259307P | 2015-11-24 | 2015-11-24 | |
| US62/259,307 | 2015-11-24 | ||
| PCT/US2015/064003 WO2016090251A1 (en) | 2014-12-05 | 2015-12-04 | Treating seizure with recombinant alkaline phosphatase |
| KR1020177018619A KR20170095278A (ko) | 2014-12-05 | 2015-12-04 | 재조합 알칼리성 포스파타제를 이용한 발작 치료 |
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| DE602005027461D1 (de) | 2004-04-21 | 2011-05-26 | Enobia Pharma Inc | Konjugate zur zuführung an knochen und verfahren zu deren verwendung beim hinführen von proteinen zum knochen |
| US10822596B2 (en) | 2014-07-11 | 2020-11-03 | Alexion Pharmaceuticals, Inc. | Compositions and methods for treating craniosynostosis |
| JP6787894B2 (ja) | 2014-12-05 | 2020-11-18 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 組換えアルカリホスファターゼを用いた発作の処置 |
| JP6868561B2 (ja) | 2015-01-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼ欠損を有する被験者を治療する方法 |
| JP6993961B2 (ja) | 2015-08-17 | 2022-01-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼの製造 |
| EP3355904A4 (en) | 2015-09-28 | 2019-06-12 | Alexion Pharmaceuticals, Inc. | IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA |
| WO2017074466A1 (en) | 2015-10-30 | 2017-05-04 | Alexion Pharmaceuticals, Inc. | Methods for treating craniosynostosis in a patient |
| WO2017155569A1 (en) | 2016-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| KR20240160671A (ko) | 2016-04-01 | 2024-11-11 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼리성 포스파타아제로 근육 약화의 치료 |
| US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| EP3464573B1 (en) | 2016-06-06 | 2026-03-04 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| EP3500289B1 (en) * | 2016-08-18 | 2024-10-09 | Alexion Pharmaceuticals, Inc. | Asfotase alfa for use in treating tracheobronchomalacia |
| CN106591255B (zh) * | 2017-01-13 | 2019-07-02 | 山东省医药生物技术研究中心 | 人碱性磷酸酶糖蛋白的癌细胞高效表达系统及其应用 |
| WO2018164995A1 (en) * | 2017-03-09 | 2018-09-13 | Alexion Pharmaceuticals, Inc . | Glycoprotein manufacturing process |
| KR20190129058A (ko) * | 2017-03-31 | 2019-11-19 | 알렉시온 파마슈티칼스, 인코포레이티드 | 성인 및 청소년에서 저포스파타제증 (hpp)을 치료하는 방법 |
| CA3087569A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| EP4275761A3 (en) | 2018-03-20 | 2024-02-28 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| WO2019183208A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| US11913039B2 (en) | 2018-03-30 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Method for producing recombinant alkaline phosphatase |
| CN110499284A (zh) * | 2018-05-17 | 2019-11-26 | 西安组织工程与再生医学研究所 | Wnt信号通路激活剂在制备治疗基因ALPL敲除小鼠牙硬组织矿化异常产品中的应用 |
| ES2972119T3 (es) | 2018-08-10 | 2024-06-11 | Alexion Pharma Inc | Cicatrización ósea en implantes utilizando fosfatasa alcalina |
| KR20220005560A (ko) | 2019-05-06 | 2022-01-13 | 신세틱 바이오로직스, 인코퍼레이티드 | 알칼리성 포스페이트-기반 종양학 치료제 |
| KR20220111693A (ko) | 2019-12-09 | 2022-08-09 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼리성 포스파타제 폴리펩티드 및 이의 이용 방법 |
| AU2021338361A1 (en) * | 2020-09-03 | 2023-04-06 | Chen, Irvin S.Y | Soluble alkaline phosphatase constructs and expression vectors including a polynucleotide encoding for soluble alkaline phosphatase constructs |
| US12083169B2 (en) | 2021-02-12 | 2024-09-10 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| JP7720105B2 (ja) * | 2021-03-23 | 2025-08-07 | 学校法人日本医科大学 | 組織非特異型アルカリホスファターゼの送達のための遺伝子療法構築物およびその使用方法 |
| CN115575646B (zh) * | 2022-11-21 | 2023-04-28 | 四川大学华西医院 | 一种代谢标志物组在制备预测癫痫发作的试剂盒中的用途 |
| WO2025097067A2 (en) * | 2023-11-02 | 2025-05-08 | Be Biopharma, Inc. | Engineered cell preparations for treatment of hypophosphatasia |
Family Cites Families (192)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1339210C (en) | 1988-05-31 | 1997-08-05 | John Lewicki | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
| US6406697B1 (en) | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US6541610B1 (en) | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
| DK0478797T3 (da) | 1990-04-20 | 1995-06-26 | Hisayuki Matsuo | Nyt fysiologisk aktivt peptid stammende fra gris |
| JP3026351B2 (ja) | 1990-07-13 | 2000-03-27 | 壽之 松尾 | ブタｃｎｐ遺伝子及び前駆体蛋白 |
| JP2930380B2 (ja) | 1990-07-13 | 1999-08-03 | 壽之 松尾 | ブタ由来新規生理活性ペプチド（ｃｎｐ―５３） |
| JP2977159B2 (ja) | 1990-09-07 | 1999-11-10 | 壽之 松尾 | カエル由来新規生理活性ペプチド（カエルｃｎｐ） |
| JP2977158B2 (ja) | 1990-09-07 | 1999-11-10 | 壽之 松尾 | トリ由来新規生理活性ペプチド（ニワトリｃｎｐ） |
| JP3026352B2 (ja) | 1990-09-11 | 2000-03-27 | 壽之 松尾 | ラットＣＮＰｃＤＮＡ及び前駆体蛋白 |
| JP3026354B2 (ja) | 1990-09-27 | 2000-03-27 | 壽之 松尾 | ヒトｃｎｐ遺伝子及び前駆体蛋白 |
| JP2809533B2 (ja) | 1991-01-31 | 1998-10-08 | 壽之 松尾 | Ｃｎｐ類似体ペプチド |
| JPH07500315A (ja) | 1991-05-10 | 1995-01-12 | セルトリックス ファーマシューティカルズ，インコーポレイテッド | 骨成長因子の標的送達 |
| WO1994020534A1 (en) | 1993-03-03 | 1994-09-15 | Mayo Foundation For Medical Education And Research | Vasonatrin peptide and analogs thereof |
| ES2249761T3 (es) | 1993-06-24 | 2006-04-01 | Advec Inc. | Vectores de adenovirus para terapia genica. |
| AU4835693A (en) | 1993-08-13 | 1995-03-14 | Rijksuniversiteit Te Groningen | Pharmaceutical composition comprising phosphatase or a derivative thereof |
| EP1637608B1 (en) | 1993-10-25 | 2009-07-22 | CANJI, Inc. | Recombinant adenoviral vector and methods of use |
| DE69432123T2 (de) | 1993-11-12 | 2004-01-08 | Genentech, Inc., South San Francisco | Rezeptor spezifische atrio-natriuretische peptide |
| US5665704A (en) | 1993-11-12 | 1997-09-09 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| US5846932A (en) | 1993-11-12 | 1998-12-08 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| US6525022B1 (en) | 1993-11-12 | 2003-02-25 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
| US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
| WO1995033769A1 (de) | 1994-06-02 | 1995-12-14 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von cardiodilatin-fragmenten, hochgereinigte cardiodilatin-fragmente und zwischenprodukte zu deren herstellung |
| JPH0870875A (ja) | 1994-09-05 | 1996-03-19 | Tosoh Corp | 組換えアルカリフォスファタ−ゼ融合タンパク質 |
| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| ZA979060B (en) | 1996-10-22 | 1999-04-09 | Genentech Inc | Receptor selective BNP |
| US6028055A (en) | 1996-10-22 | 2000-02-22 | Genetech, Inc. | Receptor selective BNP |
| CA2280957A1 (en) | 1997-02-14 | 1998-08-20 | Leslie Orgel | Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents |
| JP4394279B2 (ja) | 1998-03-09 | 2010-01-06 | ジーランド ファーマ アクティーゼルスカブ | 酵素加水分解に対する傾向が減少した薬理学的に活性なペプチド複合体 |
| CA2245903A1 (en) | 1998-09-28 | 2000-03-28 | Mcgill University | Use of pex in the treatment of metabolic bone diseases |
| CA2260376A1 (en) | 1999-02-11 | 2000-08-11 | Universite De Montreal | New metalloproteases of the neprilysin family |
| CA2262056A1 (en) | 1999-02-24 | 2000-08-24 | Guy Boileau | Composition, methods and reagents for the synthesis of a soluble form of human pex |
| AU2495200A (en) | 1999-03-08 | 2000-09-28 | Genentech Inc. | Compositions and methods for the treatment of tumor |
| EP1176985A2 (en) | 1999-04-28 | 2002-02-06 | Vectramed, Inc. | Enzymatically activated polymeric drug conjugates |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US20040266673A1 (en) | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| JP2000327583A (ja) | 1999-05-17 | 2000-11-28 | Medei Sci Puraningu:Kk | 骨指向性ホルモン誘導体 |
| PT1105409E (pt) | 1999-05-17 | 2006-07-31 | Conjuchem Inc | Proteccao de peptidos terapeuticos endogenos da actividade de peptidases por conjugacao a componentes do sangue |
| DE19942230C2 (de) | 1999-09-03 | 2003-09-25 | Wolf-Georg Forssmann | Verwendung natriuretischer Peptide als antibiotisch wirksame Subsanzen zur Behandlung von bakteriellen Infektionen |
| ES2284545T3 (es) | 1999-11-16 | 2007-11-16 | Genzyme Corporation | Vectores y transgenes con elementos reguladores para la administracion de genes del higado. |
| US6407211B1 (en) | 1999-12-17 | 2002-06-18 | Mayo Foundation For Medical Education And Research | Chimeric natriuretic peptides |
| US20020103161A1 (en) | 1999-12-17 | 2002-08-01 | Manfred Weigele | Novel heterocycles |
| CN1233331C (zh) * | 2000-01-10 | 2005-12-28 | 李世林 | 以头部渗透疗法为主治疗癫痫症的药物 |
| JP4237375B2 (ja) | 2000-03-31 | 2009-03-11 | アスビオファーマ株式会社 | 虚血性疾患の処置又は予防に用いる医薬組成物 |
| US7678391B2 (en) | 2000-04-26 | 2010-03-16 | Queen's University At Kingston | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype |
| EP1502604A1 (en) | 2000-04-26 | 2005-02-02 | Cellegy Pharmaceuticals, Inc | Use of nitric oxide mimetics in cancer treatment |
| JP2003531179A (ja) | 2000-04-26 | 2003-10-21 | クイーンズ ユニバーシティ アット キングストン | 悪性細胞表現型に対し一酸化窒素模倣体を使用する処方および方法 |
| US20050142217A1 (en) | 2000-04-26 | 2005-06-30 | Adams Michael A. | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype |
| US6830885B1 (en) | 2000-08-18 | 2004-12-14 | Phenogene Therapeutiques Inc. | Nucleic acid molecule, method and kit for selecting a nucleic acid having a desired feature |
| CA2418461A1 (en) | 2000-08-23 | 2002-02-28 | Biomep Inc. | Method and compositions for promoting osteogenesis |
| US6436386B1 (en) | 2000-11-14 | 2002-08-20 | Shearwater Corporation | Hydroxyapatite-targeting poly (ethylene glycol) and related polymers |
| BR0116024A (pt) | 2000-12-07 | 2005-12-13 | Lilly Co Eli | Proteìna de fusão heteróloga e uso da mesma |
| JP2002178279A (ja) | 2000-12-12 | 2002-06-25 | Ulvac Japan Ltd | 基板搬送方法 |
| AU2002255478A1 (en) | 2001-01-10 | 2002-09-12 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| JP2002246704A (ja) | 2001-02-16 | 2002-08-30 | Philips Japan Ltd | 電子装置及び回路装置 |
| IL142118A0 (en) | 2001-03-20 | 2002-03-10 | Prochon Biotech Ltd | Method and composition for treatment of skeletal dysplasias |
| WO2002092020A2 (en) | 2001-03-23 | 2002-11-21 | The Burnham Institute | Compositions and methods for modulating bone mineral deposition |
| US7888372B2 (en) | 2001-03-23 | 2011-02-15 | National Institutes Of Health (Nih) | Compositions and methods for modulating bone mineral deposition |
| ATE437221T1 (de) | 2001-05-14 | 2009-08-15 | Gbp Ip Llc | Lentivirale vektoren kodierend für gerinnungsfaktoren für die gentherapie |
| JP3935487B2 (ja) | 2001-07-16 | 2007-06-20 | フーベルト・ケスター | 捕獲化合物、その収集物、ならびにプロテオームおよび複合組成物の分析方法 |
| BRPI0203172B8 (pt) | 2001-09-28 | 2021-05-25 | Nakao Kazuwa | composição farmacêutica para acondroplasia |
| US20050202442A1 (en) | 2003-12-15 | 2005-09-15 | Morris David W. | Novel therapeutic targets in cancer |
| AU2002356392A1 (en) | 2001-12-20 | 2003-07-09 | Phenogene Therapeutiques Inc. | Bone polypeptide-1 |
| EP2261250B1 (en) | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin fusion proteins |
| US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| US20030158132A1 (en) | 2002-01-22 | 2003-08-21 | Genvec, Inc. | Method for enhancing bone density or formation |
| JP2005527510A (ja) | 2002-03-06 | 2005-09-15 | セレジー ファーマシューティカルズ インコーポレーティッド | 癌の治療において一酸化窒素模倣体を使用するための製剤および方法 |
| US20050113286A1 (en) | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| US20040077537A1 (en) | 2002-03-18 | 2004-04-22 | Schreiner George F. | Method for treating congestive heart failure |
| IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
| CA2433479A1 (en) | 2002-07-22 | 2004-01-22 | F. Hoffmann-La Roche Ag | Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof |
| AU2003246500A1 (en) | 2002-07-31 | 2004-02-16 | Conjuchem Biotechnologies Inc. | Long lasting natriuretic peptide derivatives |
| AU2003270427A1 (en) | 2002-09-06 | 2004-03-29 | University Of South Florida | Cellular delivery of natriuretic peptides |
| WO2004046194A2 (en) | 2002-11-18 | 2004-06-03 | Syn X Pharma, Inc. | Polyclonal-monoclonal elisa assay for detecting n-terminus probnp |
| US7648962B2 (en) | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
| AU2003297583B2 (en) | 2002-11-26 | 2010-01-14 | Biocon, Ltd | Modified naturetic compounds, conjugates, and uses thereof |
| US7105539B2 (en) | 2002-12-03 | 2006-09-12 | Enobia Pharma | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex |
| WO2004062555A2 (en) | 2003-01-13 | 2004-07-29 | Gudrun Rappold-Hoerbrand | Use of natriuretic peptides for the treatment of stature disorders related to the shox gene |
| CA2516128A1 (en) | 2003-02-14 | 2004-09-02 | Sagres Discovery, Inc. | Therapeutic targets in cancer |
| US7488713B2 (en) | 2004-03-18 | 2009-02-10 | University Of South Florida | Cancer treatment using C-type natriuretic peptides |
| WO2004094460A2 (en) | 2003-04-17 | 2004-11-04 | Ciphergen Biosystems, Inc. | Polypeptides related to natriuretic peptides and methods of their identification and use |
| JP2007501021A (ja) | 2003-05-30 | 2007-01-25 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 遺伝子操作された定常領域を含む、抗体および融合タンパク質 |
| DK1644740T3 (da) | 2003-06-17 | 2011-02-21 | Otago Innovation Ltd | Vurdering af skeletal vækst ved anvendelse af målinger af NT-CNP-peptider |
| PT1638443E (pt) | 2003-06-20 | 2011-01-25 | Mayo Foundation | Isoformas de péptido natriurético cerebral |
| WO2005052593A1 (en) | 2003-10-29 | 2005-06-09 | The University Of Leicester | Detection |
| US7431915B2 (en) | 2003-10-31 | 2008-10-07 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
| ATE555133T1 (de) | 2003-11-13 | 2012-05-15 | Hanmi Holdings Co Ltd | Igg fc fragment für einen arzneimittelträger und verfahren zu dessen herstellung |
| US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| WO2005070446A1 (en) | 2004-01-15 | 2005-08-04 | Scios Inc. | Method for treating cardiac remodeling following myocardial injury |
| US20080182299A1 (en) | 2004-01-27 | 2008-07-31 | Compugent Ltd. | Novel brain natriuretic peptide variants and methods of use thereof |
| CA2554599A1 (en) | 2004-01-27 | 2005-08-11 | Compugen Usa, Inc. | Novel brain natriuretic peptide variants and methods of use thereof |
| RU2433185C2 (ru) | 2004-03-11 | 2011-11-10 | Дженентек, Инк. | Способ получения полипептидов |
| CN1960758B (zh) | 2004-03-31 | 2014-10-22 | 中外制药株式会社 | 关节炎的治疗剂或预防剂 |
| CN1960757A (zh) | 2004-03-31 | 2007-05-09 | 中尾一和 | 身高增加用组合物 |
| JP2005292718A (ja) | 2004-04-05 | 2005-10-20 | Furukawa Electric Co Ltd:The | 光導波路、光導波路モジュールおよび光導波路の作成方法 |
| DE602005027461D1 (de) | 2004-04-21 | 2011-05-26 | Enobia Pharma Inc | Konjugate zur zuführung an knochen und verfahren zu deren verwendung beim hinführen von proteinen zum knochen |
| US20090298120A1 (en) | 2004-05-04 | 2009-12-03 | National University Of Singapore | Method for expressing sialylated glycoproteins in mammalian cells and cells thereof |
| US20070142339A1 (en) | 2004-05-10 | 2007-06-21 | Novacea, Inc. | Prevention of arterial restenosis with active vitamin d compounds |
| US7863238B2 (en) | 2004-06-10 | 2011-01-04 | Saint Louis University | Proteins with an attached short peptide of acidic amino acids |
| US7972593B2 (en) | 2004-06-10 | 2011-07-05 | Saint Louis University | Delivery of therapeutic agents to the bone |
| US20070081986A1 (en) | 2005-10-07 | 2007-04-12 | Shunji Tomatsu | Beta-glucuronidase with an attached short peptide of acidic amino acids |
| US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| EP1781318A4 (en) | 2004-06-23 | 2009-12-23 | Genzyme Corp | METHODS AND COMPOSITIONS FOR THE TREATMENT OF POLYKYSTIC DISEASES |
| ATE496060T1 (de) | 2004-07-15 | 2011-02-15 | Univ Queensland | Proteinartige verbindungen und anwendungen davon |
| US20090142347A1 (en) | 2004-09-29 | 2009-06-04 | The Burnham Institute For Medical Research | Tissue-Nonspecific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification |
| CN101068575A (zh) | 2004-12-01 | 2007-11-07 | 建新公司 | 向肝脏定向递送遗传物质的方法 |
| DK2510942T3 (en) | 2005-04-07 | 2015-12-14 | Cardiorentis Ag | Use of natriuretic peptides for the treatment of heart failure |
| WO2006116260A2 (en) | 2005-04-26 | 2006-11-02 | Medimmune, Inc. | Modulation of antibody effector function by hinge domain engineering |
| US20070042957A1 (en) | 2005-08-19 | 2007-02-22 | Mayo Foundation For Medical Education And Research | Type v phosphodiesterase inhibitors and natriuretic polypeptides |
| US7470668B2 (en) | 2005-08-24 | 2008-12-30 | Enobia Pharma Inc. | Method of use of specific natriuretic peptide receptor c ligands, transgenic non-human mammals expressing specific natriuretic peptide receptor c antagonists and cells thereof |
| WO2007130113A2 (en) | 2005-09-06 | 2007-11-15 | Zelos Therapeutics, Inc. | Parathyroid hormone analogues and methods of use |
| US7803901B2 (en) | 2005-09-16 | 2010-09-28 | Mayo Foundation For Medical Education And Research | Polypeptides with natriuresis activity |
| WO2007041645A2 (en) | 2005-10-03 | 2007-04-12 | Scios Inc. | Oxidized human bnp |
| RU2316334C2 (ru) | 2005-12-19 | 2008-02-10 | Медитек Индастриз ЛЛС | Способ активации утраченных двигательных функций, а также определения эффективности их восстановления при повреждении центральной нервной системы |
| US7625564B2 (en) | 2006-01-27 | 2009-12-01 | Novagen Holding Corporation | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
| JP5576610B2 (ja) | 2006-02-20 | 2014-08-20 | フィロジカ リミテッド | ペプチド構造のライブラリーの構築およびスクリーニング方法 |
| US7787945B2 (en) * | 2006-03-08 | 2010-08-31 | Neuropace, Inc. | Implantable seizure monitor |
| US8784833B2 (en) | 2006-06-27 | 2014-07-22 | Saint Louis University | Prenatal enzyme replacement therapy for hypophosphatasia |
| CA2656112A1 (en) | 2006-06-30 | 2008-05-08 | Hanje Chen | Bioresponsive polymers |
| US7825092B2 (en) | 2006-08-08 | 2010-11-02 | University Of South Florida | Dendroaspis natriuretic peptide for treatment of cancer |
| CA2660294C (en) | 2006-08-08 | 2017-08-29 | Mayo Foundation For Medical Education And Research | Diuretic and natriuretic polypeptides |
| CN106008699A (zh) | 2006-09-08 | 2016-10-12 | Ambrx公司 | 经修饰的人类血浆多肽或Fc骨架和其用途 |
| JP2010502231A (ja) | 2006-09-08 | 2010-01-28 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 血管拡張作用を欠く水利尿およびナトリウム利尿ポリペプチド |
| PE20081140A1 (es) | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
| US20100168443A1 (en) | 2006-11-02 | 2010-07-01 | University Of Virginia Patent Foundation | Ethoid-Containing Compounds, Methods for Preparing Ethoid-Containing Compounds, and Methods of Use |
| JP5645408B2 (ja) | 2006-11-16 | 2014-12-24 | カイ ファーマシューティカルズ インコーポレーティッド | 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド |
| KR100856413B1 (ko) * | 2006-12-06 | 2008-09-04 | 삼성전자주식회사 | 정착기 및 이를 포함하는 화상형성장치 |
| US20080181903A1 (en) | 2006-12-21 | 2008-07-31 | Pdl Biopharma, Inc. | Conjugate of natriuretic peptide and antibody constant region |
| US8298774B2 (en) | 2007-03-12 | 2012-10-30 | Biomedica Medizinprodukte Gmbh & Co Kg | Diagnosis of septic complications |
| EP1985697A1 (en) | 2007-04-27 | 2008-10-29 | AM-Pharma B.V. | Modified phosphatases |
| KR20080098216A (ko) | 2007-05-04 | 2008-11-07 | 한미약품 주식회사 | 캐리어 물질을 이용한 나트륨 배설 펩타이드 약물 결합체 |
| PT2662448T (pt) * | 2007-05-11 | 2017-03-29 | Alexion Pharma Inc | Fosfatase alcalina dirigida ao osso, kits e métodos para a utilização da mesma |
| MX2009012343A (es) | 2007-05-14 | 2010-02-10 | Biogen Idec Inc | Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello. |
| EP2162464A1 (en) | 2007-06-06 | 2010-03-17 | Boehringer Ingelheim International GmbH | Natriuretic fusion proteins |
| EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
| WO2009006520A1 (en) | 2007-07-03 | 2009-01-08 | Medimmune, Llc | Hinge domain engineering |
| AU2008274845A1 (en) | 2007-07-06 | 2009-01-15 | Theratechnologies Inc. | Bifunctional fusion proteins of the alpha-melanocyte stimulating hormone (alpha-MSH) and atrial natriuretic protein (ANP) and uses in hypertension and acute kidney injury |
| AU2008279379B2 (en) | 2007-07-20 | 2016-03-24 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides |
| CA2696113A1 (en) | 2007-08-10 | 2009-04-02 | Burnham Institute For Medical Research | Tissue-nonspecific alkaline phosphatase (tnap) activators and uses thereof |
| US8933197B2 (en) | 2007-08-15 | 2015-01-13 | Amunix Operating Inc. | Compositions comprising modified biologically active polypeptides |
| EP2197469A2 (en) | 2007-09-11 | 2010-06-23 | Mondobiotech Laboratories AG | Use of nf-kappab inhibitor sn50 and optionally angiotensin iii as therapeutic agents in the treatment of eg hbv infection |
| CA2699073A1 (en) | 2007-09-11 | 2009-04-02 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| WO2009046848A1 (en) | 2007-09-11 | 2009-04-16 | Mondobiotech Laboratories Ag | Use of the peptide thymosin beta 4 alone or in combination with cecropin a as a therapeutic agent |
| KR20100057642A (ko) | 2007-09-11 | 2010-05-31 | 몬도바이오테크 래보래토리즈 아게 | 치료제로서의 ｃｎｐ-２２ 단독 또는 피살라에민과 배합된 이의 용도 |
| US8293711B2 (en) | 2007-09-11 | 2012-10-23 | Pharis Biotech Gmbh | Use of natriuretic peptides for treating angioedema syndromes |
| AU2008297411A1 (en) | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| US8357656B2 (en) | 2007-09-15 | 2013-01-22 | Mayo Foundation For Medical Education And Research | Natriuretic peptide receptor-C agonists |
| AR069409A1 (es) | 2007-11-21 | 2010-01-20 | Biomarin Pharm Inc | Variantes de peptidos natriureticos de tipo c |
| WO2009086126A2 (en) | 2007-12-21 | 2009-07-09 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides |
| CN101322866A (zh) * | 2008-01-11 | 2008-12-17 | 梁树立 | 脑深部癫痫放电引导治疗方法与设备 |
| EP2080812A1 (en) | 2008-01-18 | 2009-07-22 | Transmedi SA | Compositions and methods of detecting post-stop peptides |
| CN101809029B (zh) | 2008-05-23 | 2016-06-15 | 第一三共株式会社 | 具有延长目标肽的血浆半衰期作用的肽 |
| WO2009149161A2 (en) | 2008-06-06 | 2009-12-10 | Mayo Foundation For Medical Education And Research | Chimeric natriuretic polypeptides and methods for inhibiting cardiac remodeling |
| WO2009156481A1 (en) | 2008-06-25 | 2009-12-30 | Ascendis Pharma As | Pegylated bnp |
| AU2009262970A1 (en) | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
| DK2307447T3 (da) | 2008-07-02 | 2016-06-20 | Mayo Foundation | Natriuretiske polypeptider med unikke farmakologiske profiler |
| UA101670C2 (ru) | 2008-07-23 | 2013-04-25 | Ханми Сайенс Ко., Лтд. | Полипептидный комплекс, содержащий непептидильный полимер, который имеет три функциональных конца |
| US20100093678A1 (en) | 2008-10-10 | 2010-04-15 | The University Of Georgia Research Foundation, Inc | Compositions and methods of the treatment of obesity and osteoporosis |
| US8642550B2 (en) | 2008-10-24 | 2014-02-04 | Mayo Foundation For Medical Education And Research | Chimeric natriuretic peptides without hypotensive inducing capability |
| US8455438B2 (en) | 2008-12-29 | 2013-06-04 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides for reducing or preventing restenosis |
| WO2010082804A2 (en) | 2009-01-19 | 2010-07-22 | Hanmi Pharm. Co., Ltd. | Method for producing physiologically active protein or peptide using immunoglobulin fragment |
| CA2754408A1 (en) | 2009-03-30 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Fusion proteins comprising canine fc portions |
| US20120053123A1 (en) | 2009-05-05 | 2012-03-01 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides having mutations within their disulfide rings |
| ES2608457T3 (es) | 2009-05-20 | 2017-04-11 | Biomarin Pharmaceutical Inc. | Variantes de péptido natriurético de tipo C |
| US8685024B2 (en) | 2010-04-14 | 2014-04-01 | Arrowhead Medical Device Technologies, Llc | Intramedullary fixation device and methods for bone fixation and stabilization |
| BR112012027765A2 (pt) * | 2010-04-30 | 2019-09-24 | Enobia Pharma Inc. | métodos, composições e kits para tratamento de distúrbios de mineralização da matriz. |
| JP6055779B2 (ja) | 2010-12-27 | 2016-12-27 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | ナトリウム利尿ペプチドを含む組成物およびその使用方法 |
| CA2852874A1 (en) | 2011-10-19 | 2013-04-25 | Alexion Pharma Holding | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| CN104168955A (zh) | 2011-11-10 | 2014-11-26 | 凯伊药品公司 | 拟钙剂及其使用方法 |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| EP2877247A1 (en) | 2012-07-25 | 2015-06-03 | Psioxus Therapeutics Limited | Use of s-pindolol for treating cachexia and sarcopenia |
| US20160097100A1 (en) | 2013-05-17 | 2016-04-07 | Jeffrey Trent | Genetic test to predict patient response to bone morphogenetic protein in arthrodesis |
| US9926544B2 (en) | 2014-01-24 | 2018-03-27 | Am-Pharma B.V. | Chimeric alkaline phosphatase-like proteins |
| EP3097188B1 (en) | 2014-01-24 | 2018-08-29 | AM-Pharma B.V. | Downstream processing of an alkaline phosphatase |
| PE20170248A1 (es) | 2014-06-09 | 2017-04-14 | Ultragenyx Pharmaceutical Inc | El control efectivo y eficaz del fosfato serico para una osificacion optima |
| US10822596B2 (en) | 2014-07-11 | 2020-11-03 | Alexion Pharmaceuticals, Inc. | Compositions and methods for treating craniosynostosis |
| WO2016061065A1 (en) | 2014-10-15 | 2016-04-21 | Alexion Pharmaceuticals, Inc. | Methods of shifting an isoelectric profile of a protein product and uses thereof |
| JP6787894B2 (ja) | 2014-12-05 | 2020-11-18 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 組換えアルカリホスファターゼを用いた発作の処置 |
| JP6868561B2 (ja) | 2015-01-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼ欠損を有する被験者を治療する方法 |
| KR101867134B1 (ko) | 2015-03-23 | 2018-06-12 | 한양대학교 산학협력단 | 포유류 세포를 이용하여 목적 물질을 고효율로 생산하기 위한 세포 배양 배지, 이를 이용한 세포 배양 방법 및 목적 물질의 생산 방법 |
| JP6993961B2 (ja) | 2015-08-17 | 2022-01-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼの製造 |
| EP3355904A4 (en) | 2015-09-28 | 2019-06-12 | Alexion Pharmaceuticals, Inc. | IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA |
| WO2017074466A1 (en) | 2015-10-30 | 2017-05-04 | Alexion Pharmaceuticals, Inc. | Methods for treating craniosynostosis in a patient |
| WO2017155569A1 (en) | 2016-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| KR20240160671A (ko) | 2016-04-01 | 2024-11-11 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼리성 포스파타아제로 근육 약화의 치료 |
| WO2017171871A1 (en) | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| EP3464573B1 (en) | 2016-06-06 | 2026-03-04 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| WO2018004517A1 (en) | 2016-06-27 | 2018-01-04 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children and adolescents |
| EP3500289B1 (en) | 2016-08-18 | 2024-10-09 | Alexion Pharmaceuticals, Inc. | Asfotase alfa for use in treating tracheobronchomalacia |
| WO2018164995A1 (en) | 2017-03-09 | 2018-09-13 | Alexion Pharmaceuticals, Inc . | Glycoprotein manufacturing process |
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| ES3038086T3 (en) | 2025-10-09 |
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| EP3226891A1 (en) | 2017-10-11 |
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| US20170360899A1 (en) | 2017-12-21 |
| CA2967851C (en) | 2024-02-27 |
| KR20170095278A (ko) | 2017-08-22 |
| CA2967851A1 (en) | 2016-06-09 |
| WO2016090251A1 (en) | 2016-06-09 |
| AU2015357551A1 (en) | 2017-05-25 |
| US11224638B2 (en) | 2022-01-18 |
| US10449236B2 (en) | 2019-10-22 |
| MX389350B (es) | 2025-03-19 |
| JP2018502836A (ja) | 2018-02-01 |
| RU2017123540A (ru) | 2019-01-10 |
| EP3226891B1 (en) | 2025-06-25 |
| CN107405390A (zh) | 2017-11-28 |
| US20200093898A1 (en) | 2020-03-26 |
| MX2017007392A (es) | 2019-01-24 |
| RU2708068C2 (ru) | 2019-12-04 |
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