ATE528989T1 - Kristalline feste rasagilin-base - Google Patents

Kristalline feste rasagilin-base

Info

Publication number
ATE528989T1
ATE528989T1 AT07862906T AT07862906T ATE528989T1 AT E528989 T1 ATE528989 T1 AT E528989T1 AT 07862906 T AT07862906 T AT 07862906T AT 07862906 T AT07862906 T AT 07862906T AT E528989 T1 ATE528989 T1 AT E528989T1
Authority
AT
Austria
Prior art keywords
rasagilin
base
crystalline solid
aminoindan
propargyl
Prior art date
Application number
AT07862906T
Other languages
English (en)
Inventor
Anton Frenkel
Tamas Koltai
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39536623&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE528989(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharma filed Critical Teva Pharma
Application granted granted Critical
Publication of ATE528989T1 publication Critical patent/ATE528989T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
AT07862906T 2006-12-14 2007-12-13 Kristalline feste rasagilin-base ATE528989T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87501106P 2006-12-14 2006-12-14
PCT/US2007/025583 WO2008076348A1 (en) 2006-12-14 2007-12-13 Crystalline solid rasagiline base

Publications (1)

Publication Number Publication Date
ATE528989T1 true ATE528989T1 (de) 2011-11-15

Family

ID=39536623

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07862906T ATE528989T1 (de) 2006-12-14 2007-12-13 Kristalline feste rasagilin-base

Country Status (24)

Country Link
US (4) US7750051B2 (de)
EP (1) EP2101569B1 (de)
JP (1) JP5623081B2 (de)
KR (1) KR101459744B1 (de)
CN (1) CN101557706B (de)
AT (1) ATE528989T1 (de)
AU (1) AU2007334428B2 (de)
CA (1) CA2672414A1 (de)
CY (1) CY1112511T1 (de)
DK (1) DK2101569T3 (de)
EA (1) EA016820B1 (de)
ES (1) ES2375761T3 (de)
HR (1) HRP20110980T1 (de)
IL (1) IL198985A0 (de)
MX (1) MX2009006251A (de)
NO (1) NO20092611L (de)
NZ (1) NZ577460A (de)
PL (1) PL2101569T3 (de)
PT (1) PT2101569E (de)
RS (1) RS52183B (de)
SI (1) SI2101569T1 (de)
UA (1) UA97502C2 (de)
WO (1) WO2008076348A1 (de)
ZA (1) ZA200903903B (de)

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EP2007369A4 (de) * 2006-04-03 2009-07-01 Teva Pharma Verwendung von rasagilin zur behandlung des syndroms der ruhelosen beine
EP1892233A1 (de) 2006-08-18 2008-02-27 Ratiopharm GmbH Neue Salze des Wirkstoffs Rasagilin
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US8188149B2 (en) * 2007-09-17 2012-05-29 Teva Pharmaceutical Industries, Ltd. Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
WO2009089049A1 (en) * 2008-01-11 2009-07-16 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations, their preparation and use
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BRPI0909997A2 (pt) 2008-06-19 2015-10-27 Teva Pharma r(+)-n-propargil-1-aminoindano cristalino, composição farmacêutica, processo de secagem de r(+)-n-propargil-1-aminoindano sólido, processo de preparação de uma composição farmacêutica, processo de produção de um lote validado de um produto de farmaco que contém r(+)-n-propargil-1-aminoindano cristalino e pelo menos um veículo farmaceuticamente aceitável para distribuição e processo de prudução de r(+)-n-propargil-1-aminoindano cristalino
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CN101606923B (zh) * 2008-06-20 2013-01-09 重庆医药工业研究院有限责任公司 一种稳定的控释释放的雷沙吉兰透皮贴片及其制备方法
ITMI20081406A1 (it) * 2008-07-29 2010-01-30 Dipharma Francis Srl Forma cristallina di rasagilina e procedimento per la sua preparazione
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RU2587330C2 (ru) 2010-07-27 2016-06-20 Тева Фармасьютикал Индастриз Лтд. Применение разагилина для лечения обонятельной дисфункции
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CN103476404B (zh) 2011-03-24 2017-09-29 帝国制药美国公司 包含活性剂层和活性剂转化层的透皮组合物
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US8188149B2 (en) 2007-09-17 2012-05-29 Teva Pharmaceutical Industries, Ltd. Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
WO2009089049A1 (en) 2008-01-11 2009-07-16 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations, their preparation and use
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BRPI0909997A2 (pt) * 2008-06-19 2015-10-27 Teva Pharma r(+)-n-propargil-1-aminoindano cristalino, composição farmacêutica, processo de secagem de r(+)-n-propargil-1-aminoindano sólido, processo de preparação de uma composição farmacêutica, processo de produção de um lote validado de um produto de farmaco que contém r(+)-n-propargil-1-aminoindano cristalino e pelo menos um veículo farmaceuticamente aceitável para distribuição e processo de prudução de r(+)-n-propargil-1-aminoindano cristalino
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Also Published As

Publication number Publication date
IL198985A0 (en) 2010-02-17
EP2101569A1 (de) 2009-09-23
US20100145101A1 (en) 2010-06-10
US20150038744A1 (en) 2015-02-05
DK2101569T3 (da) 2012-01-30
WO2008076348A1 (en) 2008-06-26
MX2009006251A (es) 2009-10-12
US7750051B2 (en) 2010-07-06
HK1129276A1 (en) 2009-11-27
CN101557706B (zh) 2013-08-07
US20100144887A1 (en) 2010-06-10
EA200970581A1 (ru) 2009-12-30
JP5623081B2 (ja) 2014-11-12
AU2007334428A1 (en) 2008-06-26
NZ577460A (en) 2012-01-12
KR20090089894A (ko) 2009-08-24
EP2101569A4 (de) 2009-12-02
EA016820B1 (ru) 2012-07-30
RS52183B (sr) 2012-10-31
WO2008076348A8 (en) 2008-08-21
CA2672414A1 (en) 2008-06-26
JP2010513282A (ja) 2010-04-30
EP2101569B1 (de) 2011-10-19
US8614252B2 (en) 2013-12-24
UA97502C2 (ru) 2012-02-27
KR101459744B1 (ko) 2014-11-20
CN101557706A (zh) 2009-10-14
SI2101569T1 (sl) 2012-02-29
ZA200903903B (en) 2010-08-25
AU2007334428B2 (en) 2014-05-29
NO20092611L (no) 2009-09-11
CY1112511T1 (el) 2015-12-09
ES2375761T3 (es) 2012-03-06
US20080161408A1 (en) 2008-07-03
PL2101569T3 (pl) 2012-03-30
HRP20110980T1 (hr) 2012-02-29
PT2101569E (pt) 2012-01-13

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