JPWO2021206158A5 - - Google Patents
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- JPWO2021206158A5 JPWO2021206158A5 JP2022514127A JP2022514127A JPWO2021206158A5 JP WO2021206158 A5 JPWO2021206158 A5 JP WO2021206158A5 JP 2022514127 A JP2022514127 A JP 2022514127A JP 2022514127 A JP2022514127 A JP 2022514127A JP WO2021206158 A5 JPWO2021206158 A5 JP WO2021206158A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- cancer
- pyridin
- isoxazolo
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003795 chemical substances by application Substances 0.000 claims 41
- 206010028980 Neoplasm Diseases 0.000 claims 21
- 201000011510 cancer Diseases 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 19
- 229940044665 STING agonist Drugs 0.000 claims 17
- 239000004480 active ingredient Substances 0.000 claims 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 11
- 239000003246 corticosteroid Substances 0.000 claims 10
- 238000001990 intravenous administration Methods 0.000 claims 10
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 8
- 239000003470 adrenal cortex hormone Substances 0.000 claims 8
- -1 methyl- d3 group Chemical group 0.000 claims 8
- 238000010253 intravenous injection Methods 0.000 claims 7
- 229960003957 dexamethasone Drugs 0.000 claims 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 6
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 6
- 238000002347 injection Methods 0.000 claims 6
- 239000007924 injection Substances 0.000 claims 6
- 230000037396 body weight Effects 0.000 claims 5
- 201000005787 hematologic cancer Diseases 0.000 claims 5
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 5
- 229960003301 nivolumab Drugs 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims 4
- 229910019142 PO4 Inorganic materials 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 239000010452 phosphate Substances 0.000 claims 4
- QTQGHKVYLQBJLO-UHFFFAOYSA-N 4-methylbenzenesulfonate;(4-methyl-1-oxo-1-phenylmethoxypentan-2-yl)azanium Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.CC(C)CC(N)C(=O)OCC1=CC=CC=C1 QTQGHKVYLQBJLO-UHFFFAOYSA-N 0.000 claims 3
- 230000009876 antimalignant effect Effects 0.000 claims 3
- 229960005354 betamethasone sodium phosphate Drugs 0.000 claims 3
- PLCQGRYPOISRTQ-LWCNAHDDSA-L betamethasone sodium phosphate Chemical compound [Na+].[Na+].C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COP([O-])([O-])=O)(O)[C@@]1(C)C[C@@H]2O PLCQGRYPOISRTQ-LWCNAHDDSA-L 0.000 claims 3
- BGSOJVFOEQLVMH-VWUMJDOOSA-N cortisol phosphate Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 BGSOJVFOEQLVMH-VWUMJDOOSA-N 0.000 claims 3
- 229960002344 dexamethasone sodium phosphate Drugs 0.000 claims 3
- PLCQGRYPOISRTQ-FCJDYXGNSA-L dexamethasone sodium phosphate Chemical compound [Na+].[Na+].C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COP([O-])([O-])=O)(O)[C@@]1(C)C[C@@H]2O PLCQGRYPOISRTQ-FCJDYXGNSA-L 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 229960000890 hydrocortisone Drugs 0.000 claims 3
- 229960004204 hydrocortisone sodium phosphate Drugs 0.000 claims 3
- 229960001401 hydrocortisone sodium succinate Drugs 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 3
- 229960000334 methylprednisolone sodium succinate Drugs 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 229960002621 pembrolizumab Drugs 0.000 claims 3
- 229960002176 prednisolone sodium succinate Drugs 0.000 claims 3
- FKKAEMQFOIDZNY-CODXZCKSSA-M prednisolone sodium succinate Chemical compound [Na+].O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COC(=O)CCC([O-])=O)[C@@H]4[C@@H]3CCC2=C1 FKKAEMQFOIDZNY-CODXZCKSSA-M 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- ZDQYTUBEMHLJFE-UHFFFAOYSA-N 1-[2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-fluorophenyl]ethanone Chemical compound NC1=C(C=C(C(=C1)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)C(C)=O ZDQYTUBEMHLJFE-UHFFFAOYSA-N 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229960002537 betamethasone Drugs 0.000 claims 2
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 210000003236 esophagogastric junction Anatomy 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 208000006178 malignant mesothelioma Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000005282 malignant pleural mesothelioma Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 229960005205 prednisolone Drugs 0.000 claims 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- LSTJLJYRJLFTJD-UHFFFAOYSA-N 1-[2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-fluorophenyl]butan-1-one Chemical compound NC1=C(C=C(C(=C1)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)C(CCC)=O LSTJLJYRJLFTJD-UHFFFAOYSA-N 0.000 claims 1
- LYOZDCBEZDXVSR-UHFFFAOYSA-N 1-[2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-fluorophenyl]propan-1-one Chemical compound NC1=C(C=C(C(=C1)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)C(CC)=O LYOZDCBEZDXVSR-UHFFFAOYSA-N 0.000 claims 1
- DOMUPAPZOLMKRZ-UHFFFAOYSA-N 1-[2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-hydroxyphenyl]ethanone Chemical compound NC1=C(C=C(C(=C1)O)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)C(C)=O DOMUPAPZOLMKRZ-UHFFFAOYSA-N 0.000 claims 1
- DTIOWIXJIMZWTL-UHFFFAOYSA-N 1-[2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]phenyl]butan-1-one Chemical compound NC1=C(C=C(C=C1)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)C(CCC)=O DTIOWIXJIMZWTL-UHFFFAOYSA-N 0.000 claims 1
- UMUFWMJHSBRMIO-UHFFFAOYSA-N 1-[2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]phenyl]ethanone Chemical compound NC1=C(C=C(C=C1)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)C(C)=O UMUFWMJHSBRMIO-UHFFFAOYSA-N 0.000 claims 1
- ZKAQPCMSICOAKT-UHFFFAOYSA-N 1-[2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]phenyl]propan-1-one Chemical compound NC1=C(C=C(C=C1)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)C(CC)=O ZKAQPCMSICOAKT-UHFFFAOYSA-N 0.000 claims 1
- SKZIOYDQLATRFA-UHFFFAOYSA-N 1-[2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]thiazolo[4,5-c]pyridin-4-yl]-4-fluorophenyl]ethanone Chemical compound NC1=C(C=C(C(=C1)F)C1=NC=C(C2=C1C(=NS2)N)C=2C=NNC2)C(C)=O SKZIOYDQLATRFA-UHFFFAOYSA-N 0.000 claims 1
- BGMWFYXYJZUNJA-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-chloro-N-ethylbenzamide Chemical compound NC1=C(C(=O)NCC)C=C(C(=C1)Cl)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 BGMWFYXYJZUNJA-UHFFFAOYSA-N 0.000 claims 1
- MJUUZZSMBBSHTP-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-fluoro-N-methylbenzamide Chemical compound NC1=C(C(=O)NC)C=C(C(=C1)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 MJUUZZSMBBSHTP-UHFFFAOYSA-N 0.000 claims 1
- HGUTWJDKLXVXBF-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-fluoro-N-propylbenzamide Chemical compound NC1=C(C(=O)NCCC)C=C(C(=C1)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 HGUTWJDKLXVXBF-UHFFFAOYSA-N 0.000 claims 1
- RVISIVQEGFHZGI-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-fluorobenzamide Chemical compound NC1=C(C(=O)N)C=C(C(=C1)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 RVISIVQEGFHZGI-UHFFFAOYSA-N 0.000 claims 1
- KYZZDINTLXUBRZ-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-fluorobenzoic acid Chemical compound NC1=C(C(=O)O)C=C(C(=C1)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 KYZZDINTLXUBRZ-UHFFFAOYSA-N 0.000 claims 1
- OKNUSGOSKGSQQK-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-N-ethyl-4-fluorobenzamide Chemical compound NC1=C(C(=O)NCC)C=C(C(=C1)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 OKNUSGOSKGSQQK-UHFFFAOYSA-N 0.000 claims 1
- VUFHPBPWOIBDGK-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-N-ethylbenzamide Chemical compound NC1=C(C(=O)NCC)C=C(C=C1)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 VUFHPBPWOIBDGK-UHFFFAOYSA-N 0.000 claims 1
- XDSWQNMGJJKWLP-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-N-methylbenzamide Chemical compound NC1=C(C(=O)NC)C=C(C=C1)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 XDSWQNMGJJKWLP-UHFFFAOYSA-N 0.000 claims 1
- PCCPHFKIFNKXAO-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-N-propylbenzamide Chemical compound NC1=C(C(=O)NCCC)C=C(C=C1)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 PCCPHFKIFNKXAO-UHFFFAOYSA-N 0.000 claims 1
- VYRSHRFJTVQAJU-UHFFFAOYSA-N 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]benzamide Chemical compound NC1=C(C(=O)N)C=C(C=C1)C1=NC=C(C2=C1C(=NO2)N)C=1C=NNC=1 VYRSHRFJTVQAJU-UHFFFAOYSA-N 0.000 claims 1
- HHJDAJHHWHTQJE-UHFFFAOYSA-N 2-hydroxyethyl 2-amino-5-[3-amino-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-4-yl]-4-fluorobenzoate Chemical compound NC1=C(C(=O)OCCO)C=C(C(=C1)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 HHJDAJHHWHTQJE-UHFFFAOYSA-N 0.000 claims 1
- YNTURPJHANIJQY-UHFFFAOYSA-N 4-(2-fluoro-5-methoxy-4-nitrophenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound FC1=C(C=C(C(=C1)[N+](=O)[O-])OC)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2 YNTURPJHANIJQY-UHFFFAOYSA-N 0.000 claims 1
- WGZGWSNFTNFCFB-UHFFFAOYSA-N 4-(4-amino-2-chloro-5-methylsulfanylphenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1SC)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)Cl WGZGWSNFTNFCFB-UHFFFAOYSA-N 0.000 claims 1
- PPVADNNKDQPXSF-UHFFFAOYSA-N 4-(4-amino-2-fluoro-3-methoxyphenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=C(C(=C(C=C1)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)F)OC PPVADNNKDQPXSF-UHFFFAOYSA-N 0.000 claims 1
- PWLHWAARAJDKCT-UHFFFAOYSA-N 4-(4-amino-2-fluoro-5-methoxyphenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1OC)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)F PWLHWAARAJDKCT-UHFFFAOYSA-N 0.000 claims 1
- KTFVQPMFMICGKC-UHFFFAOYSA-N 4-(4-amino-2-fluoro-5-methoxyphenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[5,4-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1OC)C1=C2C(=C(N=C1)C=1C=NNC1)ON=C2N)F KTFVQPMFMICGKC-UHFFFAOYSA-N 0.000 claims 1
- FAOWAHOTVSCQEC-UHFFFAOYSA-N 4-(4-amino-2-fluoro-5-methoxyphenyl)-7-(5-methyl-1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1OC)C1=NC=C(C2=C1C(=NO2)N)C=2C(=NNC2)C)F FAOWAHOTVSCQEC-UHFFFAOYSA-N 0.000 claims 1
- VJJKTXNNGGUFTR-UHFFFAOYSA-N 4-(4-amino-2-fluoro-5-methylsulfanylphenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1SC)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)F VJJKTXNNGGUFTR-UHFFFAOYSA-N 0.000 claims 1
- INVFBBPUZZBJJD-UHFFFAOYSA-N 4-(4-amino-2-fluoro-5-methylsulfinylphenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1S(=O)C)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)F INVFBBPUZZBJJD-UHFFFAOYSA-N 0.000 claims 1
- NREUAAKBKNPNKX-UHFFFAOYSA-N 4-(4-amino-2-fluoro-5-methylsulfonylphenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1S(=O)(=O)C)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)F NREUAAKBKNPNKX-UHFFFAOYSA-N 0.000 claims 1
- KQOPQATWGFWENY-UHFFFAOYSA-N 4-(4-amino-3-methoxyphenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=C(C=C(C=C1)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)OC KQOPQATWGFWENY-UHFFFAOYSA-N 0.000 claims 1
- GZOSBWSAZZJQOM-UHFFFAOYSA-N 4-(4-amino-5-ethylsulfanyl-2-fluorophenyl)-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1SCC)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)F GZOSBWSAZZJQOM-UHFFFAOYSA-N 0.000 claims 1
- PWLHWAARAJDKCT-FIBGUPNXSA-N 4-[4-amino-2-fluoro-5-(trideuteriomethoxy)phenyl]-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1OC([2H])([2H])[2H])C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)F PWLHWAARAJDKCT-FIBGUPNXSA-N 0.000 claims 1
- DCGYCUQIYSBJFO-UHFFFAOYSA-N 4-[4-amino-2-fluoro-5-(trifluoromethyl)phenyl]-7-(1H-pyrazol-4-yl)-[1,2]oxazolo[4,5-c]pyridin-3-amine Chemical compound NC1=CC(=C(C=C1C(F)(F)F)C1=NC=C(C2=C1C(=NO2)N)C=2C=NNC2)F DCGYCUQIYSBJFO-UHFFFAOYSA-N 0.000 claims 1
- 229940126253 ADU-S100 Drugs 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000032494 Clear cell adenocarcinoma of the ovary Diseases 0.000 claims 1
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 208000021309 Germ cell tumor Diseases 0.000 claims 1
- 208000032271 Malignant tumor of penis Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 1
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Family Cites Families (177)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1212422B1 (en) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| JP5017103B2 (ja) | 2004-06-17 | 2012-09-05 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | 薬剤共結晶組成物および関連した使用方法 |
| DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| BR122017025062B8 (pt) | 2007-06-18 | 2021-07-27 | Merck Sharp & Dohme | anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento |
| US9695212B2 (en) | 2012-12-13 | 2017-07-04 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| EP2975031A4 (en) * | 2013-03-14 | 2017-04-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| WO2014189806A1 (en) | 2013-05-18 | 2014-11-27 | Aduro Biotech, Inc. | Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling |
| PE20160080A1 (es) | 2013-05-18 | 2016-02-21 | Aduro Biotech Inc | Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon |
| CN105705489B (zh) | 2013-09-04 | 2019-04-26 | 百时美施贵宝公司 | 用作免疫调节剂的化合物 |
| US9850225B2 (en) | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| CR20160564A (es) | 2014-06-04 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Dinucleótidos cíclicos como moduladores de sting |
| WO2016039749A1 (en) | 2014-09-11 | 2016-03-17 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions |
| US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| EP3546473B1 (en) | 2014-12-16 | 2025-12-10 | Kayla Therapeutics | Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction |
| US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
| US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| EA035817B1 (ru) | 2015-03-10 | 2020-08-14 | Адуро Байотек, Инк. | Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона" |
| US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
| WO2016164619A2 (en) | 2015-04-07 | 2016-10-13 | Spring Bank Pharmaceuticals, Inc. | Compositions and methods for the treatment of hbv infection |
| TW201717968A (zh) | 2015-07-14 | 2017-06-01 | 春季銀行製藥公司 | 誘導ｒｉｇ－ｉ和其他模式辨識受體之化合物及組成物 |
| EP3328418A1 (en) * | 2015-07-29 | 2018-06-06 | Novartis AG | Combination therapies comprising antibody molecules to pd-1 |
| KR102222186B1 (ko) | 2015-08-13 | 2021-03-03 | 머크 샤프 앤드 돔 코포레이션 | Sting 효능제로서 시클릭 디-뉴클레오티드 화합물 |
| US9809597B2 (en) | 2015-08-20 | 2017-11-07 | The Board Of Trustees Of The Leland Stanford Junior University | Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy |
| US10745382B2 (en) | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| WO2017070089A1 (en) | 2015-10-19 | 2017-04-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| JP2018534295A (ja) | 2015-10-28 | 2018-11-22 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達を活性化するための組成物および方法 |
| SG10202004618TA (en) | 2015-11-19 | 2020-06-29 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| US20170146519A1 (en) | 2015-11-20 | 2017-05-25 | Oregon Health & Science University | Sting agonists and methods of selecting sting agonists |
| CN107849084B (zh) | 2015-12-03 | 2021-09-14 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为sting调节剂的环状嘌呤二核苷酸 |
| US20180369268A1 (en) | 2015-12-16 | 2018-12-27 | Aduro Biotech, Inc. | Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production |
| MA44075A (fr) | 2015-12-17 | 2021-05-19 | Incyte Corp | Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1 |
| AU2016379372A1 (en) | 2015-12-22 | 2018-08-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3190103A1 (en) | 2016-01-08 | 2017-07-12 | Rijksuniversiteit Groningen | Inhibitors of the pd-1/pd-l1 protein/protein interaction |
| KR102789862B1 (ko) | 2016-01-11 | 2025-04-03 | 인네이트 튜머 이뮤니티, 인코포레이티드 | Sting 활성과 연관된 상태 예컨대 암의 치료를 위한 시클릭 디뉴클레오티드 |
| US10723756B2 (en) | 2016-01-11 | 2020-07-28 | Innate Tumor Immunity Inc. | Cyclic dinucleotides for treating conditions associated with STING activity such as cancer |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| NZ746112A (en) | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| US10358463B2 (en) | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| PT3440076T (pt) | 2016-04-07 | 2022-07-29 | Glaxosmithkline Ip Dev Ltd | Amidas heterocíclicas úteis como modeladores de proteína |
| JP2019510802A (ja) | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節物質として有用な複素環アミド |
| EP3448393A1 (en) | 2016-04-25 | 2019-03-06 | Invivogen | Novel complexes of immunostimulatory compounds, and uses thereof |
| AR108396A1 (es) | 2016-05-06 | 2018-08-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| WO2017202275A1 (zh) | 2016-05-23 | 2017-11-30 | 中国医学科学院药物研究所 | 溴代苄醚衍生物、及其制法和药物组合物与用途 |
| WO2017205464A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| IL264049B2 (en) | 2016-07-06 | 2023-11-01 | Sperovie Biosciences Inc | Compounds, preparations and methods for treating the disease |
| CN109715202A (zh) | 2016-07-15 | 2019-05-03 | 斯必乐维生物科学公司 | 用于治疗疾病的化合物、组合物和方法 |
| US10300145B2 (en) | 2016-07-15 | 2019-05-28 | Massachusetts Institute Of Technology | Synthetic nanoparticles for delivery of immunomodulatory compounds |
| WO2018013887A1 (en) | 2016-07-15 | 2018-01-18 | Sperovie Biosciences, Inc. | Compounds, compositions, and methods for the treatment of disease |
| AU2017321609C1 (en) * | 2016-08-30 | 2023-11-09 | Dana-Farber Cancer Institute, Inc. | Drug delivery compositions and uses thereof |
| US20190345191A1 (en) | 2016-08-31 | 2019-11-14 | Innate Tumor Immunity, Inc. | Cyclic dinucleotide analogs for treating conditions associated with sting (stimulator of interferon genes) activity |
| US10537590B2 (en) | 2016-09-30 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds |
| PT3523287T (pt) | 2016-10-04 | 2021-10-06 | Merck Sharp & Dohme | Compostos de benzo[b]tiofeno como agonistas de sting |
| US11001605B2 (en) | 2016-10-07 | 2021-05-11 | Biolog Life Science Institute Gmbh & Co. Kg | Cyclic dinucleotides containing benzimidazole, method for the production of same, and use of same to activate stimulator of interferon genes (sting)-dependent signaling pathways |
| JOP20170188A1 (ar) | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
| PE20210255A1 (es) | 2016-12-01 | 2021-02-10 | Takeda Pharmaceuticals Co | Dinucleotido ciclico como agonistas de sting (estimulador de genes de interferon) |
| AU2017378782A1 (en) | 2016-12-20 | 2019-07-04 | Merck Sharp & Dohme Corp. | Combinations of PD-1 antagonists and cyclic dinucleotide sting agonists for cancer treatment |
| WO2018118665A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Cyclic dinucleotide sting agonists for cancer treatment |
| LT3558990T (lt) * | 2016-12-22 | 2022-12-27 | Incyte Corporation | Tetrahidroimidazo[4,5-c]piridino dariniai kaip pd-l1 internalizavimo induktoriai |
| CN110234403A (zh) | 2017-01-27 | 2019-09-13 | 詹森生物科技公司 | 作为sting激动剂的环状二核苷酸 |
| US11021511B2 (en) | 2017-01-27 | 2021-06-01 | Janssen Biotech, Inc. | Cyclic dinucleotides as sting agonists |
| US20200055883A1 (en) | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
| WO2018156625A1 (en) | 2017-02-21 | 2018-08-30 | Board Of Regents,The University Of Texas System | Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling |
| JOP20190218A1 (ar) | 2017-03-22 | 2019-09-22 | Boehringer Ingelheim Int | مركبات ثنائية النيوكليوتيدات حلقية معدلة |
| AR113224A1 (es) | 2017-04-28 | 2020-02-19 | Novartis Ag | Conjugados de anticuerpo que comprenden un agonista de sting |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| US11466047B2 (en) | 2017-05-12 | 2022-10-11 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| US20200138827A1 (en) | 2017-06-22 | 2020-05-07 | Curadev Pharma Limited | Small molecule modulators of human sting |
| WO2018234807A1 (en) | 2017-06-22 | 2018-12-27 | Curadev Pharma Limited | Heterocyclic small molecule modulators of human sting |
| UA125730C2 (uk) | 2017-06-22 | 2022-05-25 | Курадев Фарма Лімітед | Низькомолекулярні модулятори sting людини |
| JP7186764B2 (ja) | 2017-07-28 | 2022-12-09 | ブリストル－マイヤーズ スクイブ カンパニー | 抗癌剤としての環状ジヌクレオチド |
| JP2020530838A (ja) | 2017-08-04 | 2020-10-29 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | がん治療のためのベンゾ［ｂ］チオフェンＳＴＩＮＧアゴニスト |
| RU2020109328A (ru) * | 2017-08-04 | 2021-09-06 | Мерк Шарп И Доум Корп. | Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака |
| MX2020002303A (es) | 2017-08-30 | 2020-09-10 | Beijing Xuanyi Pharmasciences Co Ltd | Dinucleotidos ciclicos como moduladores del estimulador de genes de interferon. |
| WO2019046511A1 (en) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE |
| JP7208225B2 (ja) | 2017-08-31 | 2023-01-18 | ブリストル－マイヤーズ スクイブ カンパニー | 抗癌剤としての環状ジヌクレオチド |
| US10947263B2 (en) | 2017-08-31 | 2021-03-16 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| KR102812783B1 (ko) | 2017-08-31 | 2025-05-26 | 브리스톨-마이어스 스큅 컴퍼니 | 항암제로서의 시클릭 디뉴클레오티드 |
| US11707531B2 (en) | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| US11584774B2 (en) | 2017-09-11 | 2023-02-21 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| CA3077337A1 (en) | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | Modulators of stimulator of interferon genes (sting) |
| EP3691640A1 (en) | 2017-10-05 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Methods for administering sting agonists |
| AU2018344902B2 (en) | 2017-10-05 | 2021-06-03 | Glaxosmithkline Intellectual Property Development Limited | Modulators of stimulator of interferon genes (STING) useful in treating HIV |
| US11660311B2 (en) | 2017-10-10 | 2023-05-30 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| KR20200098511A (ko) | 2017-11-10 | 2020-08-20 | 다케다 야쿠힌 고교 가부시키가이샤 | Sting 조절제 화합물, 및 제조 및 사용 방법 |
| KR20200100081A (ko) | 2017-11-20 | 2020-08-25 | 실리콘 스왓, 인크. | 옥소아크리디닐 아세트산 유도체 및 사용 방법 |
| CN111712509A (zh) | 2017-12-15 | 2020-09-25 | 詹森生物科技公司 | 作为sting激动剂的环状二核苷酸 |
| US20190185509A1 (en) | 2017-12-20 | 2019-06-20 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'2' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| EP3727401A4 (en) | 2017-12-20 | 2022-04-06 | Merck Sharp & Dohme Corp. | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019122202A1 (en) | 2017-12-20 | 2019-06-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Sting inhibitors |
| EP3505188A1 (en) | 2017-12-29 | 2019-07-03 | Invivogen | Pro-cyclic dinucleotide conjugates for cytokine induction |
| WO2019134707A1 (zh) | 2018-01-08 | 2019-07-11 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN110016025B (zh) | 2018-01-08 | 2021-08-06 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| US10519187B2 (en) | 2018-02-13 | 2019-12-31 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| MX2020008265A (es) | 2018-02-16 | 2020-09-21 | UCB Biopharma SRL | Derivados farmaceuticos del anillo heterobiciclico 6,5. |
| WO2019161171A1 (en) | 2018-02-16 | 2019-08-22 | Sperovie Biosciences, Inc. | Nanoparticle formulations of sting agonists |
| WO2019165032A1 (en) | 2018-02-21 | 2019-08-29 | The Scripps Research Institute | Agonists of stimulator of interferon genes sting |
| ES2980374T3 (es) | 2018-03-08 | 2024-10-01 | Bristol Myers Squibb Co | Dinucleótidos cíclicos como agentes anticancerosos |
| WO2019170912A1 (en) | 2018-03-09 | 2019-09-12 | Lidds Ab | Bioresorbable controlled-release compositions with sting modulating molecules |
| US10538542B2 (en) | 2018-03-15 | 2020-01-21 | Pfizer Inc. | Cyclopentane-based modulators of STING (stimulator of interferon genes) |
| CA3093849A1 (en) | 2018-03-23 | 2019-09-26 | Codiak Biosciences, Inc. | Extracellular vesicles comprising sting-agonist |
| WO2019180683A1 (en) | 2018-03-23 | 2019-09-26 | Takeda Pharmaceutical Company Limited | Sting modulator compounds with sulfamate linkages, and methods of making and using |
| WO2019185477A1 (en) | 2018-03-27 | 2019-10-03 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds containing 2-aza-hypoxanthine or 6h-pytazolo[1,5-d][1,2,4]triazin-7-one as sting agonists |
| JP2021519279A (ja) | 2018-03-27 | 2021-08-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 修飾環式ジヌクレオチド化合物 |
| JP7326319B2 (ja) | 2018-04-03 | 2023-08-15 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｓｔｉｎｇアゴニストとしてのベンゾチオフェン類及び関連する化合物 |
| EP3774765A4 (en) | 2018-04-03 | 2021-12-29 | Merck Sharp & Dohme Corp. | Aza-benzothiophene compounds as sting agonists |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| WO2019201283A1 (en) * | 2018-04-20 | 2019-10-24 | Xrad Therapeutics, Inc. | Dual atm and dna-pk inhibitors for use in anti-tumor therapy |
| US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| JP7570235B2 (ja) | 2018-05-25 | 2024-10-21 | インサイト・コーポレイション | Ｓｔｉｎｇ活性化剤としての三環式複素環式化合物 |
| BR112020024605A2 (pt) | 2018-06-01 | 2021-04-06 | Eisai R&D Management Co., Ltd. | Métodos para o tratamento de câncer de bexiga |
| US12162863B2 (en) | 2018-06-12 | 2024-12-10 | Ryvu Therapeutics S.A. | Modulators of stimulator of interferon genes (STING) |
| TW202016081A (zh) | 2018-06-21 | 2020-05-01 | 英商克拉德夫製藥有限公司 | 人類ｓｔｉｎｇ之小分子調節劑、結合物及治療應用 |
| WO2019243823A1 (en) | 2018-06-21 | 2019-12-26 | Curadev Pharma Limited | Azaheterocyclic small molecule modulators of human sting |
| US11535633B2 (en) | 2018-06-28 | 2022-12-27 | Jiangsu Hengrui Medicine Co., Ltd. | Fused tricyclic heterocycle compounds and therapeutic uses thereof |
| CN120004785A (zh) | 2018-07-03 | 2025-05-16 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| JP7482122B2 (ja) | 2018-07-03 | 2024-05-13 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| US20210177831A1 (en) * | 2018-07-05 | 2021-06-17 | The General Hospital Corporation | Compositions and methods for local delivery of pharmaceutical agents to treat cancer |
| WO2020014127A1 (en) | 2018-07-10 | 2020-01-16 | Sperovie Biosciences, Inc. | Compounds, compositions, and methods for the treatment of disease |
| WO2020010451A1 (en) | 2018-07-10 | 2020-01-16 | Trillium Therapeutics Inc. | Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists |
| TW202030199A (zh) | 2018-07-17 | 2020-08-16 | 美商健生生物科技公司 | 作為ｓｔｉｎｇ促效劑之環狀二核苷酸 |
| US11008344B2 (en) | 2018-07-31 | 2021-05-18 | Incyte Corporation | Tricyclic heteroaryl compounds as STING activators |
| WO2020028566A1 (en) | 2018-07-31 | 2020-02-06 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| AU2019326633B2 (en) | 2018-08-24 | 2022-09-08 | Adlai Nortye Biopharma Co., Ltd. | High activity sting protein agonist |
| CN111655682B (zh) | 2018-08-29 | 2024-05-31 | 杭州阿诺生物医药科技有限公司 | 一种高活性sting蛋白激动剂化合物 |
| EP3848054B1 (en) | 2018-09-06 | 2025-01-29 | Daiichi Sankyo Company, Limited | Antibody-drug conjugates of cyclic dinucleotide derivatives |
| CN110938104B (zh) | 2018-09-21 | 2024-07-12 | 上海迪诺医药科技有限公司 | 环状二核苷酸类似物、其药物组合物及应用 |
| WO2020072492A1 (en) | 2018-10-02 | 2020-04-09 | Baruch S. Blumberg Institute | Benzamide derivatives as cgas-sting pathway agonists |
| TWI855000B (zh) * | 2018-10-11 | 2024-09-11 | 日商小野藥品工業股份有限公司 | Ｓｔｉｎｇ促效化合物 |
| CN112867727B (zh) | 2018-10-12 | 2024-05-17 | 上海济煜医药科技有限公司 | 环二核苷酸类化合物及其应用 |
| WO2020092127A1 (en) | 2018-10-29 | 2020-05-07 | Venenum Biodesign, LLC | Novel sting agonists |
| JP2022507697A (ja) | 2018-11-19 | 2022-01-18 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| US20220362253A1 (en) | 2018-12-06 | 2022-11-17 | Glaxosmithkline Intellectual Property Development Limited | Novel pharmaceutical formulation |
| WO2020117623A1 (en) | 2018-12-07 | 2020-06-11 | Merck Sharp & Dohme Corp. | Cyclic di-nucleotide compounds as sting agonists |
| US20220033431A1 (en) | 2018-12-07 | 2022-02-03 | Merck Sharp & Dohme Corp. | Cyclic Di-Nucleotide Compounds as STING Agonists |
| WO2020117624A1 (en) | 2018-12-07 | 2020-06-11 | Merck Sharp & Dohme Corp. | Cyclic di-nucleotide compounds as sting agonists |
| US20220056044A1 (en) | 2018-12-14 | 2022-02-24 | Jiangsu Hengrui Medicine Co., Ltd. | Tricyclic compounds as sting agonists, and preparation methods and medicinal uses thereof |
| CN111655712B (zh) | 2018-12-29 | 2021-02-05 | 上海济煜医药科技有限公司 | 作为肿瘤免疫类的化合物及其应用 |
| WO2020146237A1 (en) | 2019-01-07 | 2020-07-16 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| CN111471056B (zh) | 2019-01-23 | 2021-07-02 | 成都先导药物开发股份有限公司 | 一种大环类免疫调节剂 |
| CN113563313B (zh) | 2019-01-31 | 2022-11-04 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN113423713A (zh) | 2019-02-05 | 2021-09-21 | 百时美施贵宝公司 | 1,2,5-三-o-苯甲酰基-3-二苄基氨基-3-脱氧核糖作为生产3′-氨基-3′-脱氧腺苷和3′-氨基-3′-脱氧鸟苷的中间体及其受保护的衍生物的合成 |
| WO2020178770A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| EP3934757B1 (en) | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| BR112021018947A2 (pt) | 2019-03-28 | 2022-02-08 | Lupin Ltd | Compostos macrocíclicos como agonistas de sting |
| TW202104214A (zh) | 2019-04-05 | 2021-02-01 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | 化合物 |
| EP3964504A4 (en) | 2019-04-30 | 2022-12-28 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | AMINOPYRIMIDINE COMPOUND, METHOD OF PRODUCTION THEREOF AND USE THEREOF |
| WO2020227421A1 (en) | 2019-05-09 | 2020-11-12 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as sting modulators |
| US20220227761A1 (en) | 2019-05-16 | 2022-07-21 | Stingthera, Inc. | Oxoacridinyl acetic acid derivatives and methods of use |
| WO2020232378A1 (en) | 2019-05-16 | 2020-11-19 | Silicon Swat, Inc. | Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use |
| WO2020236586A1 (en) | 2019-05-17 | 2020-11-26 | Ifm Due, Inc. | N-hetaryl-squaramide compounds for treating conditions associated with sting activity |
| WO2020243519A1 (en) | 2019-05-29 | 2020-12-03 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| BR112021024948A2 (pt) | 2019-06-12 | 2022-01-25 | Ryvu Therapeutics S A | Moduladores de próxima geração de estimulador de genes de interferon (sting) |
| WO2020252240A1 (en) | 2019-06-14 | 2020-12-17 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2021000770A1 (zh) | 2019-07-02 | 2021-01-07 | 凯复制药有限公司 | 可增强免疫活性的杂环化合物、其制备方法及其在医药上的应用 |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| CR20220029A (es) | 2019-07-22 | 2022-03-14 | Lupin Ltd | Compuestos macrocíclicos como agonistas de sting y métodos y usos de los mismos |
| US20220267364A1 (en) | 2019-07-25 | 2022-08-25 | Shanghai Jemincare Pharmaceuticals Co., Ltd. | Heterocyclic amide compound, preparation method therefor and use thereof |
| US12435104B2 (en) | 2019-07-25 | 2025-10-07 | Beigene, Ltd. | Cyclic dinucleotides as sting agonists |
| JP7843695B2 (ja) | 2019-08-02 | 2026-04-10 | メルサナ セラピューティクス インコーポレイテッド | がんの処置用のＳＴＩＮＧ（インターフェロン遺伝子刺激因子）アゴニストとしてのビス－［Ｎ－（（５－カルバモイル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－イル）－ピラゾール－５－カルボキサミド］誘導体および関連化合物 |
| CN115003383B (zh) | 2019-08-21 | 2024-10-01 | 斯克里普斯研究学院 | 干扰素基因刺激物sting的双环激动剂 |
| KR102851570B1 (ko) | 2019-08-21 | 2025-09-01 | 더 스크립스 리서치 인스티튜트 | 인터페론 유전자의 자극인자 sting의 모노시클릭 효능제 |
| CN112442033A (zh) | 2019-08-28 | 2021-03-05 | 迈德欣国际有限公司 | Sting通路调节剂及其用途 |
| US20220267270A1 (en) | 2019-08-30 | 2022-08-25 | University Of South Florida | Sting modulators, compositions, and methods of use |
| US20230151024A1 (en) * | 2020-04-10 | 2023-05-18 | Ono Pharmaceutical Co., Ltd. | Sting agonistic compound |
| JP2023072104A (ja) * | 2020-04-10 | 2023-05-24 | 小野薬品工業株式会社 | 抗体薬物複合体 |
-
2021
- 2021-04-09 TW TW110112953A patent/TW202200136A/zh unknown
- 2021-04-09 KR KR1020227033933A patent/KR20220167275A/ko active Pending
- 2021-04-09 WO PCT/JP2021/014973 patent/WO2021206158A1/ja not_active Ceased
- 2021-04-09 US US17/916,268 patent/US20230141284A1/en not_active Abandoned
- 2021-04-09 JP JP2022514127A patent/JPWO2021206158A1/ja active Pending
- 2021-04-09 EP EP21785563.4A patent/EP4134098A4/en not_active Withdrawn
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