BRPI0605937A2 - processo para a sìntese de brometo de rocurÈnio - Google Patents
processo para a sìntese de brometo de rocurÈnioInfo
- Publication number
- BRPI0605937A2 BRPI0605937A2 BRPI0605937-6A BRPI0605937A BRPI0605937A2 BR PI0605937 A2 BRPI0605937 A2 BR PI0605937A2 BR PI0605937 A BRPI0605937 A BR PI0605937A BR PI0605937 A2 BRPI0605937 A2 BR PI0605937A2
- Authority
- BR
- Brazil
- Prior art keywords
- bromide
- rocurium
- synthesis
- pyrrolidinim
- androstan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Gyroscopes (AREA)
Abstract
PROCESSO PARA A SìNTESE DE BROMETO DE ROCURÈNIO. A invenção abrange processos para sintetizar 1-[17<225>-acetiloxi-3<244>-hidroxi-2<225>-(4-morfolinil)-5<244>an drostano-16<225>-il]-1-(2propenil)pirrolidínio brometo (brometo de rocurónio) e intermediários do mesmo.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71712205P | 2005-09-13 | 2005-09-13 | |
US75267105P | 2005-12-19 | 2005-12-19 | |
US75243505P | 2005-12-20 | 2005-12-20 | |
US77632206P | 2006-02-23 | 2006-02-23 | |
US78474606P | 2006-03-21 | 2006-03-21 | |
PCT/US2006/035948 WO2007033348A2 (en) | 2005-09-13 | 2006-09-13 | Process for the synthesis of rocuronium bromide |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0605937A2 true BRPI0605937A2 (pt) | 2009-05-26 |
Family
ID=37757118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0605937-6A BRPI0605937A2 (pt) | 2005-09-13 | 2006-09-13 | processo para a sìntese de brometo de rocurÈnio |
Country Status (13)
Country | Link |
---|---|
US (4) | US7569687B2 (pt) |
EP (4) | EP1828221B2 (pt) |
JP (2) | JP2008522983A (pt) |
KR (3) | KR20070085703A (pt) |
CN (1) | CN101687905A (pt) |
AT (1) | ATE496933T1 (pt) |
BR (1) | BRPI0605937A2 (pt) |
CA (2) | CA2618272A1 (pt) |
DE (2) | DE602006019822D1 (pt) |
ES (1) | ES2288811T5 (pt) |
MX (1) | MX2008000933A (pt) |
TW (2) | TW200804409A (pt) |
WO (2) | WO2007033348A2 (pt) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005065018A2 (en) * | 2003-11-17 | 2005-07-21 | Merck Eprova Ag | Crystalline forms of (6r) -l-erythro-tetrahydrobiopterin dihydrochloride |
US20070249827A1 (en) * | 2004-06-02 | 2007-10-25 | Sandoz Ag | Meropenem Intermediatein in Crystalling Form |
ES2288811T5 (es) | 2005-09-13 | 2014-02-24 | Sicor Inc. | Procedimiento para la preparación de bromuro de rocuronio puro |
AU2006298881A1 (en) * | 2005-09-21 | 2007-04-12 | 4Sc Ag | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors |
CN101389617A (zh) * | 2005-10-31 | 2009-03-18 | 詹森药业有限公司 | 制备哌嗪基和二氮杂环庚烷基苯甲酰胺衍生物的新方法 |
CA2656057C (en) * | 2006-06-16 | 2012-10-02 | H. Lundbeck A/S | Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain |
ES2567051T3 (es) * | 2006-10-27 | 2016-04-19 | Signal Pharmaceuticals, Llc | Formas sólidas que comprenden 4-[9-(3S)-(tetrahidro-furan-3-il)-8-(2,4,6-trifluoro-fenilamino)-9H-purin-2-ilamino]-trans-ciclohexan-1-ol, sus composiciones y sus usos |
GB2445746A (en) * | 2007-01-17 | 2008-07-23 | Texcontor Ets | Use of carbonated water as a solvent for freeze drying, and method of purification comprising dissolution of material in carbonated water and freeze drying |
WO2009016648A2 (en) * | 2007-07-30 | 2009-02-05 | Gland Pharma Limited | Process for the preparation of rocuronium bromide and intermediate thereof |
EP2085397A1 (en) * | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
US7935817B2 (en) * | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
AR071318A1 (es) * | 2008-04-15 | 2010-06-09 | Basilea Pharmaceutica Ag | Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso |
US8097719B2 (en) * | 2008-07-15 | 2012-01-17 | Genesen Labs | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem |
KR101016608B1 (ko) * | 2008-12-03 | 2011-02-22 | (주) 성운파마코피아 | 로큐로니움 브로마이드의 제조방법 |
CN101863948B (zh) * | 2009-04-17 | 2013-07-24 | 重庆医药工业研究院有限责任公司 | 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法 |
BR112012022910B1 (pt) | 2010-03-12 | 2021-08-10 | Omeros Corporation | Compostos inibidores de pde10, composição farmacêutica compreendendo os referidos compostos e uso dos mesmos para tratar distúrbios neurológicos em um animal de sangue quente |
CN101824066B (zh) * | 2010-04-08 | 2012-06-13 | 浙江仙琚制药股份有限公司 | 制备罗库溴铵中间体化合物结晶物的方法 |
MX2013002421A (es) * | 2010-09-01 | 2013-05-17 | Arena Pharm Inc | Sales no hidroscopicas de agonistas de 5-ht2c. |
US9067965B2 (en) | 2011-01-26 | 2015-06-30 | Zhejiang Huahai Pharmaceutical Co., Ltd. | Preparation method of rocuronium |
EP2703408B1 (en) * | 2011-04-25 | 2015-08-26 | Zhejiang Huahai Pharmaceutical Co., Ltd. | Method for purifying rocuronium bromide |
WO2013044816A1 (en) * | 2011-09-30 | 2013-04-04 | Sunshine Lake Pharma Co., Ltd. | Crystalline forms of azilsartan and preparation and uses thereof |
CN102633858A (zh) * | 2012-03-06 | 2012-08-15 | 连云港贵科药业有限公司 | 罗库溴铵关键中间体2α,3α-环氧-16β-(1-吡咯烷基)-5α-雄甾烷-17羟基的制备方法 |
CN103588847A (zh) * | 2012-08-17 | 2014-02-19 | 重庆医药工业研究院有限责任公司 | 一种罗库溴铵中间体的制备方法 |
TWI679978B (zh) * | 2013-07-24 | 2019-12-21 | 日商田邊三菱製藥股份有限公司 | 眼科疾病治療劑 |
CN103435674B (zh) * | 2013-09-09 | 2015-05-06 | 山东新华制药股份有限公司 | 高纯度、高稳定性罗库溴铵的制备方法 |
CN103435675B (zh) * | 2013-09-25 | 2015-05-13 | 宜昌人福药业有限责任公司 | 一种甾类肌松药的精制方法 |
NZ716462A (en) * | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
JP2016121073A (ja) * | 2014-12-24 | 2016-07-07 | ニプロ株式会社 | 注射剤用医薬組成物の製造方法 |
CN107530313A (zh) | 2015-04-24 | 2018-01-02 | 奥默罗斯公司 | Pde10抑制剂以及相关组合物和方法 |
WO2017079678A1 (en) | 2015-11-04 | 2017-05-11 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
CN106950314A (zh) * | 2017-04-17 | 2017-07-14 | 南京健友生化制药股份有限公司 | 一种检测罗库溴铵或其注射液中烯丙基溴含量的方法 |
CN107312055A (zh) * | 2017-06-08 | 2017-11-03 | 江苏正大清江制药有限公司 | 一种罗库溴铵新的制备方法 |
CN111278808B (zh) * | 2017-09-07 | 2024-04-26 | 安兹克斯特殊目的有限责任公司 | 2-(5-(4-(2-吗啉代乙氧基)苯基)吡啶-2-基)-n-苄基乙酰胺的固体形式 |
CN108676052B (zh) * | 2018-08-16 | 2020-05-22 | 北京市新里程医药科技有限公司 | 一种罗库溴铵的制备方法及其药物组合物 |
CN109053855B (zh) * | 2018-10-08 | 2020-02-14 | 台州仙琚药业有限公司 | 一种16β-四氢吡咯基雄甾-2α-环氧-17-酮的合成方法 |
CN111196835B (zh) * | 2019-12-27 | 2021-10-26 | 成都新恒创药业有限公司 | 一种罗库溴铵晶型 |
CN111303230B (zh) * | 2020-03-09 | 2021-07-13 | 中国食品药品检定研究院 | 一种黄体酮共晶物及其制备方法和用途 |
CN114088842B (zh) * | 2021-11-19 | 2023-03-21 | 江苏正济药业股份有限公司 | 一种罗库溴铵中间体及杂质的检测方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1138605A (en) * | 1965-02-19 | 1969-01-01 | Organon Labor Ltd | Improvements in or relating to new 2-ß,16-ß-diamino-androstanes |
IE53463B1 (en) | 1981-06-15 | 1988-11-23 | Akzo Nv | Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same |
GB8708886D0 (en) * | 1987-04-14 | 1987-05-20 | Akzo Nv | 2beta-morpholino-androstane derivatives |
GB8709565D0 (en) | 1987-04-23 | 1987-05-28 | Akzo Nv | 2beta,16beta-diaminoandrostanes |
HU210076B (en) * | 1992-11-02 | 1995-01-30 | Tuba | Process for producing androstane derivatives substituted with quaternisaeted amino group in 16-position and for producing pharmaceutical compositions containing them |
IT1277700B1 (it) | 1995-12-22 | 1997-11-11 | Poli Ind Chimica Spa | Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura |
JP3440741B2 (ja) * | 1997-03-04 | 2003-08-25 | 戸田工業株式会社 | 磁気カード用マグネトプランバイト型フェライト粒子粉末 |
DE19903894A1 (de) | 1999-02-01 | 2000-08-03 | Scheiber Gerd | Arzneimittelkombination zur Muskelrelaxation in Anaestesie und Intensivmedizin |
DE112005000178T5 (de) | 2004-01-15 | 2007-01-25 | Chemagis Ltd. | Verfahren zur Herstellung von Rocuroniumbromid und Zwischenprodukte davon |
US20060058275A1 (en) * | 2004-07-15 | 2006-03-16 | Oded Friedman | Processes for preparing stabilized, highly pure rocuronium bromide |
US20060058276A1 (en) * | 2004-07-15 | 2006-03-16 | Oded Friedman | Processes for the preparation and purification of rocuronium bromide |
US20060009485A1 (en) * | 2005-06-23 | 2006-01-12 | Chemagis Ltd | Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents |
ES2288811T5 (es) | 2005-09-13 | 2014-02-24 | Sicor Inc. | Procedimiento para la preparación de bromuro de rocuronio puro |
KR20070075390A (ko) | 2007-06-25 | 2007-07-18 | 진철 | 금나노입자를 이용한 근이완제 Rocuronium의 효능개선 및작열감해소 |
-
2006
- 2006-09-13 ES ES06803587.2T patent/ES2288811T5/es active Active
- 2006-09-13 TW TW095133885A patent/TW200804409A/zh unknown
- 2006-09-13 BR BRPI0605937-6A patent/BRPI0605937A2/pt not_active IP Right Cessation
- 2006-09-13 EP EP06803587.2A patent/EP1828221B2/en active Active
- 2006-09-13 EP EP09004578A patent/EP2119723A1/en not_active Withdrawn
- 2006-09-13 CA CA002618272A patent/CA2618272A1/en not_active Abandoned
- 2006-09-13 US US11/521,282 patent/US7569687B2/en not_active Expired - Fee Related
- 2006-09-13 TW TW095133922A patent/TW200804410A/zh unknown
- 2006-09-13 EP EP06814698A patent/EP1924592A2/en not_active Withdrawn
- 2006-09-13 CA CA002617816A patent/CA2617816A1/en not_active Abandoned
- 2006-09-13 KR KR1020077012548A patent/KR20070085703A/ko not_active Application Discontinuation
- 2006-09-13 WO PCT/US2006/035948 patent/WO2007033348A2/en active Application Filing
- 2006-09-13 KR KR1020087003514A patent/KR20080025763A/ko active Application Filing
- 2006-09-13 AT AT06803587T patent/ATE496933T1/de not_active IP Right Cessation
- 2006-09-13 WO PCT/US2006/035828 patent/WO2007073424A1/en active Application Filing
- 2006-09-13 CN CN200680033278A patent/CN101687905A/zh active Pending
- 2006-09-13 EP EP09007478A patent/EP2107066A3/en not_active Withdrawn
- 2006-09-13 MX MX2008000933A patent/MX2008000933A/es not_active Application Discontinuation
- 2006-09-13 DE DE602006019822T patent/DE602006019822D1/de active Active
- 2006-09-13 JP JP2007544657A patent/JP2008522983A/ja active Pending
- 2006-09-13 KR KR1020107015602A patent/KR20100095013A/ko not_active Application Discontinuation
- 2006-09-13 US US11/521,197 patent/US7642246B2/en active Active
- 2006-09-14 JP JP2007551495A patent/JP2008519865A/ja active Pending
- 2006-09-14 DE DE06803587T patent/DE06803587T1/de active Pending
-
2008
- 2008-10-16 US US12/288,243 patent/US20090137794A1/en not_active Abandoned
- 2008-10-16 US US12/288,310 patent/US20090093632A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0605937A2 (pt) | processo para a sìntese de brometo de rocurÈnio | |
NL301113I1 (nl) | Tucatinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout of solvaat | |
ATE536354T1 (de) | Neuartige 1-aza-bizykloalkyl-derivate für die behandlung psychotischer und neurodegenerativer störungen | |
ATE443038T1 (de) | Verfahren zur herstellung von cinacalcet hydrochlorid | |
DE602004016796D1 (de) | Reinigungverfahren für Synthesegas | |
ES2380489T8 (es) | Proceso para la síntesis de compuestos orgánicos | |
DE602006010132D1 (de) | Zwischenprodukte für die Herstellung von Trans-5-Chlor-2-Methyl-2,3,3a,12b-Tetrahydro-1h-DibenzÄ2,3:6,7ÜOxepinoÄ4,5-cÜPyrrol | |
IL185494A0 (en) | Purification of cinacalcet | |
DE602006017918D1 (de) | Verfahren zur Herstellung von Telmisartan | |
BRPI0606118A2 (pt) | uma sìntese assimétrica de (s) - (+) -3- (aminometil) -5- ácido metilhexanóico | |
ATE398121T1 (de) | Neue synthese von irbesartan | |
DE602006019870D1 (de) | Verfahren zur synthese von triazolen | |
DE602006021397D1 (de) | Verfahren zur herstellung von (z)-1-phenyl-1-(n,n-diethylaminocarbonyl)idomethylcyclopropan | |
WO2008015584A3 (en) | Improved process for synthesizing desvenlafaxine free base and salts or solvates thereof | |
DE60324848D1 (de) | Ausgleichsmechanismus für drehwelle | |
PA8659601A1 (es) | Procedimiento para la preparacion de alcoholes aminoetoxibencilicos | |
EP1890711A4 (en) | COMPOUNDS FOR THE TREATMENT OR PREVENTION OF AMINOXIDASE-RELATED DISEASES OR DISEASES | |
DE602006003204D1 (de) | Reinigungsverfahren von Moxonidine | |
ATE464280T1 (de) | Synthese von idarubin-aglycon | |
DE602006017064D1 (de) | Asymmetrische hydrierung zur herstellung von diphenylalaninderivaten | |
DE502006004812D1 (de) | Fungizide 6-phenyl-pyrazolopyrimidin-7-ylamine | |
DE50104093D1 (de) | Verwindungssteifer Fahrgastkäfig, insbesondere für Zweiräder | |
ITMO20030353A1 (it) | Pannello fono-direzionale per condizionamento del suono. | |
EP2272855A3 (en) | Production of l-iduronate containing polysaccharides | |
ITSA20040012A1 (it) | Processo di sterilizzazione di un glucocorticosteroide. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A E 5A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |