KR100756252B1 - 일렉트로포레이션에 의한 약제와 유전자 전달 방법 및 장치 - Google Patents
일렉트로포레이션에 의한 약제와 유전자 전달 방법 및 장치 Download PDFInfo
- Publication number
- KR100756252B1 KR100756252B1 KR1019997002781A KR19997002781A KR100756252B1 KR 100756252 B1 KR100756252 B1 KR 100756252B1 KR 1019997002781 A KR1019997002781 A KR 1019997002781A KR 19997002781 A KR19997002781 A KR 19997002781A KR 100756252 B1 KR100756252 B1 KR 100756252B1
- Authority
- KR
- South Korea
- Prior art keywords
- electrode
- applicator
- needles
- electroporation
- needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004520 electroporation Methods 0.000 title claims abstract description 146
- 238000000034 method Methods 0.000 title claims abstract description 99
- 239000003814 drug Substances 0.000 title description 32
- 229940079593 drug Drugs 0.000 title description 26
- 238000012377 drug delivery Methods 0.000 title description 2
- 238000001476 gene delivery Methods 0.000 title 1
- 238000001727 in vivo Methods 0.000 claims abstract description 24
- 239000002246 antineoplastic agent Substances 0.000 claims abstract description 14
- 229940127089 cytotoxic agent Drugs 0.000 claims abstract description 11
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 5
- 238000011282 treatment Methods 0.000 claims description 155
- 210000001519 tissue Anatomy 0.000 claims description 67
- 230000005684 electric field Effects 0.000 claims description 49
- 108010006654 Bleomycin Proteins 0.000 claims description 34
- 229960001561 bleomycin Drugs 0.000 claims description 29
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims description 29
- 238000012545 processing Methods 0.000 claims description 17
- 238000000338 in vitro Methods 0.000 claims description 12
- QZGIWPZCWHMVQL-UIYAJPBUSA-N neocarzinostatin chromophore Chemical compound O1[C@H](C)[C@H](O)[C@H](O)[C@@H](NC)[C@H]1O[C@@H]1C/2=C/C#C[C@H]3O[C@@]3([C@@H]3OC(=O)OC3)C#CC\2=C[C@H]1OC(=O)C1=C(O)C=CC2=C(C)C=C(OC)C=C12 QZGIWPZCWHMVQL-UIYAJPBUSA-N 0.000 claims description 12
- 229950009268 zinostatin Drugs 0.000 claims description 12
- 238000002347 injection Methods 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- 238000003825 pressing Methods 0.000 claims description 8
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 7
- 230000007246 mechanism Effects 0.000 claims description 7
- 210000000496 pancreas Anatomy 0.000 claims description 7
- 102000040430 polynucleotide Human genes 0.000 claims description 7
- 108091033319 polynucleotide Proteins 0.000 claims description 7
- 239000002157 polynucleotide Substances 0.000 claims description 7
- 206010023841 laryngeal neoplasm Diseases 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 5
- 241001313288 Labia Species 0.000 claims description 5
- 210000003238 esophagus Anatomy 0.000 claims description 5
- 210000002216 heart Anatomy 0.000 claims description 5
- 238000013507 mapping Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 4
- 229960004316 cisplatin Drugs 0.000 claims description 4
- 210000000867 larynx Anatomy 0.000 claims description 4
- 210000004072 lung Anatomy 0.000 claims description 4
- 210000001989 nasopharynx Anatomy 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 210000002307 prostate Anatomy 0.000 claims description 4
- 206010023825 Laryngeal cancer Diseases 0.000 claims description 3
- 210000000481 breast Anatomy 0.000 claims description 3
- 229960004562 carboplatin Drugs 0.000 claims description 3
- 210000001072 colon Anatomy 0.000 claims description 3
- 210000003734 kidney Anatomy 0.000 claims description 3
- 229960004857 mitomycin Drugs 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 210000001672 ovary Anatomy 0.000 claims description 3
- 210000001550 testis Anatomy 0.000 claims description 3
- 210000001541 thymus gland Anatomy 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 2
- 229960004679 doxorubicin Drugs 0.000 claims description 2
- 230000002601 intratumoral effect Effects 0.000 claims description 2
- -1 shuramin Chemical compound 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 claims 2
- 190000008236 carboplatin Chemical compound 0.000 claims 1
- 230000009897 systematic effect Effects 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 114
- 238000002560 therapeutic procedure Methods 0.000 abstract description 15
- 210000004027 cell Anatomy 0.000 description 86
- 108090000623 proteins and genes Proteins 0.000 description 19
- 238000002474 experimental method Methods 0.000 description 16
- 241000700159 Rattus Species 0.000 description 15
- 230000004044 response Effects 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 11
- 239000002671 adjuvant Substances 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 10
- 108020004999 messenger RNA Proteins 0.000 description 10
- 210000004881 tumor cell Anatomy 0.000 description 10
- 230000000692 anti-sense effect Effects 0.000 description 8
- 238000010586 diagram Methods 0.000 description 8
- 238000011580 nude mouse model Methods 0.000 description 8
- 230000004083 survival effect Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241000699660 Mus musculus Species 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 7
- 201000011510 cancer Diseases 0.000 description 7
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 6
- 241000700605 Viruses Species 0.000 description 6
- 238000003491 array Methods 0.000 description 6
- 230000003833 cell viability Effects 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 238000001125 extrusion Methods 0.000 description 6
- 238000001802 infusion Methods 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 6
- WUIABRMSWOKTOF-OYALTWQYSA-N 3-[[2-[2-[2-[[(2s,3r)-2-[[(2s,3s,4r)-4-[[(2s,3r)-2-[[6-amino-2-[(1s)-3-amino-1-[[(2s)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2r,3s,4s,5s,6s)-3-[(2r,3s,4s,5r,6r)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)ox Chemical compound OS([O-])(=O)=O.N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1NC=NC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C WUIABRMSWOKTOF-OYALTWQYSA-N 0.000 description 5
- 102000053642 Catalytic RNA Human genes 0.000 description 5
- 108090000994 Catalytic RNA Proteins 0.000 description 5
- 229960004395 bleomycin sulfate Drugs 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 108091092562 ribozyme Proteins 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 230000001093 anti-cancer Effects 0.000 description 4
- 238000001574 biopsy Methods 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 4
- 239000004020 conductor Substances 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- 231100000517 death Toxicity 0.000 description 4
- 230000003211 malignant effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000001338 necrotic effect Effects 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 238000007920 subcutaneous administration Methods 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 229930012538 Paclitaxel Natural products 0.000 description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 239000006285 cell suspension Substances 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 201000004959 laryngeal benign neoplasm Diseases 0.000 description 3
- 201000001441 melanoma Diseases 0.000 description 3
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 3
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 229960001592 paclitaxel Drugs 0.000 description 3
- 201000002528 pancreatic cancer Diseases 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- 206010004146 Basal cell carcinoma Diseases 0.000 description 2
- 208000032612 Glial tumor Diseases 0.000 description 2
- 206010018338 Glioma Diseases 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- 241000251131 Sphyrna Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 239000003990 capacitor Substances 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000002254 cytotoxic agent Substances 0.000 description 2
- 231100000599 cytotoxic agent Toxicity 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 239000013536 elastomeric material Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000001839 endoscopy Methods 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 238000002357 laparoscopic surgery Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000004091 panning Methods 0.000 description 2
- 230000036278 prepulse Effects 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000003705 ribosome Anatomy 0.000 description 2
- 208000018655 severe necrosis Diseases 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 125000003831 tetrazolyl group Chemical group 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 241001430294 unidentified retrovirus Species 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- MONCZSPIFIQNAX-UHFFFAOYSA-N 1-chloro-4-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl]benzene;dimethoxy-(4-nitrophenoxy)-sulfanylidene-$l^{5}-phosphane Chemical compound COP(=S)(OC)OC1=CC=C([N+]([O-])=O)C=C1.C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 MONCZSPIFIQNAX-UHFFFAOYSA-N 0.000 description 1
- CFBVWCHTNQHZLT-UHFFFAOYSA-N 4-methoxy-5-[3-(2-methoxy-4-nitro-5-sulfophenyl)-5-(phenylcarbamoyl)tetrazol-3-ium-2-yl]-2-nitrobenzenesulfonate Chemical compound COC1=CC([N+]([O-])=O)=C(S([O-])(=O)=O)C=C1N1[N+](C=2C(=CC(=C(C=2)S(O)(=O)=O)[N+]([O-])=O)OC)=NC(C(=O)NC=2C=CC=CC=2)=N1 CFBVWCHTNQHZLT-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102100022641 Coagulation factor IX Human genes 0.000 description 1
- 101710112752 Cytotoxin Proteins 0.000 description 1
- 230000007023 DNA restriction-modification system Effects 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010076282 Factor IX Proteins 0.000 description 1
- 108010054218 Factor VIII Proteins 0.000 description 1
- 102000001690 Factor VIII Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 102000003996 Interferon-beta Human genes 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 102000008072 Lymphokines Human genes 0.000 description 1
- 108010074338 Lymphokines Proteins 0.000 description 1
- 102000004083 Lymphotoxin-alpha Human genes 0.000 description 1
- 108090000542 Lymphotoxin-alpha Proteins 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010053156 Musculoskeletal discomfort Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 206010029098 Neoplasm skin Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108010057150 Peplomycin Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000223892 Tetrahymena Species 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 206010054094 Tumour necrosis Diseases 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 230000003527 anti-angiogenesis Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 210000000270 basal cell Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000034303 cell budding Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012829 chemotherapy agent Substances 0.000 description 1
- 238000007398 colorimetric assay Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 239000002619 cytotoxin Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- FJKFBLLIOVQLFS-UHFFFAOYSA-L dibenzoyloxymercury Chemical compound [Hg+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 FJKFBLLIOVQLFS-UHFFFAOYSA-L 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000009513 drug distribution Methods 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 238000010292 electrical insulation Methods 0.000 description 1
- 239000012777 electrically insulating material Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000001827 electrotherapy Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229960004222 factor ix Drugs 0.000 description 1
- 229960000301 factor viii Drugs 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 239000000367 immunologic factor Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 235000005772 leucine Nutrition 0.000 description 1
- 150000002614 leucines Chemical class 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 150000002895 organic esters Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000003300 oropharynx Anatomy 0.000 description 1
- 230000037324 pain perception Effects 0.000 description 1
- 238000002638 palliative care Methods 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229950003180 peplomycin Drugs 0.000 description 1
- QIMGFXOHTOXMQP-GFAGFCTOSA-N peplomycin Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCCN[C@@H](C)C=1C=CC=CC=1)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1NC=NC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C QIMGFXOHTOXMQP-GFAGFCTOSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 210000005267 prostate cell Anatomy 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000012958 reprocessing Methods 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000013298 xenograft nude mouse model Methods 0.000 description 1
- 229940072358 xylocaine Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0502—Skin piercing electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Electrotherapy Devices (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/905,240 US6055453A (en) | 1997-08-01 | 1997-08-01 | Apparatus for addressing needle array electrodes for electroporation therapy |
| US8/905,240 | 1997-08-01 | ||
| US08/905,240 | 1997-08-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20000068678A KR20000068678A (ko) | 2000-11-25 |
| KR100756252B1 true KR100756252B1 (ko) | 2007-09-07 |
Family
ID=25420478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019997002781A Expired - Lifetime KR100756252B1 (ko) | 1997-08-01 | 1998-07-31 | 일렉트로포레이션에 의한 약제와 유전자 전달 방법 및 장치 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US6055453A (enExample) |
| EP (1) | EP0999867B1 (enExample) |
| JP (2) | JP2000503586A (enExample) |
| KR (1) | KR100756252B1 (enExample) |
| CN (2) | CN1768873B (enExample) |
| AT (1) | ATE480294T1 (enExample) |
| AU (1) | AU734343B2 (enExample) |
| BR (1) | BR9806069A (enExample) |
| CA (1) | CA2268026C (enExample) |
| DE (1) | DE69841888D1 (enExample) |
| RU (1) | RU2195332C2 (enExample) |
| TW (1) | TW396043B (enExample) |
| WO (1) | WO1999006101A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017048037A1 (ko) * | 2015-09-17 | 2017-03-23 | 주식회사 엘림텍 | 전기천공장치 및 그 제어방법 |
Families Citing this family (395)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277112B1 (en) | 1996-07-16 | 2001-08-21 | Arthrocare Corporation | Methods for electrosurgical spine surgery |
| US6602248B1 (en) * | 1995-06-07 | 2003-08-05 | Arthro Care Corp. | Methods for repairing damaged intervertebral discs |
| US20050004634A1 (en) * | 1995-06-07 | 2005-01-06 | Arthrocare Corporation | Methods for electrosurgical treatment of spinal tissue |
| US7393351B2 (en) | 1995-06-07 | 2008-07-01 | Arthrocare Corporation | Apparatus and methods for treating cervical inter-vertebral discs |
| CA2246332C (en) | 1996-02-15 | 2009-04-14 | Biosense, Inc. | Catheter based surgery |
| US7357798B2 (en) * | 1996-07-16 | 2008-04-15 | Arthrocare Corporation | Systems and methods for electrosurgical prevention of disc herniations |
| US6726684B1 (en) * | 1996-07-16 | 2004-04-27 | Arthrocare Corporation | Methods for electrosurgical spine surgery |
| US6708066B2 (en) * | 1999-12-10 | 2004-03-16 | Ewa Herbst | Electrochemical treatment of tissues, especially tumors |
| US20060089751A1 (en) * | 1997-01-27 | 2006-04-27 | Ewa Herbst | Electronic delivery systems and methods with feedback |
| KR20010020570A (ko) | 1997-06-30 | 2001-03-15 | 자끄 사비나 | 다세포 진핵 생물 세포중으로 개선된 핵산 전달방법 및이를 위한 콤비네이션 |
| CA2294793A1 (fr) | 1997-06-30 | 1999-01-14 | Rhone-Poulenc Rorer S.A. | Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede |
| US6778853B1 (en) * | 1997-12-17 | 2004-08-17 | University Of South Florida | Electroporation device |
| US6208893B1 (en) * | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| US20030129750A1 (en) * | 1998-02-05 | 2003-07-10 | Yitzhack Schwartz | Homing of donor cells to a target zone in tissue using active therapeutics or substances |
| DE69838526T2 (de) * | 1998-02-05 | 2008-07-03 | Biosense Webster, Inc., Diamond Bar | Gerät zum Freisetzen eines Medikaments im Herzen |
| US7749215B1 (en) | 1998-02-05 | 2010-07-06 | Biosense, Inc. | Intracardiac cell delivery and cell transplantation |
| US20030113303A1 (en) * | 1998-02-05 | 2003-06-19 | Yitzhack Schwartz | Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances |
| US6045532A (en) * | 1998-02-20 | 2000-04-04 | Arthrocare Corporation | Systems and methods for electrosurgical treatment of tissue in the brain and spinal cord |
| JP4612186B2 (ja) | 1998-02-24 | 2011-01-12 | ナビリスト メディカル， インコーポレイテッド | 高流速透析カテーテルおよび関連方法 |
| US6022316A (en) * | 1998-03-06 | 2000-02-08 | Spectrx, Inc. | Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications |
| US6347247B1 (en) | 1998-05-08 | 2002-02-12 | Genetronics Inc. | Electrically induced vessel vasodilation |
| AU4368699A (en) * | 1998-05-29 | 1999-12-20 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | New method for transferring biological material |
| DK1100576T3 (da) * | 1998-06-26 | 2007-12-03 | Genetronics Inc | Synergisme af fotodynamisk effekt og elektropermeringseffekt på cellevitalitet som nyt cytotoksisk middel |
| JP2003505114A (ja) | 1998-07-13 | 2003-02-12 | ジェネトロニクス、インコーポレーテッド | パルス電場による皮膚および筋肉を標的とした遺伝子治療 |
| US6678556B1 (en) * | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
| US7922709B2 (en) | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
| CA2341446C (en) | 1998-08-31 | 2008-10-07 | Johnson & Johnson Consumer Companies, Inc. | Electrotransport device comprising blades |
| US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| WO2000056395A1 (en) | 1999-03-25 | 2000-09-28 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US6678558B1 (en) * | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| DE60018726T2 (de) | 1999-04-16 | 2006-04-13 | Johnson & Johnson Consumer Companies, Inc. | Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren |
| US6514762B1 (en) | 1999-04-23 | 2003-02-04 | New Mexico State University Technology Transfer Corporation | Delivery of nucleotides by electrochemical release |
| US6221071B1 (en) * | 1999-06-04 | 2001-04-24 | Scimed Life Systems, Inc. | Rapid electrode deployment |
| US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US7074747B1 (en) * | 1999-07-01 | 2006-07-11 | Johnson & Johnson Consumer Companies, Inc. | Cleansing compositions |
| US20050009717A1 (en) * | 1999-07-01 | 2005-01-13 | Lukenbach Elvin R. | Foaming make-up removing cleansing compositions |
| US6762158B2 (en) | 1999-07-01 | 2004-07-13 | Johnson & Johnson Consumer Companies, Inc. | Personal care compositions comprising liquid ester mixtures |
| AU5764800A (en) | 1999-07-01 | 2001-01-22 | Johnson & Johnson Consumer Companies, Inc. | Cleansing compositions |
| US6300108B1 (en) * | 1999-07-21 | 2001-10-09 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
| US6326177B1 (en) | 1999-08-04 | 2001-12-04 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Method and apparatus for intracellular electro-manipulation |
| US6611793B1 (en) | 1999-09-07 | 2003-08-26 | Scimed Life Systems, Inc. | Systems and methods to identify and disable re-use single use devices based on detecting environmental changes |
| US6237604B1 (en) | 1999-09-07 | 2001-05-29 | Scimed Life Systems, Inc. | Systems and methods for preventing automatic identification of re-used single use devices |
| US6651669B1 (en) | 1999-09-07 | 2003-11-25 | Scimed Life Systems, Inc. | Systems and methods to identify and disable re-used single use devices based on cataloging catheter usage |
| US6387092B1 (en) * | 1999-09-07 | 2002-05-14 | Scimed Life Systems, Inc. | Systems and methods to identify and disable re-used single use devices based on time elapsed from first therapeutic use |
| US6587718B2 (en) * | 1999-10-08 | 2003-07-01 | Scimed Life Systems, Inc. | Iontophoretic delivery to heart tissue |
| US6912424B2 (en) * | 1999-12-01 | 2005-06-28 | Meagan, Medical, Inc. | Apparatus and method for coupling therapeutic and/or monitoring equipment to a patient |
| US6529776B1 (en) | 1999-12-01 | 2003-03-04 | Vertis Neuroscience, Inc. | Method and apparatus for repositioning a percutaneous probe |
| US6904324B2 (en) * | 1999-12-01 | 2005-06-07 | Meagan Medical, Inc. | Method and apparatus for deploying a percutaneous probe |
| US6560491B1 (en) | 1999-12-01 | 2003-05-06 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system providing electrode axial support |
| US6539264B1 (en) | 1999-12-01 | 2003-03-25 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with sharp point protection |
| US6493592B1 (en) * | 1999-12-01 | 2002-12-10 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode position maintenance |
| US6522927B1 (en) | 1999-12-01 | 2003-02-18 | Vertis Neuroscience, Inc. | Electrode assembly for a percutaneous electrical therapy system |
| US6556869B1 (en) | 1999-12-01 | 2003-04-29 | Vertis Neuroscience, Inc. | Electrode introducer for a percutaneous electrical therapy system |
| US6516226B1 (en) | 1999-12-01 | 2003-02-04 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system for minimizing electrode insertion discomfort |
| US6549810B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode depth control |
| US6622051B1 (en) | 1999-12-01 | 2003-09-16 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode entry angle control |
| US6549797B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Electrode remover for a percutaneous electrical therapy system |
| KR100406729B1 (ko) * | 2000-02-15 | 2003-11-21 | 사회복지법인삼성생명공익재단(삼성서울병원) | 생리학적 전기신호에 동조화된 의료기기 |
| US7805201B2 (en) * | 2000-02-17 | 2010-09-28 | Standen Ltd. | Treating a tumor or the like with an electric field |
| US7016725B2 (en) * | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US8447395B2 (en) * | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| WO2001060994A1 (en) * | 2000-02-17 | 2001-08-23 | Palti Yoram Prof | Method and apparatus for destroying dividing cells |
| US7146210B2 (en) * | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US7089054B2 (en) * | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US7136699B2 (en) * | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US8175698B2 (en) * | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US6868289B2 (en) * | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US7473244B2 (en) * | 2000-06-02 | 2009-01-06 | The University Of Utah Research Foundation | Active needle devices with integrated functionality |
| WO2002000278A2 (en) * | 2000-06-26 | 2002-01-03 | Microheart, Inc. | Method and apparatus for treating ischemic tissue |
| USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
| US6892099B2 (en) | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
| US8251986B2 (en) | 2000-08-17 | 2012-08-28 | Angiodynamics, Inc. | Method of destroying tissue cells by eletroporation |
| US6697670B2 (en) | 2001-08-17 | 2004-02-24 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients |
| US6795728B2 (en) | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
| US7118555B2 (en) * | 2000-09-21 | 2006-10-10 | Meagan Medical, Inc. | Method and apparatus for repositioning a percutaneous probe |
| USD480478S1 (en) | 2000-09-28 | 2003-10-07 | Vertis Neuroscience, Inc. | Percutaneous probe applicator |
| US20030158545A1 (en) * | 2000-09-28 | 2003-08-21 | Arthrocare Corporation | Methods and apparatus for treating back pain |
| US6846306B1 (en) * | 2000-10-10 | 2005-01-25 | Cold Spring Harbor Laboratory | Single cell electroporation |
| US6671557B1 (en) | 2000-10-10 | 2003-12-30 | Meagan Medical, Inc. | System and method for providing percutaneous electrical therapy |
| US7108681B2 (en) * | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
| US7131987B2 (en) | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
| US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US6821274B2 (en) | 2001-03-07 | 2004-11-23 | Gendel Ltd. | Ultrasound therapy for selective cell ablation |
| AU2002215115A1 (en) | 2000-11-17 | 2002-05-27 | Gendel Limited | Ablation of cells using combined electric field and ultrasound therapy |
| US20050043726A1 (en) * | 2001-03-07 | 2005-02-24 | Mchale Anthony Patrick | Device II |
| US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| US6625486B2 (en) | 2001-04-11 | 2003-09-23 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for intracellular delivery of an agent |
| US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
| ATE502657T1 (de) * | 2001-05-01 | 2011-04-15 | Av Topchiev Inst Petrochemical | Zweiphasige, wasserabsorbierende bioadhäsive zusammenstezung |
| EP1390085B1 (en) * | 2001-05-01 | 2009-08-05 | A.V. Topchiev Institute of Petrochemical Synthesis | Hydrogel compositions |
| US8840918B2 (en) * | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
| US8206738B2 (en) * | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
| US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
| US20050215727A1 (en) * | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
| US6733485B1 (en) | 2001-05-25 | 2004-05-11 | Advanced Bionics Corporation | Microstimulator-based electrochemotherapy methods and systems |
| ITTO20010534A1 (it) * | 2001-06-04 | 2002-12-04 | Igea Srl | Dispositivo e metodo per elettroporazione che riduce la contrazione muscolare e la sensazione di dolore. |
| US7127284B2 (en) * | 2001-06-11 | 2006-10-24 | Mercator Medsystems, Inc. | Electroporation microneedle and methods for its use |
| US20040204669A1 (en) * | 2001-07-05 | 2004-10-14 | Hofmann Gunter A. | Apparatus for electroporation mediated delivery for drugs and genes |
| USRE42016E1 (en) | 2001-08-13 | 2010-12-28 | Angiodynamics, Inc. | Apparatus and method for the treatment of benign prostatic hyperplasia |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| US7130697B2 (en) * | 2002-08-13 | 2006-10-31 | Minnesota Medical Physics Llc | Apparatus and method for the treatment of benign prostatic hyperplasia |
| US7879610B1 (en) * | 2001-08-24 | 2011-02-01 | University Of South Florida | Electroporation system and method for facilitating entry of molecules into cells in vivo |
| US7713740B2 (en) * | 2001-08-24 | 2010-05-11 | University Of South Florida | Method of using electric fields to facilitate the entry of molecules into cells in vivo |
| US20040087992A1 (en) * | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| AU2002362310A1 (en) * | 2001-09-14 | 2003-04-01 | Arthrocare Corporation | Methods and apparatus for treating intervertebral discs |
| USD475463S1 (en) | 2001-09-28 | 2003-06-03 | Vertis Neuroscience, Inc. | Control device for delivering electrical therapy |
| FR2831026B1 (fr) * | 2001-10-18 | 2004-05-28 | Commissariat Energie Atomique | Dispositif et procede de traitement par champ electrique pulse d'une substance en ecoulement colonisee par des organismes indesirables |
| US8812114B2 (en) | 2001-10-18 | 2014-08-19 | Uroplasty, Inc. | Lead set for nerve stimulator and method of operation thereof |
| PT2308553E (pt) * | 2001-10-18 | 2014-03-04 | Uroplasty Inc | Sistema de neuroestimulação eléctrica |
| EP1448771B1 (en) * | 2001-11-27 | 2007-01-03 | Cellectricon AB | A method for combined parallel agent delivery and electroporation for cell structures and use thereof |
| US20030170898A1 (en) * | 2001-12-04 | 2003-09-11 | Gundersen Martin A. | Method for intracellular modifications within living cells using pulsed electric fields |
| WO2003068906A1 (en) * | 2002-02-12 | 2003-08-21 | Cellectricon Ab | Systems and methods for rapidly changing the solution environment around sensors |
| EP1482974A4 (en) * | 2002-02-15 | 2006-08-02 | Zycos Inc | ELECTROPORATION PROCESSES FOR INTRODUCING BIOACTIVE AGENTS INTO CELLS |
| EP1480720B1 (en) * | 2002-03-07 | 2018-08-22 | Inovio Pharmaceuticals, Inc. | Electrode assembly for constant-current electroporation |
| US7245963B2 (en) * | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| US8209006B2 (en) | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
| WO2003082007A2 (en) * | 2002-03-22 | 2003-10-09 | The Regent Of The University Of California | Method and apparatus for using an electromagnetic field in cellular transplantation |
| US7218962B2 (en) * | 2002-03-29 | 2007-05-15 | Boston Scientific Scimed, Inc. | Magnetically enhanced injection catheter |
| US6912417B1 (en) * | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
| CA2482183A1 (en) * | 2002-04-16 | 2003-10-30 | Cyto Pulse Sciences, Inc. | Method of treating biological materials with translating electrical fields and electrode polarity reversal |
| US20030204161A1 (en) * | 2002-04-25 | 2003-10-30 | Bozidar Ferek-Petric | Implantable electroporation therapy device and method for using same |
| US8871241B2 (en) | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
| ES2315493T3 (es) * | 2002-05-23 | 2009-04-01 | Gendel Limited | Dispositivo de ablacion. |
| US10130415B2 (en) * | 2002-06-10 | 2018-11-20 | Wisconsin Alumni Research Foundation | Circumferential electrode array for tissue ablation |
| US7328064B2 (en) * | 2002-07-04 | 2008-02-05 | Inovio As | Electroporation device and injection apparatus |
| US20050070841A1 (en) * | 2002-07-04 | 2005-03-31 | Inovio As | Electroporation device and injection apparatus |
| US20040127893A1 (en) * | 2002-12-13 | 2004-07-01 | Arthrocare Corporation | Methods for visualizing and treating intervertebral discs |
| US6997903B2 (en) * | 2003-02-10 | 2006-02-14 | Bandula Wijay | Local drug delivery catheter |
| US7578954B2 (en) * | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
| US7794456B2 (en) * | 2003-05-13 | 2010-09-14 | Arthrocare Corporation | Systems and methods for electrosurgical intervertebral disc replacement |
| US6969604B1 (en) | 2003-06-20 | 2005-11-29 | Yakovenko Sergey A | Electroporation chamber |
| GB0322766D0 (en) * | 2003-09-29 | 2003-10-29 | Emcision Ltd | Surgical resection device |
| US7708733B2 (en) | 2003-10-20 | 2010-05-04 | Arthrocare Corporation | Electrosurgical method and apparatus for removing tissue within a bone body |
| US8500713B2 (en) * | 2003-10-29 | 2013-08-06 | Medtronic, Inc. | Implantable electroporation therapy device and method for using same |
| EP2474281B1 (en) | 2003-12-24 | 2019-03-27 | The Regents of The University of California | Tissue ablation with irreversible electroporation |
| US8298222B2 (en) | 2003-12-24 | 2012-10-30 | The Regents Of The University Of California | Electroporation to deliver chemotherapeutics and enhance tumor regression |
| CN102764247B (zh) | 2004-01-30 | 2016-04-20 | 考里安国际公司 | 递送活性剂的快速溶解膜 |
| RU2252793C1 (ru) * | 2004-02-02 | 2005-05-27 | Карасев Александр Александрович | Электродное устройство |
| FR2867054B1 (fr) | 2004-03-04 | 2006-09-15 | Future Medical System | Systeme d'endoscopie et connecteur a detecteur de pression destine a un tel systeme |
| DK1729848T3 (en) | 2004-03-08 | 2015-07-20 | Ichor Medical Systems Inc | IMPROVED APPARATUS FOR ELECTRICAL COMMUNICATED administration of therapeutic agents |
| US7611481B2 (en) * | 2004-03-24 | 2009-11-03 | Corium International, Inc. | Transdermal delivery device |
| JP4899020B2 (ja) * | 2004-03-25 | 2012-03-21 | ユニバーシティ・カレッジ・コークーナショナル・ユニバーシティ・オブ・アイルランド，コーク | 組織の予防的処置又は治療に用いるための装置 |
| JP4443278B2 (ja) * | 2004-03-26 | 2010-03-31 | テルモ株式会社 | 拡張体付カテーテル |
| AU2005231443B2 (en) | 2004-04-01 | 2012-02-23 | The General Hospital Corporation | Method and apparatus for dermatological treatment and tissue reshaping |
| US20050226991A1 (en) * | 2004-04-07 | 2005-10-13 | Hossainy Syed F | Methods for modifying balloon of a catheter assembly |
| CA2562699C (en) | 2004-04-16 | 2015-07-21 | Critical Care Innovations, Inc. | Systems and methods for improving image-guided tissue ablation |
| TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
| FR2872055B1 (fr) | 2004-06-24 | 2008-02-08 | Yves Leon Scherman | Dispositif pour le transfert de molecules aux cellules utilisant une force d'origine physique et combinaison permettant la mise en oeuvre du procede |
| FR2880808A1 (fr) | 2005-01-20 | 2006-07-21 | Yves Scherman | Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives |
| FR2872056B1 (fr) | 2004-06-24 | 2007-08-10 | Yves Scherman | Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques |
| CA2572122A1 (fr) | 2004-06-24 | 2006-02-02 | Sphergen | Dispositif pour le transfert de molecules aux cellules utilisant une force electrique |
| WO2006017807A2 (en) * | 2004-08-05 | 2006-02-16 | Corium International, Inc. | Adhesive composition |
| PT2345451T (pt) * | 2004-12-07 | 2018-04-19 | Novocure Ltd | Eléctrodos para aplicar um campo eléctrico in-vivo ao longo de um extenso período de tempo |
| EP3666328B1 (en) * | 2004-12-27 | 2022-04-06 | Novocure GmbH | Treating a tumor or the like with electric fields at different orientations |
| WO2007012907A2 (en) * | 2005-02-08 | 2007-02-01 | Allen, John | Electric therapy machine |
| US7850645B2 (en) * | 2005-02-11 | 2010-12-14 | Boston Scientific Scimed, Inc. | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power |
| JP2008532560A (ja) * | 2005-03-19 | 2008-08-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 微弱電界ネットワークを仲介して行う、生体外で細胞内に遺伝子、タンパク質および薬剤を送達する方法および装置 |
| US20060264752A1 (en) * | 2005-04-27 | 2006-11-23 | The Regents Of The University Of California | Electroporation controlled with real time imaging |
| WO2006124639A1 (en) * | 2005-05-11 | 2006-11-23 | Corium International, Inc. | Permeabilization of biological membranes |
| EP2790207B1 (en) * | 2005-06-20 | 2016-01-06 | Nippon Telegraph And Telephone Corporation | Diamond semiconductor element and process for producing the same |
| US8114070B2 (en) * | 2005-06-24 | 2012-02-14 | Angiodynamics, Inc. | Methods and systems for treating BPH using electroporation |
| US20060293725A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating fatty tissue sites using electroporation |
| US20060293730A1 (en) | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating restenosis sites using electroporation |
| US20060293731A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating tumors using electroporation |
| EP1908057B1 (en) * | 2005-06-30 | 2012-06-20 | LG Electronics Inc. | Method and apparatus for decoding an audio signal |
| US20070066934A1 (en) * | 2005-09-19 | 2007-03-22 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system and methods therefor |
| WO2007039799A2 (en) | 2005-10-03 | 2007-04-12 | Novocure Ltd. | Optimizing characteristics of an electric field to increase the field's effect on proliferating cells |
| US20070156135A1 (en) * | 2006-01-03 | 2007-07-05 | Boris Rubinsky | System and methods for treating atrial fibrillation using electroporation |
| US20080287857A1 (en) * | 2006-02-11 | 2008-11-20 | Rune Kjeken | Device and method for single-needle in vivo electroporation |
| EP1981581B1 (en) * | 2006-02-11 | 2016-04-13 | Genetronics, Inc. | Device for single-needle in vivo electroporation |
| US20080045880A1 (en) * | 2006-02-11 | 2008-02-21 | Rune Kjeken | Device and method for single-needle in vivo electroporation |
| US7879034B2 (en) | 2006-03-02 | 2011-02-01 | Arthrocare Corporation | Internally located return electrode electrosurgical apparatus, system and method |
| WO2007103070A2 (en) * | 2006-03-03 | 2007-09-13 | Genetronics, Inc. | Method and device for treating microscopic residual tumors remaining in tissues following surgical resection |
| US20070232984A1 (en) * | 2006-03-30 | 2007-10-04 | Michael Lovell | Hand-held electrical stimulation device |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| WO2007117651A2 (en) | 2006-04-07 | 2007-10-18 | University Of South Florida | Passive electric field focus system for in vivo and in vitro applications |
| US7856272B2 (en) * | 2006-04-28 | 2010-12-21 | Flint Hills Scientific, L.L.C. | Implantable interface for a medical device system |
| WO2007136694A2 (en) * | 2006-05-18 | 2007-11-29 | Uroplasty, Inc. | Method and apparatus for stimulating a nerve of a patient |
| DK2032057T3 (da) * | 2006-06-12 | 2010-02-08 | Region Hovedstaden V Herlev Ho | Elektrodeindføringsindretning |
| WO2007148256A2 (en) * | 2006-06-22 | 2007-12-27 | Koninklijke Philips Electronics N. V. | Iontophoretic electrotransport device |
| JP2010500103A (ja) * | 2006-08-08 | 2010-01-07 | ピーク バイオサイエンシーズ， インコーポレイテッド | 抗癌治療のためのカテーテルおよびアレイ |
| WO2008048620A2 (en) * | 2006-10-16 | 2008-04-24 | The Regents Of The University Of California | Gels with predetermined conductivity used in irreversible electroporation of tissue |
| ES2993941T3 (en) | 2006-10-17 | 2025-01-14 | Inovio Pharmaceuticals Inc | Electroporation devices for electroporation of cells in mammals |
| DK2094086T3 (da) * | 2006-11-08 | 2013-11-25 | Veritas Bio LLC | Indgivelse in vivo af dobbeltstrenget rna til en målcelle |
| US20080132884A1 (en) * | 2006-12-01 | 2008-06-05 | Boris Rubinsky | Systems for treating tissue sites using electroporation |
| AU2008209537B2 (en) * | 2007-01-22 | 2013-01-31 | Corium Pharma Solutions, Inc. | Applicators for microneedle arrays |
| EP2167194B1 (en) | 2007-03-06 | 2017-04-19 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| WO2008115511A1 (en) * | 2007-03-20 | 2008-09-25 | Peak Biosciences, Inc. | Method for therapeutic administration of radionucleosides |
| US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
| WO2008140808A1 (en) * | 2007-05-10 | 2008-11-20 | Peak Biosciences, Inc. | Methods for administration of radiotherapeutic agents |
| US20080312648A1 (en) * | 2007-06-12 | 2008-12-18 | Darion Peterson | Fat removal and sculpting device |
| CA2696352C (en) * | 2007-08-14 | 2017-03-21 | Novocure Limited | Treating parasites with electric fields |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| JP5178132B2 (ja) * | 2007-10-11 | 2013-04-10 | キヤノン株式会社 | 画像処理システム並びに画像処理方法 |
| CN101888874B (zh) * | 2007-10-11 | 2013-11-13 | 京畿州海莱乌医院 | 用于改进的电场控制的电穿孔装置 |
| WO2009121017A1 (en) | 2008-03-27 | 2009-10-01 | The Regents Of The University Of California | Balloon catheter for reducing restenosis via irreversible electroporation |
| US20100004623A1 (en) * | 2008-03-27 | 2010-01-07 | Angiodynamics, Inc. | Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation |
| WO2009124312A2 (en) * | 2008-04-04 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same |
| AU2009231598B2 (en) | 2008-04-04 | 2015-03-12 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same |
| WO2009134876A1 (en) | 2008-04-29 | 2009-11-05 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation to create tissue scaffolds |
| US10272178B2 (en) | 2008-04-29 | 2019-04-30 | Virginia Tech Intellectual Properties Inc. | Methods for blood-brain barrier disruption using electrical energy |
| US8926606B2 (en) * | 2009-04-09 | 2015-01-06 | Virginia Tech Intellectual Properties, Inc. | Integration of very short electric pulses for minimally to noninvasive electroporation |
| US10245098B2 (en) | 2008-04-29 | 2019-04-02 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
| US9283051B2 (en) | 2008-04-29 | 2016-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating a treatment volume for administering electrical-energy based therapies |
| US10117707B2 (en) | 2008-04-29 | 2018-11-06 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| US10238447B2 (en) | 2008-04-29 | 2019-03-26 | Virginia Tech Intellectual Properties, Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
| US11254926B2 (en) | 2008-04-29 | 2022-02-22 | Virginia Tech Intellectual Properties, Inc. | Devices and methods for high frequency electroporation |
| US10702326B2 (en) | 2011-07-15 | 2020-07-07 | Virginia Tech Intellectual Properties, Inc. | Device and method for electroporation based treatment of stenosis of a tubular body part |
| US11272979B2 (en) | 2008-04-29 | 2022-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
| US9867652B2 (en) | 2008-04-29 | 2018-01-16 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds |
| US8992517B2 (en) | 2008-04-29 | 2015-03-31 | Virginia Tech Intellectual Properties Inc. | Irreversible electroporation to treat aberrant cell masses |
| US8348938B2 (en) * | 2008-05-06 | 2013-01-08 | Old Dominian University Research Foundation | Apparatus, systems and methods for treating a human tissue condition |
| US20090281477A1 (en) | 2008-05-09 | 2009-11-12 | Angiodynamics, Inc. | Electroporation device and method |
| US8849395B2 (en) * | 2008-05-30 | 2014-09-30 | Boston Scientific Scimed, Inc. | Guide catheter having vasomodulating electrodes |
| WO2009155526A2 (en) * | 2008-06-20 | 2009-12-23 | Angiodynamics, Inc. | Device and method for the ablation of fibrin sheath formation on a venous catheter |
| US9681909B2 (en) * | 2008-06-23 | 2017-06-20 | Angiodynamics, Inc. | Treatment devices and methods |
| US20100152725A1 (en) * | 2008-12-12 | 2010-06-17 | Angiodynamics, Inc. | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
| AU2010204986B2 (en) | 2009-01-14 | 2016-06-02 | Corium International, Inc. | Transdermal administration of tamsulosin |
| KR100943089B1 (ko) * | 2009-01-23 | 2010-02-18 | 강동환 | 피부처치 장치 |
| WO2010085765A2 (en) * | 2009-01-23 | 2010-07-29 | Moshe Meir H | Therapeutic energy delivery device with rotational mechanism |
| US8231603B2 (en) * | 2009-02-10 | 2012-07-31 | Angiodynamics, Inc. | Irreversible electroporation and tissue regeneration |
| US8632534B2 (en) | 2009-04-03 | 2014-01-21 | Angiodynamics, Inc. | Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD) |
| US11382681B2 (en) | 2009-04-09 | 2022-07-12 | Virginia Tech Intellectual Properties, Inc. | Device and methods for delivery of high frequency electrical pulses for non-thermal ablation |
| US11638603B2 (en) | 2009-04-09 | 2023-05-02 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| CA2759850C (en) * | 2009-04-24 | 2019-10-22 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| USD630321S1 (en) | 2009-05-08 | 2011-01-04 | Angio Dynamics, Inc. | Probe handle |
| US20100298825A1 (en) * | 2009-05-08 | 2010-11-25 | Cellutions, Inc. | Treatment System With A Pulse Forming Network For Achieving Plasma In Tissue |
| WO2010138919A2 (en) | 2009-05-28 | 2010-12-02 | Angiodynamics, Inc. | System and method for synchronizing energy delivery to the cardiac rhythm |
| US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
| WO2011030322A2 (en) * | 2009-09-10 | 2011-03-17 | University College Cork - National University Of Ireland, Cork | A device for treating tissue |
| WO2011032179A1 (en) | 2009-09-14 | 2011-03-17 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same |
| US20110118732A1 (en) | 2009-11-19 | 2011-05-19 | The Regents Of The University Of California | Controlled irreversible electroporation |
| WO2011109399A1 (en) * | 2010-03-01 | 2011-09-09 | Inovio Pharmaceuticals, Inc. | Multiple tissue layer electroporation applicator and device |
| US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| US8979838B2 (en) | 2010-05-24 | 2015-03-17 | Arthrocare Corporation | Symmetric switching electrode method and related system |
| US9289606B2 (en) * | 2010-09-02 | 2016-03-22 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System for electroporation therapy |
| CA2809360A1 (en) | 2010-09-27 | 2012-04-05 | China Agricultural University | Combined antigen and dna vaccine for preventing and treating autoimmune diseases |
| WO2012051433A2 (en) | 2010-10-13 | 2012-04-19 | Angiodynamics, Inc. | System and method for electrically ablating tissue of a patient |
| WO2012088149A2 (en) | 2010-12-20 | 2012-06-28 | Virginia Tech Intellectual Properties, Inc. | High-frequency electroporation for cancer therapy |
| US20120220813A1 (en) * | 2011-01-25 | 2012-08-30 | Sanford Lane | Devices and methods for applying energy to a muscular layer |
| WO2012158132A1 (en) | 2011-05-18 | 2012-11-22 | Eteka Llc | Apparatus for the enhancement of food properties by electroporation or pulsed electric fields |
| EP2720740A1 (en) | 2011-06-15 | 2014-04-23 | ChronTech Pharma AB | Injection needle and device |
| WO2012178095A1 (en) * | 2011-06-22 | 2012-12-27 | Ifluidics, Inc. | Electromotive system for high-throughput screening |
| EP3473296B1 (en) * | 2011-06-28 | 2020-08-05 | Inovio Pharmaceuticals, Inc. | A minimally invasive dermal electroporation device |
| CN104203287B (zh) | 2011-07-12 | 2017-07-14 | 费城健康及教育公司，d/b/a,德雷克塞尔大学医学院 | 新型艰难梭菌dna疫苗 |
| CN102334988B (zh) * | 2011-07-28 | 2013-07-03 | 河海大学常州校区 | 手动组合式微电极推进器及制作方法 |
| SG11201400527XA (en) | 2011-09-16 | 2014-04-28 | Univ Pennsylvania | Rna engineered t cells for the treatment of cancer |
| WO2013044225A1 (en) | 2011-09-22 | 2013-03-28 | The Trustees Of The University Of Pennsylvania | A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens |
| US9078665B2 (en) | 2011-09-28 | 2015-07-14 | Angiodynamics, Inc. | Multiple treatment zone ablation probe |
| WO2013063419A2 (en) | 2011-10-28 | 2013-05-02 | The Trustees Of The University Of Pennsylvania | A fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
| US8951251B2 (en) | 2011-11-08 | 2015-02-10 | Boston Scientific Scimed, Inc. | Ostial renal nerve ablation |
| CN103169510B (zh) * | 2011-12-20 | 2016-07-06 | 刘兴鹏 | 用于治疗房颤的化学消融装置 |
| US9414881B2 (en) | 2012-02-08 | 2016-08-16 | Angiodynamics, Inc. | System and method for increasing a target zone for electrical ablation |
| CN103239734B (zh) | 2012-02-10 | 2016-02-24 | 北京艾棣维欣生物技术有限公司 | 用于预防和/或治疗呼吸道合胞病毒感染的疫苗 |
| EP2817330B1 (en) | 2012-02-22 | 2020-07-08 | The Trustees of the University of Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| MX2014010185A (es) | 2012-02-22 | 2014-11-14 | Univ Pennsylvania | Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion. |
| CN104583230A (zh) | 2012-07-13 | 2015-04-29 | 宾夕法尼亚大学董事会 | 通过共同引入双特异性抗体增强car t细胞的活性 |
| US9365641B2 (en) | 2012-10-01 | 2016-06-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| WO2014055771A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| KR102877281B1 (ko) | 2012-12-13 | 2025-10-28 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Ｗｔ１ 백신 |
| JP6865524B2 (ja) | 2012-12-21 | 2021-04-28 | コリウム， インコーポレイテッド | 治療剤を送達するためのマイクロアレイおよび使用方法 |
| JP6487899B2 (ja) | 2013-03-12 | 2019-03-20 | コリウム インターナショナル， インコーポレイテッド | 微小突起アプリケータ |
| EP2968118B1 (en) | 2013-03-15 | 2022-02-09 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| WO2014144973A1 (en) | 2013-03-15 | 2014-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| WO2014160886A2 (en) * | 2013-03-27 | 2014-10-02 | Washington State University | Systems and methods for treating material surfaces |
| US9592303B2 (en) | 2013-05-30 | 2017-03-14 | Duke University | Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates |
| US10364451B2 (en) | 2013-05-30 | 2019-07-30 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| US10392611B2 (en) | 2013-05-30 | 2019-08-27 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| CA2919835A1 (en) | 2013-07-31 | 2015-02-05 | Board Of Trustees Of The University Of Arkansas | Compositions for and methods of treating and preventing cancer targeting tumor associated carbohydrate antigens |
| KR101582988B1 (ko) * | 2013-09-30 | 2016-01-06 | (주)휴먼드림 | 전립선 고주파 치료기 |
| CA2926025A1 (en) | 2013-10-07 | 2015-04-16 | The Trustees Of The University Of Pennsylvania | Vaccines with interleukin-33 as an adjuvant |
| WO2015070027A1 (en) | 2013-11-07 | 2015-05-14 | University Of Southern California | Use of ikk epsilon inhibitors to activate nfat and t cell response |
| KR102395493B1 (ko) | 2013-11-14 | 2022-05-09 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Hiv-1 env dna 백신과 단백질 부스터 |
| KR20230122181A (ko) | 2013-11-29 | 2023-08-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 중동 호흡기 증후군 코로나바이러스(MERS-CoV) 백신 |
| EP4070818A3 (en) | 2014-01-06 | 2023-01-11 | The Trustees of the University of Pennsylvania | Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy |
| US10166321B2 (en) | 2014-01-09 | 2019-01-01 | Angiodynamics, Inc. | High-flow port and infusion needle systems |
| ES2963718T3 (es) | 2014-01-21 | 2024-04-01 | Novartis Ag | Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras |
| CN103861202B (zh) * | 2014-03-18 | 2016-06-01 | 苏州壹达生物科技有限公司 | 一种利用空心电极针电穿孔给药的装置 |
| US12070601B2 (en) * | 2014-03-28 | 2024-08-27 | Pinnacle Bionics. Inc. | Stimulation system for exercising diaphragm and method of operation thereof |
| CN112807074A (zh) | 2014-05-12 | 2021-05-18 | 弗吉尼亚暨州立大学知识产权公司 | 电穿孔系统 |
| US12114911B2 (en) | 2014-08-28 | 2024-10-15 | Angiodynamics, Inc. | System and method for ablating a tissue site by electroporation with real-time pulse monitoring |
| EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| US10166288B2 (en) | 2014-10-01 | 2019-01-01 | The Trustees Of The University Of Pennsylvania | Vaccines having an antigen and interleukin-21 as an adjuvant |
| KR102583138B1 (ko) | 2014-10-31 | 2023-09-26 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | T 세포를 자극 및 증대시키는 조성물 및 방법 |
| EP4427809A3 (en) | 2014-10-31 | 2024-12-04 | The Trustees of The University of Pennsylvania | Altering gene expression in car-t cells and uses thereof |
| KR20170074243A (ko) | 2014-10-31 | 2017-06-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 변형된 t 세포의 생성 방법 및 조성물 |
| WO2016100325A1 (en) | 2014-12-15 | 2016-06-23 | Virginia Tech Intellectual Properties, Inc. | Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment |
| KR20240132103A (ko) | 2015-01-29 | 2024-09-02 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 관문 억제제 및 백신 조합 및 면역요법을 위한 이들의 사용 |
| AU2015380397B2 (en) | 2015-01-31 | 2021-10-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| US10385115B2 (en) | 2015-03-26 | 2019-08-20 | Duke University | Fibronectin type III domain-based fusion proteins |
| JP7340221B2 (ja) | 2015-05-01 | 2023-09-07 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニア | グリカン依存性免疫療法分子 |
| WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| JP6882782B2 (ja) | 2015-08-04 | 2021-06-02 | デューク ユニバーシティ | 遺伝子コードされた本質的に無秩序な送達用ステルスポリマーおよびその使用方法 |
| EP3340998B1 (en) | 2015-08-28 | 2023-01-11 | The Trustees of the University of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
| CN108135653B (zh) | 2015-10-07 | 2022-02-11 | 梅约医学教育与研究基金会 | 用于肥胖症或糖尿病治疗的电穿孔 |
| WO2017070196A1 (en) * | 2015-10-21 | 2017-04-27 | The Methodist Hospital System | Cellular vectors for delivery of therapeutics |
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| WO2017112825A2 (en) | 2015-12-21 | 2017-06-29 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| PL3397335T3 (pl) * | 2015-12-28 | 2023-02-13 | Inovio Pharmaceuticals, Inc. | Urządzenie do elektroporacji z ulepszonym generatorem sygnału |
| SG10202110370PA (en) * | 2015-12-30 | 2021-11-29 | Inovio Pharmaceuticals Inc | Electroporation device with detachable needle array with lock-out system |
| EP3432924A1 (en) | 2016-03-23 | 2019-01-30 | Novartis AG | Cell secreted minibodies and uses thereof |
| EP3436139B1 (en) | 2016-03-28 | 2025-04-30 | PapiVax Biotech, Inc. | METHOD AND APPARATUS FOR ADMINISTERING THERAPEUTIC AGENTS |
| US11246924B2 (en) | 2016-04-01 | 2022-02-15 | Duke University | Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform |
| KR102443064B1 (ko) | 2016-04-29 | 2022-09-14 | 이노비오 파마수티컬즈, 인크. | 제제의 전달을 향상시키기 위한 콘드로이티나제 및/또는 히알루로니다제의 생체내 용도 |
| WO2017210476A1 (en) | 2016-06-01 | 2017-12-07 | Duke University | Nonfouling biosensors |
| EP4209190A1 (en) | 2016-06-27 | 2023-07-12 | Galvanize Therapeutics, Inc. | System comprising a generator and a catheter with an electrode for treating a lung passageway |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| US10233419B2 (en) | 2016-06-30 | 2019-03-19 | Zymergen Inc. | Apparatuses and methods for electroporation |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| US11135301B2 (en) | 2016-09-14 | 2021-10-05 | Duke University | Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs |
| JP2020500150A (ja) | 2016-09-23 | 2020-01-09 | デューク ユニバーシティ | 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド |
| US10613005B2 (en) * | 2016-10-31 | 2020-04-07 | Agilent Technologies, Inc. | Deparaffinization of tissue by electric field generation and ionization |
| US10905492B2 (en) | 2016-11-17 | 2021-02-02 | Angiodynamics, Inc. | Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode |
| US10376495B2 (en) | 2016-11-23 | 2019-08-13 | University Of South Florida | Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF) |
| WO2018119090A1 (en) | 2016-12-22 | 2018-06-28 | Ohio State Innovation Foundation | Interpentrating microstructures for nanochannel-based cargo delivery |
| US11648200B2 (en) | 2017-01-12 | 2023-05-16 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
| CN107212920A (zh) * | 2017-01-23 | 2017-09-29 | 杭州安杰思医学科技有限公司 | 内窥镜用处理装置、内窥镜、及扩展支架 |
| US10813935B2 (en) | 2017-02-23 | 2020-10-27 | Transgenex Nanobiotech, Inc. | Methods and compositions for treating drug resistance in cancer |
| US11318155B2 (en) | 2017-02-24 | 2022-05-03 | University Of South Florida | Hsp90 activator Aha1 drives production of pathological tau aggregates |
| US10272052B2 (en) | 2017-02-24 | 2019-04-30 | University Of South Florida | Compositions and methods for the treatment of tauopathies |
| JP7618192B2 (ja) | 2017-03-28 | 2025-01-21 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 移植された組織を拒絶反応から保護するための方法 |
| WO2018213320A1 (en) | 2017-05-15 | 2018-11-22 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
| WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS |
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| SE541651C2 (en) * | 2017-07-28 | 2019-11-19 | Scandinavian Chemotech Ab | An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal |
| US11590345B2 (en) | 2017-08-08 | 2023-02-28 | Pulse Biosciences, Inc. | Treatment of tissue by the application of energy |
| US10850095B2 (en) | 2017-08-08 | 2020-12-01 | Pulse Biosciences, Inc. | Treatment of tissue by the application of energy |
| US10857347B2 (en) | 2017-09-19 | 2020-12-08 | Pulse Biosciences, Inc. | Treatment instrument and high-voltage connectors for robotic surgical system |
| US11607537B2 (en) | 2017-12-05 | 2023-03-21 | Virginia Tech Intellectual Properties, Inc. | Method for treating neurological disorders, including tumors, with electroporation |
| JP2021508533A (ja) | 2017-12-26 | 2021-03-11 | ギャラリー，インコーポレイテッド | 様々な用途のためのエネルギー送達の最適化 |
| US12365733B2 (en) | 2017-12-29 | 2025-07-22 | Cellectis | Method for improving production of car T cells |
| WO2019147954A1 (en) | 2018-01-26 | 2019-08-01 | Duke University | Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same |
| US11311329B2 (en) | 2018-03-13 | 2022-04-26 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for immunotherapy based treatments using non-thermal ablation techniques |
| US11925405B2 (en) | 2018-03-13 | 2024-03-12 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| US12390262B2 (en) | 2018-03-13 | 2025-08-19 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| US11525759B2 (en) | 2018-04-24 | 2022-12-13 | Agilent Technologies, Inc. | Deparaffinization of tissue utilizing electric field |
| EP3788343B1 (en) | 2018-04-30 | 2024-03-27 | Duke University | Stimuli-responsive peg-like polymer-based drug delivery platform |
| MX2020011618A (es) | 2018-05-02 | 2021-02-16 | Oncosec Medical Inc | Sistemas, métodos y aparatos de electroporación. |
| AU2019269601A1 (en) | 2018-05-17 | 2020-11-26 | Regents Of The University Of Minnesota | Drug-resistant immune cells and methods of use thereof |
| WO2020028806A1 (en) | 2018-08-02 | 2020-02-06 | Duke University | Dual agonist fusion proteins |
| WO2020092455A2 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
| DK3877039T3 (da) * | 2018-11-05 | 2023-07-03 | Herlev Hospital | Elektrodeanordning til forbedret fordeling af et elektrisk felt |
| TWI850282B (zh) | 2018-11-27 | 2024-08-01 | 香港商弘年發展有限公司 | 用於治療癌症之質體建構體和使用方法 |
| JP7489116B2 (ja) * | 2018-12-13 | 2024-05-23 | ニューサウス イノヴェイションズ プロプライエタリィ リミティッド | 分子エレクトロトランスファーを制御するための方法及びシステム |
| US11071860B2 (en) * | 2019-02-06 | 2021-07-27 | Oncosec Medical Incorporated | Systems and methods for detecting fault conditions in electroporation therapy |
| US11571569B2 (en) | 2019-02-15 | 2023-02-07 | Pulse Biosciences, Inc. | High-voltage catheters for sub-microsecond pulsing |
| WO2020191102A1 (en) | 2019-03-18 | 2020-09-24 | The Broad Institute, Inc. | Type vii crispr proteins and systems |
| TW202042824A (zh) | 2019-03-27 | 2020-12-01 | 賓夕法尼亞大學董事會 | Tn-MUC1嵌合抗原受體（CAR）T細胞療法 |
| EP3952972A4 (en) | 2019-04-08 | 2023-06-21 | Udayan Patel | INFLATABLE BALLOON OVER BYPASS CATHETER |
| US11950835B2 (en) | 2019-06-28 | 2024-04-09 | Virginia Tech Intellectual Properties, Inc. | Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| JP7586890B2 (ja) | 2019-07-16 | 2024-11-19 | ガルヴァナイズ セラピューティクス，インコーポレイテッド | パルス電界による生殖器の治療 |
| US12214189B2 (en) | 2019-07-24 | 2025-02-04 | Virginia Tech Intellectual Properties, Inc. | Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies |
| CN114364433A (zh) * | 2019-08-30 | 2022-04-15 | 诺沃库勒有限责任公司 | 向颈部输送肿瘤治疗场（TTFields） |
| TW202128775A (zh) | 2019-10-16 | 2021-08-01 | 英商阿法克塔生命科學有限公司 | PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分 |
| EP4048179A1 (en) | 2019-10-21 | 2022-08-31 | Endogenex, Inc. | Devices, systems, and methods for pulsed electric field treatment of the duodenum |
| WO2021108050A2 (en) | 2019-10-23 | 2021-06-03 | Yale University | Compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy |
| CN110946642A (zh) * | 2019-12-13 | 2020-04-03 | 天津市鹰泰利安康医疗科技有限责任公司 | 一种高频双极性不可恢复电穿孔系统 |
| CA3168353A1 (en) | 2020-02-25 | 2021-09-02 | Jian Yan | Vaccines against coronavirus and methods of use |
| JP2023516080A (ja) | 2020-03-06 | 2023-04-17 | ジーオー セラピューティクス，インコーポレイテッド | 抗グリコｃｄ４４抗体およびその使用 |
| WO2021191871A1 (en) | 2020-03-27 | 2021-09-30 | Dcprime B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| WO2021191870A1 (en) | 2020-03-27 | 2021-09-30 | Dcprime B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| PE20230349A1 (es) | 2020-05-14 | 2023-03-02 | Inovio Pharmaceuticals Inc | Vacunas para la papilomatosis respiratoria recurrente y metodos para usar estas |
| GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
| US20230272378A1 (en) | 2020-06-12 | 2023-08-31 | University Of Rochester | ENCODING AND EXPRESSION OF ACE-tRNAs |
| EP4171617A1 (en) | 2020-06-30 | 2023-05-03 | Mendus B.V. | Use of leukemia-derived cells in ovarian cancer vaccines |
| WO2022056490A1 (en) | 2020-09-14 | 2022-03-17 | Vor Biopharma, Inc. | Chimeric antigen receptors for treatment of cancer |
| EP4240405A1 (en) | 2020-11-05 | 2023-09-13 | Mendus B.V. | Use of tumor-independent antigens in immunotherapies |
| US12485279B2 (en) | 2020-11-25 | 2025-12-02 | Virginia Tech Intellectual Properties, Inc. | Methods for modulating temporal infrastructure of pulsed electric fields |
| CA3203705A1 (en) | 2021-01-22 | 2022-07-28 | Erik Hans MANTING | Methods of tumor vaccination |
| US20250326855A1 (en) | 2021-03-05 | 2025-10-23 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
| US20220305100A1 (en) | 2021-03-12 | 2022-09-29 | Dcprime B.V. | Methods of vaccination and use of cd47 blockade |
| WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
| WO2023010118A1 (en) | 2021-07-29 | 2023-02-02 | Vor Biopharma Inc. | Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same |
| US20250082755A1 (en) | 2021-07-29 | 2025-03-13 | Vor Biopharma Inc. | Chimeric antigen receptors for treatment of cancer |
| EP4380604A1 (en) | 2021-08-05 | 2024-06-12 | Go Therapeutics, Inc. | Anti-glyco-muc4 antibodies and their uses |
| JP2024531192A (ja) | 2021-08-13 | 2024-08-29 | イノビオ ファーマシューティカルズ，インコーポレイティド | 脳がんを治療するための併用療法 |
| JP2024534910A (ja) | 2021-09-03 | 2024-09-26 | ジーオー セラピューティクス，インコーポレイテッド | 抗グリコｌａｍｐ１抗体およびその使用 |
| CA3230934A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-cmet antibodies and their uses |
| EP4413038A1 (en) | 2021-10-07 | 2024-08-14 | Avacta Life Sciences Limited | Pd-l1 binding affimers |
| TW202332694A (zh) | 2021-10-07 | 2023-08-16 | 英商阿凡克塔生命科學公司 | 血清半衰期延長之ｐｄ－ｌ１結合多肽 |
| AU2023215397A1 (en) | 2022-02-07 | 2024-08-22 | University Of Rochester | Optimized sequences for enhanced trna expression or/and nonsense mutation suppression. |
| CN119213021A (zh) | 2022-02-10 | 2024-12-27 | 艾菲赛尔治疗株式会社 | 与CD40L特异性结合的Stefin A蛋白变体及其用途 |
| US20240002800A1 (en) | 2022-05-16 | 2024-01-04 | Mendus B.V. | Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy |
| CN120457146A (zh) | 2022-11-07 | 2025-08-08 | 松树治疗公司 | 包含含有nrp1结合结构域的双特异性抗体的组合疗法 |
| WO2024129459A1 (en) | 2022-12-16 | 2024-06-20 | University Of Rochester | Repairmen! of barrier dysfunction in esophagus |
| WO2024236547A1 (en) | 2023-05-18 | 2024-11-21 | Inceptor Bio, Llc | Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof |
| WO2025046513A1 (en) | 2023-08-29 | 2025-03-06 | Inceptor Bio, Llc | Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof |
| WO2025101685A1 (en) | 2023-11-09 | 2025-05-15 | University Of Rochester | Suppression of nonsense mutations using anticodon engineered (ace)-trnas |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674267A (en) * | 1993-03-30 | 1997-10-07 | Centre National De La Recherche Scientifique | Electric pulse applicator using pairs of needle electrodes for the treatment of biological tissue |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE863111C (de) | 1951-07-03 | 1953-01-15 | Walter Hallegger | Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung |
| DE2800039C2 (de) | 1978-01-02 | 1984-06-20 | Horst Dr.Med. 6700 Ludwigshafen Kief | Akupunkturgerät |
| US5421819A (en) * | 1992-08-12 | 1995-06-06 | Vidamed, Inc. | Medical probe device |
| US5370675A (en) * | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
| US4712559A (en) * | 1985-06-28 | 1987-12-15 | Bsd Medical Corporation | Local current capacitive field applicator for interstitial array |
| US4931046A (en) * | 1987-05-15 | 1990-06-05 | Newman Martin H | Iontophoresis drug delivery system |
| US5389069A (en) * | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| WO1989006555A1 (en) * | 1988-01-21 | 1989-07-27 | Massachusetts Institute Of Technology | Transport of molecules across tissue using electroporation |
| US5547467A (en) | 1988-01-21 | 1996-08-20 | Massachusettes Institute Of Technology | Method for rapid temporal control of molecular transport across tissue |
| US5749847A (en) | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
| US4860752A (en) * | 1988-02-18 | 1989-08-29 | Bsd Medical Corporation | Invasive microwave array with destructive and coherent phase |
| EP0346513A1 (de) | 1988-06-15 | 1989-12-20 | Etama Ag | Anordnung zur Elektrotherapie |
| ES2012944A6 (es) | 1989-01-09 | 1990-04-16 | Tomas Justribo Jose Ramon | Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales. |
| CS275292B2 (en) | 1989-02-22 | 1992-02-19 | Cvut Fakulta Elektrotechnick | Private rehabilitation apparatus with ion transcutaneous acceleration |
| US6001617A (en) | 1989-06-07 | 1999-12-14 | Queen's University At Kingston | Electroporation device and method of use |
| US5215088A (en) | 1989-11-07 | 1993-06-01 | The University Of Utah | Three-dimensional electrode device |
| DE4000893A1 (de) | 1990-01-15 | 1991-07-18 | Bosch Gmbh Robert | Mehrkanaliges geraet zur elektrostimulation |
| US5620481A (en) * | 1991-07-05 | 1997-04-15 | Desai; Jawahar M. | Device for multi-phase radio-frequency ablation |
| US5328451A (en) | 1991-08-15 | 1994-07-12 | Board Of Regents, The University Of Texas System | Iontophoretic device and method for killing bacteria and other microbes |
| NZ245015A (en) | 1991-11-05 | 1995-12-21 | Transkaryotic Therapies Inc | Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production |
| US5425752A (en) | 1991-11-25 | 1995-06-20 | Vu'nguyen; Dung D. | Method of direct electrical myostimulation using acupuncture needles |
| US5545130A (en) * | 1992-04-08 | 1996-08-13 | Genetronics, Inc. | Flow through electroporation method |
| US5304120A (en) | 1992-07-01 | 1994-04-19 | Btx Inc. | Electroporation method and apparatus for insertion of drugs and genes into endothelial cells |
| US5507724A (en) | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
| US5514131A (en) | 1992-08-12 | 1996-05-07 | Stuart D. Edwards | Method for the ablation treatment of the uvula |
| US5273525A (en) * | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| US5688233A (en) * | 1992-08-17 | 1997-11-18 | Genetronics, Inc. | Electronincorporation enhanced transdermal delivery of molecules |
| US5468223A (en) * | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| IL108532A (en) * | 1993-02-02 | 1997-07-13 | Vidamed Inc | Transurethral needle ablation device |
| US5439440A (en) | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| WO1994027670A1 (en) * | 1993-06-02 | 1994-12-08 | Cardiac Pathways Corporation | Catheter having tip with fixation means |
| US5551426A (en) * | 1993-07-14 | 1996-09-03 | Hummel; John D. | Intracardiac ablation and mapping catheter |
| US5536267A (en) * | 1993-11-08 | 1996-07-16 | Zomed International | Multiple electrode ablation apparatus |
| US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
| US5571083A (en) * | 1994-02-18 | 1996-11-05 | Lemelson; Jerome H. | Method and system for cell transplantation |
| IL108775A (en) * | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5728094A (en) | 1996-02-23 | 1998-03-17 | Somnus Medical Technologies, Inc. | Method and apparatus for treatment of air way obstructions |
| US5786454A (en) | 1994-09-16 | 1998-07-28 | Washington University School Of Medicine | Modified SH2 domains |
| US5645526A (en) * | 1994-09-30 | 1997-07-08 | Becton Dickinson And Company | Apparatus and method for ensuring compatibility of a reusable iontophoretic controller with an iontophoretic patch |
| US5720921A (en) | 1995-03-10 | 1998-02-24 | Entremed, Inc. | Flow electroporation chamber and method |
| US5868740A (en) | 1995-03-24 | 1999-02-09 | Board Of Regents-Univ Of Nebraska | Method for volumetric tissue ablation |
| US5810762A (en) * | 1995-04-10 | 1998-09-22 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| US5780052A (en) | 1995-04-24 | 1998-07-14 | Northeastern University | Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell |
| US5789213A (en) | 1995-05-11 | 1998-08-04 | Health Research Inc. | Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses |
| US6041252A (en) | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
| US6002961A (en) | 1995-07-25 | 1999-12-14 | Massachusetts Institute Of Technology | Transdermal protein delivery using low-frequency sonophoresis |
| US6041253A (en) | 1995-12-18 | 2000-03-21 | Massachusetts Institute Of Technology | Effect of electric field and ultrasound for transdermal drug delivery |
| US5983131A (en) | 1995-08-11 | 1999-11-09 | Massachusetts Institute Of Technology | Apparatus and method for electroporation of tissue |
| US5980517A (en) * | 1995-08-15 | 1999-11-09 | Rita Medical Systems, Inc. | Cell necrosis apparatus |
| WO1997007826A1 (en) | 1995-08-29 | 1997-03-06 | Cbr Laboratories, Inc. | In vivo electroporation of cells |
| US5688232A (en) * | 1995-09-28 | 1997-11-18 | Becton Dickinson And Company | Iontophoretic drug delivery device having an improved controller |
| US6010613A (en) | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
| AU3309097A (en) | 1996-06-12 | 1998-01-07 | Alza Corporation | Reduction of skin sensitization in electrotransport drug delivery |
| GB2314274A (en) | 1996-06-20 | 1997-12-24 | Gyrus Medical Ltd | Electrode construction for an electrosurgical instrument |
| US5911223A (en) | 1996-08-09 | 1999-06-15 | Massachusetts Institute Of Technology | Introduction of modifying agents into skin by electroporation |
| US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US5874268A (en) | 1996-09-23 | 1999-02-23 | Duke University | Method of introducing exogenous compounds into cells by electroporation and apparatus for same |
| US5908753A (en) | 1996-10-04 | 1999-06-01 | Merck & Co., Inc. | Transformation of Candida albicans by electroporation |
| US5845646A (en) | 1996-11-05 | 1998-12-08 | Lemelson; Jerome | System and method for treating select tissue in a living being |
| US6110161A (en) | 1997-04-03 | 2000-08-29 | Electrofect As | Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle |
| US5873849A (en) | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| US5879891A (en) | 1997-09-17 | 1999-03-09 | Merck & Co., Inc. | Transformation of saccharomyces cerevisiae by electroporation |
| TW368420B (en) | 1997-11-04 | 1999-09-01 | Genetronics Inc | Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum |
| US6022316A (en) | 1998-03-06 | 2000-02-08 | Spectrx, Inc. | Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications |
| AU742057B2 (en) | 1998-04-14 | 2001-12-13 | Gmp Drug Delivery, Inc. | Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues |
| US6040184A (en) | 1998-10-09 | 2000-03-21 | Stratagene | Method for more efficient electroporation |
-
1997
- 1997-08-01 US US08/905,240 patent/US6055453A/en not_active Expired - Lifetime
-
1998
- 1998-07-31 AU AU86823/98A patent/AU734343B2/en not_active Expired
- 1998-07-31 CN CN2005100847339A patent/CN1768873B/zh not_active Expired - Lifetime
- 1998-07-31 EP EP98938256A patent/EP0999867B1/en not_active Expired - Lifetime
- 1998-07-31 RU RU99109111/14A patent/RU2195332C2/ru not_active IP Right Cessation
- 1998-07-31 CA CA002268026A patent/CA2268026C/en not_active Expired - Lifetime
- 1998-07-31 DE DE69841888T patent/DE69841888D1/de not_active Expired - Lifetime
- 1998-07-31 AT AT98938256T patent/ATE480294T1/de not_active IP Right Cessation
- 1998-07-31 KR KR1019997002781A patent/KR100756252B1/ko not_active Expired - Lifetime
- 1998-07-31 BR BR9806069-4A patent/BR9806069A/pt not_active Application Discontinuation
- 1998-07-31 JP JP11511309A patent/JP2000503586A/ja active Pending
- 1998-07-31 CN CN988014610A patent/CN1217717C/zh not_active Expired - Lifetime
- 1998-07-31 WO PCT/US1998/016042 patent/WO1999006101A1/en not_active Ceased
- 1998-09-18 TW TW087115609A patent/TW396043B/zh not_active IP Right Cessation
- 1998-11-09 US US09/189,360 patent/US6181964B1/en not_active Expired - Lifetime
- 1998-11-09 US US09/189,070 patent/US6068650A/en not_active Expired - Lifetime
- 1998-11-09 US US09/189,062 patent/US6233482B1/en not_active Expired - Lifetime
-
1999
- 1999-01-08 US US09/227,416 patent/US6014584A/en not_active Expired - Lifetime
-
2002
- 2002-03-04 JP JP2002057679A patent/JP4180285B2/ja not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674267A (en) * | 1993-03-30 | 1997-10-07 | Centre National De La Recherche Scientifique | Electric pulse applicator using pairs of needle electrodes for the treatment of biological tissue |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017048037A1 (ko) * | 2015-09-17 | 2017-03-23 | 주식회사 엘림텍 | 전기천공장치 및 그 제어방법 |
| KR101788301B1 (ko) * | 2015-09-17 | 2017-10-20 | 주식회사 엘림텍 | 전기천공장치 및 그 제어방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000068678A (ko) | 2000-11-25 |
| EP0999867B1 (en) | 2010-09-08 |
| CN1248923A (zh) | 2000-03-29 |
| ATE480294T1 (de) | 2010-09-15 |
| AU8682398A (en) | 1999-02-22 |
| DE69841888D1 (de) | 2010-10-21 |
| CN1217717C (zh) | 2005-09-07 |
| CA2268026A1 (en) | 1999-02-11 |
| US6055453A (en) | 2000-04-25 |
| BR9806069A (pt) | 2000-01-25 |
| CA2268026C (en) | 2003-07-29 |
| RU2195332C2 (ru) | 2002-12-27 |
| US6181964B1 (en) | 2001-01-30 |
| EP0999867A4 (en) | 2008-03-26 |
| JP2000503586A (ja) | 2000-03-28 |
| JP2002291910A (ja) | 2002-10-08 |
| US6068650A (en) | 2000-05-30 |
| WO1999006101A1 (en) | 1999-02-11 |
| EP0999867A1 (en) | 2000-05-17 |
| CN1768873A (zh) | 2006-05-10 |
| CN1768873B (zh) | 2011-04-13 |
| US6014584A (en) | 2000-01-11 |
| JP4180285B2 (ja) | 2008-11-12 |
| TW396043B (en) | 2000-07-01 |
| US6233482B1 (en) | 2001-05-15 |
| AU734343B2 (en) | 2001-06-14 |
| HK1027049A1 (en) | 2001-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100756252B1 (ko) | 일렉트로포레이션에 의한 약제와 유전자 전달 방법 및 장치 | |
| US7412284B2 (en) | Apparatus for electroporation mediated delivery for drugs and genes | |
| US6216034B1 (en) | Method of programming an array of needle electrodes for electroporation therapy of tissue | |
| US20040204669A1 (en) | Apparatus for electroporation mediated delivery for drugs and genes | |
| RU2168337C2 (ru) | Способ лечения с введением лекарственных препаратов и генов посредством электропорации | |
| US9020605B2 (en) | Electroporation device | |
| JP4050331B2 (ja) | 接続電極テンプレートを有する電気穿孔装置 | |
| HK1027049B (en) | Method and apparatus for using electroporation mediated delivery of drugs and genes | |
| MXPA97008316A (en) | Method of treatment using administration of drugs and genes through electroporac | |
| HK1024645B (en) | Electroporation apparatus with connective electrode template |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 19990331 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20030730 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20050829 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20070531 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20070831 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20070903 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration | ||
| G170 | Re-publication after modification of scope of protection [patent] | ||
| PG1701 | Publication of correction | ||
| PR1001 | Payment of annual fee |
Payment date: 20100813 Start annual number: 4 End annual number: 4 |
|
| PR1001 | Payment of annual fee |
Payment date: 20110811 Start annual number: 5 End annual number: 5 |
|
| FPAY | Annual fee payment |
Payment date: 20120808 Year of fee payment: 6 |
|
| PR1001 | Payment of annual fee |
Payment date: 20120808 Start annual number: 6 End annual number: 6 |
|
| FPAY | Annual fee payment |
Payment date: 20130812 Year of fee payment: 7 |
|
| PR1001 | Payment of annual fee |
Payment date: 20130812 Start annual number: 7 End annual number: 7 |
|
| FPAY | Annual fee payment |
Payment date: 20140808 Year of fee payment: 8 |
|
| PR1001 | Payment of annual fee |
Payment date: 20140808 Start annual number: 8 End annual number: 8 |
|
| FPAY | Annual fee payment |
Payment date: 20150810 Year of fee payment: 9 |
|
| PR1001 | Payment of annual fee |
Payment date: 20150810 Start annual number: 9 End annual number: 9 |
|
| FPAY | Annual fee payment |
Payment date: 20160811 Year of fee payment: 10 |
|
| PR1001 | Payment of annual fee |
Payment date: 20160811 Start annual number: 10 End annual number: 10 |
|
| FPAY | Annual fee payment |
Payment date: 20170814 Year of fee payment: 11 |
|
| PR1001 | Payment of annual fee |
Payment date: 20170814 Start annual number: 11 End annual number: 11 |
|
| EXPY | Expiration of term | ||
| PC1801 | Expiration of term |
Termination date: 20190131 Termination category: Expiration of duration |