CR9866A - Novedosos derivados de 1-aza-bicicloalquilo para el tratamiento de trastornos psicoticos y neurodegenerativos - Google Patents
Novedosos derivados de 1-aza-bicicloalquilo para el tratamiento de trastornos psicoticos y neurodegenerativosInfo
- Publication number
- CR9866A CR9866A CR9866A CR9866A CR9866A CR 9866 A CR9866 A CR 9866A CR 9866 A CR9866 A CR 9866A CR 9866 A CR9866 A CR 9866A CR 9866 A CR9866 A CR 9866A
- Authority
- CR
- Costa Rica
- Prior art keywords
- novedosos
- bicicloalquilo
- psychotic
- aza
- derived
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
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Abstract
La presente invencion proporciona un compuesto de la formual (I), en donde X, R, Y, D, A, y B, son como se definen en la presente. Estos compuestos son adecuados como agonistas de nic-alfa 7, y como tales, para el tratamiento de trastornos psicoticos o neurodegenerativos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0521508.2A GB0521508D0 (en) | 2005-10-21 | 2005-10-21 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CR9866A true CR9866A (es) | 2008-06-09 |
Family
ID=35458483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR9866A CR9866A (es) | 2005-10-21 | 2008-04-04 | Novedosos derivados de 1-aza-bicicloalquilo para el tratamiento de trastornos psicoticos y neurodegenerativos |
Country Status (23)
Country | Link |
---|---|
US (1) | US8173667B2 (es) |
EP (1) | EP1940832B1 (es) |
JP (1) | JP4838313B2 (es) |
KR (1) | KR101026330B1 (es) |
CN (1) | CN101268071A (es) |
AT (1) | ATE536354T1 (es) |
AU (1) | AU2006303453B2 (es) |
BR (1) | BRPI0617508A2 (es) |
CA (1) | CA2622356A1 (es) |
CR (1) | CR9866A (es) |
EC (1) | ECSP088369A (es) |
ES (1) | ES2376890T3 (es) |
GB (1) | GB0521508D0 (es) |
IL (1) | IL190394A0 (es) |
MA (1) | MA29870B1 (es) |
MY (1) | MY143250A (es) |
NO (1) | NO20082266L (es) |
NZ (1) | NZ567081A (es) |
RU (1) | RU2008119692A (es) |
TN (1) | TNSN08174A1 (es) |
UA (1) | UA95257C2 (es) |
WO (1) | WO2007045478A1 (es) |
ZA (1) | ZA200802725B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6262265A (ja) * | 1985-09-13 | 1987-03-18 | Hitachi Ltd | 復水器自動検査補修システム |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
AR049401A1 (es) * | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
GB0415746D0 (en) * | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
WO2011009890A2 (en) | 2009-07-23 | 2011-01-27 | Novartis Ag | Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives |
JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
CN103442701A (zh) * | 2011-01-27 | 2013-12-11 | 诺瓦提斯公司 | 烟碱乙酰胆碱受体α7激活剂的用途 |
JP6031458B2 (ja) | 2011-03-18 | 2016-11-24 | ノバルティス アーゲー | パーキンソン病におけるドーパミン誘発ジスキネジアに使用するためのアルファ7ニコチン性アセチルコリン受容体アクティベーターとmGluR5アンタゴニストの組み合わせ剤 |
JO3766B1 (ar) | 2011-10-20 | 2021-01-31 | Novartis Ag | منشط مستقبل أسيتيل كولين الفا - 7 النيكوتيني |
JP6114951B2 (ja) | 2012-12-11 | 2017-04-19 | ノバルティス アーゲー | アルファ7ニコチン性アセチルコリン受容体アクチベーターによる処置に対する応答性を予測するバイオマーカー |
CN105263495B (zh) | 2013-01-15 | 2019-05-14 | 诺华有限公司 | α7烟碱型乙酰胆碱受体激动剂的应用 |
US20150313884A1 (en) | 2013-01-15 | 2015-11-05 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
WO2014111837A1 (en) | 2013-01-15 | 2014-07-24 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
JP6137336B2 (ja) * | 2013-01-15 | 2017-05-31 | ノバルティス アーゲー | ナルコレプシーの処置のためのアルファ7ニコチン性受容体アゴニストの使用 |
AU2015362790A1 (en) | 2014-12-16 | 2017-07-20 | Axovant Sciences Gmbh | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
RU2017145964A (ru) | 2015-06-10 | 2019-07-10 | Аксовант Сайенсиз Гмбх | Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов |
US10428062B2 (en) | 2015-08-12 | 2019-10-01 | Axovant Sciences Gmbh | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
CN111491920B (zh) | 2017-10-20 | 2024-01-30 | 范德比尔特大学 | 毒蕈碱性乙酰胆碱受体m4的拮抗剂 |
CN111565718A (zh) | 2017-10-31 | 2020-08-21 | 范德比尔特大学 | 毒蕈碱性乙酰胆碱受体m4的拮抗剂 |
JP7352294B2 (ja) * | 2018-02-02 | 2023-09-28 | ヴァンダービルト ユニバーシティー | ムスカリン性アセチルコリン受容体m4のアンタゴニスト |
Family Cites Families (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2139107A1 (de) | 1971-08-04 | 1973-02-15 | Merck Patent Gmbh | Heterocyclisch substituierte adenosinverbindungen |
DD213107A1 (de) | 1983-01-05 | 1984-08-29 | Funkwerk Erfurt Veb K | Verfahren zur reinigung von schaltungsplatten |
ZA848275B (en) | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
US4605652A (en) | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
EP0247266B1 (en) | 1986-01-07 | 1993-03-10 | Beecham Group Plc | Indole derivatives having an azabicyclic side chain, process for their preparation, intermediates, and pharmaceutical compositions |
NZ224237A (en) | 1987-04-15 | 1991-04-26 | Beecham Group Plc | Bicyclic compounds (n bridged compounds) |
CA1307790C (en) | 1987-08-04 | 1992-09-22 | Ian Anthony Cliffe | Ethers |
GB8718445D0 (en) | 1987-08-04 | 1987-09-09 | Wyeth John & Brother Ltd | Pyridyl-ethers |
DE3839385A1 (de) | 1988-11-22 | 1990-05-23 | Boehringer Ingelheim Kg | Neue quinuclidine, ihre herstellung als arzneimittel und verfahren zu ihrer herstellung |
DE4116582A1 (de) | 1990-05-19 | 1991-11-21 | Boehringer Ingelheim Kg | Bicyclische 1-aza-cycloalkane |
YU84791A (sh) | 1990-05-19 | 1994-06-10 | Boehringer Ingelheim Kg. | Biciklicni 1-aza-cikloalkalni |
CA2090027A1 (en) | 1990-08-31 | 1992-03-01 | Shoichi Chokai | Pyrimidine derivatives and drugs |
JP3087763B2 (ja) | 1990-11-30 | 2000-09-11 | 三井化学株式会社 | 新規な複素環式化合物およびそれを含有する医薬組成物 |
US5260303A (en) * | 1991-03-07 | 1993-11-09 | G. D. Searle & Co. | Imidazopyridines as serotonergic 5-HT3 antagonists |
US5385912A (en) | 1991-03-08 | 1995-01-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Multicyclic tertiary amine polyaromatic squalene synthase inhibitors |
JPH06506467A (ja) | 1991-03-08 | 1994-07-21 | ローヌ−プーラン ローラー インターナショナル(ホウルディングス) インコーポレイテッド | 多環式三級アミンポリ芳香族スクアレンシンセターゼインヒビター |
JPH05310732A (ja) | 1992-03-12 | 1993-11-22 | Mitsubishi Kasei Corp | シンノリン−3−カルボン酸誘導体 |
AU3901393A (en) | 1992-04-10 | 1993-11-18 | Zeneca Limited | Biphenylylquinuclidine derivatives as squalene synthase inhibitors |
IL107184A (en) | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
AU7394394A (en) | 1992-10-13 | 1995-12-05 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | 3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors |
WO1994018201A1 (en) | 1993-02-12 | 1994-08-18 | Sankyo Company, Limited | Isoxazoleoxy derivative |
JPH06293768A (ja) | 1993-02-12 | 1994-10-21 | Sankyo Co Ltd | イソオキサゾールオキシ誘導体 |
JP3235913B2 (ja) | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | アミノ安息香酸誘導体 |
US5998404A (en) | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
JPH11512443A (ja) | 1995-09-22 | 1999-10-26 | ノボ ノルディスク アクティーゼルスカブ | 新規な置換アザ環式またはアザ二環式化合物 |
SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
ZA984637B (en) | 1997-05-30 | 1998-12-21 | Neurosearch As | Spiro-quinuclidine derivatives their preparation and use |
AR013184A1 (es) | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
US6432975B1 (en) * | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
DK1202736T3 (da) | 1999-07-28 | 2008-12-15 | Univ Leland Stanford Junior | Nikotin i terapeutisk angiogenese og vasculogenese |
SE9903760D0 (sv) | 1999-10-18 | 1999-10-18 | Astra Ab | New compounds |
SE9904176D0 (sv) | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
AU2001241056A1 (en) | 2000-03-09 | 2001-09-17 | Mitsubishi Pharma Corporation | Spiro compounds, process for preparing the same and use thereof as drugs |
GB0010955D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
JP4616971B2 (ja) | 2000-07-18 | 2011-01-19 | 田辺三菱製薬株式会社 | 1−アザビシクロアルカン化合物およびその医薬用途 |
AU2001282874A1 (en) | 2000-08-18 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
WO2002015662A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists |
GB0021885D0 (en) | 2000-09-06 | 2000-10-18 | Fujisawa Pharmaceutical Co | New use |
PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
MXPA04003986A (es) | 2001-10-26 | 2004-07-23 | Upjohn Co | Carboxamidas hetero-biciclicas n-azabiciclico sustituidas como agonistas nachr. |
DE10156719A1 (de) | 2001-11-19 | 2003-05-28 | Bayer Ag | Heteroarylcarbonsäureamide |
DE10162375A1 (de) | 2001-12-19 | 2003-07-10 | Bayer Ag | Bicyclische N-Aryl-amide |
WO2003072578A1 (en) | 2002-02-20 | 2003-09-04 | Pharmacia & Upjohn Company | Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity |
DE10211416A1 (de) * | 2002-03-15 | 2003-09-25 | Bayer Ag | Essig- und Propionsäureamide |
DE10211415A1 (de) * | 2002-03-15 | 2003-09-25 | Bayer Ag | Bicyclische N-Biarylamide |
DE10234424A1 (de) * | 2002-07-29 | 2004-02-12 | Bayer Ag | Benzothiophen-, Benzofuran- und Indolharnstoffe |
KR20050055711A (ko) | 2002-08-14 | 2005-06-13 | 뉴로서치 에이/에스 | 신규한 퀴누클리딘 유도체 및 이를 포함하는 약제학적 조성물 |
GB0220581D0 (en) * | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
AU2003276919B2 (en) | 2002-09-25 | 2013-05-16 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
AU2003284898A1 (en) | 2002-10-29 | 2004-05-25 | Micro, Inc. | Combinative nicotinic/d1 agonism therapy for the treatment of alzheimer's disease |
BR0315056A (pt) | 2002-11-01 | 2005-08-16 | Pharmacia & Upjohn Co Llc | Compostos tendo tanto atividade agonista nicotìnica de alfa7 quanto atividade antagonista de 5ht3 para o tratamento de doenças do sistema nervoso central |
WO2004039366A1 (en) | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
BR0317110A (pt) * | 2002-12-11 | 2005-10-25 | Pharmacia & Upjohn Co Llc | Tratamento de doenças com combinações de agonistas do receptor nicotìnico da acetilcolina alfa 7 e outros compostos |
BRPI0406834A (pt) * | 2003-01-22 | 2005-12-27 | Pharmacia & Upjohn Co Llc | Tratamento de doença com agonistas totais do receptor nach alfa-7 |
WO2005013910A2 (en) * | 2003-08-07 | 2005-02-17 | University Of South Florida | Cholinergic modulation of microglial activation via alpha-7 nicotinic receptors |
US20070060588A1 (en) * | 2003-12-22 | 2007-03-15 | Jianguo Ji | Fused bicycloheterocycle substituted quinuclidine derivatives |
US7241773B2 (en) * | 2003-12-22 | 2007-07-10 | Abbott Laboratories | 3-quinuclidinyl heteroatom bridged biaryl derivatives |
US7160876B2 (en) * | 2003-12-22 | 2007-01-09 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
US20050137204A1 (en) * | 2003-12-22 | 2005-06-23 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
US7655657B2 (en) * | 2003-12-22 | 2010-02-02 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
US20050137398A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | 3-Quinuclidinyl heteroatom bridged biaryl derivatives |
US20050137203A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | 3-quinuclidinyl amino-substituted biaryl derivatives |
US20050245531A1 (en) * | 2003-12-22 | 2005-11-03 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
JP2007516275A (ja) * | 2003-12-23 | 2007-06-21 | ファイザー・プロダクツ・インク | 認知増強および精神病性障害のための治療的組合せ |
JP5019884B2 (ja) | 2004-02-20 | 2012-09-05 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 炎症プロセスおよび転移プロセスの調節 |
JP2007532676A (ja) * | 2004-04-13 | 2007-11-15 | イカジェン インコーポレイテッド | カリウムイオンチャネル調節剤としての多環式ピリジン |
US7514450B2 (en) | 2004-05-19 | 2009-04-07 | Neurosearch A/S | Azabicyclic aryl derivatives |
AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
GB0415746D0 (en) * | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
CA2584836A1 (en) | 2004-10-15 | 2006-04-20 | Neurosearch A/S | Novel azabicyclic aryl derivatives and their medical use |
GB0424564D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
JP2008523058A (ja) | 2004-12-10 | 2008-07-03 | アボット・ラボラトリーズ | 縮合ビシクロ複素環置換キヌクリジン誘導体 |
WO2006087305A1 (en) * | 2005-02-16 | 2006-08-24 | Neurosearch A/S | Novel diazabicyclic aryl derivatives and their medical use |
MX2007011436A (es) * | 2005-03-18 | 2007-10-12 | Abbott Lab | Ligando del receptor nicotinico neuronal 7 y composiciones antipsicoticas. |
CA2606174A1 (en) * | 2005-04-18 | 2006-10-26 | Saeed R. Khan | Design and synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (bpu) sulfur analogs |
FR2884822B1 (fr) * | 2005-04-22 | 2007-06-29 | Aventis Pharma Sa | Derives de triazines, leur preparation et leur application en therapeutique |
TW201004961A (en) * | 2005-06-14 | 2010-02-01 | Schering Corp | Aspartyl protease inhibitors |
GB0525672D0 (en) * | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
TW200813067A (en) | 2006-05-17 | 2008-03-16 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
-
2005
- 2005-10-21 GB GBGB0521508.2A patent/GB0521508D0/en not_active Ceased
-
2006
- 2006-10-19 KR KR1020087009341A patent/KR101026330B1/ko not_active IP Right Cessation
- 2006-10-19 CN CNA2006800348672A patent/CN101268071A/zh active Pending
- 2006-10-19 JP JP2008534950A patent/JP4838313B2/ja not_active Expired - Fee Related
- 2006-10-19 CA CA002622356A patent/CA2622356A1/en not_active Abandoned
- 2006-10-19 ES ES06806403T patent/ES2376890T3/es active Active
- 2006-10-19 AU AU2006303453A patent/AU2006303453B2/en not_active Ceased
- 2006-10-19 US US12/090,931 patent/US8173667B2/en not_active Expired - Fee Related
- 2006-10-19 BR BRPI0617508-2A patent/BRPI0617508A2/pt not_active IP Right Cessation
- 2006-10-19 UA UAA200805038A patent/UA95257C2/ru unknown
- 2006-10-19 RU RU2008119692/04A patent/RU2008119692A/ru not_active Application Discontinuation
- 2006-10-19 WO PCT/EP2006/010099 patent/WO2007045478A1/en active Application Filing
- 2006-10-19 AT AT06806403T patent/ATE536354T1/de active
- 2006-10-19 NZ NZ567081A patent/NZ567081A/en not_active IP Right Cessation
- 2006-10-19 EP EP06806403A patent/EP1940832B1/en active Active
-
2008
- 2008-03-24 IL IL190394A patent/IL190394A0/en unknown
- 2008-03-27 ZA ZA200802725A patent/ZA200802725B/xx unknown
- 2008-04-04 CR CR9866A patent/CR9866A/es not_active Application Discontinuation
- 2008-04-15 EC EC2008008369A patent/ECSP088369A/es unknown
- 2008-04-15 MA MA30848A patent/MA29870B1/fr unknown
- 2008-04-18 MY MYPI20081171A patent/MY143250A/en unknown
- 2008-04-18 TN TNP2008000174A patent/TNSN08174A1/en unknown
- 2008-05-16 NO NO20082266A patent/NO20082266L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ECSP088369A (es) | 2008-05-30 |
ATE536354T1 (de) | 2011-12-15 |
ZA200802725B (en) | 2009-10-28 |
NZ567081A (en) | 2011-05-27 |
ES2376890T3 (es) | 2012-03-20 |
UA95257C2 (ru) | 2011-07-25 |
US8173667B2 (en) | 2012-05-08 |
JP2009515820A (ja) | 2009-04-16 |
EP1940832A1 (en) | 2008-07-09 |
TNSN08174A1 (en) | 2009-10-30 |
MA29870B1 (fr) | 2008-10-03 |
KR101026330B1 (ko) | 2011-03-31 |
KR20080048082A (ko) | 2008-05-30 |
CN101268071A (zh) | 2008-09-17 |
US20080255135A1 (en) | 2008-10-16 |
AU2006303453B2 (en) | 2011-07-14 |
BRPI0617508A2 (pt) | 2011-07-26 |
NO20082266L (no) | 2008-05-16 |
CA2622356A1 (en) | 2007-04-26 |
IL190394A0 (en) | 2008-11-03 |
AU2006303453A1 (en) | 2007-04-26 |
EP1940832B1 (en) | 2011-12-07 |
GB0521508D0 (en) | 2005-11-30 |
MY143250A (en) | 2011-04-15 |
JP4838313B2 (ja) | 2011-12-14 |
WO2007045478A1 (en) | 2007-04-26 |
RU2008119692A (ru) | 2009-11-27 |
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