WO2005077370A8 - カンプトテシン類含有水溶液製剤 - Google Patents

カンプトテシン類含有水溶液製剤

Info

Publication number
WO2005077370A8
WO2005077370A8 PCT/JP2005/001902 JP2005001902W WO2005077370A8 WO 2005077370 A8 WO2005077370 A8 WO 2005077370A8 JP 2005001902 W JP2005001902 W JP 2005001902W WO 2005077370 A8 WO2005077370 A8 WO 2005077370A8
Authority
WO
WIPO (PCT)
Prior art keywords
aqueous solution
solution preparation
preparation containing
camptothecins
containing camptothecins
Prior art date
Application number
PCT/JP2005/001902
Other languages
English (en)
French (fr)
Other versions
WO2005077370A1 (ja
Inventor
Masako Nakazawa
Ritsuo Aiyama
Original Assignee
Yakult Honsha Kk
Masako Nakazawa
Ritsuo Aiyama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk, Masako Nakazawa, Ritsuo Aiyama filed Critical Yakult Honsha Kk
Priority to DE602005024923T priority Critical patent/DE602005024923D1/de
Priority to CA002556254A priority patent/CA2556254A1/en
Priority to EP05709954A priority patent/EP1714653B1/en
Priority to JP2005517946A priority patent/JP4451850B2/ja
Priority to US10/586,879 priority patent/US20080242691A1/en
Priority to AT05709954T priority patent/ATE489094T1/de
Publication of WO2005077370A1 publication Critical patent/WO2005077370A1/ja
Publication of WO2005077370A8 publication Critical patent/WO2005077370A8/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

　製造時に加熱する必要がなく、カンプトテシン類が安定に溶解しているカンプトテシン類含有水溶液製剤の提供。 　酢酸及び酢酸ナトリウムを含有し、ｐＨが２～５であることを特徴とするカンプトテシン類含有水溶液製剤。
PCT/JP2005/001902 2004-02-13 2005-02-09 カンプトテシン類含有水溶液製剤 WO2005077370A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE602005024923T DE602005024923D1 (de) 2004-02-13 2005-02-09 Wässrige lösung mit einem camptothecin
CA002556254A CA2556254A1 (en) 2004-02-13 2005-02-09 Aqueous solution preparation containing camptothecins
EP05709954A EP1714653B1 (en) 2004-02-13 2005-02-09 Aqueous solution preparation containing a camptothecin
JP2005517946A JP4451850B2 (ja) 2004-02-13 2005-02-09 カンプトテシン類含有水溶液製剤
US10/586,879 US20080242691A1 (en) 2004-02-13 2005-02-09 Aqueous Solution Preparation Containing Camptothecins
AT05709954T ATE489094T1 (de) 2004-02-13 2005-02-09 Wässrige lösung mit einem camptothecin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2004035985 2004-02-13
JP2004-035986 2004-02-13
JP2004-035985 2004-02-13
JP2004035986 2004-02-13

Publications (2)

Publication Number Publication Date
WO2005077370A1 WO2005077370A1 (ja) 2005-08-25
WO2005077370A8 true WO2005077370A8 (ja) 2006-01-05

Family

ID=34863456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/001902 WO2005077370A1 (ja) 2004-02-13 2005-02-09 カンプトテシン類含有水溶液製剤

Country Status (8)

Country Link
US (1) US20080242691A1 (ja)
EP (1) EP1714653B1 (ja)
JP (1) JP4451850B2 (ja)
AT (1) ATE489094T1 (ja)
CA (1) CA2556254A1 (ja)
DE (1) DE602005024923D1 (ja)
TW (1) TW200538457A (ja)
WO (1) WO2005077370A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110177161A1 (en) * 2007-05-24 2011-07-21 Dr. Reddy's Laboratories Limited Pharmaceutical compositions of [5(s)-(2'-hydroxyethoxy)-20(s)-camptothecin
AU2009234283B2 (en) * 2008-04-11 2015-04-02 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Diterpene glycosides as natural solubilizers
US8551507B2 (en) 2009-06-24 2013-10-08 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Terpene glycosides and their combinations as solubilizing agents
US10098813B2 (en) 2014-09-03 2018-10-16 Sun Pharmaceutical Industries Limited Perfusion dosage form

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5447936A (en) * 1993-12-22 1995-09-05 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
JP4094710B2 (ja) * 1997-11-06 2008-06-04 株式会社ヤクルト本社 新規なカンプトテシン誘導体
CA2340020A1 (fr) 1998-08-05 2000-02-17 Aventis Pharma S.A. Utilisation de derives de la camptothecine, avec une toxicite gastro-intestinale reduite
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
AU4550801A (en) * 2000-03-09 2001-09-17 Univ Yale Herbal composition phy906 and its use in chemotheraphy
US6653319B1 (en) * 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
JP4245384B2 (ja) 2003-03-18 2009-03-25 株式会社ヤクルト本社 カンプトテシン類含有医薬組成物

Also Published As

Publication number Publication date
TW200538457A (en) 2005-12-01
JPWO2005077370A1 (ja) 2007-10-18
EP1714653B1 (en) 2010-11-24
ATE489094T1 (de) 2010-12-15
DE602005024923D1 (de) 2011-01-05
WO2005077370A1 (ja) 2005-08-25
EP1714653A4 (en) 2008-05-21
US20080242691A1 (en) 2008-10-02
JP4451850B2 (ja) 2010-04-14
CA2556254A1 (en) 2005-08-25
EP1714653A1 (en) 2006-10-25

Similar Documents

Publication Publication Date Title
AU2001236685A1 (en) Preparation of aqueous clear solution dosage forms with bile acids
WO2007005633A8 (en) Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
AU2001257270A1 (en) Ethanol production with dilute acid hydrolysis using partially dried lignocellulosics
WO2008022777A8 (de) Verfahren zum herstellen von 3-dihalomethyl-pyrazol-4-carbonsäurederivaten
WO2007136762A3 (en) Production of fatty acids and derivatives thereof
AU2003301508A1 (en) Processes for producing glutamic acid derivative and pyroglutamic acid derivative and novel intermediate for production
AU7105000A (en) Aqueous solution or dispersion of an acid salt of a polyetheramine
WO2007047863A3 (en) Crystals of laquinimod sodium, and process for the manufacture thereof
EP1660669A4 (en) ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
WO2002096457A3 (en) Stable liquid formulations of antibodies
CA2384283A1 (en) Process for preparing 4-trifluoromethylsulphinylpyrazole derivative
NO20054694D0 (no) Fremgangsmate for fremstilling av eddiksyre
WO2005077370A8 (ja) カンプトテシン類含有水溶液製剤
WO2004031141A3 (en) Process for preparing fluorocarboxylic acids
MY146013A (en) Process for purifying mesotrione
WO2006129160A3 (en) Stable aqueous oral solution of risperidone
AU6701300A (en) Method for the production of a solvent-free alpha- liponic acid
WO2008084823A1 (ja) 褐色皮膜組成物およびその調製方法
PT1543826E (pt) Solução aquosa concentrada de ambroxol
WO2009016069A3 (en) Stable liquid pharmaceutical composition based on trazodone
WO2006025051A3 (en) Process of preparing a crystalline azithromycin monohydrate
EP1798235A4 (en) ACIDIC ACID SALT OF IRINOTECAN
WO2008053206A3 (en) Process for preparation of aldonic acids and derivatives thereof
WO2001093910A3 (de) Verfahren zur erhöhung des antioxidativen potentials selehaltigen wässrigen losungen
WO2004089863A8 (en) Process for the production of 2-hydroxy-4-methylthiobutyric acid ammonium salt

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 34/2005 UNDER (81) ADD "SM"

WWE Wipo information: entry into national phase

Ref document number: 2005517946

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2005709954

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10586879

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2556254

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

WWP Wipo information: published in national office

Ref document number: 2005709954

Country of ref document: EP