KR102496552B1 - Pde10 억제제의 제조를 위한 방법 및 중간체 - Google Patents
Pde10 억제제의 제조를 위한 방법 및 중간체 Download PDFInfo
- Publication number
- KR102496552B1 KR102496552B1 KR1020167032983A KR20167032983A KR102496552B1 KR 102496552 B1 KR102496552 B1 KR 102496552B1 KR 1020167032983 A KR1020167032983 A KR 1020167032983A KR 20167032983 A KR20167032983 A KR 20167032983A KR 102496552 B1 KR102496552 B1 KR 102496552B1
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- metal
- compound
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/02—Lithium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461985400P | 2014-04-28 | 2014-04-28 | |
| US61/985,400 | 2014-04-28 | ||
| PCT/US2015/027647 WO2015167969A1 (en) | 2014-04-28 | 2015-04-24 | Processes and intermediates for the preparation of a pde10 inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160147275A KR20160147275A (ko) | 2016-12-22 |
| KR102496552B1 true KR102496552B1 (ko) | 2023-02-06 |
Family
ID=54359190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167032983A Active KR102496552B1 (ko) | 2014-04-28 | 2015-04-24 | Pde10 억제제의 제조를 위한 방법 및 중간체 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9650368B2 (enExample) |
| EP (1) | EP3137462B1 (enExample) |
| JP (1) | JP6474430B2 (enExample) |
| KR (1) | KR102496552B1 (enExample) |
| CN (1) | CN106459026B (enExample) |
| AU (1) | AU2015253464B2 (enExample) |
| BR (1) | BR112016025287B1 (enExample) |
| CA (1) | CA2946756C (enExample) |
| ES (1) | ES2723437T3 (enExample) |
| IL (1) | IL248585B (enExample) |
| NZ (2) | NZ716494A (enExample) |
| RU (1) | RU2718863C2 (enExample) |
| WO (1) | WO2015167969A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2742195T3 (es) * | 2010-03-12 | 2020-02-13 | Omeros Corp | Inhibidores de PDE10 y composiciones y métodos relacionados |
| NZ716462A (en) * | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
| CA3003611C (en) | 2015-11-04 | 2022-11-01 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
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| NZ257955A (en) | 1992-12-02 | 1996-05-28 | Pfizer | Catechol diethers pharmaceutical compositions |
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| DE4343286A1 (de) | 1993-12-17 | 1995-06-22 | Hoechst Ag | Heteroaromatische Verbindungen und ihre Verwendung in flüssigkristallinen Mischungen |
| DE4409501A1 (de) | 1994-03-19 | 1995-09-21 | Didier Werke Ag | Verschleißfutter eines Schachtofens und Stein hierfür |
| MX9700068A (es) | 1994-06-24 | 1997-12-31 | Euro Celtique Sa | Compuestos y metodo para inhibir a la fosfodiesterasa iv. |
| US5789434A (en) | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| TW424087B (en) | 1995-04-06 | 2001-03-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives |
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| AU4015497A (en) | 1996-08-26 | 1998-03-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thiazole derivatives useful as selective inhibitors of pde-iv |
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| ES2624791T3 (es) * | 2006-11-21 | 2017-07-17 | Omeros Corporation | Inhibidores de PDE10 y composiciones y métodos relacionados |
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| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| US8377930B2 (en) | 2008-08-05 | 2013-02-19 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
| ES2742195T3 (es) | 2010-03-12 | 2020-02-13 | Omeros Corp | Inhibidores de PDE10 y composiciones y métodos relacionados |
| NZ716462A (en) * | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
-
2014
- 2014-09-10 NZ NZ716494A patent/NZ716494A/en unknown
- 2014-09-10 NZ NZ630810A patent/NZ630810A/en unknown
-
2015
- 2015-04-24 ES ES15785376T patent/ES2723437T3/es active Active
- 2015-04-24 AU AU2015253464A patent/AU2015253464B2/en active Active
- 2015-04-24 RU RU2016146118A patent/RU2718863C2/ru active
- 2015-04-24 US US14/696,287 patent/US9650368B2/en active Active
- 2015-04-24 EP EP15785376.3A patent/EP3137462B1/en active Active
- 2015-04-24 JP JP2016564031A patent/JP6474430B2/ja active Active
- 2015-04-24 CA CA2946756A patent/CA2946756C/en active Active
- 2015-04-24 KR KR1020167032983A patent/KR102496552B1/ko active Active
- 2015-04-24 WO PCT/US2015/027647 patent/WO2015167969A1/en not_active Ceased
- 2015-04-24 BR BR112016025287-0A patent/BR112016025287B1/pt active IP Right Grant
- 2015-04-24 CN CN201580023525.XA patent/CN106459026B/zh active Active
-
2016
- 2016-10-27 IL IL248585A patent/IL248585B/en active IP Right Grant
-
2017
- 2017-04-07 US US15/482,604 patent/US20180057484A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN106459026A (zh) | 2017-02-22 |
| RU2016146118A3 (enExample) | 2018-12-24 |
| BR112016025287A2 (pt) | 2017-08-15 |
| NZ716494A (en) | 2017-07-28 |
| IL248585A0 (en) | 2016-12-29 |
| JP2017513885A (ja) | 2017-06-01 |
| US20180057484A1 (en) | 2018-03-01 |
| BR112016025287B1 (pt) | 2022-10-11 |
| AU2015253464A1 (en) | 2016-10-27 |
| RU2016146118A (ru) | 2018-05-30 |
| NZ630810A (en) | 2016-03-31 |
| CA2946756C (en) | 2022-03-29 |
| CA2946756A1 (en) | 2015-11-05 |
| KR20160147275A (ko) | 2016-12-22 |
| CN106459026B (zh) | 2019-07-05 |
| RU2718863C2 (ru) | 2020-04-15 |
| US9650368B2 (en) | 2017-05-16 |
| JP6474430B2 (ja) | 2019-02-27 |
| AU2015253464B2 (en) | 2018-11-22 |
| EP3137462A1 (en) | 2017-03-08 |
| ES2723437T3 (es) | 2019-08-27 |
| EP3137462B1 (en) | 2019-01-30 |
| WO2015167969A1 (en) | 2015-11-05 |
| US20160024069A1 (en) | 2016-01-28 |
| EP3137462A4 (en) | 2017-12-27 |
| IL248585B (en) | 2020-03-31 |
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