RS50374B - Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-il-sirćetne kiseline - Google Patents
Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-il-sirćetne kiselineInfo
- Publication number
- RS50374B RS50374B YUP-565/02A YUP56502A RS50374B RS 50374 B RS50374 B RS 50374B YU P56502 A YUP56502 A YU P56502A RS 50374 B RS50374 B RS 50374B
- Authority
- RS
- Serbia
- Prior art keywords
- pyrrolizine
- chlorophenyl
- dihydro
- dimethyl
- phenyl
- Prior art date
Links
- UAWXGRJVZSAUSZ-UHFFFAOYSA-N licofelone Chemical compound OC(=O)CC=1N2CC(C)(C)CC2=C(C=2C=CC=CC=2)C=1C1=CC=C(Cl)C=C1 UAWXGRJVZSAUSZ-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 abstract 2
- 239000012071 phase Substances 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Postupak za dobijanje jedinjenja formule I naznačen time što jedinjenje formule III reaguje sa oksalil hloridom i proizvod koji se dobije se tretira sa hidrazinom i hidroksidom alkalnog metala u vodenoj fazi na od 120 do 180°C u prisustvu alifatičnog mono- ili dialkohola čija je tačka ključanja najmanje 140°C, nakon što je tretiranje završeno stvoren je trofazni sistem dodavanjem etra i jedinjenje formule I se dobija kiseljenjem srednje faze.Prijava sadrži još 20 patentnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MXPA/A/2000/001047A MXPA00001047A (en) | 2000-01-28 | Method for producing 6-(4-chlorophenyl) -2,2-dimethyl-7- phenyl -2,3-dihydro- 1h-pyrrolizine- 5-yl acetic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU56502A YU56502A (sh) | 2005-06-10 |
| RS50374B true RS50374B (sr) | 2009-11-10 |
Family
ID=32589023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-565/02A RS50374B (sr) | 2000-01-28 | 2001-01-26 | Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-il-sirćetne kiseline |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6417371B1 (sr) |
| EP (1) | EP1252164B1 (sr) |
| JP (1) | JP5143326B2 (sr) |
| KR (1) | KR100749222B1 (sr) |
| CN (1) | CN1160357C (sr) |
| AT (1) | ATE262529T1 (sr) |
| AU (1) | AU779616B2 (sr) |
| BG (1) | BG65567B1 (sr) |
| BR (1) | BR0107898A (sr) |
| CA (1) | CA2397767C (sr) |
| CU (1) | CU23193A3 (sr) |
| DE (1) | DE50101761D1 (sr) |
| DK (1) | DK1252164T3 (sr) |
| EA (1) | EA004938B1 (sr) |
| EE (1) | EE05125B1 (sr) |
| ES (1) | ES2218382T3 (sr) |
| GE (1) | GEP20043408B (sr) |
| HK (1) | HK1047590A1 (sr) |
| HR (1) | HRP20020707B1 (sr) |
| HU (1) | HUP0300604A3 (sr) |
| IS (1) | IS2404B (sr) |
| NZ (1) | NZ520429A (sr) |
| PL (1) | PL208027B1 (sr) |
| PT (1) | PT1252164E (sr) |
| RS (1) | RS50374B (sr) |
| SK (1) | SK286608B6 (sr) |
| TR (1) | TR200400691T4 (sr) |
| TW (1) | TWI289561B (sr) |
| UA (1) | UA72580C2 (sr) |
| WO (1) | WO2001055149A1 (sr) |
| ZA (1) | ZA200206832B (sr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10141285A1 (de) * | 2001-08-23 | 2003-03-27 | Merckle Gmbh | Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
| DE102005012971A1 (de) | 2005-03-21 | 2006-09-28 | Merckle Gmbh | Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
| WO2007108006A1 (en) * | 2006-03-23 | 2007-09-27 | Unichem Laboratories Limited | Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates |
| WO2010049525A1 (en) * | 2008-10-31 | 2010-05-06 | C-A-I-R Biosciences Gmbh | Choline and tromethamine salt of licofelone |
| EP3324959B1 (en) | 2015-07-17 | 2023-07-12 | The Board Of Regents Of The University Of Oklahoma | Licofelone derivatives and methods of use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3915450A1 (de) * | 1989-05-11 | 1990-11-15 | Gerd Prof Dr Dannhardt | Substituierte pyrrolverbindungen und deren anwendung in der pharmazie |
| US5260451A (en) | 1989-05-11 | 1993-11-09 | Merckle Gmbh | Substituted pyrrole compounds and use thereof in pharmaceutical compositions |
| DE4419315A1 (de) * | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie |
| DE4419247A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie |
| DE4419246A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie |
-
2001
- 2001-01-26 RS YUP-565/02A patent/RS50374B/sr unknown
- 2001-01-26 DE DE50101761T patent/DE50101761D1/de not_active Expired - Lifetime
- 2001-01-26 GE GE4919A patent/GEP20043408B/en unknown
- 2001-01-26 CN CNB01804235XA patent/CN1160357C/zh not_active Expired - Fee Related
- 2001-01-26 SK SK1043-2002A patent/SK286608B6/sk not_active IP Right Cessation
- 2001-01-26 KR KR1020027009706A patent/KR100749222B1/ko active IP Right Grant
- 2001-01-26 EE EEP200200417A patent/EE05125B1/xx not_active IP Right Cessation
- 2001-01-26 WO PCT/EP2001/000852 patent/WO2001055149A1/de active IP Right Grant
- 2001-01-26 AU AU33711/01A patent/AU779616B2/en not_active Ceased
- 2001-01-26 UA UA2002086986A patent/UA72580C2/uk unknown
- 2001-01-26 NZ NZ520429A patent/NZ520429A/en not_active IP Right Cessation
- 2001-01-26 JP JP2001561008A patent/JP5143326B2/ja not_active Expired - Fee Related
- 2001-01-26 PT PT01905691T patent/PT1252164E/pt unknown
- 2001-01-26 TR TR2004/00691T patent/TR200400691T4/xx unknown
- 2001-01-26 EA EA200200740A patent/EA004938B1/ru not_active IP Right Cessation
- 2001-01-26 PL PL356774A patent/PL208027B1/pl unknown
- 2001-01-26 US US09/769,742 patent/US6417371B1/en not_active Expired - Lifetime
- 2001-01-26 AT AT01905691T patent/ATE262529T1/de active
- 2001-01-26 HU HU0300604A patent/HUP0300604A3/hu unknown
- 2001-01-26 ES ES01905691T patent/ES2218382T3/es not_active Expired - Lifetime
- 2001-01-26 BR BR0107898-4A patent/BR0107898A/pt not_active Application Discontinuation
- 2001-01-26 EP EP01905691A patent/EP1252164B1/de not_active Expired - Lifetime
- 2001-01-26 CA CA002397767A patent/CA2397767C/en not_active Expired - Fee Related
- 2001-01-26 DK DK01905691T patent/DK1252164T3/da active
- 2001-05-09 TW TW090111072A patent/TWI289561B/zh not_active IP Right Cessation
-
2002
- 2002-07-17 CU CU20020150A patent/CU23193A3/es not_active IP Right Cessation
- 2002-07-19 IS IS6475A patent/IS2404B/is unknown
- 2002-07-24 BG BG106951A patent/BG65567B1/bg unknown
- 2002-08-27 ZA ZA200206832A patent/ZA200206832B/en unknown
- 2002-08-28 HR HR20020707A patent/HRP20020707B1/xx not_active IP Right Cessation
- 2002-12-17 HK HK02109153A patent/HK1047590A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2004031141A3 (en) | Process for preparing fluorocarboxylic acids | |
| RS50374B (sr) | Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-il-sirćetne kiseline | |
| GB1105819A (en) | Novel oxadicarboxylic acids and processes for the preparation thereof | |
| CN105037218A (zh) | 十二烷基羟磺基甜菜碱生产工艺 | |
| RU2013121728A (ru) | Способ получения моно- и билигандных комплексных соединений ионов двухвалентных металлов- цинка, меди (ii) и кальция с дигидрокверцетином, обладающих усиленной антиоксидантной активностью | |
| NZ530173A (en) | Method for producing an essentially chlorite-free, stable, aqueous chlorine-oxygen solution, the chlorine-oxygen solution obtained by means of said method, and the use of the same | |
| CN107129466B (zh) | 4-氯-3-甲氧基-2-甲基吡啶-n-氧化物的合成方法 | |
| CN108794424A (zh) | 一种bit的溶剂精制方法 | |
| MY128460A (en) | Method for producing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | |
| CN105664786A (zh) | 阴离子型妥尔油双子表面活性剂及其制备方法 | |
| CN104042451A (zh) | 醇醚三乙醇胺盐溶液和适用于婴幼儿洗护用品的表面活性剂及其制备方法 | |
| CN105454291A (zh) | 一种纳米银泡腾片杀菌剂及其制备方法 | |
| GB1022733A (en) | Triaminobenzene | |
| CO5280193A1 (es) | Proceso para preparar acido 6-(4-clorofenil)-2,2-dimetil-7- fenil-2,3-dihidro-1h-pirrolizin-5-il acetico | |
| CN105924423A (zh) | 一种合成胡椒醛的脱色还原方法 | |
| JP2005002062A (ja) | ヒノキチオール・脂肪酸亜鉛複合錯体及びその製造方法 | |
| GB1167274A (en) | Process for the Production of Cyclic Carboxylic Acids | |
| IE20180288U1 (en) | P-methoxphenylacetic acid drug intermediates synthesis method | |
| KR960041319A (ko) | 분말상 토양고결제의 제조방법 | |
| IE20180283U1 (en) | O-toluene formamide organic intermediates synthesis method | |
| GB678508A (en) | Preparation of crystalline benzylpenicillinic acid-diisopropyl etherate | |
| CN102329203A (zh) | 一种4-氧代-β-大马酮的一步合成方法 | |
| CN107236623A (zh) | 一种海藻肥皂及其制备方法 | |
| JPS57102867A (en) | Allantoin derivative and its preparation | |
| CN106397185A (zh) | 一种间溴苯甲酸的环保制备方法 |