KR102222186B1 - Sting 효능제로서 시클릭 디-뉴클레오티드 화합물 - Google Patents

Sting 효능제로서 시클릭 디-뉴클레오티드 화합물 Download PDF

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KR102222186B1
KR102222186B1 KR1020187006715A KR20187006715A KR102222186B1 KR 102222186 B1 KR102222186 B1 KR 102222186B1 KR 1020187006715 A KR1020187006715 A KR 1020187006715A KR 20187006715 A KR20187006715 A KR 20187006715A KR 102222186 B1 KR102222186 B1 KR 102222186B1
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group
formula
compound
mmol
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KR20180030926A (ko
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마이클 디. 알트만
브라이언 안드레센
원석 창
매튜 로이드 칠더스
제러드 엔. 쿠밍
앤드류 마르크 하이들
티모시 제이. 헨더슨
제임스 피. 쥬얼
뤼 리앙
종원 임
홍 리우
민 루
앨런 비. 노스럽
라이언 디. 오트
토니 시우
벤자민 웨슬리 트로터
창 티. 트룽
숀 피. 월쉬
카케 자오
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머크 샤프 앤드 돔 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

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  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020187006715A 2015-08-13 2016-08-11 Sting 효능제로서 시클릭 디-뉴클레오티드 화합물 Expired - Fee Related KR102222186B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020207027731A KR102271750B1 (ko) 2015-08-13 2016-08-11 Sting 효능제로서 시클릭 디-뉴클레오티드 화합물

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562204677P 2015-08-13 2015-08-13
US62/204,677 2015-08-13
US201562268723P 2015-12-17 2015-12-17
US62/268,723 2015-12-17
US201662356125P 2016-06-29 2016-06-29
US62/356,125 2016-06-29
PCT/US2016/046444 WO2017027646A1 (en) 2015-08-13 2016-08-11 Cyclic di-nucleotide compounds as sting agonists

Related Child Applications (1)

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KR1020207027731A Division KR102271750B1 (ko) 2015-08-13 2016-08-11 Sting 효능제로서 시클릭 디-뉴클레오티드 화합물

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KR20180030926A KR20180030926A (ko) 2018-03-26
KR102222186B1 true KR102222186B1 (ko) 2021-03-03

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KR1020187006715A Expired - Fee Related KR102222186B1 (ko) 2015-08-13 2016-08-11 Sting 효능제로서 시클릭 디-뉴클레오티드 화합물
KR1020207027731A Expired - Fee Related KR102271750B1 (ko) 2015-08-13 2016-08-11 Sting 효능제로서 시클릭 디-뉴클레오티드 화합물

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US (4) US10106574B2 (https=)
EP (2) EP3334745B1 (https=)
JP (1) JP6596146B2 (https=)
KR (2) KR102222186B1 (https=)
CN (1) CN108137641B (https=)
AU (1) AU2016304899B2 (https=)
BR (1) BR112018002757A8 (https=)
CA (1) CA2995365C (https=)
CL (1) CL2018000385A1 (https=)
CO (1) CO2018001425A2 (https=)
CR (1) CR20180101A (https=)
DO (1) DOP2018000046A (https=)
EA (1) EA034786B1 (https=)
GE (2) GEAP202014726A (https=)
HK (1) HK1249109A1 (https=)
IL (1) IL257142B (https=)
JO (1) JOP20200224A1 (https=)
MA (1) MA42608A (https=)
MX (1) MX2018001814A (https=)
NI (1) NI201800025A (https=)
PE (1) PE20180688A1 (https=)
PH (1) PH12018500299A1 (https=)
SG (1) SG10202010609QA (https=)
SV (1) SV2018005632A (https=)
TN (1) TN2018000023A1 (https=)
TW (1) TWI696629B (https=)
UA (1) UA123701C2 (https=)
WO (2) WO2017027646A1 (https=)
ZA (1) ZA201800442B (https=)

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