EA200200740A1 - Способ получения 6-(4-хлорфенил)-2,2-диметил-7-фенил-2,3-дигидро-1н-пирролизин-5-илуксусной кислоты - Google Patents

Способ получения 6-(4-хлорфенил)-2,2-диметил-7-фенил-2,3-дигидро-1н-пирролизин-5-илуксусной кислоты

Info

Publication number
EA200200740A1
EA200200740A1 EA200200740A EA200200740A EA200200740A1 EA 200200740 A1 EA200200740 A1 EA 200200740A1 EA 200200740 A EA200200740 A EA 200200740A EA 200200740 A EA200200740 A EA 200200740A EA 200200740 A1 EA200200740 A1 EA 200200740A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
formula
luksus
pyrrolizin
chlorophenyl
Prior art date
Application number
EA200200740A
Other languages
English (en)
Other versions
EA004938B1 (ru
Inventor
Томас Каммермайер
Штефан Лауфер
Филипп Меркле
Ханс-Гюнтер Штригель
Original Assignee
Меркле Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from MXPA/A/2000/001047A external-priority patent/MXPA00001047A/xx
Application filed by Меркле Гмбх filed Critical Меркле Гмбх
Publication of EA200200740A1 publication Critical patent/EA200200740A1/ru
Publication of EA004938B1 publication Critical patent/EA004938B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В заявке описывается способ получения соединения формулы (I)заключающийся в том, что соединение формулы (III)подвергают взаимодействию с оксалилхлоридом и полученный продукт обрабатывают гидразином и гидроксидом щелочного металла в водной фазе при повышенной температуре, по завершении обработки добавлением простого эфира образуют трехфазную систему и подкислением средней фазы получают соединение формулы (I). В заявке описывается, кроме того, полиморфная модификация соединения формулы (I).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200740A 2000-01-28 2001-01-26 Способ получения 6-(4-хлорфенил)-2,2-диметил-7-фенил-2,3-дигидро-1h-пирролизин-5-илуксусной кислоты EA004938B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXPA/A/2000/001047A MXPA00001047A (en) 2000-01-28 Method for producing 6-(4-chlorophenyl) -2,2-dimethyl-7- phenyl -2,3-dihydro- 1h-pyrrolizine- 5-yl acetic acid
PCT/EP2001/000852 WO2001055149A1 (de) 2000-01-28 2001-01-26 Verfahren zur herstellung von 6-(4-chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-yl-essigsäure

Publications (2)

Publication Number Publication Date
EA200200740A1 true EA200200740A1 (ru) 2002-12-26
EA004938B1 EA004938B1 (ru) 2004-10-28

Family

ID=32589023

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200740A EA004938B1 (ru) 2000-01-28 2001-01-26 Способ получения 6-(4-хлорфенил)-2,2-диметил-7-фенил-2,3-дигидро-1h-пирролизин-5-илуксусной кислоты

Country Status (31)

Country Link
US (1) US6417371B1 (ru)
EP (1) EP1252164B1 (ru)
JP (1) JP5143326B2 (ru)
KR (1) KR100749222B1 (ru)
CN (1) CN1160357C (ru)
AT (1) ATE262529T1 (ru)
AU (1) AU779616B2 (ru)
BG (1) BG65567B1 (ru)
BR (1) BR0107898A (ru)
CA (1) CA2397767C (ru)
CU (1) CU23193A3 (ru)
DE (1) DE50101761D1 (ru)
DK (1) DK1252164T3 (ru)
EA (1) EA004938B1 (ru)
EE (1) EE05125B1 (ru)
ES (1) ES2218382T3 (ru)
GE (1) GEP20043408B (ru)
HK (1) HK1047590A1 (ru)
HR (1) HRP20020707B1 (ru)
HU (1) HUP0300604A3 (ru)
IS (1) IS2404B (ru)
NZ (1) NZ520429A (ru)
PL (1) PL208027B1 (ru)
PT (1) PT1252164E (ru)
RS (1) RS50374B (ru)
SK (1) SK286608B6 (ru)
TR (1) TR200400691T4 (ru)
TW (1) TWI289561B (ru)
UA (1) UA72580C2 (ru)
WO (1) WO2001055149A1 (ru)
ZA (1) ZA200206832B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141285A1 (de) * 2001-08-23 2003-03-27 Merckle Gmbh Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
DE102005012971A1 (de) 2005-03-21 2006-09-28 Merckle Gmbh Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
WO2007108006A1 (en) * 2006-03-23 2007-09-27 Unichem Laboratories Limited Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates
AU2009309575B2 (en) * 2008-10-31 2015-02-26 C-A-I-R Biosciences Gmbh Choline and tromethamine salt of Licofelone
EP3324959B1 (en) 2015-07-17 2023-07-12 The Board Of Regents Of The University Of Oklahoma Licofelone derivatives and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
US5260451A (en) 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE4419315A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419246A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419247A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie

Also Published As

Publication number Publication date
AU779616B2 (en) 2005-02-03
GEP20043408B (en) 2004-06-10
JP5143326B2 (ja) 2013-02-13
IS6475A (is) 2002-07-19
HRP20020707B1 (en) 2006-05-31
ZA200206832B (en) 2003-10-07
US20020028953A1 (en) 2002-03-07
HK1047590A1 (en) 2003-02-28
EA004938B1 (ru) 2004-10-28
RS50374B (sr) 2009-11-10
DE50101761D1 (de) 2004-04-29
US6417371B1 (en) 2002-07-09
NZ520429A (en) 2003-08-29
HUP0300604A2 (hu) 2003-07-28
EP1252164B1 (de) 2004-03-24
CA2397767C (en) 2008-05-06
SK286608B6 (sk) 2009-02-05
PT1252164E (pt) 2004-08-31
CN1396922A (zh) 2003-02-12
KR100749222B1 (ko) 2007-08-13
BG65567B1 (bg) 2008-12-30
JP2004517799A (ja) 2004-06-17
ES2218382T3 (es) 2004-11-16
WO2001055149A1 (de) 2001-08-02
CN1160357C (zh) 2004-08-04
CA2397767A1 (en) 2001-08-02
UA72580C2 (en) 2005-03-15
BR0107898A (pt) 2002-11-05
BG106951A (en) 2003-07-31
PL208027B1 (pl) 2011-03-31
PL356774A1 (en) 2004-07-12
IS2404B (is) 2008-09-15
CU23193A3 (es) 2007-03-23
SK10432002A3 (sk) 2003-02-04
ATE262529T1 (de) 2004-04-15
HUP0300604A3 (en) 2003-10-28
HRP20020707A2 (en) 2004-12-31
TR200400691T4 (tr) 2004-11-22
YU56502A (sh) 2005-06-10
KR20020075895A (ko) 2002-10-07
DK1252164T3 (da) 2004-07-05
EE05125B1 (et) 2009-02-16
AU3371101A (en) 2001-08-07
TWI289561B (en) 2007-11-11
EP1252164A1 (de) 2002-10-30
EE200200417A (et) 2003-12-15

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY MD RU