KR102038895B1 - 바이러스 감염 및 기타 질환 치료용 퀴나졸린 유도체 - Google Patents
바이러스 감염 및 기타 질환 치료용 퀴나졸린 유도체 Download PDFInfo
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- KR102038895B1 KR102038895B1 KR1020137030262A KR20137030262A KR102038895B1 KR 102038895 B1 KR102038895 B1 KR 102038895B1 KR 1020137030262 A KR1020137030262 A KR 1020137030262A KR 20137030262 A KR20137030262 A KR 20137030262A KR 102038895 B1 KR102038895 B1 KR 102038895B1
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- South Korea
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- 0 Cc(c(*)c1*)c(*)c2c1nc(N)nc2N* Chemical compound Cc(c(*)c1*)c(*)c2c1nc(N)nc2N* 0.000 description 2
- DPIROQSHTHCYHJ-UHFFFAOYSA-N NC(N1)=Nc2cccc(CCc3ccccn3)c2C1O Chemical compound NC(N1)=Nc2cccc(CCc3ccccn3)c2C1O DPIROQSHTHCYHJ-UHFFFAOYSA-N 0.000 description 1
- BDPCBRSHZVHPKX-UHFFFAOYSA-N Nc(nc(c1c2)O)nc1ccc2Br Chemical compound Nc(nc(c1c2)O)nc1ccc2Br BDPCBRSHZVHPKX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11166538 | 2011-05-18 | ||
EP11166538.6 | 2011-05-18 | ||
PCT/EP2012/059234 WO2012156498A1 (fr) | 2011-05-18 | 2012-05-18 | Dérivés de quinazoline pour le traitement d'infections virales et d'autres maladies |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020197031596A Division KR102119700B1 (ko) | 2011-05-18 | 2012-05-18 | 바이러스 감염 및 기타 질환 치료용 퀴나졸린 유도체 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20140051849A KR20140051849A (ko) | 2014-05-02 |
KR102038895B1 true KR102038895B1 (ko) | 2019-10-31 |
Family
ID=44849923
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020137030262A KR102038895B1 (ko) | 2011-05-18 | 2012-05-18 | 바이러스 감염 및 기타 질환 치료용 퀴나졸린 유도체 |
KR1020197031596A KR102119700B1 (ko) | 2011-05-18 | 2012-05-18 | 바이러스 감염 및 기타 질환 치료용 퀴나졸린 유도체 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020197031596A KR102119700B1 (ko) | 2011-05-18 | 2012-05-18 | 바이러스 감염 및 기타 질환 치료용 퀴나졸린 유도체 |
Country Status (29)
Country | Link |
---|---|
US (1) | US8916575B2 (fr) |
EP (1) | EP2709989B8 (fr) |
JP (1) | JP6050329B2 (fr) |
KR (2) | KR102038895B1 (fr) |
AU (1) | AU2012258220B2 (fr) |
BR (1) | BR112013029537B1 (fr) |
CA (1) | CA2835229C (fr) |
CL (1) | CL2013003313A1 (fr) |
CY (1) | CY1120429T1 (fr) |
DK (1) | DK2709989T3 (fr) |
EA (1) | EA028254B1 (fr) |
ES (1) | ES2663601T3 (fr) |
HR (1) | HRP20180447T1 (fr) |
HU (1) | HUE036220T2 (fr) |
IL (1) | IL228906A (fr) |
LT (1) | LT2709989T (fr) |
ME (1) | ME02986B (fr) |
MX (1) | MX347966B (fr) |
MY (1) | MY166557A (fr) |
NO (1) | NO2709989T3 (fr) |
PH (1) | PH12019502269A1 (fr) |
PL (1) | PL2709989T3 (fr) |
PT (1) | PT2709989T (fr) |
RS (1) | RS57023B1 (fr) |
SG (1) | SG194852A1 (fr) |
SI (1) | SI2709989T1 (fr) |
UA (1) | UA114476C2 (fr) |
WO (1) | WO2012156498A1 (fr) |
ZA (1) | ZA201308746B (fr) |
Families Citing this family (138)
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KR101481164B1 (ko) * | 2008-01-30 | 2015-01-09 | 주식회사 미래셀바이오 | 체세포 유래 다능성 줄기세포의 제조 방법 |
RS62254B1 (sr) | 2011-04-08 | 2021-09-30 | Janssen Sciences Ireland Unlimited Co | Derivati pirimidina za tretman virusnih infekcija |
SG11201401244TA (en) | 2011-11-09 | 2014-09-26 | Janssen R & D Ireland | Purine derivatives for the treatment of viral infections |
PL2872515T3 (pl) | 2012-07-13 | 2017-05-31 | Janssen Sciences Ireland Uc | Puryny makrocykliczne do leczenia infekcji wirusowych |
PT2906563T (pt) | 2012-10-10 | 2018-05-23 | Janssen Sciences Ireland Uc | Derivados de pirrolo[3,2-d]pirimidina para o tratamento de infeções virais e outras doenças |
DK2925729T3 (en) * | 2012-11-16 | 2018-01-22 | Janssen Sciences Ireland Uc | HETEROCYCLIC SUBSTITUTED 2-AMINOQUINAZOLINE DERIVATIVES FOR TREATING VIRUS INFECTIONS |
KR102300861B1 (ko) | 2013-02-21 | 2021-09-10 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체 |
SG11201508078XA (en) | 2013-03-29 | 2015-11-27 | Janssen Sciences Ireland Uc | Macrocyclic deaza-purinones for the treatment of viral infections |
CN105377833B (zh) | 2013-05-24 | 2018-11-06 | 爱尔兰詹森科学公司 | 用于治疗病毒感染和另外的疾病的吡啶酮衍生物 |
DK3030563T3 (da) | 2013-06-27 | 2017-11-20 | Janssen Sciences Ireland Uc | Pyrrolo-[3,2-d]-pyrimidin-derivater til behandling af virale infektioner og andre sygdomme |
ES2836881T3 (es) * | 2013-07-30 | 2021-06-28 | Janssen Sciences Ireland Unlimited Co | Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales |
SI3097102T1 (en) * | 2015-03-04 | 2018-02-28 | Gilead Sciences, Inc. | A TOOL RECEPTOR MODULING 4,6-DIAMINO-PYRIDO (3,2-D) PYRIMIDINE COMPOUNDS |
CA2991639A1 (fr) | 2015-08-07 | 2017-02-16 | Arrowhead Pharmaceuticals, Inc. | Therapie par interference arn pour l'infection par le virus de l'hepatite b |
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