JPH05262642A - 難溶性薬物の固体分散体の製造方法 - Google Patents

難溶性薬物の固体分散体の製造方法

Info

Publication number
JPH05262642A
JPH05262642A JP5006129A JP612993A JPH05262642A JP H05262642 A JPH05262642 A JP H05262642A JP 5006129 A JP5006129 A JP 5006129A JP 612993 A JP612993 A JP 612993A JP H05262642 A JPH05262642 A JP H05262642A
Authority
JP
Japan
Prior art keywords
solid dispersion
poorly soluble
soluble drug
drug
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5006129A
Other languages
English (en)
Japanese (ja)
Inventor
Minoru Nakano
實 中野
Toshinobu Uemura
俊信 植村
Shinichi Morisane
真一 森実
Kiyoshi Okuda
清 奥田
Keiko Nakada
圭子 中田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPH05262642A publication Critical patent/JPH05262642A/ja
Priority to NO19940291A priority Critical patent/NO322641B1/no
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP5006129A 1992-01-24 1993-01-18 難溶性薬物の固体分散体の製造方法 Pending JPH05262642A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO19940291A NO322641B1 (no) 1993-01-18 1994-01-27 Elektrisk feltterapiapparat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1079692 1992-01-24
JP4-10796 1992-01-24

Publications (1)

Publication Number Publication Date
JPH05262642A true JPH05262642A (ja) 1993-10-12

Family

ID=11760311

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5006129A Pending JPH05262642A (ja) 1992-01-24 1993-01-18 難溶性薬物の固体分散体の製造方法

Country Status (6)

Country Link
US (1) US5340591A (enExample)
EP (1) EP0552708A1 (enExample)
JP (1) JPH05262642A (enExample)
KR (1) KR930016091A (enExample)
CA (1) CA2087932A1 (enExample)
TW (1) TW259712B (enExample)

Cited By (18)

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JPH08301789A (ja) * 1995-05-02 1996-11-19 Bayer Ag 活性化合物の調節された放出性を有する製剤およびそれらの製造方法
JPWO9706781A1 (enExample) * 1995-08-11 1997-02-27
WO1998001122A1 (en) * 1996-07-08 1998-01-15 Kyowa Hakko Kogyo Co., Ltd. Solid dispersions or solid dispersion preparations of tricyclic compounds
JPH10513477A (ja) * 1995-02-14 1998-12-22 ビーエーエスエフ アクチェンゲゼルシャフト 固体の作用物質製剤
JPH11130698A (ja) * 1997-10-31 1999-05-18 Freunt Ind Co Ltd アルギン酸多価金属塩球状微粒子集合体、該球状微粒子集合体に難溶性薬剤を担持した放出制御製剤及びそれらの製造方法
JP2003146878A (ja) * 2002-11-22 2003-05-21 Sawai Pharmaceutical Co Ltd ニルバジピン含有易溶性固形製剤およびその製造法
JP2003518483A (ja) * 1999-12-23 2003-06-10 エフ エイチ フォールディング アンド カンパニー リミテッド 不良溶解性の薬物に対する改良された医薬組成物
JP2003522097A (ja) * 1998-02-16 2003-07-22 フイズ インターナショナル リミテッド 可溶化デリバリーシステムおよび製造方法
JP2004505911A (ja) * 2000-08-03 2004-02-26 ファイザー・プロダクツ・インク コレステリルエステル転移蛋白質阻害薬の医薬用組成物
JP2006347939A (ja) * 2005-06-15 2006-12-28 Tokyo Printing Ink Mfg Co Ltd 薬物高分子複合体の製造方法及び薬物高分子複合体
JP2008524291A (ja) * 2004-12-22 2008-07-10 ノバルティス アクチエンゲゼルシャフト 固体医薬組成物
WO2008133102A1 (ja) 2007-04-20 2008-11-06 Daido Chemical Corporation 新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物
US8343548B2 (en) 2006-08-08 2013-01-01 Shin-Etsu Chemical Co., Ltd. Solid dosage form comprising solid dispersion
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JP2015536978A (ja) * 2012-11-07 2015-12-24 エスケー バイオファーマスティカルズ カンパニー リミテッド 難溶性薬物の固体分散体およびその製造方法
JP6821863B1 (ja) * 2019-08-30 2021-01-27 三栄源エフ・エフ・アイ株式会社 非晶質の難水溶性素材を含有する固体組成物、及びその製造方法
WO2021040027A1 (ja) * 2019-08-30 2021-03-04 三栄源エフ・エフ・アイ株式会社 非晶質の難水溶性素材を含有する固体組成物、及びその製造方法

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