KR100654265B1 - 4-(헤테로아릴-메틸)-할로겐-1(2ｈ)-프탈라지논의 제조 방법 - Google Patents

4-(헤테로아릴-메틸)-할로겐-1(2ｈ)-프탈라지논의 제조 방법 Download PDF

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Publication number
KR100654265B1
KR100654265B1 KR1020027007997A KR20027007997A KR100654265B1 KR 100654265 B1 KR100654265 B1 KR 100654265B1 KR 1020027007997 A KR1020027007997 A KR 1020027007997A KR 20027007997 A KR20027007997 A KR 20027007997A KR 100654265 B1 KR100654265 B1 KR 100654265B1
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KR
South Korea
Prior art keywords
phthalazinone
formula
methyl
halogen
heteroaryl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020027007997A
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English (en)
Korean (ko)
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KR20020062363A (ko
Inventor
오를린 페트로프
타마스 하이너
하리베르트 네
마르틴 크뤼거
Original Assignee
쉐링 악티엔게젤샤프트
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
KR1020027007997A 1999-12-23 2000-12-20 4-(헤테로아릴-메틸)-할로겐-1(2ｈ)-프탈라지논의 제조 방법 Expired - Fee Related KR100654265B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19963607.9 1999-12-23
DE19963607A DE19963607B4 (de) 1999-12-23 1999-12-23 Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen

Publications (2)

Publication Number Publication Date
KR20020062363A KR20020062363A (ko) 2002-07-25
KR100654265B1 true KR100654265B1 (ko) 2006-12-07

Family

ID=7934888

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027007997A Expired - Fee Related KR100654265B1 (ko) 1999-12-23 2000-12-20 4-(헤테로아릴-메틸)-할로겐-1(2ｈ)-프탈라지논의 제조 방법

Country Status (31)

Country Link
US (1) US6891041B2 (https=)
EP (1) EP1242405B1 (https=)
JP (1) JP2003529555A (https=)
KR (1) KR100654265B1 (https=)
CN (1) CN1221545C (https=)
AT (1) ATE273972T1 (https=)
AU (1) AU772981B2 (https=)
BG (1) BG65387B1 (https=)
BR (1) BR0016634A (https=)
CA (1) CA2395407C (https=)
CZ (1) CZ20022146A3 (https=)
DE (2) DE19963607B4 (https=)
DK (1) DK1242405T3 (https=)
EE (1) EE04940B1 (https=)
ES (1) ES2223626T3 (https=)
HR (1) HRP20020605B1 (https=)
HU (1) HUP0300992A3 (https=)
IL (2) IL150017A0 (https=)
MX (1) MXPA02006224A (https=)
NO (1) NO321357B1 (https=)
NZ (1) NZ519285A (https=)
PL (1) PL200714B1 (https=)
PT (1) PT1242405E (https=)
RO (1) RO121211B1 (https=)
RS (1) RS50458B (https=)
RU (1) RU2250900C2 (https=)
SI (1) SI1242405T1 (https=)
SK (1) SK285522B6 (https=)
UA (1) UA72021C2 (https=)
WO (1) WO2001047912A1 (https=)
ZA (1) ZA200205853B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
UY30639A1 (es) * 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
CA2702429A1 (en) * 2007-10-17 2009-04-23 Kudos Pharmaceuticals Limited Crystalline form l 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one
ES2598178T5 (es) 2008-10-07 2023-12-26 Kudos Pharm Ltd Formulación farmacéutica 514
MX365950B (es) 2013-03-13 2019-06-19 Flatley Discovery Lab Llc Compuestos de piridazinona y metodos para el tratamiento de la fibrosis quistica.
BR112017011831A2 (pt) * 2015-03-19 2017-12-26 Clariant Int Ltd tensoativos de amido açúcar biodegradáveis para recuperação avançada de petróleo

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE567431A (https=) * 1957-05-07
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
EP0634404A1 (en) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
WO1996005176A1 (en) * 1994-08-09 1996-02-22 Eisai Co., Ltd. Fused pyridazine compound
RU2128175C1 (ru) * 1994-08-09 1999-03-27 Эйсай Ко., Лтд. Конденсированный пиридазин или его фармакологически приемлемая соль, средство, проявляющее ингибирующую активность в отношении циклической гмф- фосфодиэстеразы
JP3919835B2 (ja) * 1994-08-09 2007-05-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合ピリダジン系化合物
DE69720515T2 (de) * 1996-12-18 2004-02-19 Neurogen Corp., Branford Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
ITMI981670A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI20000261A1 (it) * 2000-02-16 2001-08-16 Zambon Group Processo per la preparazione di piridiniliden-ftalidi

Also Published As

Publication number Publication date
PT1242405E (pt) 2004-11-30
HRP20020605A2 (en) 2004-12-31
PL200714B1 (pl) 2009-01-30
HK1055296A1 (en) 2004-01-02
ES2223626T3 (es) 2005-03-01
IL150017A (en) 2006-12-31
AU2012201A (en) 2001-07-09
US20040192695A1 (en) 2004-09-30
SK8922002A3 (en) 2002-11-06
JP2003529555A (ja) 2003-10-07
SK285522B6 (sk) 2007-03-01
DE50007520D1 (de) 2004-09-23
BR0016634A (pt) 2002-10-15
EE04940B1 (et) 2007-12-17
PL355525A1 (en) 2004-05-04
NZ519285A (en) 2004-12-24
SI1242405T1 (en) 2005-02-28
EP1242405A1 (de) 2002-09-25
US6891041B2 (en) 2005-05-10
RS50458B (sr) 2010-03-02
BG106843A (en) 2003-02-28
HUP0300992A2 (hu) 2003-08-28
DE19963607A1 (de) 2001-07-12
EP1242405B1 (de) 2004-08-18
DE19963607B4 (de) 2005-12-15
CA2395407A1 (en) 2001-07-05
ATE273972T1 (de) 2004-09-15
ZA200205853B (en) 2004-02-18
MXPA02006224A (es) 2002-12-05
NO321357B1 (no) 2006-05-02
RO121211B1 (ro) 2007-01-30
CA2395407C (en) 2009-04-28
AU772981B2 (en) 2004-05-13
WO2001047912A1 (de) 2001-07-05
CZ20022146A3 (cs) 2002-09-11
HRP20020605B1 (en) 2007-06-30
CN1221545C (zh) 2005-10-05
EE200200307A (et) 2003-06-16
CN1413203A (zh) 2003-04-23
RU2002119559A (ru) 2004-01-10
UA72021C2 (en) 2005-01-17
DK1242405T3 (da) 2004-11-01
NO20023014L (no) 2002-06-21
RU2250900C2 (ru) 2005-04-27
IL150017A0 (en) 2002-12-01
HUP0300992A3 (en) 2005-11-28
KR20020062363A (ko) 2002-07-25
BG65387B1 (bg) 2008-05-30
NO20023014D0 (no) 2002-06-21
YU47302A (sh) 2005-06-10

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