YU56502A - Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-ilsirćetne kiseline - Google Patents

Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-ilsirćetne kiseline

Info

Publication number
YU56502A
YU56502A YU56502A YUP56502A YU56502A YU 56502 A YU56502 A YU 56502A YU 56502 A YU56502 A YU 56502A YU P56502 A YUP56502 A YU P56502A YU 56502 A YU56502 A YU 56502A
Authority
YU
Yugoslavia
Prior art keywords
producing
compound
formula
pyrrolizine
chlorophenyl
Prior art date
Application number
YU56502A
Other languages
English (en)
Inventor
Thomas Kammermeier
Stefan Laufer
Philip Merckle
Hans-Gunter Striegel
Original Assignee
Merckle Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from MXPA/A/2000/001047A external-priority patent/MXPA00001047A/xx
Application filed by Merckle Gmbh. filed Critical Merckle Gmbh.
Publication of YU56502A publication Critical patent/YU56502A/sh
Publication of RS50374B publication Critical patent/RS50374B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ovaj pronalazak se odnosi na postupak za dobijanje jedinjenja formule I gde jedinjenje formule III reaguje sa oksalil hloridom i proizvod koji se dobije se tretira sa hidrazinom i hidroksidom alkalnog metala u vodenoj fazi na povišenoj temperaturi, nakon što je tretiranje završeno stvoren je trofazni sistem dodavanjem etra i jedinjenje formule I se dobija kišeljenjem srednje faze. Pronalazak se štaviše odnosi na polimorf jedinjenja formule I.[The invention relates to a method for producing the compound of formula (I), by reacting the compound of formula (III) with oxalyl chloride and treating the product obtained with hydrazine and an alkali metal hydroxide in the aqueous phase at elevated temperatures. Once the treatment is terminated, a 3-phase system is established by adding an ether, and the compound of formula (I) is obtained by acidifying the middle phase. The invention further relates in to a polymorphous form of the compound of formula (I).
YUP-565/02A 2000-01-28 2001-01-26 Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-il-sirćetne kiseline RS50374B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MXPA/A/2000/001047A MXPA00001047A (en) 2000-01-28 Method for producing 6-(4-chlorophenyl) -2,2-dimethyl-7- phenyl -2,3-dihydro- 1h-pyrrolizine- 5-yl acetic acid

Publications (2)

Publication Number Publication Date
YU56502A true YU56502A (sh) 2005-06-10
RS50374B RS50374B (sr) 2009-11-10

Family

ID=32589023

Country Status (31)

Country Link
US (1) US6417371B1 (sh)
EP (1) EP1252164B1 (sh)
JP (1) JP5143326B2 (sh)
KR (1) KR100749222B1 (sh)
CN (1) CN1160357C (sh)
AT (1) ATE262529T1 (sh)
AU (1) AU779616B2 (sh)
BG (1) BG65567B1 (sh)
BR (1) BR0107898A (sh)
CA (1) CA2397767C (sh)
CU (1) CU23193A3 (sh)
DE (1) DE50101761D1 (sh)
DK (1) DK1252164T3 (sh)
EA (1) EA004938B1 (sh)
EE (1) EE05125B1 (sh)
ES (1) ES2218382T3 (sh)
GE (1) GEP20043408B (sh)
HK (1) HK1047590A1 (sh)
HR (1) HRP20020707B1 (sh)
HU (1) HUP0300604A3 (sh)
IS (1) IS2404B (sh)
NZ (1) NZ520429A (sh)
PL (1) PL208027B1 (sh)
PT (1) PT1252164E (sh)
RS (1) RS50374B (sh)
SK (1) SK286608B6 (sh)
TR (1) TR200400691T4 (sh)
TW (1) TWI289561B (sh)
UA (1) UA72580C2 (sh)
WO (1) WO2001055149A1 (sh)
ZA (1) ZA200206832B (sh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141285A1 (de) * 2001-08-23 2003-03-27 Merckle Gmbh Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
DE102005012971A1 (de) * 2005-03-21 2006-09-28 Merckle Gmbh Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
WO2007108006A1 (en) * 2006-03-23 2007-09-27 Unichem Laboratories Limited Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates
AU2009309575B2 (en) * 2008-10-31 2015-02-26 C-A-I-R Biosciences Gmbh Choline and tromethamine salt of Licofelone
US10206904B2 (en) 2015-07-17 2019-02-19 The Board Of Regents Of The University Of Oklahoma Licofelone derivatives and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
US5260451A (en) 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE4419315A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419246A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419247A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie

Also Published As

Publication number Publication date
WO2001055149A1 (de) 2001-08-02
CA2397767C (en) 2008-05-06
AU3371101A (en) 2001-08-07
CU23193A3 (es) 2007-03-23
GEP20043408B (en) 2004-06-10
EA200200740A1 (ru) 2002-12-26
ATE262529T1 (de) 2004-04-15
TR200400691T4 (tr) 2004-11-22
PL356774A1 (en) 2004-07-12
CN1160357C (zh) 2004-08-04
HRP20020707A2 (en) 2004-12-31
EP1252164B1 (de) 2004-03-24
PL208027B1 (pl) 2011-03-31
ZA200206832B (en) 2003-10-07
IS6475A (is) 2002-07-19
EE05125B1 (et) 2009-02-16
SK286608B6 (sk) 2009-02-05
KR100749222B1 (ko) 2007-08-13
JP5143326B2 (ja) 2013-02-13
SK10432002A3 (sk) 2003-02-04
IS2404B (is) 2008-09-15
HUP0300604A3 (en) 2003-10-28
DE50101761D1 (de) 2004-04-29
EE200200417A (et) 2003-12-15
CA2397767A1 (en) 2001-08-02
RS50374B (sr) 2009-11-10
JP2004517799A (ja) 2004-06-17
ES2218382T3 (es) 2004-11-16
HRP20020707B1 (en) 2006-05-31
DK1252164T3 (da) 2004-07-05
TWI289561B (en) 2007-11-11
US20020028953A1 (en) 2002-03-07
NZ520429A (en) 2003-08-29
AU779616B2 (en) 2005-02-03
CN1396922A (zh) 2003-02-12
BG65567B1 (bg) 2008-12-30
EA004938B1 (ru) 2004-10-28
EP1252164A1 (de) 2002-10-30
HK1047590A1 (en) 2003-02-28
HUP0300604A2 (hu) 2003-07-28
BG106951A (en) 2003-07-31
UA72580C2 (en) 2005-03-15
KR20020075895A (ko) 2002-10-07
BR0107898A (pt) 2002-11-05
PT1252164E (pt) 2004-08-31
US6417371B1 (en) 2002-07-09

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