KR20150027267A - LRRK2 억제제로서의 4-(치환된-아미노)-7H-피롤로[2,3-d]피리미딘 - Google Patents

LRRK2 억제제로서의 4-(치환된-아미노)-7H-피롤로[2,3-d]피리미딘 Download PDF

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KR20150027267A
KR20150027267A KR20157002334A KR20157002334A KR20150027267A KR 20150027267 A KR20150027267 A KR 20150027267A KR 20157002334 A KR20157002334 A KR 20157002334A KR 20157002334 A KR20157002334 A KR 20157002334A KR 20150027267 A KR20150027267 A KR 20150027267A
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pyrrolo
pyrimidin
morpholin
benzonitrile
pyrimidine
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Korean (ko)
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폴 갈라트시스
매튜 메릴 헤이워드
재클린 헨더슨
베타니 린 코르모스
라비 지 쿠룸베일
안토니아 프라이데릭 스테판
패트릭 로버트 베르호스트
트래비스 티 웨이저
레이 장
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화이자 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR20157002334A 2012-06-29 2013-06-19 LRRK2 억제제로서의 4-(치환된-아미노)-7H-피롤로[2,3-d]피리미딘 Ceased KR20150027267A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261666299P 2012-06-29 2012-06-29
US61/666,299 2012-06-29
US201361820828P 2013-05-08 2013-05-08
US61/820,828 2013-05-08
PCT/IB2013/055039 WO2014001973A1 (en) 2012-06-29 2013-06-19 NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS

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KR20150027267A true KR20150027267A (ko) 2015-03-11

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KR20157002334A Ceased KR20150027267A (ko) 2012-06-29 2013-06-19 LRRK2 억제제로서의 4-(치환된-아미노)-7H-피롤로[2,3-d]피리미딘

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US (2) US9156845B2 (https=)
EP (2) EP2867236B1 (https=)
JP (3) JP6189948B2 (https=)
KR (1) KR20150027267A (https=)
CN (2) CN105732639A (https=)
AP (1) AP3902A (https=)
AR (1) AR091628A1 (https=)
AU (1) AU2013282869B2 (https=)
BR (1) BR112014032913A2 (https=)
CA (1) CA2878054C (https=)
CL (1) CL2014003566A1 (https=)
CO (1) CO7160063A2 (https=)
CR (1) CR20140566A (https=)
DO (1) DOP2014000303A (https=)
EA (1) EA025186B1 (https=)
ES (1) ES2637245T3 (https=)
GE (1) GEP201706620B (https=)
GT (1) GT201400301A (https=)
IL (1) IL236294A (https=)
MD (1) MD20140130A2 (https=)
MX (1) MX2014015769A (https=)
NI (1) NI201400151A (https=)
NZ (1) NZ702571A (https=)
PE (1) PE20150153A1 (https=)
PH (1) PH12014502886A1 (https=)
SG (1) SG11201408044QA (https=)
TN (1) TN2014000537A1 (https=)
TW (1) TWI482774B (https=)
UY (1) UY34883A (https=)
WO (1) WO2014001973A1 (https=)
ZA (1) ZA201409136B (https=)

Cited By (4)

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WO2019221566A1 (ko) * 2018-05-18 2019-11-21 재단법인 대구경북첨단의료산업진흥재단 외상성 뇌손상 또는 뇌졸중의 예방 또는 치료용 약학적 조성물
WO2020040591A1 (ko) * 2018-08-23 2020-02-27 재단법인 대구경북첨단의료산업진흥재단 Lrrk 키나아제 저해제를 유효성분으로 함유하는 피리미딘 유도체의 신규용도
WO2025170397A1 (ko) * 2024-02-07 2025-08-14 노보렉스 주식회사 Lrrk2 단백질 키나제 도메인 억제제로서 신규한 화합물
KR20250123656A (ko) * 2024-02-07 2025-08-18 노보렉스 주식회사 Lrrk2 단백질 키나제 도메인 억제제로서 신규한 화합물

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EP3083618B1 (en) 2013-12-17 2018-02-21 Pfizer Inc Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
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KR101990739B1 (ko) * 2018-07-24 2019-06-19 재단법인 대구경북첨단의료산업진흥재단 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물
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JP2019073522A (ja) 2019-05-16
JP6189948B2 (ja) 2017-08-30
EA201492125A1 (ru) 2015-06-30
ZA201409136B (en) 2016-08-31
CA2878054A1 (en) 2014-01-03
MD20140130A2 (ro) 2015-04-30
ES2637245T3 (es) 2017-10-11
DOP2014000303A (es) 2015-03-15
WO2014001973A1 (en) 2014-01-03
IL236294A (en) 2016-09-29
AR091628A1 (es) 2015-02-18
EP2867236A1 (en) 2015-05-06
SG11201408044QA (en) 2015-01-29
BR112014032913A2 (pt) 2017-06-27
AU2013282869A1 (en) 2015-01-15
US20140005183A1 (en) 2014-01-02
AP3902A (en) 2016-11-17
EA025186B1 (ru) 2016-11-30
MX2014015769A (es) 2015-04-10
CL2014003566A1 (es) 2015-04-10
CA2878054C (en) 2018-09-11
JP2017226684A (ja) 2017-12-28
US9642855B2 (en) 2017-05-09

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