PL3397335T3 - Urządzenie do elektroporacji z ulepszonym generatorem sygnału - Google Patents

Urządzenie do elektroporacji z ulepszonym generatorem sygnału

Info

Publication number
PL3397335T3
PL3397335T3 PL16882581.8T PL16882581T PL3397335T3 PL 3397335 T3 PL3397335 T3 PL 3397335T3 PL 16882581 T PL16882581 T PL 16882581T PL 3397335 T3 PL3397335 T3 PL 3397335T3
Authority
PL
Poland
Prior art keywords
signal generator
improved signal
electroporation device
electroporation
improved
Prior art date
Application number
PL16882581.8T
Other languages
English (en)
Inventor
Beat Stadelmann
Original Assignee
Inovio Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inovio Pharmaceuticals, Inc. filed Critical Inovio Pharmaceuticals, Inc.
Publication of PL3397335T3 publication Critical patent/PL3397335T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/025—Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M1/00—Details of apparatus for conversion
    • H02M1/0083—Converters characterised by their input or output configuration
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M11/00—Power conversion systems not covered by the preceding groups
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M3/00—Conversion of DC power input into DC power output
    • H02M3/02—Conversion of DC power input into DC power output without intermediate conversion into AC
    • H02M3/04—Conversion of DC power input into DC power output without intermediate conversion into AC by static converters
    • H02M3/06—Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using resistors or capacitors, e.g. potential divider
    • H02M3/07—Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using resistors or capacitors, e.g. potential divider using capacitors charged and discharged alternately by semiconductor devices with control electrode, e.g. charge pumps
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M3/00—Conversion of DC power input into DC power output
    • H02M3/22—Conversion of DC power input into DC power output with intermediate conversion into AC
    • H02M3/24—Conversion of DC power input into DC power output with intermediate conversion into AC by static converters
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M3/00—Conversion of DC power input into DC power output
    • H02M3/22—Conversion of DC power input into DC power output with intermediate conversion into AC
    • H02M3/24—Conversion of DC power input into DC power output with intermediate conversion into AC by static converters
    • H02M3/28—Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC
    • H02M3/325—Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal
    • H02M3/335—Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M1/00—Details of apparatus for conversion
    • H02M1/0067—Converter structures employing plural converter units, other than for parallel operation of the units on a single load
    • H02M1/0077—Plural converter units whose outputs are connected in series

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Power Engineering (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Electrotherapy Devices (AREA)
  • Circuits Of Receivers In General (AREA)
  • Dc-Dc Converters (AREA)
  • Amplifiers (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Charge And Discharge Circuits For Batteries Or The Like (AREA)
  • Meter Arrangements (AREA)
  • Electromechanical Clocks (AREA)
PL16882581.8T 2015-12-28 2016-12-28 Urządzenie do elektroporacji z ulepszonym generatorem sygnału PL3397335T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562271955P 2015-12-28 2015-12-28
PCT/US2016/068940 WO2017117251A1 (en) 2015-12-28 2016-12-28 Electroporation device with improved signal generator

Publications (1)

Publication Number Publication Date
PL3397335T3 true PL3397335T3 (pl) 2023-02-13

Family

ID=59225638

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16882581.8T PL3397335T3 (pl) 2015-12-28 2016-12-28 Urządzenie do elektroporacji z ulepszonym generatorem sygnału

Country Status (18)

Country Link
US (1) US20190009081A1 (pl)
EP (2) EP3397335B1 (pl)
JP (3) JP7025332B2 (pl)
KR (3) KR20250150694A (pl)
CN (2) CN108472482B (pl)
AU (3) AU2016382944B2 (pl)
BR (1) BR112018013242B1 (pl)
CA (1) CA3009347A1 (pl)
DK (1) DK3397335T3 (pl)
ES (1) ES2929478T3 (pl)
HU (1) HUE060331T2 (pl)
IL (3) IL319962A (pl)
MX (2) MX393015B (pl)
PL (1) PL3397335T3 (pl)
PT (1) PT3397335T (pl)
RU (2) RU2737328C2 (pl)
SG (1) SG11201805315RA (pl)
WO (1) WO2017117251A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250150694A (ko) * 2015-12-28 2025-10-20 이노비오 파마수티컬즈, 인크. 개선된 신호 발생기를 가진 전기천공 디바이스
IT202100004601A1 (it) 2021-02-26 2022-08-26 Igea S P A Generatore di impulsi ad alta tensione per elettroporazione

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US4888545A (en) * 1988-06-01 1989-12-19 International Business Machines Corp. Improved tap switching power supply
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6369893B1 (en) * 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
US6150148A (en) * 1998-10-21 2000-11-21 Genetronics, Inc. Electroporation apparatus for control of temperature during the process
US7127285B2 (en) * 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
US7412285B2 (en) * 1999-04-09 2008-08-12 Oncostim, Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US6118679A (en) * 1999-04-26 2000-09-12 Astec International, Limited Current sharing transformer circuit for power converters
US7010343B2 (en) * 2001-04-06 2006-03-07 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
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US6603352B2 (en) * 2001-12-03 2003-08-05 Icefyre Semiconductor Corporation Switched-mode power amplifier integrally performing power combining
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
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US7449841B2 (en) * 2006-04-24 2008-11-11 Microsemi Corp.—Analog Mixed Signal Group Ltd. Charge limited high voltage switch circuits
KR101188944B1 (ko) * 2006-06-15 2012-10-08 한국과학기술원 다중 변압기의 2차 권선을 병렬로 연결한 전하 균일 장치
US7816894B2 (en) * 2006-06-23 2010-10-19 Electro-Chance, Llc Method and apparatus for regulating voltage
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CN201766514U (zh) * 2010-08-26 2011-03-16 珠海金电电源工业有限公司 一种大功率高电压输出电路
CN102447395A (zh) * 2011-12-30 2012-05-09 深圳麦格米特电气股份有限公司 一种多电平平衡电路的实现方法和多电平平衡电路
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KR20250150694A (ko) * 2015-12-28 2025-10-20 이노비오 파마수티컬즈, 인크. 개선된 신호 발생기를 가진 전기천공 디바이스

Also Published As

Publication number Publication date
IL260073B2 (en) 2023-06-01
JP2025148561A (ja) 2025-10-07
CN108472482A (zh) 2018-08-31
JP7716353B2 (ja) 2025-07-31
AU2022202761A1 (en) 2022-05-19
ES2929478T3 (es) 2022-11-29
IL260073A (en) 2018-07-31
KR102723743B1 (ko) 2024-10-30
MX2018008003A (es) 2019-03-28
MX393015B (es) 2025-03-24
AU2016382944A1 (en) 2018-07-12
MX2022007014A (es) 2022-06-17
CN108472482B (zh) 2022-06-14
CA3009347A1 (en) 2017-07-06
CN115068812A (zh) 2022-09-20
EP3397335A1 (en) 2018-11-07
IL300103A (en) 2023-03-01
JP2022051934A (ja) 2022-04-01
RU2018127473A (ru) 2020-01-30
BR112018013242B1 (pt) 2023-10-10
EP3397335A4 (en) 2018-12-26
IL300103B1 (en) 2025-04-01
DK3397335T3 (da) 2022-11-07
US20190009081A1 (en) 2019-01-10
SG11201805315RA (en) 2018-07-30
IL319962A (en) 2025-05-01
CN115068812B (zh) 2025-02-11
IL300103B2 (en) 2025-08-01
JP7025332B2 (ja) 2022-02-24
RU2737328C2 (ru) 2020-11-27
JP2019500151A (ja) 2019-01-10
RU2750970C1 (ru) 2021-07-07
KR20180099747A (ko) 2018-09-05
AU2024219737A1 (en) 2024-10-10
KR102870706B1 (ko) 2025-10-15
KR20250150694A (ko) 2025-10-20
EP3397335B1 (en) 2022-08-03
WO2017117251A1 (en) 2017-07-06
RU2018127473A3 (pl) 2020-05-13
AU2016382944B2 (en) 2022-01-27
EP4098315A1 (en) 2022-12-07
BR112018013242A2 (pt) 2018-12-04
HUE060331T2 (hu) 2023-02-28
PT3397335T (pt) 2022-11-21
KR20240160232A (ko) 2024-11-08
AU2022202761B2 (en) 2024-06-13

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