BE2013C004I2 - Phosphonocephem derivatives, process for the preparation of the same, and use thereof - Google Patents

Phosphonocephem derivatives, process for the preparation of the same, and use thereof

Info

Publication number
BE2013C004I2
BE2013C004I2 BE2013C004C BE2013C004C BE2013C004I2 BE 2013C004 I2 BE2013C004 I2 BE 2013C004I2 BE 2013C004 C BE2013C004 C BE 2013C004C BE 2013C004 C BE2013C004 C BE 2013C004C BE 2013C004 I2 BE2013C004 I2 BE 2013C004I2
Authority
BE
Belgium
Prior art keywords
group
substituted
preparation
same
hydrogen atom
Prior art date
Application number
BE2013C004C
Other languages
French (fr)
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18417716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2013C004(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of BE2013C004I2 publication Critical patent/BE2013C004I2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

A novel cephem compound of the formula: <CHEM> wherein R<1> is a phosphono group or a group convertible to a phosphono group; R<2> is a hydrogen atom or a group having a linkage through a carbon atom; each of Q and X is a nitrogen atom or CH; Y is S, O or CH2; n is 0 or 1; one of R<3> and R<4> is a pyridinium group which may be substituted and the other is a hydrogen atom or hydrocarbon group which may be substituted, or R<3> and R<4> taken together may form a quaternalized nitrogen-containing heterocyclic ring which may be substituted, or its ester or its salt, which has a superior anti-bacterial activity, stability, absorbability, etc., a production thereof and a pharmaceutical composition containing it, is provided.
BE2013C004C 1997-12-19 2013-01-08 Phosphonocephem derivatives, process for the preparation of the same, and use thereof BE2013C004I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35149997 1997-12-19
PCT/JP1998/005709 WO1999032497A1 (en) 1997-12-19 1998-12-17 Phosphonocephem derivatives, process for the preparation of the same, and use thereof

Publications (1)

Publication Number Publication Date
BE2013C004I2 true BE2013C004I2 (en) 2018-01-29

Family

ID=18417716

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2013C004C BE2013C004I2 (en) 1997-12-19 2013-01-08 Phosphonocephem derivatives, process for the preparation of the same, and use thereof

Country Status (19)

Country Link
US (1) US6417175B1 (en)
EP (2) EP2080765A1 (en)
JP (3) JP3467418B2 (en)
KR (1) KR100384047B1 (en)
CN (2) CN1679595B (en)
AT (1) ATE430155T1 (en)
AU (1) AU1683299A (en)
BE (1) BE2013C004I2 (en)
CA (1) CA2314564C (en)
CY (2) CY1109276T1 (en)
DE (1) DE69840796D1 (en)
DK (1) DK1043327T3 (en)
ES (1) ES2325139T3 (en)
FR (1) FR13C0008I2 (en)
LU (1) LU92134I2 (en)
NL (1) NL300568I1 (en)
PT (1) PT1043327E (en)
TW (1) TW473479B (en)
WO (1) WO1999032497A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001277753A1 (en) * 2000-08-10 2002-02-25 Takeda Chemical Industries Ltd. Phosphonocephem compound
US20070238720A1 (en) * 2005-05-10 2007-10-11 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070238719A1 (en) * 2005-05-10 2007-10-11 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
US20070249577A1 (en) * 2005-05-10 2007-10-25 Hopkins Scott J Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures
CN101357929B (en) * 2007-06-22 2010-12-15 山东轩竹医药科技有限公司 Cephalosporin derivative containing sulfhydryl thiadiazole
BRPI0816412A2 (en) 2007-09-21 2017-05-16 Forest Laboratories Holdings Ltd dosage form and method for treating a bacterial infection
MX2011002185A (en) 2008-08-28 2011-04-04 Astrazeneca Ab Compositions and methods of treatment comprising ceftaroline.
WO2010096798A1 (en) * 2009-02-23 2010-08-26 Forest Laboratories Holdings Limited Novel cephem compounds useful for the treatment of bacterial infections
SG178936A1 (en) * 2009-09-21 2012-04-27 Astrazeneca Ab Compositions and methods for treating bacterial infections using ceftaroline
FR2951171A1 (en) * 2009-10-09 2011-04-15 Novexel NOVEL SODIUM SALT OF A CRYSTALLIZED ENANTIOMER AZABICYCLIC COMPOUND AND NOVEL POLYMORPHIC AND PSEUDOPOLYMORPHIC FORMS AND THEIR PREPARATION
CA2780403C (en) 2011-06-17 2020-04-21 Forest Laboratories Holdings Ltd. Processes for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
EP2788361A1 (en) 2011-12-07 2014-10-15 Ranbaxy Laboratories Limited Process for preparing ceftaroline salts or hydrates thereof
JP6301346B2 (en) * 2012-10-19 2018-03-28 サンド・アクチエンゲゼルシヤフト New method for producing ceftaroline fosamil
CN102977124B (en) * 2012-12-13 2014-11-26 山东诚创医药技术开发有限公司 Preparation method of 7beta-[(phenylacetyl) amino]-3-[4-(1-methyl-4-pyridine onium)-2-thiothiazole]-3-cephem-4-benzhydryl carboxylate
JP2016501903A (en) * 2012-12-20 2016-01-21 サンド・アクチエンゲゼルシヤフト A new crystalline form of ceftaroline fosamil.
WO2015127316A1 (en) 2014-02-21 2015-08-27 Micurx Pharmaceuticals, Inc. Water-soluble o-carbonyl phosphoramidate prodrugs for therapeutic administration
CN106565784B (en) * 2016-10-31 2019-02-26 瑞阳制药有限公司 The purification process of Ceftaroline Fosamil disodium salt
CN110872322B (en) * 2018-08-29 2022-08-02 上海博志研新药物技术有限公司 Preparation method of cefaloside acetate monohydrate and intermediate thereof
CN113072567B (en) * 2021-03-26 2022-10-14 海南海灵化学制药有限公司 Synthesis process of latamoxef sodium
CN113214323A (en) * 2021-04-30 2021-08-06 瑞阳制药股份有限公司 Sectional type efficient and stable crystallization method for cefaloside

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5941999B2 (en) 1975-07-24 1984-10-11 武田薬品工業株式会社 Method for producing cefem or venam compounds
JPS5511600A (en) 1978-07-10 1980-01-26 Fujisawa Pharmaceut Co Ltd Cephem compound, its salt, their preparation and remedy and prophylactic for microbism containing mainly the same
US4268509A (en) * 1978-07-10 1981-05-19 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
FR2511372A1 (en) 1981-08-17 1983-02-18 Rhone Poulenc Sante NEW DERIVATIVES OF CEPHALOSPORINE AND THEIR PREPARATION
JPS5931791A (en) * 1982-07-19 1984-02-20 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation and preventive and remedy for bacterial infectious disease
US4563449A (en) * 1982-07-19 1986-01-07 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS62238291A (en) * 1986-04-10 1987-10-19 Fujisawa Pharmaceut Co Ltd Cephem compound and pharmaceutically acceptable salt thereof
US4978663A (en) 1989-08-16 1990-12-18 Hoechst-Roussel Pharmaceuticals Inc. 5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility
JP3514495B2 (en) 1992-10-02 2004-03-31 エーザイ株式会社 Method for producing halogenated aminothiadiazolylacetic acid derivatives
JP3927262B2 (en) * 1995-07-19 2007-06-06 武田薬品工業株式会社 Cephem compound, production method thereof and antibacterial composition
JPH10265488A (en) * 1997-03-27 1998-10-06 Takeda Chem Ind Ltd Phosphonocephem derivative

Also Published As

Publication number Publication date
FR13C0008I2 (en) 2013-08-16
ATE430155T1 (en) 2009-05-15
CY2013003I2 (en) 2015-08-05
JP2001048893A (en) 2001-02-20
CN1282335A (en) 2001-01-31
EP1043327B1 (en) 2009-04-29
EP2080765A1 (en) 2009-07-22
CN1679595B (en) 2010-05-12
TW473479B (en) 2002-01-21
CA2314564A1 (en) 1999-07-01
CN1679595A (en) 2005-10-12
KR20010015885A (en) 2001-02-26
FR13C0008I1 (en) 2013-03-22
WO1999032497A1 (en) 1999-07-01
LU92134I2 (en) 2013-03-18
JPH11255772A (en) 1999-09-21
ES2325139T3 (en) 2009-08-26
CY1109276T1 (en) 2014-07-02
JP2009114202A (en) 2009-05-28
NL300568I2 (en) 2016-01-18
CA2314564C (en) 2008-11-18
PT1043327E (en) 2009-07-02
EP1043327A4 (en) 2001-12-12
CY2013003I1 (en) 2014-07-02
EP1043327A1 (en) 2000-10-11
DE69840796D1 (en) 2009-06-10
US6417175B1 (en) 2002-07-09
AU1683299A (en) 1999-07-12
DK1043327T3 (en) 2009-08-17
CN1194980C (en) 2005-03-30
NL300568I1 (en) 2016-01-18
JP3467418B2 (en) 2003-11-17
KR100384047B1 (en) 2003-05-14

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