KR20150036606A - 항-cd3 구조체를 포함하는 이중특이적 비대칭 이형이합체 - Google Patents

항-cd3 구조체를 포함하는 이중특이적 비대칭 이형이합체 Download PDF

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KR20150036606A
KR20150036606A KR20157003872A KR20157003872A KR20150036606A KR 20150036606 A KR20150036606 A KR 20150036606A KR 20157003872 A KR20157003872 A KR 20157003872A KR 20157003872 A KR20157003872 A KR 20157003872A KR 20150036606 A KR20150036606 A KR 20150036606A
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polypeptide
cell
construct
cells
binding
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서짓 비마라오 디지트
토마스 스프레터 폰 그루덴스타인
고든 유곤 엔지
니나 이. 와이서
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자임워크스 인코포레이티드
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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KR20157003872A 2012-07-13 2013-07-13 항-cd3 구조체를 포함하는 이중특이적 비대칭 이형이합체 Withdrawn KR20150036606A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261671640P 2012-07-13 2012-07-13
US61/671,640 2012-07-13
US201361845948P 2013-07-12 2013-07-12
US61/845,948 2013-07-12
PCT/US2013/050411 WO2014012085A2 (en) 2012-07-13 2013-07-13 Bispecific asymmetric heterodimers comprising anti-cd3 constructs

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KR20150036606A true KR20150036606A (ko) 2015-04-07

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US (4) US20140154253A1 (enExample)
EP (1) EP2872170A4 (enExample)
JP (1) JP2015528003A (enExample)
KR (1) KR20150036606A (enExample)
CN (1) CN104640562A (enExample)
AU (1) AU2013289883B2 (enExample)
BR (1) BR112015000798A2 (enExample)
CA (1) CA2878843A1 (enExample)
HK (1) HK1207575A1 (enExample)
RU (1) RU2650868C2 (enExample)
WO (1) WO2014012085A2 (enExample)

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