RS50458B - Postupak za dobijanje 4-(heteroaril-metil)-1 (2h)- ftalazinona - Google Patents

Postupak za dobijanje 4-(heteroaril-metil)-1 (2h)- ftalazinona

Info

Publication number
RS50458B
RS50458B YUP-473/02A YUP47302A RS50458B RS 50458 B RS50458 B RS 50458B YU P47302 A YUP47302 A YU P47302A RS 50458 B RS50458 B RS 50458B
Authority
RS
Serbia
Prior art keywords
general formula
heteroaryl
methyl
pyridinyl
pyrazinyl
Prior art date
Application number
YUP-473/02A
Other languages
English (en)
Inventor
Orlin Petrov
Tamas Heiner
Harribert Neh
Martin Krüger
Original Assignee
Bayer Schering Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Aktiengesellschaft filed Critical Bayer Schering Pharma Aktiengesellschaft
Publication of YU47302A publication Critical patent/YU47302A/sh
Publication of RS50458B publication Critical patent/RS50458B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

Postupak za dobijanje 4-(heteroaril-metil)- 1(2H)-ftalazinona opšte formule Igde R1 = fluor, hlor, brom ili vodonik iAr = piridinil, pirazinil ili pirimidinil, naznačen time što supstituisane ftalidil-3-trifenilfosfonijum soli opšte formule II koja sledi:gde R1= fluor, hlor, brom ili vodonik, reaguju sa aldehidima opšte formule IIIAr-CHO IIIgde Ar = piridinil, pirazinil ili pirimidinil, u prisustvu baze i daljom reakcijom sa hidrazin hidratom u datom slučaju pri kiselim uslovima.Prijava sadrži još 3 patentna zahteva.
YUP-473/02A 1999-12-23 2000-12-20 Postupak za dobijanje 4-(heteroaril-metil)-1 (2h)- ftalazinona RS50458B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19963607A DE19963607B4 (de) 1999-12-23 1999-12-23 Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen

Publications (2)

Publication Number Publication Date
YU47302A YU47302A (sh) 2005-06-10
RS50458B true RS50458B (sr) 2010-03-02

Family

ID=7934888

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-473/02A RS50458B (sr) 1999-12-23 2000-12-20 Postupak za dobijanje 4-(heteroaril-metil)-1 (2h)- ftalazinona

Country Status (32)

Country Link
US (1) US6891041B2 (sr)
EP (1) EP1242405B1 (sr)
JP (1) JP2003529555A (sr)
KR (1) KR100654265B1 (sr)
CN (1) CN1221545C (sr)
AT (1) ATE273972T1 (sr)
AU (1) AU772981B2 (sr)
BG (1) BG65387B1 (sr)
BR (1) BR0016634A (sr)
CA (1) CA2395407C (sr)
CZ (1) CZ20022146A3 (sr)
DE (2) DE19963607B4 (sr)
DK (1) DK1242405T3 (sr)
EE (1) EE04940B1 (sr)
ES (1) ES2223626T3 (sr)
HK (1) HK1055296A1 (sr)
HR (1) HRP20020605B1 (sr)
HU (1) HUP0300992A3 (sr)
IL (2) IL150017A0 (sr)
MX (1) MXPA02006224A (sr)
NO (1) NO321357B1 (sr)
NZ (1) NZ519285A (sr)
PL (1) PL200714B1 (sr)
PT (1) PT1242405E (sr)
RO (1) RO121211B1 (sr)
RS (1) RS50458B (sr)
RU (1) RU2250900C2 (sr)
SI (1) SI1242405T1 (sr)
SK (1) SK285522B6 (sr)
UA (1) UA72021C2 (sr)
WO (1) WO2001047912A1 (sr)
ZA (1) ZA200205853B (sr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
UY30639A1 (es) * 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
MX2010004028A (es) * 2007-10-17 2010-04-30 Kudos Pharm Ltd 4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona.
HUE030800T2 (en) 2008-10-07 2017-05-29 Astrazeneca Uk Ltd Pharmaceutical Form No. 514
CA2906008C (en) 2013-03-13 2019-07-09 Flatley Discovery Lab, Llc Pyridazinone compounds and methods for the treatment of cystic fibrosis
EA034145B1 (ru) * 2015-03-19 2020-01-09 Клариант Интернэшнл Лтд Биоразлагаемые поверхностно-активные сахароамиды для повышения нефтеотдачи

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE567431A (sr) * 1957-05-07
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
EP0634404A1 (en) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
JP3919835B2 (ja) * 1994-08-09 2007-05-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合ピリダジン系化合物
NZ290952A (en) * 1994-08-09 1998-05-27 Eisai Co Ltd Phthalazine derivatives optionally substituted in position-1 by (generally benzyl) amino groups
ATE236134T1 (de) * 1996-12-18 2003-04-15 Neurogen Corp Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981670A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
ITMI20000261A1 (it) * 2000-02-16 2001-08-16 Zambon Group Processo per la preparazione di piridiniliden-ftalidi

Also Published As

Publication number Publication date
CN1413203A (zh) 2003-04-23
DE19963607A1 (de) 2001-07-12
CA2395407C (en) 2009-04-28
WO2001047912A1 (de) 2001-07-05
PL200714B1 (pl) 2009-01-30
CA2395407A1 (en) 2001-07-05
BR0016634A (pt) 2002-10-15
US20040192695A1 (en) 2004-09-30
AU772981B2 (en) 2004-05-13
EP1242405B1 (de) 2004-08-18
SK8922002A3 (en) 2002-11-06
RU2002119559A (ru) 2004-01-10
NO321357B1 (no) 2006-05-02
HUP0300992A2 (hu) 2003-08-28
HK1055296A1 (en) 2004-01-02
PL355525A1 (en) 2004-05-04
KR20020062363A (ko) 2002-07-25
CN1221545C (zh) 2005-10-05
PT1242405E (pt) 2004-11-30
NO20023014D0 (no) 2002-06-21
EE04940B1 (et) 2007-12-17
SK285522B6 (sk) 2007-03-01
BG65387B1 (bg) 2008-05-30
RO121211B1 (ro) 2007-01-30
CZ20022146A3 (cs) 2002-09-11
RU2250900C2 (ru) 2005-04-27
BG106843A (en) 2003-02-28
YU47302A (sh) 2005-06-10
AU2012201A (en) 2001-07-09
ZA200205853B (en) 2004-02-18
EP1242405A1 (de) 2002-09-25
DK1242405T3 (da) 2004-11-01
EE200200307A (et) 2003-06-16
DE19963607B4 (de) 2005-12-15
NO20023014L (no) 2002-06-21
MXPA02006224A (es) 2002-12-05
HRP20020605A2 (en) 2004-12-31
HUP0300992A3 (en) 2005-11-28
UA72021C2 (en) 2005-01-17
ES2223626T3 (es) 2005-03-01
SI1242405T1 (en) 2005-02-28
DE50007520D1 (de) 2004-09-23
IL150017A (en) 2006-12-31
HRP20020605B1 (en) 2007-06-30
NZ519285A (en) 2004-12-24
KR100654265B1 (ko) 2006-12-07
US6891041B2 (en) 2005-05-10
ATE273972T1 (de) 2004-09-15
JP2003529555A (ja) 2003-10-07
IL150017A0 (en) 2002-12-01

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