YU47302A - Postupak za dobijanje 4-(heteroaril-metil)-halogen-1 (2h)- ftalazinona - Google Patents
Postupak za dobijanje 4-(heteroaril-metil)-halogen-1 (2h)- ftalazinonaInfo
- Publication number
- YU47302A YU47302A YU47302A YUP47302A YU47302A YU 47302 A YU47302 A YU 47302A YU 47302 A YU47302 A YU 47302A YU P47302 A YUP47302 A YU P47302A YU 47302 A YU47302 A YU 47302A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- phthalazinones
- heteroaryl
- halogen
- methyl
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
Opisan je postupak za dobijanje 4-(heteroaril-metil)-halogen-1(2H)ftalazinona, naročito 4-(4-piridilmetil)-1(2H)-ftalazinona, koji je naznačen reakcijom ftalidil-3-trifenilfosfonijum-soli sa 4-piridinaldehidom u prisustvu baznog sredstva i daljom reakcijom sa hidrazin hidratom kao i daljom obradom sa kiselinom, čime se ovim postupkom otklanjaju problemi osiguranja i zaštite čovekove sredine, a koje su postojale u ranije postojećim postupcima.[The invention relates to a method for producing 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones, especially 4-(4-pyridylmethyl)-1(2H)-phthalazinone, which is characterized by the reaction of phthalidyl-3-triphenylphosphonium salt with 4- pyridine aldehyde in the presence of a basic auxiliary agent, by the subsequent reaction with hydrazine hydrate and by the subsequent acid treatment, whereby this method avoids the technical safety and environmental problems posed by prior art methods.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19963607A DE19963607B4 (de) | 1999-12-23 | 1999-12-23 | Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU47302A true YU47302A (sh) | 2005-06-10 |
| RS50458B RS50458B (sr) | 2010-03-02 |
Family
ID=7934888
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6891041B2 (sh) |
| EP (1) | EP1242405B1 (sh) |
| JP (1) | JP2003529555A (sh) |
| KR (1) | KR100654265B1 (sh) |
| CN (1) | CN1221545C (sh) |
| AT (1) | ATE273972T1 (sh) |
| AU (1) | AU772981B2 (sh) |
| BG (1) | BG65387B1 (sh) |
| BR (1) | BR0016634A (sh) |
| CA (1) | CA2395407C (sh) |
| CZ (1) | CZ20022146A3 (sh) |
| DE (2) | DE19963607B4 (sh) |
| DK (1) | DK1242405T3 (sh) |
| EE (1) | EE04940B1 (sh) |
| ES (1) | ES2223626T3 (sh) |
| HK (1) | HK1055296A1 (sh) |
| HR (1) | HRP20020605B1 (sh) |
| HU (1) | HUP0300992A3 (sh) |
| IL (2) | IL150017A0 (sh) |
| MX (1) | MXPA02006224A (sh) |
| NO (1) | NO321357B1 (sh) |
| NZ (1) | NZ519285A (sh) |
| PL (1) | PL200714B1 (sh) |
| PT (1) | PT1242405E (sh) |
| RO (1) | RO121211B1 (sh) |
| RS (1) | RS50458B (sh) |
| RU (1) | RU2250900C2 (sh) |
| SI (1) | SI1242405T1 (sh) |
| SK (1) | SK285522B6 (sh) |
| UA (1) | UA72021C2 (sh) |
| WO (1) | WO2001047912A1 (sh) |
| ZA (1) | ZA200205853B (sh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1296984B1 (it) * | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0419072D0 (en) * | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| UY30639A1 (es) * | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
| CA2702429A1 (en) * | 2007-10-17 | 2009-04-23 | Kudos Pharmaceuticals Limited | Crystalline form l 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one |
| EA020783B1 (ru) | 2008-10-07 | 2015-01-30 | Астразенека Юк Лимитед | Фармацевтическая композиция, содержащая 4-[3-(4-циклопропанкарбонилпиперазин-1-карбонил)-4-фторбензил]-2н-фталазин-1-он и коповидон |
| US9783529B2 (en) | 2013-03-13 | 2017-10-10 | Flatley Discovery Lab, Llc | Pyridazinone compounds and methods for the treatment of cystic fibrosis |
| CA2980028A1 (en) * | 2015-03-19 | 2016-09-22 | Clariant International Ltd | Biodegradable sugar-amide-surfactants for enhanced oil recovery |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE567431A (sh) * | 1957-05-07 | |||
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| IE47592B1 (en) * | 1977-12-29 | 1984-05-02 | Ici Ltd | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture |
| EP0634404A1 (en) * | 1993-07-13 | 1995-01-18 | Rhone Poulenc Agriculture Ltd. | Phtalazin derivatives and their use as pesticides |
| HU219864B (hu) * | 1994-08-09 | 2001-08-28 | Eisai Co., Ltd. | cGMP-PDE inhibitor kondenzált piridazinszármazékok és alkalmazásuk |
| JP3919835B2 (ja) * | 1994-08-09 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリダジン系化合物 |
| AU5614198A (en) * | 1996-12-18 | 1998-07-15 | Neurogen Corporation | Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| IT1296984B1 (it) * | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| ITMI981670A1 (it) * | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| ITMI981671A1 (it) * | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
| ITMI20000261A1 (it) * | 2000-02-16 | 2001-08-16 | Zambon Group | Processo per la preparazione di piridiniliden-ftalidi |
-
1999
- 1999-12-23 DE DE19963607A patent/DE19963607B4/de not_active Expired - Fee Related
-
2000
- 2000-12-20 UA UA2002076049A patent/UA72021C2/uk unknown
- 2000-12-20 AT AT00983354T patent/ATE273972T1/de not_active IP Right Cessation
- 2000-12-20 DK DK00983354T patent/DK1242405T3/da active
- 2000-12-20 KR KR1020027007997A patent/KR100654265B1/ko not_active IP Right Cessation
- 2000-12-20 SI SI200030486T patent/SI1242405T1/xx unknown
- 2000-12-20 DE DE50007520T patent/DE50007520D1/de not_active Expired - Fee Related
- 2000-12-20 NZ NZ519285A patent/NZ519285A/xx unknown
- 2000-12-20 CA CA002395407A patent/CA2395407C/en not_active Expired - Fee Related
- 2000-12-20 EP EP00983354A patent/EP1242405B1/de not_active Expired - Lifetime
- 2000-12-20 JP JP2001549382A patent/JP2003529555A/ja active Pending
- 2000-12-20 BR BR0016634-0A patent/BR0016634A/pt not_active Application Discontinuation
- 2000-12-20 RS YUP-473/02A patent/RS50458B/sr unknown
- 2000-12-20 RO ROA200200653A patent/RO121211B1/ro unknown
- 2000-12-20 ES ES00983354T patent/ES2223626T3/es not_active Expired - Lifetime
- 2000-12-20 WO PCT/EP2000/013027 patent/WO2001047912A1/de active IP Right Grant
- 2000-12-20 MX MXPA02006224A patent/MXPA02006224A/es active IP Right Grant
- 2000-12-20 PT PT00983354T patent/PT1242405E/pt unknown
- 2000-12-20 RU RU2002119559/04A patent/RU2250900C2/ru not_active IP Right Cessation
- 2000-12-20 US US10/168,794 patent/US6891041B2/en not_active Expired - Fee Related
- 2000-12-20 EE EEP200200307A patent/EE04940B1/xx not_active IP Right Cessation
- 2000-12-20 CZ CZ20022146A patent/CZ20022146A3/cs unknown
- 2000-12-20 SK SK892-2002A patent/SK285522B6/sk not_active IP Right Cessation
- 2000-12-20 HU HU0300992A patent/HUP0300992A3/hu unknown
- 2000-12-20 AU AU20122/01A patent/AU772981B2/en not_active Ceased
- 2000-12-20 CN CNB008175608A patent/CN1221545C/zh not_active Expired - Fee Related
- 2000-12-20 IL IL15001700A patent/IL150017A0/xx active IP Right Grant
- 2000-12-20 PL PL355525A patent/PL200714B1/pl not_active IP Right Cessation
-
2002
- 2002-06-04 IL IL150017A patent/IL150017A/en not_active IP Right Cessation
- 2002-06-19 BG BG106843A patent/BG65387B1/bg unknown
- 2002-06-21 NO NO20023014A patent/NO321357B1/no not_active IP Right Cessation
- 2002-07-19 HR HR20020605A patent/HRP20020605B1/xx not_active IP Right Cessation
- 2002-07-22 ZA ZA200205853A patent/ZA200205853B/en unknown
-
2003
- 2003-10-15 HK HK03107465A patent/HK1055296A1/xx not_active IP Right Cessation
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