KR20120112644A - 록소프로펜 함유 의약 조성물 - Google Patents

록소프로펜 함유 의약 조성물 Download PDF

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Publication number
KR20120112644A
KR20120112644A KR1020127019610A KR20127019610A KR20120112644A KR 20120112644 A KR20120112644 A KR 20120112644A KR 1020127019610 A KR1020127019610 A KR 1020127019610A KR 20127019610 A KR20127019610 A KR 20127019610A KR 20120112644 A KR20120112644 A KR 20120112644A
Authority
KR
South Korea
Prior art keywords
salt
roxofene
white powder
hydrochloride
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020127019610A
Other languages
English (en)
Korean (ko)
Inventor
도시키 우스이
마사아키 스노하라
마사야 다카미야
Original Assignee
코와 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 코와 가부시키가이샤 filed Critical 코와 가부시키가이샤
Publication of KR20120112644A publication Critical patent/KR20120112644A/ko
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127019610A 2010-01-29 2011-01-31 록소프로펜 함유 의약 조성물 Abandoned KR20120112644A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP2010018015 2010-01-29
JPJP-P-2010-018015 2010-01-29
JPJP-P-2010-149089 2010-06-30
JP2010149089 2010-06-30
JP2010149115 2010-06-30
JPJP-P-2010-149061 2010-06-30
JPJP-P-2010-149115 2010-06-30
JP2010149061 2010-06-30

Publications (1)

Publication Number Publication Date
KR20120112644A true KR20120112644A (ko) 2012-10-11

Family

ID=44319475

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127019610A Abandoned KR20120112644A (ko) 2010-01-29 2011-01-31 록소프로펜 함유 의약 조성물

Country Status (4)

Country Link
JP (5) JP4787912B2 (cg-RX-API-DMAC10.html)
KR (1) KR20120112644A (cg-RX-API-DMAC10.html)
CN (1) CN102740854A (cg-RX-API-DMAC10.html)
WO (1) WO2011093498A1 (cg-RX-API-DMAC10.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5525324B2 (ja) * 2009-04-28 2014-06-18 興和株式会社 ロキソプロフェン含有医薬製剤
JP5525323B2 (ja) * 2009-04-28 2014-06-18 興和株式会社 ロキソプロフェン含有医薬製剤
JP5624367B2 (ja) * 2009-05-28 2014-11-12 興和株式会社 ロキソプロフェン含有医薬製剤
TWI680757B (zh) * 2010-12-28 2020-01-01 日商興和股份有限公司 解熱鎮痛組成物
WO2013018766A1 (ja) * 2011-07-29 2013-02-07 興和株式会社 安定な医薬組成物
JP6008857B2 (ja) * 2011-07-29 2016-10-19 興和株式会社 ロキソプロフェンを含有する医薬組成物
WO2013047869A1 (ja) * 2011-09-29 2013-04-04 興和株式会社 ロキソプロフェン又はその塩を含有する医薬組成物
JP6114573B2 (ja) * 2012-02-29 2017-04-12 第一三共ヘルスケア株式会社 ロキソプロフェンナトリウムと制酸剤を含有する固形製剤
JP6030130B2 (ja) * 2012-06-25 2016-11-24 興和株式会社 生薬等含有医薬組成物
JP6197513B2 (ja) * 2012-11-09 2017-09-20 大正製薬株式会社 医薬組成物
JP6149625B2 (ja) * 2012-11-09 2017-06-21 大正製薬株式会社 医薬組成物
JP6252177B2 (ja) * 2013-01-28 2017-12-27 大正製薬株式会社 固形製剤
CN103333064B (zh) * 2013-07-17 2014-04-23 珠海金鸿药业股份有限公司 洛索洛芬钠化合物及其药物组合物
CN104225187A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的知柏地黄丸的制备方法
CN104224740A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的百合固金丸的制备方法
CN104225162A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的桂附地黄丸的制备方法
CN104225160A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的七味都气丸的制备方法
CN104257984A (zh) * 2014-09-28 2015-01-07 白杨 一种包衣处理的六味地黄丸的制备方法
CN104225161A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的归芍地黄丸的制备方法
CN104288433A (zh) * 2014-09-28 2015-01-21 白杨 一种包衣处理的枸菊地黄丸的制备方法
CN106580968A (zh) * 2016-11-22 2017-04-26 郑州仁宏医药科技有限公司 一种治疗牙齿肿痛的西药散剂及其制备方法
EP3415143A1 (en) * 2017-06-16 2018-12-19 Kai-Uwe Kern Bromhexine for the treatment of pain
CN113332252A (zh) * 2021-06-07 2021-09-03 大桐制药（中国）有限责任公司 一种洛索洛芬钠片的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4052603B2 (ja) * 1995-04-26 2008-02-27 大正製薬株式会社 経口投与用製剤
JP4357016B2 (ja) * 1998-11-06 2009-11-04 第一三共株式会社 ロキソプロフェンを含有する医薬組成物
JP4828707B2 (ja) * 2000-02-28 2011-11-30 武田薬品工業株式会社 固形圧縮製剤
WO2004017954A1 (ja) * 2002-08-22 2004-03-04 Ono Pharmaceutical Co., Ltd. ジクロフェナクの副作用軽減剤
KR101121890B1 (ko) * 2004-11-05 2012-03-19 리도 케미칼 가부시키가이샤 비스테로이드 소염 진통약을 함유하는 비수계 경피흡수제제
JP4853818B2 (ja) * 2005-08-24 2012-01-11 大正製薬株式会社 イブプロフェン及び塩酸アンブロキソール含有固形製剤
JP5465824B2 (ja) * 2006-03-24 2014-04-09 第一三共ヘルスケア株式会社 医薬用製剤およびその製造方法
JP2008163017A (ja) * 2006-12-06 2008-07-17 Saitama Daiichi Seiyaku Kk 外用医薬組成物及び貼付剤
JP5232520B2 (ja) * 2007-04-17 2013-07-10 第一三共ヘルスケア株式会社 ロキソプロフェンを含有する抗アデノウイルス剤
JP2010215611A (ja) * 2009-01-28 2010-09-30 Kowa Co ロキソプロフェン含有医薬製剤
JP2010235599A (ja) * 2009-03-11 2010-10-21 Kowa Co ロキソプロフェン含有医薬製剤
JP2011006407A (ja) * 2009-05-28 2011-01-13 Kowa Co ロキソプロフェン含有医薬製剤

Also Published As

Publication number Publication date
JP5809736B2 (ja) 2015-11-11
JP2014169345A (ja) 2014-09-18
JPWO2011093498A1 (ja) 2013-06-06
CN102740854A (zh) 2012-10-17
JP2012031147A (ja) 2012-02-16
WO2011093498A1 (ja) 2011-08-04
JP2013237710A (ja) 2013-11-28
JP5575961B2 (ja) 2014-08-20
JP4787912B2 (ja) 2011-10-05
JP2012031131A (ja) 2012-02-16

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