ES2129426T3 - Polipeptidos antitrombinicos. - Google Patents
Polipeptidos antitrombinicos.Info
- Publication number
- ES2129426T3 ES2129426T3 ES92301721T ES92301721T ES2129426T3 ES 2129426 T3 ES2129426 T3 ES 2129426T3 ES 92301721 T ES92301721 T ES 92301721T ES 92301721 T ES92301721 T ES 92301721T ES 2129426 T3 ES2129426 T3 ES 2129426T3
- Authority
- ES
- Spain
- Prior art keywords
- polypeptides
- thrombin
- preparation
- hirudinaria manillensis
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A POLIPEPTIDOS ANTI-TROMBINA AISLADOS A PARTIR DE LA SANGUIJUELA HIRUDINARIA MANILLENSIS Y AL PROCESO PARA SU PREPARACION. LOS POLIPEPTIDOS DE LA INVENCION PUEDEN SER MODIFICADOS MEDIANTE UNA ADICION AMINOACIDA EN CUALQUIERA O CADA UNO DE LOS EXTREMOS, PUDIENDO SER SOMETIDOS A UNA MODIFICACION POST-TRANSLACIONAL. LOS POLIPEPTIDOS ANTI-TROMBINA PUEDEN SER PREPARADOS MEDIANTE EL AISLAMIENTO DEL TEJIDO O SECRECIONES DE LA SANGUIJUELA HIRUDINARIA MANILLENSIS, PERO PUEDEN SER TAMBIEN SINTETIZADOS MEDIANTE METODOS DE ADN RECOMBINANTE. DE ACUERDO CON ESTE ULTIMO ASPECTO, LA INVENCION PROPORCIONA SECUENCIAS DE ADN, VECTORES DE EXPRESION Y LINEAS CELULARES HUESPED PARA LA PREPARACION RECOMBINANTE DE LOS POLIPEPTIDOS. LOS POLIPEPTIDOS ANTI-TROMBINA DE LA INVENCION SON UTILES PARA EL TRATAMIENTO DE TROMBOSIS VENOSA, OCLUSION DE DERIVACION VASCULAR Y COAGULACION INTRAVASCULAR DISEMINADA TROMBINA INDUCIDA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919104260A GB9104260D0 (en) | 1991-02-28 | 1991-02-28 | Anti-thrombin polypeptides |
GB919119954A GB9119954D0 (en) | 1991-09-18 | 1991-09-18 | Antithrombin polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2129426T3 true ES2129426T3 (es) | 1999-06-16 |
Family
ID=26298509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92301721T Expired - Lifetime ES2129426T3 (es) | 1991-02-28 | 1992-02-28 | Polipeptidos antitrombinicos. |
Country Status (23)
Country | Link |
---|---|
US (2) | US5356875A (es) |
EP (1) | EP0501821B1 (es) |
JP (1) | JPH05247090A (es) |
KR (1) | KR100218818B1 (es) |
CN (1) | CN1044479C (es) |
AT (1) | ATE175236T1 (es) |
AU (1) | AU643876B2 (es) |
CA (1) | CA2061920A1 (es) |
CZ (1) | CZ283458B6 (es) |
DE (1) | DE69228015T2 (es) |
DK (1) | DK0501821T3 (es) |
ES (1) | ES2129426T3 (es) |
FI (1) | FI920861A (es) |
GR (1) | GR3029364T3 (es) |
HU (1) | HU215580B (es) |
IE (1) | IE920622A1 (es) |
IL (1) | IL101062A0 (es) |
MX (1) | MX9200795A (es) |
MY (1) | MY110327A (es) |
NO (1) | NO300138B1 (es) |
NZ (1) | NZ241715A (es) |
TW (1) | TW214556B (es) |
YU (1) | YU19792A (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1266561B1 (it) * | 1993-07-22 | 1997-01-09 | Mini Ricerca Scient Tecnolog | Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione |
CN1064968C (zh) * | 1996-07-10 | 2001-04-25 | 中国人民解放军第一军医大学 | 重组蛋白提取纯化方法 |
US6274553B1 (en) | 1997-01-20 | 2001-08-14 | Japan Energy Corporation | Method for stabilizing peptides and freeze-dried medicinal compositions containing peptides obtained by using the method |
US6077825A (en) * | 1997-03-13 | 2000-06-20 | Auburn University | Antithrombin protein and DNA sequences from black fly |
JP2000080046A (ja) * | 1998-09-03 | 2000-03-21 | Dai Ichi Seiyaku Co Ltd | 多臓器障害の予防・治療剤 |
CN102876654A (zh) * | 2012-10-19 | 2013-01-16 | 广东海洋大学 | 一种桑蚕丝素固定化凝血酶的制备方法 |
CN104193807B (zh) * | 2014-09-28 | 2016-06-15 | 广州贝奥吉因生物科技有限公司 | 凝血酶抑制多肽及其制备方法、应用 |
CN104193809B (zh) * | 2014-09-28 | 2016-08-17 | 顾玉奎 | 一种凝血酶抑制及其制备方法、应用 |
CN105646702B (zh) * | 2016-04-13 | 2019-03-01 | 中国科学院昆明动物研究所 | 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用 |
CN108059672B (zh) * | 2016-11-08 | 2021-06-11 | 中国科学院昆明动物研究所 | 森林山蛭抗血栓肽Sylvestin及其基因和应用 |
CN110468174A (zh) * | 2019-08-21 | 2019-11-19 | 北京中医药大学 | 一种水蛭活性寡肽的制备方法 |
CN111454352B (zh) * | 2020-03-05 | 2021-07-23 | 中国科学院昆明动物研究所 | 一种活性蛋白hmei-a、活性蛋白hmei-a的编码基因及应用 |
CN112114069B (zh) * | 2020-09-18 | 2023-05-16 | 江苏艾迪药业股份有限公司 | 凝血酶的亲和色谱柱、制备方法及应用 |
CN112480210B (zh) * | 2020-11-25 | 2021-09-17 | 广东海洋大学 | 一种抗凝血活性肽及其用途 |
KR102354461B1 (ko) * | 2021-02-19 | 2022-01-20 | 김건언 | 덕트 일체형 조명등기구 |
CN115572329B (zh) * | 2021-06-21 | 2024-02-06 | 王大勇 | 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5268296A (en) * | 1988-06-11 | 1993-12-07 | Ciba-Geigy Corporation | DNA vector and recombinant host cell for production of hirullin P6 and P18 |
EP0347376B1 (en) * | 1988-06-11 | 1994-03-23 | Ciba-Geigy Ag | Novel polypeptides with an anticoagulant activity |
GB8826428D0 (en) * | 1988-11-11 | 1988-12-14 | Biopharm Ltd | Antithrombin |
IT1250689B (it) * | 1991-07-22 | 1995-04-21 | Marco Gerna | Analoghi dell'irudina e procedimento per la loro preparazione |
-
1992
- 1992-02-24 IL IL101062A patent/IL101062A0/xx unknown
- 1992-02-25 MX MX9200795A patent/MX9200795A/es not_active IP Right Cessation
- 1992-02-25 NZ NZ241715A patent/NZ241715A/en unknown
- 1992-02-25 AU AU11221/92A patent/AU643876B2/en not_active Ceased
- 1992-02-25 TW TW081101387A patent/TW214556B/zh active
- 1992-02-25 HU HU9200620A patent/HU215580B/hu not_active IP Right Cessation
- 1992-02-26 CA CA002061920A patent/CA2061920A1/en not_active Abandoned
- 1992-02-26 YU YU19792A patent/YU19792A/sh unknown
- 1992-02-26 KR KR1019920002964A patent/KR100218818B1/ko not_active IP Right Cessation
- 1992-02-26 US US07/842,089 patent/US5356875A/en not_active Expired - Fee Related
- 1992-02-26 FI FI920861A patent/FI920861A/fi unknown
- 1992-02-27 CZ CS92584A patent/CZ283458B6/cs not_active IP Right Cessation
- 1992-02-27 NO NO920777A patent/NO300138B1/no unknown
- 1992-02-27 IE IE062292A patent/IE920622A1/en not_active Application Discontinuation
- 1992-02-27 MY MYPI92000321A patent/MY110327A/en unknown
- 1992-02-27 JP JP4075594A patent/JPH05247090A/ja active Pending
- 1992-02-27 CN CN92101143A patent/CN1044479C/zh not_active Expired - Fee Related
- 1992-02-28 AT AT92301721T patent/ATE175236T1/de not_active IP Right Cessation
- 1992-02-28 DE DE69228015T patent/DE69228015T2/de not_active Expired - Fee Related
- 1992-02-28 ES ES92301721T patent/ES2129426T3/es not_active Expired - Lifetime
- 1992-02-28 EP EP92301721A patent/EP0501821B1/en not_active Expired - Lifetime
- 1992-02-28 DK DK92301721T patent/DK0501821T3/da active
-
1994
- 1994-06-23 US US08/264,485 patent/US5439820A/en not_active Expired - Fee Related
-
1999
- 1999-02-10 GR GR990400451T patent/GR3029364T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0501821B1 (en) | 1998-12-30 |
TW214556B (es) | 1993-10-11 |
JPH05247090A (ja) | 1993-09-24 |
MX9200795A (es) | 1992-08-01 |
EP0501821A3 (en) | 1993-03-03 |
CN1066272A (zh) | 1992-11-18 |
CN1044479C (zh) | 1999-08-04 |
IE920622A1 (en) | 1992-09-09 |
CZ283458B6 (cs) | 1998-04-15 |
US5356875A (en) | 1994-10-18 |
IL101062A0 (en) | 1992-11-15 |
FI920861A (fi) | 1992-08-29 |
NO920777D0 (no) | 1992-02-27 |
DE69228015T2 (de) | 1999-06-02 |
NO920777L (no) | 1992-08-31 |
AU643876B2 (en) | 1993-11-25 |
HUT64592A (en) | 1994-01-28 |
GR3029364T3 (en) | 1999-05-28 |
HU215580B (hu) | 1999-01-28 |
MY110327A (en) | 1998-04-30 |
KR100218818B1 (ko) | 1999-10-01 |
EP0501821A2 (en) | 1992-09-02 |
NO300138B1 (no) | 1997-04-14 |
HU9200620D0 (en) | 1992-05-28 |
US5439820A (en) | 1995-08-08 |
AU1122192A (en) | 1992-09-03 |
ATE175236T1 (de) | 1999-01-15 |
CS58492A3 (en) | 1992-09-16 |
YU19792A (sh) | 1994-06-10 |
KR920016468A (ko) | 1992-09-24 |
CA2061920A1 (en) | 1992-08-29 |
DK0501821T3 (da) | 1999-08-30 |
NZ241715A (en) | 1993-07-27 |
DE69228015D1 (de) | 1999-02-11 |
FI920861A0 (fi) | 1992-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2129426T3 (es) | Polipeptidos antitrombinicos. | |
WO1996004378A3 (en) | Chimeric proteins and muteins of tissue factor pathway inhibitors tfpi and tfpi-2 | |
CA2102208A1 (en) | Binding domains in notch and delta proteins | |
BR0109494A (pt) | Produção de fatores recombinantes de coagulação do sangue em linhas celulares humanas | |
EP1484339A3 (en) | Kallikrein-inhibiting "Kunitz Domain" proteins and nucleic acids encoding the same | |
DK0662827T4 (da) | Terapeutiske og diagnostiske fremgangsmåder og sammensætninger baseret på Notch-proteiner og nucleinsyrer | |
ATE173478T1 (de) | Varianten des pankreatischen rinder- trypsininhibitors, deren herstellung und verwendung | |
HUT68021A (en) | Improved activating process of recombinant proteins | |
DE68926679T2 (de) | Physiologisch aktives polypeptid, rekombinantes plasmid, rekombinante mikrobielle zellen, medizinisches präparat sowie verfahren zur gewinnung des gereinigten polypeptids | |
WO2001005810A3 (de) | CYCLISCHE PEPTIDDERIVATE ALS INHIBITOREN DES INTEGRINS αvβ¿6? | |
WO2003016472A3 (en) | Hybrid interferon/interferon tau proteins, compositions and methods of use | |
KR950702579A (ko) | 트롬빈 억제제(thrombin inhibitors) | |
EP0345614A3 (en) | Amblyommine as an agent for use in antithrombotic therapy | |
JP2004521076A5 (es) | ||
DK0769056T3 (da) | Ikke-splejsende verianter af gp350/220 | |
ATE338770T1 (de) | Mit bh4 fusionierte polypeptide | |
Sarmientos et al. | Anti-thrombin polypeptides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 501821 Country of ref document: ES |