KR100654265B1 - 4-(헤테로아릴-메틸)-할로겐-1(2ｈ)-프탈라지논의 제조 방법 - Google Patents

4-(헤테로아릴-메틸)-할로겐-1(2ｈ)-프탈라지논의 제조 방법 Download PDF

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Publication number
KR100654265B1
KR100654265B1 KR1020027007997A KR20027007997A KR100654265B1 KR 100654265 B1 KR100654265 B1 KR 100654265B1 KR 1020027007997 A KR1020027007997 A KR 1020027007997A KR 20027007997 A KR20027007997 A KR 20027007997A KR 100654265 B1 KR100654265 B1 KR 100654265B1
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KR
South Korea
Prior art keywords
phthalazinone
formula
methyl
halogen
heteroaryl
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Expired - Fee Related
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KR1020027007997A
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English (en)
Korean (ko)
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KR20020062363A (ko
Inventor
오를린 페트로프
타마스 하이너
하리베르트 네
마르틴 크뤼거
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쉐링 악티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
KR1020027007997A 1999-12-23 2000-12-20 4-(헤테로아릴-메틸)-할로겐-1(2ｈ)-프탈라지논의 제조 방법 Expired - Fee Related KR100654265B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19963607.9 1999-12-23
DE19963607A DE19963607B4 (de) 1999-12-23 1999-12-23 Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen

Publications (2)

Publication Number Publication Date
KR20020062363A KR20020062363A (ko) 2002-07-25
KR100654265B1 true KR100654265B1 (ko) 2006-12-07

Family

ID=7934888

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020027007997A Expired - Fee Related KR100654265B1 (ko) 1999-12-23 2000-12-20 4-(헤테로아릴-메틸)-할로겐-1(2ｈ)-프탈라지논의 제조 방법

Country Status (31)

Country Link
US (1) US6891041B2 (enExample)
EP (1) EP1242405B1 (enExample)
JP (1) JP2003529555A (enExample)
KR (1) KR100654265B1 (enExample)
CN (1) CN1221545C (enExample)
AT (1) ATE273972T1 (enExample)
AU (1) AU772981B2 (enExample)
BG (1) BG65387B1 (enExample)
BR (1) BR0016634A (enExample)
CA (1) CA2395407C (enExample)
CZ (1) CZ20022146A3 (enExample)
DE (2) DE19963607B4 (enExample)
DK (1) DK1242405T3 (enExample)
EE (1) EE04940B1 (enExample)
ES (1) ES2223626T3 (enExample)
HR (1) HRP20020605B1 (enExample)
HU (1) HUP0300992A3 (enExample)
IL (2) IL150017A0 (enExample)
MX (1) MXPA02006224A (enExample)
NO (1) NO321357B1 (enExample)
NZ (1) NZ519285A (enExample)
PL (1) PL200714B1 (enExample)
PT (1) PT1242405E (enExample)
RO (1) RO121211B1 (enExample)
RS (1) RS50458B (enExample)
RU (1) RU2250900C2 (enExample)
SI (1) SI1242405T1 (enExample)
SK (1) SK285522B6 (enExample)
UA (1) UA72021C2 (enExample)
WO (1) WO2001047912A1 (enExample)
ZA (1) ZA200205853B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
TWI404716B (zh) * 2006-10-17 2013-08-11 Kudos Pharm Ltd 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
KR101598231B1 (ko) * 2007-10-17 2016-02-26 쿠도스 파마슈티칼스 리미티드 4-[3-(4-시클로프로판카르보닐-피페라진-1-카르보닐)-4-플루오로-벤질]-2ｈ-프탈라진-1-온
CA2737400C (en) * 2008-10-07 2016-11-22 Astrazeneca Uk Limited Pharmaceutical formulation 514
JP6545148B2 (ja) 2013-03-13 2019-07-17 フラットリー ディスカバリー ラブ，エルエルシー ピリダジノン化合物及び嚢胞性線維症の治療のための方法
WO2016146303A1 (en) * 2015-03-19 2016-09-22 Clariant International Ltd Biodegradable sugar-amide-surfactants for enhanced oil recovery

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE567431A (enExample) * 1957-05-07
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
EP0634404A1 (en) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
JP3919835B2 (ja) * 1994-08-09 2007-05-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合ピリダジン系化合物
NZ290952A (en) * 1994-08-09 1998-05-27 Eisai Co Ltd Phthalazine derivatives optionally substituted in position-1 by (generally benzyl) amino groups
RU2128175C1 (ru) * 1994-08-09 1999-03-27 Эйсай Ко., Лтд. Конденсированный пиридазин или его фармакологически приемлемая соль, средство, проявляющее ингибирующую активность в отношении циклической гмф- фосфодиэстеразы
CA2275686C (en) * 1996-12-18 2006-10-17 Neurogen Corporation Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
ITMI981670A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI20000261A1 (it) * 2000-02-16 2001-08-16 Zambon Group Processo per la preparazione di piridiniliden-ftalidi

Also Published As

Publication number Publication date
DK1242405T3 (da) 2004-11-01
DE19963607B4 (de) 2005-12-15
RS50458B (sr) 2010-03-02
DE50007520D1 (de) 2004-09-23
US20040192695A1 (en) 2004-09-30
EE04940B1 (et) 2007-12-17
PT1242405E (pt) 2004-11-30
HK1055296A1 (en) 2004-01-02
HRP20020605B1 (en) 2007-06-30
EE200200307A (et) 2003-06-16
BG106843A (en) 2003-02-28
YU47302A (sh) 2005-06-10
MXPA02006224A (es) 2002-12-05
CA2395407C (en) 2009-04-28
NO20023014D0 (no) 2002-06-21
PL200714B1 (pl) 2009-01-30
CN1413203A (zh) 2003-04-23
HUP0300992A3 (en) 2005-11-28
NZ519285A (en) 2004-12-24
EP1242405A1 (de) 2002-09-25
JP2003529555A (ja) 2003-10-07
NO321357B1 (no) 2006-05-02
ES2223626T3 (es) 2005-03-01
IL150017A0 (en) 2002-12-01
KR20020062363A (ko) 2002-07-25
ZA200205853B (en) 2004-02-18
CA2395407A1 (en) 2001-07-05
SI1242405T1 (en) 2005-02-28
EP1242405B1 (de) 2004-08-18
BG65387B1 (bg) 2008-05-30
US6891041B2 (en) 2005-05-10
PL355525A1 (en) 2004-05-04
IL150017A (en) 2006-12-31
RU2002119559A (ru) 2004-01-10
AU772981B2 (en) 2004-05-13
SK8922002A3 (en) 2002-11-06
HRP20020605A2 (en) 2004-12-31
CN1221545C (zh) 2005-10-05
CZ20022146A3 (cs) 2002-09-11
AU2012201A (en) 2001-07-09
ATE273972T1 (de) 2004-09-15
DE19963607A1 (de) 2001-07-12
UA72021C2 (en) 2005-01-17
RU2250900C2 (ru) 2005-04-27
BR0016634A (pt) 2002-10-15
HUP0300992A2 (hu) 2003-08-28
NO20023014L (no) 2002-06-21
SK285522B6 (sk) 2007-03-01
WO2001047912A1 (de) 2001-07-05
RO121211B1 (ro) 2007-01-30

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