KR101950944B1 - 1,3-부탄다이올 생산 유기체 - Google Patents
1,3-부탄다이올 생산 유기체 Download PDFInfo
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- KR101950944B1 KR101950944B1 KR1020187031026A KR20187031026A KR101950944B1 KR 101950944 B1 KR101950944 B1 KR 101950944B1 KR 1020187031026 A KR1020187031026 A KR 1020187031026A KR 20187031026 A KR20187031026 A KR 20187031026A KR 101950944 B1 KR101950944 B1 KR 101950944B1
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- coa
- reductase
- bdo
- enzymes
- enzyme
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- C—CHEMISTRY; METALLURGY
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
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- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/0101—L-Xylulose reductase (1.1.1.10)
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- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01157—3-Hydroxybutyryl-CoA dehydrogenase (1.1.1.157)
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- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
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- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
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- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17447309P | 2009-04-30 | 2009-04-30 | |
| US61/174,473 | 2009-04-30 | ||
| PCT/US2010/033300 WO2010127319A2 (en) | 2009-04-30 | 2010-04-30 | Organisms for the production of 1,3-butanediol |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177024153A Division KR101914094B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197004508A Division KR102115497B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180121664A KR20180121664A (ko) | 2018-11-07 |
| KR101950944B1 true KR101950944B1 (ko) | 2019-02-21 |
Family
ID=43032812
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217028773A Active KR102454204B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020117028552A Active KR101774400B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020207014376A Active KR102302146B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020177024153A Active KR101914094B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020197004508A Active KR102115497B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020187031026A Expired - Fee Related KR101950944B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217028773A Active KR102454204B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020117028552A Active KR101774400B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020207014376A Active KR102302146B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020177024153A Active KR101914094B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020197004508A Active KR102115497B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9017983B2 (enExample) |
| EP (6) | EP3135760A1 (enExample) |
| JP (5) | JP5876822B2 (enExample) |
| KR (6) | KR102454204B1 (enExample) |
| CN (2) | CN102625846B (enExample) |
| AU (1) | AU2010242789B2 (enExample) |
| BR (1) | BRPI1013426A2 (enExample) |
| CA (2) | CA2759994C (enExample) |
| ES (1) | ES2593117T3 (enExample) |
| LT (1) | LT2424975T (enExample) |
| MY (1) | MY176050A (enExample) |
| WO (1) | WO2010127319A2 (enExample) |
| ZA (1) | ZA201107806B (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009155382A1 (en) | 2008-06-17 | 2009-12-23 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| AU2009327490A1 (en) | 2008-12-16 | 2011-07-28 | Genomatica, Inc. | Microorganisms and methods for conversion of syngas and other carbon sources to useful products |
| US9017983B2 (en) * | 2009-04-30 | 2015-04-28 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
| US8420375B2 (en) | 2009-06-10 | 2013-04-16 | Genomatica, Inc. | Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol |
| WO2011052718A1 (ja) * | 2009-10-30 | 2011-05-05 | ダイセル化学工業株式会社 | 1,3-ブタンジオール生産機能を付与された遺伝子組換え微生物及びその利用 |
| BR112012014062A2 (pt) | 2009-12-10 | 2017-04-04 | Genomatica Inc | organismo microbiano que não ocorre naturalmente e método para produzir 1,3 bdo |
| US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
| WO2011140171A2 (en) * | 2010-05-05 | 2011-11-10 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| CN102533870B (zh) * | 2010-12-23 | 2014-04-16 | 中国科学院青岛生物能源与过程研究所 | 一种生物法合成异戊二烯的方法、酶系统和重组细胞及其应用 |
| EP2670852A4 (en) | 2011-02-02 | 2017-04-26 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| AU2012273177A1 (en) * | 2011-06-22 | 2013-05-02 | Genomatica, Inc. | Microorganisms for producing 1,3-butanediol and methods related thereto |
| CA2845681A1 (en) * | 2011-08-19 | 2013-02-28 | Genomatica, Inc. | Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols |
| US9803209B2 (en) | 2012-05-18 | 2017-10-31 | Novozymes A/S | Bacterial mutants with improved transformation efficiency |
| WO2014036140A2 (en) * | 2012-08-28 | 2014-03-06 | Braskem S/A Ap 09 | Methods for production of a terpene and a co-product |
| BR112015006107A2 (pt) * | 2012-09-24 | 2017-08-22 | Showa Denko Kk | Método para produzir um butanodiol |
| CN104640982A (zh) | 2012-09-24 | 2015-05-20 | 昭和电工株式会社 | 基因、微生物、转换方法及制造方法 |
| JP6012371B2 (ja) * | 2012-09-27 | 2016-10-25 | 株式会社日本触媒 | 4−ヒドロキシ−2−ブタノンまたはブタノールの製造方法 |
| CN104619721A (zh) | 2012-09-27 | 2015-05-13 | 诺维信股份有限公司 | 具有改进的转化效率的细菌突变体 |
| US9677096B2 (en) | 2012-12-05 | 2017-06-13 | Showa Denko K.K. | Manufacturing method for 1,4-butanediol, microbe, and gene |
| EP2970068B1 (en) | 2013-03-15 | 2021-07-28 | Genomatica, Inc. | Process and systems for obtaining 1,4-butanediol from fermentation broths |
| WO2014145194A2 (en) * | 2013-03-15 | 2014-09-18 | Kiverdi, Inc. | Methods of using natural and engineered organisms to produce small molecules for industrial application |
| EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
| WO2014190251A1 (en) | 2013-05-24 | 2014-11-27 | Genomatica, Inc. | Microorganisms and methods for producing (3r)-hydroxybutyl (3r)-hydroxybutyrate |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
| BR122020001956B1 (pt) | 2013-12-05 | 2023-03-14 | Genomatica, Inc | Célula bacteriana recombinante para a produção de uma amina graxa e método de produção de uma amina graxa |
| ITMI20132069A1 (it) | 2013-12-11 | 2015-06-12 | Versalis Spa | Procedimento per la produzione di zuccheri da biomassa |
| CA2935069C (en) | 2013-12-27 | 2023-05-09 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
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