DE06803587T1 - Reines rocuroniumbromid - Google Patents
Reines rocuroniumbromid Download PDFInfo
- Publication number
- DE06803587T1 DE06803587T1 DE06803587T DE06803587T DE06803587T1 DE 06803587 T1 DE06803587 T1 DE 06803587T1 DE 06803587 T DE06803587 T DE 06803587T DE 06803587 T DE06803587 T DE 06803587T DE 06803587 T1 DE06803587 T1 DE 06803587T1
- Authority
- DE
- Germany
- Prior art keywords
- rocuronium bromide
- hplc
- impurity
- measured
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C[C@](C1)[C@@](*)[C@@](C)(CC2)C1C(CC1)C2[C@@](C)(C[C@](*2CCOCC2)[C@](C2)OC)[C@@]12I=C Chemical compound C[C@](C1)[C@@](*)[C@@](C)(CC2)C1C(CC1)C2[C@@](C)(C[C@](*2CCOCC2)[C@](C2)OC)[C@@]12I=C 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Gyroscopes (AREA)
Abstract
Rocuroniumbromid,
Verbindung I:
Claims (8)
- Rocuroniumbromid, Verbindung I: mit einem potentiometrischen Test von 99% bis 101% in Essigsäure und Perchlorsäure mit einem Bereich von weniger als etwa 0,2% an Verunreinigung A, gemessen durch HPLC, und mit wenigstens einem der Lösungsmittel Ethylether und Dichlormethan in einer Menge von gleich oder weniger als etwa 850 ppm bzw. 600 ppm.
- Rocuroniumbromid nach Anspruch 1 mit einem Bereich von weniger als etwa 0,1% an Verunreinigung A, gemessen durch HPLC.
- Rocuroniumbromid nach einem der Ansprüche 1 oder 2 mit einem Bereich von etwa 0,1% bis etwa 0,02% an Verunreinigung A, gemessen durch HPLC.
- Rocuroniumbromid nach einem der Ansprüche 1 bis 3 mit einem Bereich von etwa 0,07% bis etwa 0,02% an Verunreinigung A, gemessen durch HPLC.
- Rocuroniumbromid nach einem der Ansprüche 1 bis 4 mit einem gesamten Lösungsmittelgehalt von weniger als 2000 ppm.
- Pharmazeutische Formulierung, welche das Rocuroniumbromid nach einem der Ansprüche 1 bis 5 und wenigstens einen pharmazeutisch verträglichen Hilfsstoff umfaßt.
- Verfahren zur Herstellung der pharmazeutischen Formulierung nach Anspruch 6, welches das Mischen des Rocuroniumbromids und des wenigstens einen pharmazeutisch verträglichen Hilfsstoffs umfaßt.
- Verwendung der pharmazeutischen Formulierung nach Anspruch 6 bei der Herstellung eines Medikaments für die Muskelentspannung.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71712205P | 2005-09-13 | 2005-09-13 | |
US75267105P | 2005-12-19 | 2005-12-19 | |
US752671P | 2005-12-19 | ||
US75243505P | 2005-12-20 | 2005-12-20 | |
US752435P | 2005-12-20 | ||
US77632206P | 2006-02-23 | 2006-02-23 | |
US776322P | 2006-02-23 | ||
US78474606P | 2006-03-21 | 2006-03-21 | |
US784746P | 2006-03-21 | ||
PCT/US2006/035828 WO2007073424A1 (en) | 2005-09-13 | 2006-09-13 | Pure rocuronium bromide |
Publications (1)
Publication Number | Publication Date |
---|---|
DE06803587T1 true DE06803587T1 (de) | 2007-11-22 |
Family
ID=37757118
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006019822T Active DE602006019822D1 (de) | 2005-09-13 | 2006-09-13 | Reines rocuroniumbromid |
DE06803587T Pending DE06803587T1 (de) | 2005-09-13 | 2006-09-14 | Reines rocuroniumbromid |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006019822T Active DE602006019822D1 (de) | 2005-09-13 | 2006-09-13 | Reines rocuroniumbromid |
Country Status (13)
Country | Link |
---|---|
US (4) | US7642246B2 (de) |
EP (4) | EP2119723A1 (de) |
JP (2) | JP2008522983A (de) |
KR (3) | KR20100095013A (de) |
CN (1) | CN101687905A (de) |
AT (1) | ATE496933T1 (de) |
BR (1) | BRPI0605937A2 (de) |
CA (2) | CA2618272A1 (de) |
DE (2) | DE602006019822D1 (de) |
ES (1) | ES2288811T5 (de) |
MX (1) | MX2008000933A (de) |
TW (2) | TW200804410A (de) |
WO (2) | WO2007033348A2 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004311544A1 (en) * | 2003-11-17 | 2005-07-21 | Merck & Cie | Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride |
ES2370829T3 (es) * | 2004-06-02 | 2011-12-23 | Sandoz Ag | Producto intermedio de meropenem en forma cristalina. |
JP2008522983A (ja) | 2005-09-13 | 2008-07-03 | シコール インコーポレイティド | ロクロニウムブロミドの合成方法 |
EP1928826B1 (de) * | 2005-09-21 | 2013-04-24 | 4Sc Ag | Sulfonylpyrrolhydrochloridsalze als inhibitoren von histondeacetylasen |
EA014905B1 (ru) * | 2005-10-31 | 2011-02-28 | Янссен Фармацевтика Н.В. | Новый способ получения пиперазинильных производных бензамида |
MX2008016008A (es) * | 2006-06-16 | 2009-01-16 | Lundbeck & Co As H | Formas cristalinas de 4-[2-(4-metilfenilsulfonil)-fenil] piperidina con inhibicion combinada de la recaptacion de serotonina y norepinefrina para el tratamiento del dolor neuropatico. |
BRPI0717394A2 (pt) * | 2006-10-27 | 2013-10-15 | Signal Pharm Llc | Forma cristalina, composição farmacêutica, forma de dosagem unitária única, método para tratar ou prevenir uma doença ou condição, e, processo para preparar um composto |
GB2445746A (en) * | 2007-01-17 | 2008-07-23 | Texcontor Ets | Use of carbonated water as a solvent for freeze drying, and method of purification comprising dissolution of material in carbonated water and freeze drying |
WO2009016648A2 (en) * | 2007-07-30 | 2009-02-05 | Gland Pharma Limited | Process for the preparation of rocuronium bromide and intermediate thereof |
EP2085397A1 (de) * | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Kristalline Form von Abacavir |
US7935817B2 (en) * | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
AR071318A1 (es) * | 2008-04-15 | 2010-06-09 | Basilea Pharmaceutica Ag | Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso |
US8097719B2 (en) * | 2008-07-15 | 2012-01-17 | Genesen Labs | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem |
KR101016608B1 (ko) * | 2008-12-03 | 2011-02-22 | (주) 성운파마코피아 | 로큐로니움 브로마이드의 제조방법 |
CN101863948B (zh) * | 2009-04-17 | 2013-07-24 | 重庆医药工业研究院有限责任公司 | 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法 |
KR101713453B1 (ko) | 2010-03-12 | 2017-03-07 | 오메로스 코포레이션 | Pde10 억제제 및 관련 조성물 및 방법 |
CN101824066B (zh) * | 2010-04-08 | 2012-06-13 | 浙江仙琚制药股份有限公司 | 制备罗库溴铵中间体化合物结晶物的方法 |
WO2012030957A2 (en) * | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-ht2c agonists |
CN103119051B (zh) * | 2011-01-26 | 2015-09-23 | 浙江华海药业股份有限公司 | 罗库溴铵的制备方法 |
US9024013B2 (en) | 2011-04-25 | 2015-05-05 | Zhejiang Huahai Pharmaceutical Co., Ltd | Method for purifying rocuronium bromide |
CN103930419B (zh) * | 2011-09-30 | 2016-06-01 | 广东东阳光药业有限公司 | 阿齐沙坦的晶型及其制备方法 |
CN102633858A (zh) * | 2012-03-06 | 2012-08-15 | 连云港贵科药业有限公司 | 罗库溴铵关键中间体2α,3α-环氧-16β-(1-吡咯烷基)-5α-雄甾烷-17羟基的制备方法 |
CN103588847A (zh) * | 2012-08-17 | 2014-02-19 | 重庆医药工业研究院有限责任公司 | 一种罗库溴铵中间体的制备方法 |
WO2015012332A1 (ja) * | 2013-07-24 | 2015-01-29 | 田辺三菱製薬株式会社 | 眼科疾患治療剤 |
CN103435674B (zh) * | 2013-09-09 | 2015-05-06 | 山东新华制药股份有限公司 | 高纯度、高稳定性罗库溴铵的制备方法 |
CN103435675B (zh) * | 2013-09-25 | 2015-05-13 | 宜昌人福药业有限责任公司 | 一种甾类肌松药的精制方法 |
NZ630810A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
NZ716462A (en) * | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
JP2016121073A (ja) * | 2014-12-24 | 2016-07-07 | ニプロ株式会社 | 注射剤用医薬組成物の製造方法 |
AU2016250843A1 (en) | 2015-04-24 | 2017-10-12 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
JP2018535969A (ja) | 2015-11-04 | 2018-12-06 | オメロス コーポレーション | Pde10阻害剤の固体状態形態 |
CN106950314A (zh) * | 2017-04-17 | 2017-07-14 | 南京健友生化制药股份有限公司 | 一种检测罗库溴铵或其注射液中烯丙基溴含量的方法 |
CN107312055A (zh) * | 2017-06-08 | 2017-11-03 | 江苏正大清江制药有限公司 | 一种罗库溴铵新的制备方法 |
CA3074831A1 (en) * | 2017-09-07 | 2019-03-14 | Athenex HK Innovative Limited | Solid forms of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-n-benzylacetamide |
CN108676052B (zh) * | 2018-08-16 | 2020-05-22 | 北京市新里程医药科技有限公司 | 一种罗库溴铵的制备方法及其药物组合物 |
CN109053855B (zh) * | 2018-10-08 | 2020-02-14 | 台州仙琚药业有限公司 | 一种16β-四氢吡咯基雄甾-2α-环氧-17-酮的合成方法 |
CN111196835B (zh) * | 2019-12-27 | 2021-10-26 | 成都新恒创药业有限公司 | 一种罗库溴铵晶型 |
CN111303230B (zh) * | 2020-03-09 | 2021-07-13 | 中国食品药品检定研究院 | 一种黄体酮共晶物及其制备方法和用途 |
CN114088842B (zh) * | 2021-11-19 | 2023-03-21 | 江苏正济药业股份有限公司 | 一种罗库溴铵中间体及杂质的检测方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1138605A (en) * | 1965-02-19 | 1969-01-01 | Organon Labor Ltd | Improvements in or relating to new 2-ß,16-ß-diamino-androstanes |
IE53463B1 (en) * | 1981-06-15 | 1988-11-23 | Akzo Nv | Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same |
GB8708886D0 (en) | 1987-04-14 | 1987-05-20 | Akzo Nv | 2beta-morpholino-androstane derivatives |
GB8709565D0 (en) | 1987-04-23 | 1987-05-28 | Akzo Nv | 2beta,16beta-diaminoandrostanes |
HU210076B (en) * | 1992-11-02 | 1995-01-30 | Tuba | Process for producing androstane derivatives substituted with quaternisaeted amino group in 16-position and for producing pharmaceutical compositions containing them |
IT1277700B1 (it) | 1995-12-22 | 1997-11-11 | Poli Ind Chimica Spa | Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura |
JP3440741B2 (ja) * | 1997-03-04 | 2003-08-25 | 戸田工業株式会社 | 磁気カード用マグネトプランバイト型フェライト粒子粉末 |
DE19903894A1 (de) | 1999-02-01 | 2000-08-03 | Scheiber Gerd | Arzneimittelkombination zur Muskelrelaxation in Anaestesie und Intensivmedizin |
WO2005068487A2 (en) | 2004-01-15 | 2005-07-28 | Chemagis Ltd. | Processes for the preparation of rocuronium bromide and intermediates thereof |
US20060058275A1 (en) * | 2004-07-15 | 2006-03-16 | Oded Friedman | Processes for preparing stabilized, highly pure rocuronium bromide |
US20060058276A1 (en) * | 2004-07-15 | 2006-03-16 | Oded Friedman | Processes for the preparation and purification of rocuronium bromide |
US20060009485A1 (en) * | 2005-06-23 | 2006-01-12 | Chemagis Ltd | Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents |
JP2008522983A (ja) * | 2005-09-13 | 2008-07-03 | シコール インコーポレイティド | ロクロニウムブロミドの合成方法 |
KR20070075390A (ko) | 2007-06-25 | 2007-07-18 | 진철 | 금나노입자를 이용한 근이완제 Rocuronium의 효능개선 및작열감해소 |
-
2006
- 2006-09-13 JP JP2007544657A patent/JP2008522983A/ja active Pending
- 2006-09-13 CA CA002618272A patent/CA2618272A1/en not_active Abandoned
- 2006-09-13 KR KR1020107015602A patent/KR20100095013A/ko not_active Application Discontinuation
- 2006-09-13 US US11/521,197 patent/US7642246B2/en active Active
- 2006-09-13 EP EP09004578A patent/EP2119723A1/de not_active Withdrawn
- 2006-09-13 BR BRPI0605937-6A patent/BRPI0605937A2/pt not_active IP Right Cessation
- 2006-09-13 EP EP06814698A patent/EP1924592A2/de not_active Withdrawn
- 2006-09-13 AT AT06803587T patent/ATE496933T1/de not_active IP Right Cessation
- 2006-09-13 MX MX2008000933A patent/MX2008000933A/es not_active Application Discontinuation
- 2006-09-13 CA CA002617816A patent/CA2617816A1/en not_active Abandoned
- 2006-09-13 EP EP06803587.2A patent/EP1828221B2/de active Active
- 2006-09-13 WO PCT/US2006/035948 patent/WO2007033348A2/en active Application Filing
- 2006-09-13 EP EP09007478A patent/EP2107066A3/de not_active Withdrawn
- 2006-09-13 US US11/521,282 patent/US7569687B2/en not_active Expired - Fee Related
- 2006-09-13 DE DE602006019822T patent/DE602006019822D1/de active Active
- 2006-09-13 KR KR1020077012548A patent/KR20070085703A/ko not_active Application Discontinuation
- 2006-09-13 CN CN200680033278A patent/CN101687905A/zh active Pending
- 2006-09-13 KR KR1020087003514A patent/KR20080025763A/ko active Application Filing
- 2006-09-13 ES ES06803587.2T patent/ES2288811T5/es active Active
- 2006-09-13 TW TW095133922A patent/TW200804410A/zh unknown
- 2006-09-13 WO PCT/US2006/035828 patent/WO2007073424A1/en active Application Filing
- 2006-09-13 TW TW095133885A patent/TW200804409A/zh unknown
- 2006-09-14 JP JP2007551495A patent/JP2008519865A/ja active Pending
- 2006-09-14 DE DE06803587T patent/DE06803587T1/de active Pending
-
2008
- 2008-10-16 US US12/288,310 patent/US20090093632A1/en not_active Abandoned
- 2008-10-16 US US12/288,243 patent/US20090137794A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE06803587T1 (de) | Reines rocuroniumbromid | |
USRE49110E1 (en) | Pharmaceutical formulations containing dopamine receptor ligands | |
DE69333605T2 (de) | Stabile injizierbare Paclitaxel Lösung | |
EP2295422A3 (de) | Glucopyranosylsubstituierte Benzolderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung | |
EP1192212B1 (de) | Verwendung von cyclohexanpolycarbonsäuren als weichmacher zur herstellung toxikologisch günstig zu bewertender kunststoffe | |
DE19742981B4 (de) | Durch ROMP härtbare Dentalmassen | |
DE69607749T2 (de) | Analoge des calcitonin aus lachs, ihre herstellung und ihre verwendung als medizin und als analytische reagentien | |
EP3834829A3 (de) | Kompatibles solut oder solutgemisch (vorzugsweise ectoin bzw. ectoin-derivate) zur verwendung bei der prävention oder behandlung von krankheiten mit barrieredefekten in epithelgeweben | |
LU83982A1 (de) | Platin-diamin-komplexe,ein verfahren zu ihrer herstellung,ein verfahren zur herstellung eines arzneimittels unter einsatz eines derartigen platin-diamin-komplexes fuer die behandlung von krebs sowie das dabei erhaltene arzneimittel | |
DE3752109T2 (de) | Entzündungshemmende Mittel | |
DE102015013939A1 (de) | Verfahren zur Herstellung von Gadotersäure (Gd-DOTA)- Komplexen | |
DE69332636T2 (de) | Antidepressiv und gegen die Parkinsonsche Krankheit wirkende Verbindungen | |
CN103553996B (zh) | 抗胆碱药物组合物 | |
US20220082543A1 (en) | Analysis method of 3-methyl-1-phenyl-2-pyrazolin-5-one active pharmaceutical ingredient, treatment for amyotrophic lateral sclerosis, inhibition of progression of amyotrophic lateral sclerosis, and method of producing medicament containing 3-methyl-1-phenyl-2-pyrazolin-5-one active pharmaceutical ingredient | |
DE112011103711B4 (de) | Caspofungin-Analogon und Herstellungsverfahren dafür und Verwendungen desselben | |
CH632411A5 (de) | Verwendung von 2-brom-2-chlor-1,1,1-trifluorethan-d als komponente in einem anesthetischen mittel. | |
DE102005038376A1 (de) | Verfahren zur destillativen Abtrennung von Piperazin aus einem Ethylendiamin-Piperazin-Gemisch | |
Jbara et al. | Assessing The Quantity And Quality Of Ozonated Olive Oil And Studying Its Shelf-Life Stability | |
DE69925301T2 (de) | Zusammensetzung von riluzol und alpha-tocopherol | |
DE3639225A1 (de) | Verwendung von 5-(subst. phenyl)-oxazolidinonderiaten als psychopharmaka | |
DE60310717T2 (de) | Teicoplanin-Zubereitung mit verbesserter antibiotischer Wirkung | |
Horlacher | Pyridomycin as lead for new antituberculosis agents and synthesis of hypermodified epothilone A analogs | |
DE3586781T2 (de) | Behandlungsverfahren gegen hohen blutdruck bei wirbeltieren. | |
DE2154867A1 (de) | Neue tricyclische Derivate von aliphatischen omega-Aminoalkoholen und Verfahren zu deren Herstellung | |
EP2818477B1 (de) | L-lysyl-l-glutamyl-l-tryptophan zur korrektur des stoffwechselsyndroms |