KR101705158B1 - Ｅｇｆｒ 억제제 및 질환 치료방법 - Google Patents

Ｅｇｆｒ 억제제 및 질환 치료방법 Download PDF

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KR101705158B1
KR101705158B1 KR1020117029112A KR20117029112A KR101705158B1 KR 101705158 B1 KR101705158 B1 KR 101705158B1 KR 1020117029112 A KR1020117029112 A KR 1020117029112A KR 20117029112 A KR20117029112 A KR 20117029112A KR 101705158 B1 KR101705158 B1 KR 101705158B1
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egfr
heterocyclic
heteroaryl
independently
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KR20120047208A (ko
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내써낼 에스. 글레이
파시 자네
마이클 제이. 에크
웬전 저우
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다나-파버 캔서 인스티튜트 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Pharmacology & Pharmacy (AREA)
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  • Biomedical Technology (AREA)
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  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
KR1020117029112A 2009-05-05 2010-05-05 Ｅｇｆｒ 억제제 및 질환 치료방법 Expired - Fee Related KR101705158B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21541909P 2009-05-05 2009-05-05
US61/215,419 2009-05-05
PCT/US2010/001341 WO2010129053A2 (en) 2009-05-05 2010-05-05 Egfr inhibitors and methods of treating disorders

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KR20120047208A KR20120047208A (ko) 2012-05-11
KR101705158B1 true KR101705158B1 (ko) 2017-02-09

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US (2) US9908884B2 (https=)
EP (1) EP2440559B1 (https=)
JP (1) JP5918693B2 (https=)
KR (1) KR101705158B1 (https=)
CN (1) CN102482277B (https=)
CA (1) CA2760794C (https=)
ES (1) ES2659725T3 (https=)
IL (1) IL216140B (https=)
WO (1) WO2010129053A2 (https=)

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EP2440559A4 (en) 2012-11-21
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WO2010129053A3 (en) 2011-03-24
JP2012526113A (ja) 2012-10-25
JP5918693B2 (ja) 2016-05-18
EP2440559A2 (en) 2012-04-18
ES2659725T3 (es) 2018-03-19
US20190040065A1 (en) 2019-02-07
CA2760794C (en) 2017-07-25
US20120094999A1 (en) 2012-04-19
CN102482277A (zh) 2012-05-30
US9908884B2 (en) 2018-03-06
CA2760794A1 (en) 2010-11-11
WO2010129053A2 (en) 2010-11-11
IL216140A0 (en) 2012-01-31
KR20120047208A (ko) 2012-05-11
WO2010129053A8 (en) 2011-12-15
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