KR102149380B1 - 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형 - Google Patents

프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형 Download PDF

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KR102149380B1
KR102149380B1 KR1020157003613A KR20157003613A KR102149380B1 KR 102149380 B1 KR102149380 B1 KR 102149380B1 KR 1020157003613 A KR1020157003613 A KR 1020157003613A KR 20157003613 A KR20157003613 A KR 20157003613A KR 102149380 B1 KR102149380 B1 KR 102149380B1
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salt
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KR20150058154A (ko
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클라우디아 위츠시
정 민 박
마이클 디. 톰슨
마이클 죤 마르티넬리
데이빗 에이. 예오웰
마이클 피. 아렌드
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KR1020157003613A 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형 Active KR102149380B1 (ko)

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KR1020207024326A KR102318720B1 (ko) 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형

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US201261672191P 2012-07-16 2012-07-16
US61/672,191 2012-07-16
US201361768297P 2013-02-22 2013-02-22
US61/768,297 2013-02-22
US201361832566P 2013-06-07 2013-06-07
US61/832,566 2013-06-07
PCT/US2013/050539 WO2014014835A2 (en) 2012-07-16 2013-07-15 Crystalline forms of a prolyl hydroxylase inhibitor

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KR1020207024326A Division KR102318720B1 (ko) 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형

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KR20150058154A KR20150058154A (ko) 2015-05-28
KR102149380B1 true KR102149380B1 (ko) 2020-08-28

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KR1020157003613A Active KR102149380B1 (ko) 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형
KR1020217034322A Ceased KR20210130849A (ko) 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형
KR1020207024326A Active KR102318720B1 (ko) 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형
KR1020227041256A Ceased KR20220164068A (ko) 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형

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KR1020217034322A Ceased KR20210130849A (ko) 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형
KR1020207024326A Active KR102318720B1 (ko) 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형
KR1020227041256A Ceased KR20220164068A (ko) 2012-07-16 2013-07-15 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형

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CN102718708A (zh) 2003-06-06 2012-10-10 菲布罗根有限公司 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途
JP5649584B2 (ja) 2008-11-14 2015-01-07 フィブロジェン インコーポレイテッド Ｈｉｆヒドロキシラーゼ阻害剤としてのチオクロメン誘導体
US8921389B2 (en) 2011-02-02 2014-12-30 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase
US8883823B2 (en) * 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
BR112015001106B1 (pt) 2012-07-16 2021-11-09 Fibrogen, Inc Métodos para a produção de compostos de isoquinolina
CN107540607A (zh) 2012-07-16 2018-01-05 菲布罗根有限公司 脯氨酰羟化酶抑制剂的晶体形态
PT3003284T (pt) 2013-06-06 2020-08-10 Fibrogen Inc Formulações farmacêuticas de um inibidor da hidroxilase do fih
CN103694172A (zh) * 2013-12-26 2014-04-02 辽宁亿灵科创生物医药科技有限公司 含氮杂芳基化合物的衍生物
WO2016045125A1 (en) 2014-09-28 2016-03-31 Merck Sharp & Dohme Corp. Inhibitors of hif prolyl hydroxylase
CN104892509B (zh) * 2015-06-04 2018-03-09 苏州明锐医药科技有限公司 诺得司他的制备方法
CN106916105A (zh) * 2015-12-28 2017-07-04 徐州万邦金桥制药有限公司 一种纯化可博美的方法
WO2017143131A1 (en) * 2016-02-19 2017-08-24 Cornell University Hif-stabilization and prevention of hyperoxia-induced neonatal lung disease
CN106187888A (zh) * 2016-07-18 2016-12-07 江苏德源药业股份有限公司 Fg‑4592单晶及其制备方法
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