KR101950944B1 - 1,3-부탄다이올 생산 유기체 - Google Patents
1,3-부탄다이올 생산 유기체 Download PDFInfo
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- KR101950944B1 KR101950944B1 KR1020187031026A KR20187031026A KR101950944B1 KR 101950944 B1 KR101950944 B1 KR 101950944B1 KR 1020187031026 A KR1020187031026 A KR 1020187031026A KR 20187031026 A KR20187031026 A KR 20187031026A KR 101950944 B1 KR101950944 B1 KR 101950944B1
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- coa
- reductase
- bdo
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
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- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/0101—L-Xylulose reductase (1.1.1.10)
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- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01157—3-Hydroxybutyryl-CoA dehydrogenase (1.1.1.157)
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- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
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- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
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- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
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- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
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- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17447309P | 2009-04-30 | 2009-04-30 | |
| US61/174,473 | 2009-04-30 | ||
| PCT/US2010/033300 WO2010127319A2 (en) | 2009-04-30 | 2010-04-30 | Organisms for the production of 1,3-butanediol |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177024153A Division KR101914094B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197004508A Division KR102115497B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180121664A KR20180121664A (ko) | 2018-11-07 |
| KR101950944B1 true KR101950944B1 (ko) | 2019-02-21 |
Family
ID=43032812
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207014376A Active KR102302146B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020177024153A Active KR101914094B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020187031026A Expired - Fee Related KR101950944B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020197004508A Active KR102115497B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020117028552A Active KR101774400B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020217028773A Active KR102454204B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207014376A Active KR102302146B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020177024153A Active KR101914094B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197004508A Active KR102115497B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020117028552A Active KR101774400B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
| KR1020217028773A Active KR102454204B1 (ko) | 2009-04-30 | 2010-04-30 | 1,3-부탄다이올 생산 유기체 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9017983B2 (enExample) |
| EP (6) | EP3318626B1 (enExample) |
| JP (5) | JP5876822B2 (enExample) |
| KR (6) | KR102302146B1 (enExample) |
| CN (2) | CN102625846B (enExample) |
| AU (1) | AU2010242789B2 (enExample) |
| BR (1) | BRPI1013426A2 (enExample) |
| CA (2) | CA2759994C (enExample) |
| ES (1) | ES2593117T3 (enExample) |
| LT (1) | LT2424975T (enExample) |
| MY (1) | MY176050A (enExample) |
| WO (1) | WO2010127319A2 (enExample) |
| ZA (1) | ZA201107806B (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| JP2012511928A (ja) | 2008-12-16 | 2012-05-31 | ゲノマチカ, インク. | 合成ガス及び他の炭素源の有用な製品への変換のための微生物及び方法 |
| CN102625846B (zh) | 2009-04-30 | 2016-08-03 | 基因组股份公司 | 用于生产1,3-丁二醇的生物 |
| JP2012529889A (ja) | 2009-06-10 | 2012-11-29 | ゲノマチカ, インク. | Mek及び2−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
| CN102686719A (zh) * | 2009-10-30 | 2012-09-19 | 株式会社大赛璐 | 具有1,3-丁二醇生产功能的基因重组微生物及其应用 |
| RU2012128843A (ru) | 2009-12-10 | 2014-01-20 | Дженоматика, Инк. | Способы и организмы для превращения синтез-газа или других газообразных источников углерода и метанола в 1,3-бутандиол |
| US8445244B2 (en) | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
| KR20190006103A (ko) * | 2010-05-05 | 2019-01-16 | 게노마티카 인코포레이티드 | 부타디엔을 생합성하기 위한 미생물 및 방법 |
| CN102533870B (zh) * | 2010-12-23 | 2014-04-16 | 中国科学院青岛生物能源与过程研究所 | 一种生物法合成异戊二烯的方法、酶系统和重组细胞及其应用 |
| US9321701B2 (en) * | 2011-02-02 | 2016-04-26 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| WO2012177619A2 (en) * | 2011-06-22 | 2012-12-27 | Genomatica, Inc. | Microorganisms for producing 1,3-butanediol and methods related thereto |
| WO2013028519A1 (en) * | 2011-08-19 | 2013-02-28 | Genomatica, Inc. | Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols |
| WO2013173711A1 (en) | 2012-05-18 | 2013-11-21 | Novozymes A/S | Bacterial mutants with improved transformation efficiency |
| US20150211024A1 (en) * | 2012-08-28 | 2015-07-30 | Braskem S.A. | Methods for production of a terpene and a co-product |
| CN104870645A (zh) * | 2012-09-24 | 2015-08-26 | 昭和电工株式会社 | 丁二醇的制造方法 |
| US20150232830A1 (en) | 2012-09-24 | 2015-08-20 | Showa Denko K.K. | Gene, microbe, conversion method, and manufacturing method |
| JP6012371B2 (ja) * | 2012-09-27 | 2016-10-25 | 株式会社日本触媒 | 4−ヒドロキシ−2−ブタノンまたはブタノールの製造方法 |
| EP2900689B1 (en) | 2012-09-27 | 2017-08-02 | Novozymes, Inc. | Bacterial mutants with improved transformation efficiency |
| WO2014087921A1 (ja) | 2012-12-05 | 2014-06-12 | 昭和電工株式会社 | 1,4-ブタンジオールの製造方法、微生物及び遺伝子 |
| US9556462B2 (en) * | 2013-03-15 | 2017-01-31 | Kiverdi, Inc. | Methods of using natural and engineered organisms to produce small molecules for industrial application |
| MY181137A (en) | 2013-03-15 | 2020-12-18 | Genomatica Inc | Process and systems for obtaining 1,4-butanediol from fermentation broths |
| EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
| US11814664B2 (en) | 2013-05-24 | 2023-11-14 | Genomatica, Inc. | Microorganisms and methods for producing (3R)-hydroxybutyl (3R)-hydroxybutyrate |
| EP3077501B1 (en) | 2013-12-03 | 2021-07-28 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| CA2932017C (en) | 2013-12-05 | 2021-05-25 | REG Life Sciences, LLC | Microbial production of fatty amines |
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