KR101130928B1 - 치환된 이미다조 고리 시스템 및 방법 - Google Patents
치환된 이미다조 고리 시스템 및 방법 Download PDFInfo
- Publication number
- KR101130928B1 KR101130928B1 KR1020067012734A KR20067012734A KR101130928B1 KR 101130928 B1 KR101130928 B1 KR 101130928B1 KR 1020067012734 A KR1020067012734 A KR 1020067012734A KR 20067012734 A KR20067012734 A KR 20067012734A KR 101130928 B1 KR101130928 B1 KR 101130928B1
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- group
- imidazo
- formula
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 *c1nc2c(N)nc(C=*=CC=C3)c3c2[n]1*C(O*)=O Chemical compound *c1nc2c(N)nc(C=*=CC=C3)c3c2[n]1*C(O*)=O 0.000 description 2
- DSDKYFMUHFMRQC-UHFFFAOYSA-N CC(C)(CC1(C)OCCO1)C[n]1c2c(cccc3)c3nc(N)c2nc1 Chemical compound CC(C)(CC1(C)OCCO1)C[n]1c2c(cccc3)c3nc(N)c2nc1 DSDKYFMUHFMRQC-UHFFFAOYSA-N 0.000 description 1
- DXKQNOBQEOHOGH-UHFFFAOYSA-N CC(CCC[n]1c2c(cccc3)c3nc(N)c2nc1C)=O Chemical compound CC(CCC[n]1c2c(cccc3)c3nc(N)c2nc1C)=O DXKQNOBQEOHOGH-UHFFFAOYSA-N 0.000 description 1
- JNTBVLBBXHYXMX-UHFFFAOYSA-N CCCc1nc(c(N)nc2c3cccc2)c3[n]1CCCC(N(C)OC)=O Chemical compound CCCc1nc(c(N)nc2c3cccc2)c3[n]1CCCC(N(C)OC)=O JNTBVLBBXHYXMX-UHFFFAOYSA-N 0.000 description 1
- DDRVABYGPQTODO-UHFFFAOYSA-N CCCc1nc2c(N)nc(C)c(C)c2[n]1CCCC(C)=O Chemical compound CCCc1nc2c(N)nc(C)c(C)c2[n]1CCCC(C)=O DDRVABYGPQTODO-UHFFFAOYSA-N 0.000 description 1
- JYHHFVSBCXUIQF-UHFFFAOYSA-N CCCc1nc2c(N)nc(cccc3)c3c2[n]1CCCC(C)=O Chemical compound CCCc1nc2c(N)nc(cccc3)c3c2[n]1CCCC(C)=O JYHHFVSBCXUIQF-UHFFFAOYSA-N 0.000 description 1
- MNVIEIPVHFZPFW-UHFFFAOYSA-N CCCc1nc2c(N)nc(cccc3)c3c2[n]1CCCC(OCC)=O Chemical compound CCCc1nc2c(N)nc(cccc3)c3c2[n]1CCCC(OCC)=O MNVIEIPVHFZPFW-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52496103P | 2003-11-25 | 2003-11-25 | |
| US60/524,961 | 2003-11-25 | ||
| US58013904P | 2004-06-16 | 2004-06-16 | |
| US60/580,139 | 2004-06-16 | ||
| PCT/US2004/039512 WO2005051317A2 (en) | 2003-11-25 | 2004-11-24 | Substituted imidazo ring systems and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20060125818A KR20060125818A (ko) | 2006-12-06 |
| KR101130928B1 true KR101130928B1 (ko) | 2012-04-12 |
Family
ID=34636529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067012734A Expired - Fee Related KR101130928B1 (ko) | 2003-11-25 | 2004-11-24 | 치환된 이미다조 고리 시스템 및 방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8691837B2 (https=) |
| EP (1) | EP1687307B1 (https=) |
| JP (2) | JP4891088B2 (https=) |
| KR (1) | KR101130928B1 (https=) |
| AR (1) | AR046781A1 (https=) |
| AU (1) | AU2004293078B2 (https=) |
| BR (1) | BRPI0416936A (https=) |
| CA (1) | CA2547020C (https=) |
| IL (2) | IL175915A0 (https=) |
| MX (1) | MXPA06005910A (https=) |
| MY (1) | MY161812A (https=) |
| NZ (1) | NZ547467A (https=) |
| RU (1) | RU2409576C2 (https=) |
| SG (1) | SG148201A1 (https=) |
| WO (1) | WO2005051317A2 (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6677347B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamido ether substituted imidazoquinolines |
| MXPA04012199A (es) | 2002-06-07 | 2005-02-25 | 3M Innovative Properties Co | Imidazopiridinas sustituidas con eter. |
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| US20040214851A1 (en) * | 2003-04-28 | 2004-10-28 | 3M Innovative Properties Company | Compositions and methods for induction of opioid receptors |
| CA2534625A1 (en) | 2003-08-05 | 2005-02-24 | 3M Innovative Properties Company | Infection prophylaxis using immune response modifier compounds |
| BRPI0413558A (pt) * | 2003-08-12 | 2006-10-17 | 3M Innovative Properties Co | compostos contendo imidazo substituìdo por hidroxilamina |
| MXPA06002199A (es) * | 2003-08-27 | 2006-05-22 | 3M Innovative Properties Co | Imidazoquinolinas sustituidas con grupos ariloxi o arilalquilenoxi. |
| CA2537763A1 (en) | 2003-09-05 | 2005-03-17 | 3M Innovative Properties Company | Treatment for cd5+ b cell lymphoma |
| US20090075980A1 (en) * | 2003-10-03 | 2009-03-19 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and Analogs Thereof |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| CA2540541C (en) | 2003-10-03 | 2012-03-27 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| TW200526656A (en) | 2003-10-03 | 2005-08-16 | 3M Innovative Properties Co | Pyrazolopyridines and analogs thereof |
| WO2005048945A2 (en) * | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo ring compounds |
| US7897767B2 (en) | 2003-11-14 | 2011-03-01 | 3M Innovative Properties Company | Oxime substituted imidazoquinolines |
| WO2005051317A2 (en) | 2003-11-25 | 2005-06-09 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| JP2007517035A (ja) * | 2003-12-29 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン |
| EP1699788A2 (en) * | 2003-12-30 | 2006-09-13 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides |
| WO2005094531A2 (en) * | 2004-03-24 | 2005-10-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| US8017779B2 (en) * | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| US8026366B2 (en) * | 2004-06-18 | 2011-09-27 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| US8541438B2 (en) | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| US7897609B2 (en) * | 2004-06-18 | 2011-03-01 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
| US7915281B2 (en) * | 2004-06-18 | 2011-03-29 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method |
| US20070259881A1 (en) * | 2004-06-18 | 2007-11-08 | Dellaria Joseph F Jr | Substituted Imidazo Ring Systems and Methods |
| ATE555786T1 (de) | 2004-09-02 | 2012-05-15 | 3M Innovative Properties Co | 1-alkoxy 1h-imidazo-ringsysteme und verfahren |
| US20090270443A1 (en) * | 2004-09-02 | 2009-10-29 | Doris Stoermer | 1-amino imidazo-containing compounds and methods |
| US20110070575A1 (en) * | 2004-12-08 | 2011-03-24 | Coley Pharmaceutical Group, Inc. | Immunomodulatory Compositions, Combinations and Methods |
| JP5543068B2 (ja) | 2004-12-30 | 2014-07-09 | スリーエム イノベイティブ プロパティズ カンパニー | キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物 |
| CA2594253C (en) | 2004-12-30 | 2015-08-11 | 3M Innovative Properties Company | Treatment for cutaneous metastases |
| AU2005326708C1 (en) | 2004-12-30 | 2012-08-30 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20060125818A (ko) | 2006-12-06 |
| EP1687307A2 (en) | 2006-08-09 |
| US20160194322A1 (en) | 2016-07-07 |
| AU2004293078B2 (en) | 2012-01-19 |
| US9765071B2 (en) | 2017-09-19 |
| CA2547020A1 (en) | 2005-06-09 |
| US20140194628A1 (en) | 2014-07-10 |
| JP4891088B2 (ja) | 2012-03-07 |
| WO2005051317A2 (en) | 2005-06-09 |
| SG148201A1 (en) | 2008-12-31 |
| AR046781A1 (es) | 2005-12-21 |
| US20070072893A1 (en) | 2007-03-29 |
| JP2012006976A (ja) | 2012-01-12 |
| MXPA06005910A (es) | 2006-08-23 |
| RU2409576C2 (ru) | 2011-01-20 |
| EP1687307B1 (en) | 2016-01-06 |
| WO2005051317A3 (en) | 2006-05-11 |
| RU2006118033A (ru) | 2008-01-10 |
| EP1687307A4 (en) | 2009-06-17 |
| NZ547467A (en) | 2010-06-25 |
| JP2007512370A (ja) | 2007-05-17 |
| AU2004293078A1 (en) | 2005-06-09 |
| MY161812A (en) | 2017-05-15 |
| BRPI0416936A (pt) | 2007-01-16 |
| IL218494A0 (en) | 2012-04-30 |
| CA2547020C (en) | 2014-03-25 |
| IL175915A0 (en) | 2006-10-05 |
| US9328110B2 (en) | 2016-05-03 |
| US8691837B2 (en) | 2014-04-08 |
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