KR100682219B1 - 종양 전이를 저해하는 인터루킨-18 저해물질의 용도 - Google Patents
종양 전이를 저해하는 인터루킨-18 저해물질의 용도 Download PDFInfo
- Publication number
- KR100682219B1 KR100682219B1 KR1020027000682A KR20027000682A KR100682219B1 KR 100682219 B1 KR100682219 B1 KR 100682219B1 KR 1020027000682 A KR1020027000682 A KR 1020027000682A KR 20027000682 A KR20027000682 A KR 20027000682A KR 100682219 B1 KR100682219 B1 KR 100682219B1
- Authority
- KR
- South Korea
- Prior art keywords
- cells
- hse
- adhesion
- tnf
- inhibitors
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13104799A IL131047A0 (en) | 1999-07-22 | 1999-07-22 | Use of il-18 inhibitors |
| IL131047 | 1999-07-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20020027493A KR20020027493A (ko) | 2002-04-13 |
| KR100682219B1 true KR100682219B1 (ko) | 2007-02-12 |
Family
ID=11073044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020027000682A KR100682219B1 (ko) | 1999-07-22 | 2000-07-17 | 종양 전이를 저해하는 인터루킨-18 저해물질의 용도 |
Country Status (31)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101111103B1 (ko) | 2000-02-10 | 2012-02-13 | 아보트 러보러터리즈 | 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법 |
| EP1331943A4 (en) | 2000-10-11 | 2005-01-26 | Viron Therapeutics Inc | NUCLEIC ACID MOLECULES AND POLYPEPTIDES FOR IMMUNOMODULATION |
| US7718368B2 (en) | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
| ES2416510T3 (es) * | 2002-10-08 | 2013-08-01 | Ares Trading S.A. | Uso de una citocina capaz de unirse a IL 18BP y de inhibir la actividad de una segunda citocina |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| US7691611B2 (en) | 2005-06-03 | 2010-04-06 | Ares Trading S.A. | Production of recombinant IL-18 binding protein |
| JP5091127B2 (ja) | 2005-06-10 | 2012-12-05 | アレス トレーディング ソシエテ アノニム | Ｉｌ−１８結合タンパク質の精製のための方法 |
| CL2008002153A1 (es) | 2007-07-24 | 2009-06-05 | Amgen Inc | Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r. |
| US9812033B2 (en) * | 2013-03-06 | 2017-11-07 | Venkatesh R. Chari | Tactile graphic display |
| AU2023236289A1 (en) | 2022-03-15 | 2024-08-15 | Compugen Ltd. | Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994005333A1 (en) * | 1992-09-02 | 1994-03-17 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of cell adhesion |
| US7141393B2 (en) * | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
| SK122199A3 (en) * | 1997-03-18 | 2000-12-11 | Basf Ag | Methods and compositions for modulating responsiveness to corticosteroids |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
-
1999
- 1999-07-22 IL IL13104799A patent/IL131047A0/xx unknown
-
2000
- 2000-07-17 BR BR0012675-6A patent/BR0012675A/pt not_active IP Right Cessation
- 2000-07-17 NZ NZ516535A patent/NZ516535A/en not_active IP Right Cessation
- 2000-07-17 CN CNB008106894A patent/CN1173736C/zh not_active Expired - Lifetime
- 2000-07-17 JP JP2001512563A patent/JP4827352B2/ja not_active Expired - Lifetime
- 2000-07-17 TR TR2002/00169T patent/TR200200169T2/ unknown
- 2000-07-17 CA CA2380216A patent/CA2380216C/en not_active Expired - Lifetime
- 2000-07-17 AU AU58432/00A patent/AU782478B2/en not_active Expired
- 2000-07-17 KR KR1020027000682A patent/KR100682219B1/ko active IP Right Grant
- 2000-07-17 EP EP00944201A patent/EP1206274B1/en not_active Expired - Lifetime
- 2000-07-17 DK DK00944201T patent/DK1206274T3/da active
- 2000-07-17 ES ES00944201T patent/ES2186596T3/es not_active Expired - Lifetime
- 2000-07-17 UA UA2002021472A patent/UA73745C2/uk unknown
- 2000-07-17 PT PT00944201T patent/PT1206274E/pt unknown
- 2000-07-17 WO PCT/IL2000/000419 patent/WO2001007480A2/en active IP Right Grant
- 2000-07-17 DE DE60035049T patent/DE60035049T2/de not_active Expired - Lifetime
- 2000-07-17 AT AT00944201T patent/ATE363288T1/de active
- 2000-07-17 EE EEP200200032A patent/EE04838B1/xx unknown
- 2000-07-17 CZ CZ20020195A patent/CZ302114B6/cs not_active IP Right Cessation
- 2000-07-17 PL PL353732A patent/PL202477B1/pl unknown
- 2000-07-17 HU HU0202107A patent/HU228780B1/hu unknown
- 2000-07-17 DE DE1206274T patent/DE1206274T1/de active Pending
- 2000-07-17 EA EA200200189A patent/EA005419B1/ru not_active IP Right Cessation
- 2000-07-17 MX MXPA02000838A patent/MXPA02000838A/es active IP Right Grant
- 2000-07-17 SK SK88-2002A patent/SK287522B6/sk not_active IP Right Cessation
- 2000-07-21 AR ARP000103786A patent/AR024907A1/es unknown
-
2002
- 2002-01-11 NO NO20020153A patent/NO329827B1/no not_active IP Right Cessation
- 2002-01-16 ZA ZA200200390A patent/ZA200200390B/xx unknown
- 2002-01-16 BG BG106311A patent/BG65800B1/bg unknown
- 2002-01-17 IL IL147675A patent/IL147675A/en unknown
- 2002-11-11 HK HK02108154.3A patent/HK1048248B/zh not_active IP Right Cessation
-
2007
- 2007-07-06 US US11/825,548 patent/US7741276B2/en not_active Expired - Fee Related
- 2007-07-13 CY CY20071100938T patent/CY1107932T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7741276B2 (en) | Use of interleukin-18 inhibitors to inhibit tumor metastasis | |
| Li et al. | Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells | |
| Yamamura et al. | Interferon‐γ–inducing activity of interleukin‐18 in the joint with rheumatoid arthritis | |
| Dinarello | Interleukin-18 | |
| Labow et al. | Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. | |
| Bienkowski et al. | Control of collagen deposition in mammalian lung | |
| US20060039910A1 (en) | Methods and compositions for treating allergic inflammation | |
| Yamauchi et al. | Cytokine modulation in acute pancreatitis | |
| Kudo et al. | Inhibition of IL-8-induced W3/25+(CD4+) T lymphocyte recruitment into subcutaneous tissues of rats by selective depletion of in vivo neutrophils with a monoclonal antibody. | |
| Jayaraman et al. | Enhancement of in vivo cell-mediated immune responses by three distinct cytokines. | |
| Ichiyasu et al. | Functional roles of MCP-1 in Propionibacterium acnes-induced, T cell-mediated pulmonary granulomatosis in rabbits | |
| EP1466619A2 (en) | Method for modulating cell apoptosis | |
| Yamashita et al. | Interleukin-18 inhibits lodging and subsequent growth of human multiple myeloma cells in the bone marrow | |
| CA2306790A1 (en) | Application of tnf antagonists as medicaments for treating septic diseases | |
| JPH0725785A (ja) | インターロイキン−６の医薬組成物 | |
| Oliveira et al. | Participation of lnterleukin-5 and lnterleukin-8 in the Eosinophil Migration Induced by a Large Volume of Saline | |
| MXPA06006377A (es) | Metodos para modular la actividad de citocina y reactivos relacionados. | |
| CA2231433A1 (en) | Method for modulating cell apoptosis | |
| Wiltrout et al. | The Use of Cytokine Knockout Mice in Cancer Research | |
| Jiang | Increased core temperature during febrile disease modulates cytokine expression, enhances host defense, and improves survival in bacterial infection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| N231 | Notification of change of applicant | ||
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20130117 Year of fee payment: 7 |
|
| FPAY | Annual fee payment |
Payment date: 20140120 Year of fee payment: 8 |
|
| FPAY | Annual fee payment |
Payment date: 20150120 Year of fee payment: 9 |
|
| FPAY | Annual fee payment |
Payment date: 20160119 Year of fee payment: 10 |
|
| FPAY | Annual fee payment |
Payment date: 20170119 Year of fee payment: 11 |
|
| FPAY | Annual fee payment |
Payment date: 20180119 Year of fee payment: 12 |
|
| FPAY | Annual fee payment |
Payment date: 20190117 Year of fee payment: 13 |