DK1866433T3 - Fremgangsmåde til identifikation af LRRK-2interagerende molekyler og til rensning af LRRK2 - Google Patents

Fremgangsmåde til identifikation af LRRK-2interagerende molekyler og til rensning af LRRK2

Info

Publication number
DK1866433T3
DK1866433T3 DK07717962T DK07717962T DK1866433T3 DK 1866433 T3 DK1866433 T3 DK 1866433T3 DK 07717962 T DK07717962 T DK 07717962T DK 07717962 T DK07717962 T DK 07717962T DK 1866433 T3 DK1866433 T3 DK 1866433T3
Authority
DK
Denmark
Prior art keywords
lrrk2
lrrk
purifying
identifying
interacting molecules
Prior art date
Application number
DK07717962T
Other languages
English (en)
Inventor
Gerard Drewes
Valerie Reader
Carsten Hopf
Original Assignee
Cellzome Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ag filed Critical Cellzome Ag
Application granted granted Critical
Publication of DK1866433T3 publication Critical patent/DK1866433T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
DK07717962T 2006-03-14 2007-03-13 Fremgangsmåde til identifikation af LRRK-2interagerende molekyler og til rensning af LRRK2 DK1866433T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78211906P 2006-03-14 2006-03-14
PCT/EP2007/052357 WO2007104763A1 (en) 2006-03-14 2007-03-13 Methods for the identification of lrrk2 interacting molecules and for the purification of lrrk2

Publications (1)

Publication Number Publication Date
DK1866433T3 true DK1866433T3 (da) 2009-08-17

Family

ID=38093568

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07717962T DK1866433T3 (da) 2006-03-14 2007-03-13 Fremgangsmåde til identifikation af LRRK-2interagerende molekyler og til rensning af LRRK2

Country Status (11)

Country Link
US (1) US8163511B2 (da)
EP (1) EP1866433B1 (da)
JP (1) JP2009529860A (da)
CN (1) CN101426927B (da)
AT (1) ATE431426T1 (da)
AU (1) AU2007224411B2 (da)
CA (1) CA2645214A1 (da)
DE (1) DE602007001103D1 (da)
DK (1) DK1866433T3 (da)
ES (1) ES2325797T3 (da)
WO (1) WO2007104763A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0706709D0 (en) 2007-04-05 2007-05-16 Medical Res Council Methods
US8206942B2 (en) 2007-04-05 2012-06-26 Medical Research Council Methods of identifying LRRK2 inhibitors
EP2045332B1 (en) 2007-10-05 2010-07-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Proteome-wide quantification of small molecule binding to cellular target proteins
CN101965408B (zh) * 2008-02-04 2013-08-28 塞尔卓姆有限责任公司 针对多重靶的pi3k相互作用分子的选择性概况分析
GB2463656B (en) * 2008-09-18 2010-10-13 Medical Res Council Substrate of LRRK2 and methods of assessing LRRK2 activity
US8367349B2 (en) * 2010-04-19 2013-02-05 Medical Research Council Methods for identifying modulators of LRRK2
EP2710041A4 (en) * 2011-05-18 2014-11-05 Parkinson S Inst ASSAY FOR DETERMINING LRRK2 ACTIVITY IN MORBUS PARKINSON
JP6189948B2 (ja) 2012-06-29 2017-08-30 ファイザー・インク ＬＲＲＫ２阻害薬としての新規な４−（置換アミノ）−７Ｈ−ピロロ［２，３−ｄ］ピリミジン
US9695171B2 (en) 2013-12-17 2017-07-04 Pfizer Inc. 3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors
WO2017046675A1 (en) 2015-09-14 2017-03-23 Pfizer Inc. Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors
WO2019096325A1 (zh) * 2017-11-20 2019-05-23 江苏达骏生物科技有限公司 一种双酰胺复合物及其制备方法和用途
CN112505328B (zh) * 2020-11-02 2024-02-13 武汉金开瑞生物工程有限公司 一种同位素标记试剂盒和标记方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002081466A1 (en) 2001-04-09 2002-10-17 Sugen, Inc. Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US20040197792A1 (en) 2002-07-15 2004-10-07 Sugen, Inc. Novel Kinases
CA2611365C (en) * 2005-06-14 2014-02-11 Cellzome Ag Process for the identification of novel enzyme interacting compounds

Also Published As

Publication number Publication date
CN101426927B (zh) 2012-05-23
AU2007224411B2 (en) 2012-11-01
CN101426927A (zh) 2009-05-06
JP2009529860A (ja) 2009-08-27
EP1866433B1 (en) 2009-05-13
WO2007104763A1 (en) 2007-09-20
US20090220992A1 (en) 2009-09-03
AU2007224411A1 (en) 2007-09-20
US8163511B2 (en) 2012-04-24
WO2007104763A9 (en) 2007-11-15
CA2645214A1 (en) 2007-09-20
DE602007001103D1 (de) 2009-06-25
ES2325797T3 (es) 2009-09-17
EP1866433A1 (en) 2007-12-19
ATE431426T1 (de) 2009-05-15

Similar Documents

Publication Publication Date Title
DK1866433T3 (da) Fremgangsmåde til identifikation af LRRK-2interagerende molekyler og til rensning af LRRK2
WO2008054599A3 (en) Rho kinase inhibitors
EA200901313A1 (ru) Ингибиторы тирозинкиназы брутона
EA201270553A1 (ru) Ингибиторы тирозинкиназы брутона
UA101478C2 (ru) Соединения, полезные как ингибиторы raf-киназы
EA200702048A1 (ru) Фармакокинетически улучшенные соединения
WO2008033408A3 (en) Methods for identifying compounds that modulate cell signaling and methods employing such compounds
ATE451363T1 (de) 3-(indazol-5-yl)-(1,2,4)triazinderivate und verwandte verbindungen als proteinkinaseinhibitoren zur behandlung von krebs
DK1879573T3 (da) Modulatorer af indolamin 2,3-dioxygenase og fremgangsmåder til anvendelse deraf
DK1836169T3 (da) Sammensætninger og fremgangsmåder til behandling af celleproliferationslidelser
WO2008039769A3 (en) Methods and devices for analyzing small rna molecules
EA200970909A1 (ru) Новый антиген, ассоциированный с новообразованными сосудами опухолевых метастазов
ATE548374T1 (de) 2'-fluor-2'-desoxytetrahydrouridine als cytidindeaminaseinhibitoren
WO2010104598A3 (en) Kinase protein binding inhibitors
DK2781593T3 (da) Fremgangsmåde til behandling af methanemissioner
DK2101819T3 (da) Fremgangsmåder, sammensætninger og kits til behandling af smerte og pruritis
DK3567035T3 (da) N-substituerede 2,5-dioxo-azolin-forbindelser til anvendelse ved behandling af cancer
ATE404574T1 (de) Verfahren zur inhibierung der proliferation von tumorzellen, bei dem platinkomplexe eingesetzt werden
WO2010138814A3 (en) Disrupting fcrn-albumin interactions
DK2084136T3 (da) Benzoylpyrazolforbindelser, fremgangsmåde til fremstilling deraf samt herbicider indeholdende dem
WO2007076174A3 (en) Methods, systems, and apparatus for multi-domain markers
EA201000618A1 (ru) 5-цианотиенопиридины для лечения опухолей
TW200716132A (en) Novel chemical compounds
EA201001576A1 (ru) Тиенопиримидины
WO2009137795A3 (en) Methods for treating endoplasmic reticulum (er) stress disorders