RU2002119559A - Способ получения 4-(гетероарилметил)галоген -1(2H)-фталазинонов - Google Patents
Способ получения 4-(гетероарилметил)галоген -1(2H)-фталазиноновInfo
- Publication number
- RU2002119559A RU2002119559A RU2002119559/04A RU2002119559A RU2002119559A RU 2002119559 A RU2002119559 A RU 2002119559A RU 2002119559/04 A RU2002119559/04 A RU 2002119559/04A RU 2002119559 A RU2002119559 A RU 2002119559A RU 2002119559 A RU2002119559 A RU 2002119559A
- Authority
- RU
- Russia
- Prior art keywords
- reaction
- hydrazine hydrate
- phthalazinones
- halogen
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Claims (4)
1. Способ получения 4-(гетероарилметил)галоген-1(2Н)-фталазинонов общей формулы I
где R1 обозначает фтор, хлор, бром или водород;
Ar обозначает пиридин, пиразин или пиримидин,
отличающийся тем, что замещенные соли фталидил-3-трифенилфосфония общей формулы II
где R1 обозначает фтор, хлор, бром или водород,
подвергают взаимодействию с альдегидами общей формулы III
Ar-СНО, III
где Ar обозначает пиридин, пиразин или пиримидин,
в присутствии основания и затем осуществляют реакцию с гидратом гидразина при необходимости в кислых условиях.
2. Способ по п.2, в котором в качестве основания применяют амины или гидроксиды щелочных либо щелочно-земельных металлов.
3. Способ по п.1, в котором реакцию с гидратом гидразина и последующую обработку реакционной смеси осуществляют с использованием ангидрида уксусной кислоты или уксусной кислоты.
4. Способ по п.1, в котором осуществляют реакцию с 1-1,1 экв. гидрата гидразина, а последующую обработку реакционной смеси проводят с использованием 0,1-0,3 экв. ангидрида уксусной кислоты.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19963607.9 | 1999-12-23 | ||
| DE19963607A DE19963607B4 (de) | 1999-12-23 | 1999-12-23 | Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2002119559A true RU2002119559A (ru) | 2004-01-10 |
| RU2250900C2 RU2250900C2 (ru) | 2005-04-27 |
Family
ID=7934888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002119559/04A RU2250900C2 (ru) | 1999-12-23 | 2000-12-20 | Способ получения 4-(гетероарилметил)галоген -1(2h)-фталазинонов |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6891041B2 (ru) |
| EP (1) | EP1242405B1 (ru) |
| JP (1) | JP2003529555A (ru) |
| KR (1) | KR100654265B1 (ru) |
| CN (1) | CN1221545C (ru) |
| AT (1) | ATE273972T1 (ru) |
| AU (1) | AU772981B2 (ru) |
| BG (1) | BG65387B1 (ru) |
| BR (1) | BR0016634A (ru) |
| CA (1) | CA2395407C (ru) |
| CZ (1) | CZ20022146A3 (ru) |
| DE (2) | DE19963607B4 (ru) |
| DK (1) | DK1242405T3 (ru) |
| EE (1) | EE04940B1 (ru) |
| ES (1) | ES2223626T3 (ru) |
| HK (1) | HK1055296A1 (ru) |
| HR (1) | HRP20020605B1 (ru) |
| HU (1) | HUP0300992A3 (ru) |
| IL (2) | IL150017A0 (ru) |
| MX (1) | MXPA02006224A (ru) |
| NO (1) | NO321357B1 (ru) |
| NZ (1) | NZ519285A (ru) |
| PL (1) | PL200714B1 (ru) |
| PT (1) | PT1242405E (ru) |
| RO (1) | RO121211B1 (ru) |
| RS (1) | RS50458B (ru) |
| RU (1) | RU2250900C2 (ru) |
| SI (1) | SI1242405T1 (ru) |
| SK (1) | SK285522B6 (ru) |
| UA (1) | UA72021C2 (ru) |
| WO (1) | WO2001047912A1 (ru) |
| ZA (1) | ZA200205853B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1296984B1 (it) * | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| UY30639A1 (es) * | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
| KR101598231B1 (ko) * | 2007-10-17 | 2016-02-26 | 쿠도스 파마슈티칼스 리미티드 | 4-[3-(4-시클로프로판카르보닐-피페라진-1-카르보닐)-4-플루오로-벤질]-2ｈ-프탈라진-1-온 |
| EP2346495B2 (en) * | 2008-10-07 | 2023-05-24 | Kudos Pharmaceuticals Limited | Pharmaceutical formulation 514 |
| MX365950B (es) | 2013-03-13 | 2019-06-19 | Flatley Discovery Lab Llc | Compuestos de piridazinona y metodos para el tratamiento de la fibrosis quistica. |
| CA2980028A1 (en) * | 2015-03-19 | 2016-09-22 | Clariant International Ltd | Biodegradable sugar-amide-surfactants for enhanced oil recovery |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE567431A (ru) * | 1957-05-07 | |||
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| IE47592B1 (en) * | 1977-12-29 | 1984-05-02 | Ici Ltd | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture |
| EP0634404A1 (en) * | 1993-07-13 | 1995-01-18 | Rhone Poulenc Agriculture Ltd. | Phtalazin derivatives and their use as pesticides |
| ATE267174T1 (de) * | 1994-08-09 | 2004-06-15 | Eisai Co Ltd | Kondensierte pyridazinverbindungen |
| JP3919835B2 (ja) * | 1994-08-09 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリダジン系化合物 |
| DE69720515T2 (de) * | 1996-12-18 | 2004-02-19 | Neurogen Corp., Branford | Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| IT1296984B1 (it) * | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| ITMI981671A1 (it) * | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
| ITMI981670A1 (it) * | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| ITMI20000261A1 (it) * | 2000-02-16 | 2001-08-16 | Zambon Group | Processo per la preparazione di piridiniliden-ftalidi |
-
1999
- 1999-12-23 DE DE19963607A patent/DE19963607B4/de not_active Expired - Fee Related
-
2000
- 2000-12-20 KR KR1020027007997A patent/KR100654265B1/ko not_active IP Right Cessation
- 2000-12-20 SK SK892-2002A patent/SK285522B6/sk not_active IP Right Cessation
- 2000-12-20 UA UA2002076049A patent/UA72021C2/uk unknown
- 2000-12-20 HU HU0300992A patent/HUP0300992A3/hu unknown
- 2000-12-20 RU RU2002119559/04A patent/RU2250900C2/ru not_active IP Right Cessation
- 2000-12-20 AU AU20122/01A patent/AU772981B2/en not_active Ceased
- 2000-12-20 CA CA002395407A patent/CA2395407C/en not_active Expired - Fee Related
- 2000-12-20 RS YUP-473/02A patent/RS50458B/sr unknown
- 2000-12-20 EP EP00983354A patent/EP1242405B1/de not_active Expired - Lifetime
- 2000-12-20 DE DE50007520T patent/DE50007520D1/de not_active Expired - Fee Related
- 2000-12-20 SI SI200030486T patent/SI1242405T1/xx unknown
- 2000-12-20 DK DK00983354T patent/DK1242405T3/da active
- 2000-12-20 PL PL355525A patent/PL200714B1/pl not_active IP Right Cessation
- 2000-12-20 ES ES00983354T patent/ES2223626T3/es not_active Expired - Lifetime
- 2000-12-20 EE EEP200200307A patent/EE04940B1/xx not_active IP Right Cessation
- 2000-12-20 RO ROA200200653A patent/RO121211B1/ro unknown
- 2000-12-20 AT AT00983354T patent/ATE273972T1/de not_active IP Right Cessation
- 2000-12-20 WO PCT/EP2000/013027 patent/WO2001047912A1/de active IP Right Grant
- 2000-12-20 IL IL15001700A patent/IL150017A0/xx active IP Right Grant
- 2000-12-20 US US10/168,794 patent/US6891041B2/en not_active Expired - Fee Related
- 2000-12-20 PT PT00983354T patent/PT1242405E/pt unknown
- 2000-12-20 CZ CZ20022146A patent/CZ20022146A3/cs unknown
- 2000-12-20 NZ NZ519285A patent/NZ519285A/xx unknown
- 2000-12-20 CN CNB008175608A patent/CN1221545C/zh not_active Expired - Fee Related
- 2000-12-20 BR BR0016634-0A patent/BR0016634A/pt not_active Application Discontinuation
- 2000-12-20 MX MXPA02006224A patent/MXPA02006224A/es active IP Right Grant
- 2000-12-20 JP JP2001549382A patent/JP2003529555A/ja active Pending
-
2002
- 2002-06-04 IL IL150017A patent/IL150017A/en not_active IP Right Cessation
- 2002-06-19 BG BG106843A patent/BG65387B1/bg unknown
- 2002-06-21 NO NO20023014A patent/NO321357B1/no not_active IP Right Cessation
- 2002-07-19 HR HR20020605A patent/HRP20020605B1/xx not_active IP Right Cessation
- 2002-07-22 ZA ZA200205853A patent/ZA200205853B/en unknown
-
2003
- 2003-10-15 HK HK03107465A patent/HK1055296A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD4A | Correction of name of patent owner | ||
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20091221 |