DK1242405T3 - Fremgangsmåde til fremstilling af 4-(heteroaryl-methyl)-1(2H)-phthalazinoner - Google Patents

Fremgangsmåde til fremstilling af 4-(heteroaryl-methyl)-1(2H)-phthalazinoner

Info

Publication number
DK1242405T3
DK1242405T3 DK00983354T DK00983354T DK1242405T3 DK 1242405 T3 DK1242405 T3 DK 1242405T3 DK 00983354 T DK00983354 T DK 00983354T DK 00983354 T DK00983354 T DK 00983354T DK 1242405 T3 DK1242405 T3 DK 1242405T3
Authority
DK
Denmark
Prior art keywords
phthalazinones
heteroaryl
methyl
preparation
reaction
Prior art date
Application number
DK00983354T
Other languages
Danish (da)
English (en)
Inventor
Thomas Heiner
Harribert Neh
Orlin Petrov
Martin Krueger
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK1242405T3 publication Critical patent/DK1242405T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
DK00983354T 1999-12-23 2000-12-20 Fremgangsmåde til fremstilling af 4-(heteroaryl-methyl)-1(2H)-phthalazinoner DK1242405T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19963607A DE19963607B4 (de) 1999-12-23 1999-12-23 Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
PCT/EP2000/013027 WO2001047912A1 (de) 1999-12-23 2000-12-20 Verfahren zur herstellung von 4-(heteroaryl-methyl)-halogen-1(2h)-phthalazinonen

Publications (1)

Publication Number Publication Date
DK1242405T3 true DK1242405T3 (da) 2004-11-01

Family

ID=7934888

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00983354T DK1242405T3 (da) 1999-12-23 2000-12-20 Fremgangsmåde til fremstilling af 4-(heteroaryl-methyl)-1(2H)-phthalazinoner

Country Status (32)

Country Link
US (1) US6891041B2 (sh)
EP (1) EP1242405B1 (sh)
JP (1) JP2003529555A (sh)
KR (1) KR100654265B1 (sh)
CN (1) CN1221545C (sh)
AT (1) ATE273972T1 (sh)
AU (1) AU772981B2 (sh)
BG (1) BG65387B1 (sh)
BR (1) BR0016634A (sh)
CA (1) CA2395407C (sh)
CZ (1) CZ20022146A3 (sh)
DE (2) DE19963607B4 (sh)
DK (1) DK1242405T3 (sh)
EE (1) EE04940B1 (sh)
ES (1) ES2223626T3 (sh)
HK (1) HK1055296A1 (sh)
HR (1) HRP20020605B1 (sh)
HU (1) HUP0300992A3 (sh)
IL (2) IL150017A0 (sh)
MX (1) MXPA02006224A (sh)
NO (1) NO321357B1 (sh)
NZ (1) NZ519285A (sh)
PL (1) PL200714B1 (sh)
PT (1) PT1242405E (sh)
RO (1) RO121211B1 (sh)
RS (1) RS50458B (sh)
RU (1) RU2250900C2 (sh)
SI (1) SI1242405T1 (sh)
SK (1) SK285522B6 (sh)
UA (1) UA72021C2 (sh)
WO (1) WO2001047912A1 (sh)
ZA (1) ZA200205853B (sh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
TWI404716B (zh) * 2006-10-17 2013-08-11 Kudos Pharm Ltd 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
CA2702429A1 (en) * 2007-10-17 2009-04-23 Kudos Pharmaceuticals Limited Crystalline form l 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one
BRPI0920604B1 (pt) 2008-10-07 2021-11-23 Kudos Pharmaceuticals Limited Formulação farmacêutica de liberação imediata na forma de uma dispersão sólida compreendendo como ativo o composto 4-[3-(4-ciclopropanocarbonil-piperazina-1-carbonil)-4-flúor- benzil]-2h-ftalazin-1-ona (olaparibe)
CN105307655B (zh) 2013-03-13 2019-05-03 弗拉特利发现实验室有限责任公司 哒嗪酮化合物及其用于制备治疗囊肿状纤维化的药物的应用
EP3271439B1 (en) * 2015-03-19 2018-11-07 Clariant International Ltd Biodegradable sugar-amide-surfactants for enhanced oil recovery

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE567431A (sh) * 1957-05-07
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
EP0634404A1 (en) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
AU705229B2 (en) * 1994-08-09 1999-05-20 Eisai R&D Management Co., Ltd. Fused pyridazine compound
JP3919835B2 (ja) * 1994-08-09 2007-05-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合ピリダジン系化合物
ATE236134T1 (de) * 1996-12-18 2003-04-15 Neurogen Corp Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
ITMI981670A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI20000261A1 (it) * 2000-02-16 2001-08-16 Zambon Group Processo per la preparazione di piridiniliden-ftalidi

Also Published As

Publication number Publication date
CZ20022146A3 (cs) 2002-09-11
US20040192695A1 (en) 2004-09-30
SK285522B6 (sk) 2007-03-01
NO20023014D0 (no) 2002-06-21
KR20020062363A (ko) 2002-07-25
CA2395407A1 (en) 2001-07-05
RU2250900C2 (ru) 2005-04-27
BR0016634A (pt) 2002-10-15
PL355525A1 (en) 2004-05-04
ZA200205853B (en) 2004-02-18
US6891041B2 (en) 2005-05-10
SK8922002A3 (en) 2002-11-06
HK1055296A1 (en) 2004-01-02
HUP0300992A2 (hu) 2003-08-28
IL150017A0 (en) 2002-12-01
RO121211B1 (ro) 2007-01-30
HRP20020605B1 (en) 2007-06-30
IL150017A (en) 2006-12-31
DE19963607A1 (de) 2001-07-12
DE50007520D1 (de) 2004-09-23
NO321357B1 (no) 2006-05-02
JP2003529555A (ja) 2003-10-07
BG106843A (en) 2003-02-28
AU2012201A (en) 2001-07-09
AU772981B2 (en) 2004-05-13
HRP20020605A2 (en) 2004-12-31
MXPA02006224A (es) 2002-12-05
DE19963607B4 (de) 2005-12-15
YU47302A (sh) 2005-06-10
CN1413203A (zh) 2003-04-23
ES2223626T3 (es) 2005-03-01
HUP0300992A3 (en) 2005-11-28
PL200714B1 (pl) 2009-01-30
EP1242405B1 (de) 2004-08-18
ATE273972T1 (de) 2004-09-15
BG65387B1 (bg) 2008-05-30
NZ519285A (en) 2004-12-24
CA2395407C (en) 2009-04-28
WO2001047912A1 (de) 2001-07-05
EE200200307A (et) 2003-06-16
CN1221545C (zh) 2005-10-05
EP1242405A1 (de) 2002-09-25
RU2002119559A (ru) 2004-01-10
PT1242405E (pt) 2004-11-30
KR100654265B1 (ko) 2006-12-07
RS50458B (sr) 2010-03-02
NO20023014L (no) 2002-06-21
UA72021C2 (en) 2005-01-17
EE04940B1 (et) 2007-12-17
SI1242405T1 (en) 2005-02-28

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