YU56502A - Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-ilsirćetne kiseline - Google Patents
Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-ilsirćetne kiselineInfo
- Publication number
- YU56502A YU56502A YU56502A YUP56502A YU56502A YU 56502 A YU56502 A YU 56502A YU 56502 A YU56502 A YU 56502A YU P56502 A YUP56502 A YU P56502A YU 56502 A YU56502 A YU 56502A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- producing
- compound
- formula
- pyrrolizine
- chlorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Ovaj pronalazak se odnosi na postupak za dobijanje jedinjenja formule I gde jedinjenje formule III reaguje sa oksalil hloridom i proizvod koji se dobije se tretira sa hidrazinom i hidroksidom alkalnog metala u vodenoj fazi na povišenoj temperaturi, nakon što je tretiranje završeno stvoren je trofazni sistem dodavanjem etra i jedinjenje formule I se dobija kišeljenjem srednje faze. Pronalazak se štaviše odnosi na polimorf jedinjenja formule I.[The invention relates to a method for producing the compound of formula (I), by reacting the compound of formula (III) with oxalyl chloride and treating the product obtained with hydrazine and an alkali metal hydroxide in the aqueous phase at elevated temperatures. Once the treatment is terminated, a 3-phase system is established by adding an ether, and the compound of formula (I) is obtained by acidifying the middle phase. The invention further relates in to a polymorphous form of the compound of formula (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA/A/2000/001047A MXPA00001047A (en) | 2000-01-28 | Method for producing 6-(4-chlorophenyl) -2,2-dimethyl-7- phenyl -2,3-dihydro- 1h-pyrrolizine- 5-yl acetic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
YU56502A true YU56502A (sh) | 2005-06-10 |
RS50374B RS50374B (sr) | 2009-11-10 |
Family
ID=32589023
Country Status (31)
Country | Link |
---|---|
US (1) | US6417371B1 (sh) |
EP (1) | EP1252164B1 (sh) |
JP (1) | JP5143326B2 (sh) |
KR (1) | KR100749222B1 (sh) |
CN (1) | CN1160357C (sh) |
AT (1) | ATE262529T1 (sh) |
AU (1) | AU779616B2 (sh) |
BG (1) | BG65567B1 (sh) |
BR (1) | BR0107898A (sh) |
CA (1) | CA2397767C (sh) |
CU (1) | CU23193A3 (sh) |
DE (1) | DE50101761D1 (sh) |
DK (1) | DK1252164T3 (sh) |
EA (1) | EA004938B1 (sh) |
EE (1) | EE05125B1 (sh) |
ES (1) | ES2218382T3 (sh) |
GE (1) | GEP20043408B (sh) |
HK (1) | HK1047590A1 (sh) |
HR (1) | HRP20020707B1 (sh) |
HU (1) | HUP0300604A3 (sh) |
IS (1) | IS2404B (sh) |
NZ (1) | NZ520429A (sh) |
PL (1) | PL208027B1 (sh) |
PT (1) | PT1252164E (sh) |
RS (1) | RS50374B (sh) |
SK (1) | SK286608B6 (sh) |
TR (1) | TR200400691T4 (sh) |
TW (1) | TWI289561B (sh) |
UA (1) | UA72580C2 (sh) |
WO (1) | WO2001055149A1 (sh) |
ZA (1) | ZA200206832B (sh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10141285A1 (de) * | 2001-08-23 | 2003-03-27 | Merckle Gmbh | Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
DE102005012971A1 (de) * | 2005-03-21 | 2006-09-28 | Merckle Gmbh | Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
WO2007108006A1 (en) * | 2006-03-23 | 2007-09-27 | Unichem Laboratories Limited | Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates |
AU2009309575B2 (en) * | 2008-10-31 | 2015-02-26 | C-A-I-R Biosciences Gmbh | Choline and tromethamine salt of Licofelone |
US10206904B2 (en) | 2015-07-17 | 2019-02-19 | The Board Of Regents Of The University Of Oklahoma | Licofelone derivatives and methods of use |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3915450A1 (de) * | 1989-05-11 | 1990-11-15 | Gerd Prof Dr Dannhardt | Substituierte pyrrolverbindungen und deren anwendung in der pharmazie |
US5260451A (en) | 1989-05-11 | 1993-11-09 | Merckle Gmbh | Substituted pyrrole compounds and use thereof in pharmaceutical compositions |
DE4419315A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie |
DE4419246A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie |
DE4419247A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie |
-
2001
- 2001-01-26 EA EA200200740A patent/EA004938B1/ru not_active IP Right Cessation
- 2001-01-26 BR BR0107898-4A patent/BR0107898A/pt not_active Application Discontinuation
- 2001-01-26 NZ NZ520429A patent/NZ520429A/en not_active IP Right Cessation
- 2001-01-26 WO PCT/EP2001/000852 patent/WO2001055149A1/de active IP Right Grant
- 2001-01-26 DK DK01905691T patent/DK1252164T3/da active
- 2001-01-26 PL PL356774A patent/PL208027B1/pl unknown
- 2001-01-26 ES ES01905691T patent/ES2218382T3/es not_active Expired - Lifetime
- 2001-01-26 SK SK1043-2002A patent/SK286608B6/sk not_active IP Right Cessation
- 2001-01-26 AT AT01905691T patent/ATE262529T1/de active
- 2001-01-26 PT PT01905691T patent/PT1252164E/pt unknown
- 2001-01-26 UA UA2002086986A patent/UA72580C2/uk unknown
- 2001-01-26 DE DE50101761T patent/DE50101761D1/de not_active Expired - Lifetime
- 2001-01-26 HU HU0300604A patent/HUP0300604A3/hu unknown
- 2001-01-26 KR KR1020027009706A patent/KR100749222B1/ko active IP Right Grant
- 2001-01-26 GE GE4919A patent/GEP20043408B/en unknown
- 2001-01-26 CA CA002397767A patent/CA2397767C/en not_active Expired - Fee Related
- 2001-01-26 EE EEP200200417A patent/EE05125B1/xx not_active IP Right Cessation
- 2001-01-26 EP EP01905691A patent/EP1252164B1/de not_active Expired - Lifetime
- 2001-01-26 AU AU33711/01A patent/AU779616B2/en not_active Ceased
- 2001-01-26 TR TR2004/00691T patent/TR200400691T4/xx unknown
- 2001-01-26 RS YUP-565/02A patent/RS50374B/sr unknown
- 2001-01-26 JP JP2001561008A patent/JP5143326B2/ja not_active Expired - Fee Related
- 2001-01-26 CN CNB01804235XA patent/CN1160357C/zh not_active Expired - Fee Related
- 2001-01-26 US US09/769,742 patent/US6417371B1/en not_active Expired - Lifetime
- 2001-05-09 TW TW090111072A patent/TWI289561B/zh not_active IP Right Cessation
-
2002
- 2002-07-17 CU CU20020150A patent/CU23193A3/es not_active IP Right Cessation
- 2002-07-19 IS IS6475A patent/IS2404B/is unknown
- 2002-07-24 BG BG106951A patent/BG65567B1/bg unknown
- 2002-08-27 ZA ZA200206832A patent/ZA200206832B/en unknown
- 2002-08-28 HR HR20020707A patent/HRP20020707B1/xx not_active IP Right Cessation
- 2002-12-17 HK HK02109153A patent/HK1047590A1/xx not_active IP Right Cessation
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