RU2650868C2 - Биспецифические асимметричные гетеродимеры, содержащие анти-cd3 конструкции - Google Patents

Биспецифические асимметричные гетеродимеры, содержащие анти-cd3 конструкции Download PDF

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RU2650868C2
RU2650868C2 RU2015102193A RU2015102193A RU2650868C2 RU 2650868 C2 RU2650868 C2 RU 2650868C2 RU 2015102193 A RU2015102193 A RU 2015102193A RU 2015102193 A RU2015102193 A RU 2015102193A RU 2650868 C2 RU2650868 C2 RU 2650868C2
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cell
polypeptide
cells
construct
binding
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RU2015102193A
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RU2015102193A (ru
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Сержит Бхимарао ДИКСИТ
ФОН КРЕДЕНШТАЙН Томас ШПРЕТЕР
Гордон Иу Кон НГ
Нина Е. ВАЙССЕР
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Займворкс Инк.
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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RU2015102193A 2012-07-13 2013-07-13 Биспецифические асимметричные гетеродимеры, содержащие анти-cd3 конструкции RU2650868C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261671640P 2012-07-13 2012-07-13
US61/671,640 2012-07-13
US201361845948P 2013-07-12 2013-07-12
US61/845,948 2013-07-12
PCT/US2013/050411 WO2014012085A2 (en) 2012-07-13 2013-07-13 Bispecific asymmetric heterodimers comprising anti-cd3 constructs

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RU2015102193A RU2015102193A (ru) 2016-08-27
RU2650868C2 true RU2650868C2 (ru) 2018-04-17

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US (4) US20140154253A1 (enExample)
EP (1) EP2872170A4 (enExample)
JP (1) JP2015528003A (enExample)
KR (1) KR20150036606A (enExample)
CN (1) CN104640562A (enExample)
AU (1) AU2013289883B2 (enExample)
BR (1) BR112015000798A2 (enExample)
CA (1) CA2878843A1 (enExample)
HK (1) HK1207575A1 (enExample)
RU (1) RU2650868C2 (enExample)
WO (1) WO2014012085A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2826453C2 (ru) * 2019-01-30 2024-09-11 Иммунокор Лимитед Cd3-специфические связывающие молекулы
US12590152B2 (en) 2019-01-30 2026-03-31 Immunocore Limited CD3-specific binding molecules

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