BRPI0606118A2 - uma sìntese assimétrica de (s) - (+) -3- (aminometil) -5- ácido metilhexanóico - Google Patents

uma sìntese assimétrica de (s) - (+) -3- (aminometil) -5- ácido metilhexanóico

Info

Publication number
BRPI0606118A2
BRPI0606118A2 BRPI0606118-4A BRPI0606118A BRPI0606118A2 BR PI0606118 A2 BRPI0606118 A2 BR PI0606118A2 BR PI0606118 A BRPI0606118 A BR PI0606118A BR PI0606118 A2 BRPI0606118 A2 BR PI0606118A2
Authority
BR
Brazil
Prior art keywords
aminomethyl
methylhexanoic acid
asymmetric synthesis
synthesis
pregabalin
Prior art date
Application number
BRPI0606118-4A
Other languages
English (en)
Inventor
Anand Prakash Tiwari
Vinod Kumar Kansal
Brijnath P Chaurasia
V Govardhan Rao
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of BRPI0606118A2 publication Critical patent/BRPI0606118A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UMA SìNTESE ASSIMéTRICA DE (S)-(+)-3-(AMINOMETIL)-5-áCIDO METILHEXANóICO. A invençào inclui processos para a sintese de (S)-(+)-3-(aminometil)-5-ácido metilhexanólco, (5) -Pregabalina e intermediários de (5)-Pregabalina.
BRPI0606118-4A 2005-09-19 2006-09-19 uma sìntese assimétrica de (s) - (+) -3- (aminometil) -5- ácido metilhexanóico BRPI0606118A2 (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US71868905P 2005-09-19 2005-09-19
US75243405P 2005-12-20 2005-12-20
US75322005P 2005-12-21 2005-12-21
US75439205P 2005-12-27 2005-12-27
US76369606P 2006-01-30 2006-01-30
US76359306P 2006-01-30 2006-01-30
US83994706P 2006-08-23 2006-08-23
PCT/US2006/036875 WO2007035890A1 (en) 2005-09-19 2006-09-19 An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid

Publications (1)

Publication Number Publication Date
BRPI0606118A2 true BRPI0606118A2 (pt) 2009-06-02

Family

ID=37671245

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606118-4A BRPI0606118A2 (pt) 2005-09-19 2006-09-19 uma sìntese assimétrica de (s) - (+) -3- (aminometil) -5- ácido metilhexanóico

Country Status (9)

Country Link
US (11) US7563923B2 (pt)
EP (2) EP1802568A1 (pt)
KR (2) KR20070087596A (pt)
BR (1) BRPI0606118A2 (pt)
CA (2) CA2619473C (pt)
ES (1) ES2398579T3 (pt)
IL (2) IL186279A0 (pt)
MX (1) MX2007005936A (pt)
WO (2) WO2007035789A1 (pt)

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CA2646474A1 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
WO2007143113A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. The use of enzymatic resolution for the preparation of intermediates of pregabalin
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WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
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US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
JP6482465B2 (ja) 2012-11-07 2019-03-13 ハイカル リミテッド プレガバリンの調製方法
WO2014080345A2 (en) * 2012-11-20 2014-05-30 Shasun Pharmaceuticals Limited Improved process for the preparation of pregabalin
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
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Also Published As

Publication number Publication date
US7586005B2 (en) 2009-09-08
US20100324307A1 (en) 2010-12-23
US20080045747A1 (en) 2008-02-21
US8212071B2 (en) 2012-07-03
EP1841726B1 (en) 2012-10-31
US7851651B2 (en) 2010-12-14
US20090069593A1 (en) 2009-03-12
US7563923B2 (en) 2009-07-21
US20070197827A1 (en) 2007-08-23
US7960583B2 (en) 2011-06-14
IL186280A0 (en) 2008-01-20
KR20070087596A (ko) 2007-08-28
US7923575B2 (en) 2011-04-12
US20090062562A1 (en) 2009-03-05
MX2007005936A (es) 2007-07-04
US7973196B2 (en) 2011-07-05
US20070191636A1 (en) 2007-08-16
KR20080034205A (ko) 2008-04-18
US20100081841A1 (en) 2010-04-01
US20090069578A1 (en) 2009-03-12
ES2398579T3 (es) 2013-03-20
WO2007035890A1 (en) 2007-03-29
EP1802568A1 (en) 2007-07-04
US7465826B2 (en) 2008-12-16
US20090069600A1 (en) 2009-03-12
CA2619472A1 (en) 2007-03-29
IL186279A0 (en) 2008-01-20
US20080051602A1 (en) 2008-02-28
US7687656B2 (en) 2010-03-30
EP1841726A1 (en) 2007-10-10
US7470812B2 (en) 2008-12-30
US20090069596A1 (en) 2009-03-12
WO2007035789A1 (en) 2007-03-29
CA2619473C (en) 2012-04-17
CA2619473A1 (en) 2007-03-29
US7446220B2 (en) 2008-11-04

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.