JPH05247090A - 抗トロンビンポリペプチド - Google Patents

抗トロンビンポリペプチド

Info

Publication number
JPH05247090A
JPH05247090A JP4075594A JP7559492A JPH05247090A JP H05247090 A JPH05247090 A JP H05247090A JP 4075594 A JP4075594 A JP 4075594A JP 7559492 A JP7559492 A JP 7559492A JP H05247090 A JPH05247090 A JP H05247090A
Authority
JP
Japan
Prior art keywords
polypeptide
sequence
dna sequence
amino acid
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4075594A
Other languages
English (en)
Japanese (ja)
Inventor
Paolo Sarmientos
パオロ・サルミエントス
Poet Philippe De Taxis Du
フィリップ・ドゥ・タクシ・デュ・ポエ
Giampaolo Nitti
ジャンパオロ・ニッチ
Emanuela Scacheri
エマニュエラ・スカシェリ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919104260A external-priority patent/GB9104260D0/en
Priority claimed from GB919119954A external-priority patent/GB9119954D0/en
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of JPH05247090A publication Critical patent/JPH05247090A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP4075594A 1991-02-28 1992-02-27 抗トロンビンポリペプチド Pending JPH05247090A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9104260.6 1991-02-28
GB919104260A GB9104260D0 (en) 1991-02-28 1991-02-28 Anti-thrombin polypeptides
GB9119954.7 1991-09-18
GB919119954A GB9119954D0 (en) 1991-09-18 1991-09-18 Antithrombin polypeptides

Publications (1)

Publication Number Publication Date
JPH05247090A true JPH05247090A (ja) 1993-09-24

Family

ID=26298509

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4075594A Pending JPH05247090A (ja) 1991-02-28 1992-02-27 抗トロンビンポリペプチド

Country Status (23)

Country Link
US (2) US5356875A (enExample)
EP (1) EP0501821B1 (enExample)
JP (1) JPH05247090A (enExample)
KR (1) KR100218818B1 (enExample)
CN (1) CN1044479C (enExample)
AT (1) ATE175236T1 (enExample)
AU (1) AU643876B2 (enExample)
CA (1) CA2061920A1 (enExample)
CZ (1) CZ283458B6 (enExample)
DE (1) DE69228015T2 (enExample)
DK (1) DK0501821T3 (enExample)
ES (1) ES2129426T3 (enExample)
FI (1) FI920861A7 (enExample)
GR (1) GR3029364T3 (enExample)
HU (1) HU215580B (enExample)
IE (1) IE920622A1 (enExample)
IL (1) IL101062A0 (enExample)
MX (1) MX9200795A (enExample)
MY (1) MY110327A (enExample)
NO (1) NO300138B1 (enExample)
NZ (1) NZ241715A (enExample)
TW (1) TW214556B (enExample)
YU (1) YU19792A (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031386A1 (en) * 1997-01-20 1998-07-23 Japan Energy Corporation Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1266561B1 (it) * 1993-07-22 1997-01-09 Mini Ricerca Scient Tecnolog Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione
CN1064968C (zh) * 1996-07-10 2001-04-25 中国人民解放军第一军医大学 重组蛋白提取纯化方法
US6077825A (en) * 1997-03-13 2000-06-20 Auburn University Antithrombin protein and DNA sequences from black fly
JP2000080046A (ja) * 1998-09-03 2000-03-21 Dai Ichi Seiyaku Co Ltd 多臓器障害の予防・治療剤
CN102876654A (zh) * 2012-10-19 2013-01-16 广东海洋大学 一种桑蚕丝素固定化凝血酶的制备方法
CN104193809B (zh) * 2014-09-28 2016-08-17 顾玉奎 一种凝血酶抑制及其制备方法、应用
CN104193807B (zh) * 2014-09-28 2016-06-15 广州贝奥吉因生物科技有限公司 凝血酶抑制多肽及其制备方法、应用
CN105646702B (zh) * 2016-04-13 2019-03-01 中国科学院昆明动物研究所 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用
CN108059672B (zh) * 2016-11-08 2021-06-11 中国科学院昆明动物研究所 森林山蛭抗血栓肽Sylvestin及其基因和应用
CN110468174A (zh) * 2019-08-21 2019-11-19 北京中医药大学 一种水蛭活性寡肽的制备方法
CN111454352B (zh) * 2020-03-05 2021-07-23 中国科学院昆明动物研究所 一种活性蛋白hmei-a、活性蛋白hmei-a的编码基因及应用
CN112114069B (zh) * 2020-09-18 2023-05-16 江苏艾迪药业股份有限公司 凝血酶的亲和色谱柱、制备方法及应用
CN112480210B (zh) * 2020-11-25 2021-09-17 广东海洋大学 一种抗凝血活性肽及其用途
KR102354461B1 (ko) * 2021-02-19 2022-01-20 김건언 덕트 일체형 조명등기구
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
IT1250689B (it) * 1991-07-22 1995-04-21 Marco Gerna Analoghi dell'irudina e procedimento per la loro preparazione

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031386A1 (en) * 1997-01-20 1998-07-23 Japan Energy Corporation Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method
US6274553B1 (en) 1997-01-20 2001-08-14 Japan Energy Corporation Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method

Also Published As

Publication number Publication date
EP0501821A3 (en) 1993-03-03
FI920861L (fi) 1992-08-29
FI920861A7 (fi) 1992-08-29
US5356875A (en) 1994-10-18
MX9200795A (es) 1992-08-01
HU9200620D0 (en) 1992-05-28
IE920622A1 (en) 1992-09-09
AU1122192A (en) 1992-09-03
CN1066272A (zh) 1992-11-18
DE69228015D1 (de) 1999-02-11
FI920861A0 (fi) 1992-02-26
KR920016468A (ko) 1992-09-24
HU215580B (hu) 1999-01-28
CZ283458B6 (cs) 1998-04-15
DE69228015T2 (de) 1999-06-02
YU19792A (sh) 1994-06-10
ATE175236T1 (de) 1999-01-15
ES2129426T3 (es) 1999-06-16
NO300138B1 (no) 1997-04-14
CN1044479C (zh) 1999-08-04
CA2061920A1 (en) 1992-08-29
EP0501821B1 (en) 1998-12-30
NO920777D0 (no) 1992-02-27
DK0501821T3 (da) 1999-08-30
AU643876B2 (en) 1993-11-25
MY110327A (en) 1998-04-30
NO920777L (no) 1992-08-31
EP0501821A2 (en) 1992-09-02
TW214556B (enExample) 1993-10-11
CS58492A3 (en) 1992-09-16
US5439820A (en) 1995-08-08
HUT64592A (en) 1994-01-28
GR3029364T3 (en) 1999-05-28
IL101062A0 (en) 1992-11-15
KR100218818B1 (ko) 1999-10-01
NZ241715A (en) 1993-07-27

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