JP2015528003A - 抗ｃｄ３構築物を含む二重特異性の非対称ヘテロ二量体 - Google Patents

抗ｃｄ３構築物を含む二重特異性の非対称ヘテロ二量体 Download PDF

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JP2015528003A
JP2015528003A JP2015521877A JP2015521877A JP2015528003A JP 2015528003 A JP2015528003 A JP 2015528003A JP 2015521877 A JP2015521877 A JP 2015521877A JP 2015521877 A JP2015521877 A JP 2015521877A JP 2015528003 A JP2015528003 A JP 2015528003A
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polypeptide
cell
construct
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cells
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JP2015528003A5 (enExample
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スールジット ビーマラオ ディキシット
スールジット ビーマラオ ディキシット
フォン クロイデンシュタイン トマス スプレッター
フォン クロイデンシュタイン トマス スプレッター
ゴードン イウ コン エング
ゴードン イウ コン エング
ニーナ イー． ワイサー
ニーナ イー． ワイサー
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ザイムワークス，インコーポレイテッド
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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JP2015521877A 2012-07-13 2013-07-13 抗ｃｄ３構築物を含む二重特異性の非対称ヘテロ二量体 Pending JP2015528003A (ja)

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US201261671640P 2012-07-13 2012-07-13
US61/671,640 2012-07-13
US201361845948P 2013-07-12 2013-07-12
US61/845,948 2013-07-12
PCT/US2013/050411 WO2014012085A2 (en) 2012-07-13 2013-07-13 Bispecific asymmetric heterodimers comprising anti-cd3 constructs

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CN (1) CN104640562A (enExample)
AU (1) AU2013289883B2 (enExample)
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JP2021514638A (ja) * 2018-02-26 2021-06-17 アブリンクス・エヌ・フェー ペプチドリンカーをコードする改良されたヌクレオチド配列
JP2022512629A (ja) * 2018-10-23 2022-02-07 マジェンタ セラピューティクス インコーポレイテッド Ｆｃサイレンス化抗体薬物コンジュゲート（ＡＤＣ）及びその使用
JP2022023132A (ja) * 2015-05-01 2022-02-07 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニア グリカン依存性免疫療法分子
JP2022518530A (ja) * 2019-01-28 2022-03-15 ウーシー バイオロジクス アイルランド リミティド 新規二重特異性ｃｄ３／ｃｄ２０ポリペプチド複合体
JP2022064939A (ja) * 2016-05-20 2022-04-26 ハープーン セラピューティクス，インク． 単鎖可変フラグメントｃｄ３結合タンパク質
JP2023123725A (ja) * 2017-08-01 2023-09-05 エービー ストゥーディオ インコーポレイテッド 二重特異性抗体およびその使用
US11807692B2 (en) 2018-09-25 2023-11-07 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
US12084518B2 (en) 2015-05-21 2024-09-10 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
US12371504B2 (en) 2017-10-13 2025-07-29 Harpoon Therapeutics, Inc. Trispecific proteins and methods of use

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