KR100384047B1 - 포스포노세펨 유도체, 그 제법 및 용도 - Google Patents

포스포노세펨 유도체, 그 제법 및 용도 Download PDF

Info

Publication number
KR100384047B1
KR100384047B1 KR10-2000-7006796A KR20007006796A KR100384047B1 KR 100384047 B1 KR100384047 B1 KR 100384047B1 KR 20007006796 A KR20007006796 A KR 20007006796A KR 100384047 B1 KR100384047 B1 KR 100384047B1
Authority
KR
South Korea
Prior art keywords
group
compound
substituted
salt
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR10-2000-7006796A
Other languages
English (en)
Korean (ko)
Other versions
KR20010015885A (ko
Inventor
이시까와도모야스
하시구찌쇼헤이
이이자와유지
Original Assignee
다케다 야쿠힌 고교 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18417716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100384047(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 다케다 야쿠힌 고교 가부시키가이샤 filed Critical 다케다 야쿠힌 고교 가부시키가이샤
Publication of KR20010015885A publication Critical patent/KR20010015885A/ko
Application granted granted Critical
Publication of KR100384047B1 publication Critical patent/KR100384047B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
KR10-2000-7006796A 1997-12-19 1998-12-17 포스포노세펨 유도체, 그 제법 및 용도 Expired - Lifetime KR100384047B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP97-351499 1997-12-19
JP35149997 1997-12-19

Publications (2)

Publication Number Publication Date
KR20010015885A KR20010015885A (ko) 2001-02-26
KR100384047B1 true KR100384047B1 (ko) 2003-05-14

Family

ID=18417716

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2000-7006796A Expired - Lifetime KR100384047B1 (ko) 1997-12-19 1998-12-17 포스포노세펨 유도체, 그 제법 및 용도

Country Status (19)

Country Link
US (1) US6417175B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (2) EP2080765A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (3) JP3467418B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100384047B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN1194980C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE430155T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU1683299A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE2013C004I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2314564C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (2) CY1109276T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69840796D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK1043327T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2325139T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR13C0008I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU92134I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL300568I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT1043327E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW473479B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1999032497A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100826487B1 (ko) * 2000-08-10 2008-05-02 다케다 야쿠힌 고교 가부시키가이샤 포스포노세펨 화합물
US20070249577A1 (en) * 2005-05-10 2007-10-25 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070238719A1 (en) * 2005-05-10 2007-10-11 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070238720A1 (en) * 2005-05-10 2007-10-11 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
CN101357929B (zh) * 2007-06-22 2010-12-15 山东轩竹医药科技有限公司 含有巯基噻二唑的头孢菌素衍生物
CN101868240A (zh) * 2007-09-21 2010-10-20 阿斯利康(瑞典)有限公司 适合肠胃外给药的包含头孢烯衍生物的可溶剂型
CN103212076A (zh) * 2008-08-28 2013-07-24 阿斯利康(瑞典)有限公司 包含头孢洛林的组合物和治疗方法
US8247400B2 (en) * 2009-02-23 2012-08-21 Dedhiya Mahendra G Cephem compounds useful for the treatment of bacterial infections
BR112012006250B1 (pt) * 2009-09-21 2021-07-06 Pfizer Anti-Infectives Ab composições para tratar infecções bacterianas usando ceftaroline
FR2951171A1 (fr) * 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
EP2721005B1 (en) 2011-06-17 2015-11-25 AstraZeneca AB Process for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
EP2788361A1 (en) 2011-12-07 2014-10-15 Ranbaxy Laboratories Limited Process for preparing ceftaroline salts or hydrates thereof
JP6301346B2 (ja) * 2012-10-19 2018-03-28 サンド・アクチエンゲゼルシヤフト セフタロリンフォサミルの新規製造方法
CN102977124B (zh) * 2012-12-13 2014-11-26 山东诚创医药技术开发有限公司 7β-[(苯乙酰)氨基]-3-[4-(1-甲基-4-吡啶鎓)-2-噻唑硫基]-3-头孢烯-4-羧酸二苯甲基酯的制备方法
US9534004B2 (en) 2012-12-20 2017-01-03 Sandoz Ag Crystalline forms of ceftaroline fosamil
CN105612166B (zh) 2014-02-21 2019-02-19 上海盟科药业有限公司 治疗用水溶性(o-羰基)氨基磷酸酯前药
CN106565784B (zh) * 2016-10-31 2019-02-26 瑞阳制药有限公司 头孢洛林酯二钠盐的纯化方法
CN110872322B (zh) * 2018-08-29 2022-08-02 上海博志研新药物技术有限公司 乙酸头孢罗膦一水合物及其中间体的制备方法
CN113072567B (zh) * 2021-03-26 2022-10-14 海南海灵化学制药有限公司 一种拉氧头孢钠合成工艺
CN113214323A (zh) * 2021-04-30 2021-08-06 瑞阳制药股份有限公司 分段式头孢罗膦高效稳定析晶方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5941999B2 (ja) 1975-07-24 1984-10-11 武田薬品工業株式会社 セフエムまたはベナム化合物の製造法
US4268509A (en) 1978-07-10 1981-05-19 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
JPS5511600A (en) 1978-07-10 1980-01-26 Fujisawa Pharmaceut Co Ltd Cephem compound, its salt, their preparation and remedy and prophylactic for microbism containing mainly the same
FR2511372A1 (fr) 1981-08-17 1983-02-18 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur preparation
JPS5931791A (ja) 1982-07-19 1984-02-20 Fujisawa Pharmaceut Co Ltd 新規セフエム化合物およびその製造法、並びに細菌感染症予防・治療剤
US4563449A (en) 1982-07-19 1986-01-07 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS62238291A (ja) * 1986-04-10 1987-10-19 Fujisawa Pharmaceut Co Ltd セフエム化合物および医薬として許容されるその塩
US4978663A (en) 1989-08-16 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility
JP3514495B2 (ja) 1992-10-02 2004-03-31 エーザイ株式会社 ハロゲン化アミノチアジアゾリル酢酸誘導体の製造法
JP3927262B2 (ja) 1995-07-19 2007-06-06 武田薬品工業株式会社 セフェム化合物、その製造法および抗菌組成物
JPH10265488A (ja) * 1997-03-27 1998-10-06 Takeda Chem Ind Ltd ホスフォノセフェム誘導体

Also Published As

Publication number Publication date
EP1043327B1 (en) 2009-04-29
CY2013003I2 (el) 2015-08-05
EP1043327A4 (en) 2001-12-12
EP2080765A1 (en) 2009-07-22
PT1043327E (pt) 2009-07-02
JP2009114202A (ja) 2009-05-28
NL300568I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2016-01-18
DK1043327T3 (da) 2009-08-17
FR13C0008I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2013-03-22
ATE430155T1 (de) 2009-05-15
KR20010015885A (ko) 2001-02-26
CY2013003I1 (el) 2014-07-02
AU1683299A (en) 1999-07-12
CA2314564A1 (en) 1999-07-01
JP3467418B2 (ja) 2003-11-17
CN1282335A (zh) 2001-01-31
WO1999032497A1 (fr) 1999-07-01
ES2325139T3 (es) 2009-08-26
US6417175B1 (en) 2002-07-09
EP1043327A1 (en) 2000-10-11
CY1109276T1 (el) 2014-07-02
TW473479B (en) 2002-01-21
BE2013C004I2 (en) 2018-01-29
CN1679595B (zh) 2010-05-12
JP2001048893A (ja) 2001-02-20
NL300568I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2016-01-18
FR13C0008I2 (fr) 2013-08-16
CA2314564C (en) 2008-11-18
LU92134I2 (fr) 2013-03-18
CN1679595A (zh) 2005-10-12
DE69840796D1 (de) 2009-06-10
CN1194980C (zh) 2005-03-30
JPH11255772A (ja) 1999-09-21

Similar Documents

Publication Publication Date Title
KR100384047B1 (ko) 포스포노세펨 유도체, 그 제법 및 용도
DE3688477T2 (de) Antibakterielle verbindungen, ihre herstellung und verwendung.
JPH07133280A (ja) セフェム化合物、その製造法および抗菌組成物
KR920004823B1 (ko) 항균 화합물의 제조방법
DE3586547T2 (de) Antibakterielle verbindungen.
EP0216385A2 (en) Antibacterial compounds
KR920004837B1 (ko) 세펨화합물의 제조방법
US4388316A (en) Amino-substituted oxazole, oxadiazole and isoxazole-substituted cephalosporins
JP3927262B2 (ja) セフェム化合物、その製造法および抗菌組成物
WO1996023798A1 (en) Cephem compounds, their production and use
JPH07101958A (ja) セフェム化合物、その製造法および抗菌組成物
US5948774A (en) Cephem compounds, their production and use
JPH0699450B2 (ja) 抗菌性化合物
JPH0859669A (ja) セフェム化合物、その製造法及び剤
JPH10265488A (ja) ホスフォノセフェム誘導体
JPH06128268A (ja) セフェム化合物、その製造法および抗菌組成物
EP0160969A2 (en) Cephem compounds
KR920004836B1 (ko) 항균 화합물의 제조방법
JPH07101960A (ja) セフェム化合物、その製造法および抗菌組成物
HK1136833A (en) Phosphonocephem derivates, their production and use
JPS62149684A (ja) 抗菌性化合物
JPH07173169A (ja) セフェム化合物、その製造法および抗菌組成物
EP0300423A2 (en) Cephalosporin compound, method of its production and composition for prevention and treatment of bacterial infectious diseases
JPH0761987A (ja) セフェム化合物、その製造法および抗菌組成物
JPH08337585A (ja) セフェム化合物、その製造法および抗菌組成物

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

FPAY Annual fee payment

Payment date: 20130430

Year of fee payment: 11

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

FPAY Annual fee payment

Payment date: 20140418

Year of fee payment: 12

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

FPAY Annual fee payment

Payment date: 20150416

Year of fee payment: 13

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 13

FPAY Annual fee payment

Payment date: 20160419

Year of fee payment: 14

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 14

FPAY Annual fee payment

Payment date: 20160422

Year of fee payment: 15

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 15

FPAY Annual fee payment

Payment date: 20180417

Year of fee payment: 16

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 16

EXPY Expiration of term
PC1801 Expiration of term

St.27 status event code: N-4-6-H10-H14-oth-PC1801

Not in force date: 20181218

Ip right cessation event data comment text: Termination Category : EXPIRATION_OF_DURATION

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000