ATE175236T1 - Antithrombin-polypeptide - Google Patents

Antithrombin-polypeptide

Info

Publication number
ATE175236T1
ATE175236T1 AT92301721T AT92301721T ATE175236T1 AT E175236 T1 ATE175236 T1 AT E175236T1 AT 92301721 T AT92301721 T AT 92301721T AT 92301721 T AT92301721 T AT 92301721T AT E175236 T1 ATE175236 T1 AT E175236T1
Authority
AT
Austria
Prior art keywords
polypeptides
thrombin
preparation
hirudinaria manillensis
recombinant
Prior art date
Application number
AT92301721T
Other languages
English (en)
Inventor
Paolo Sarmientos
Taxis Du Poet Philippe De
Giampaolo Nitti
Emanuela Scacheri
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919104260A external-priority patent/GB9104260D0/en
Priority claimed from GB919119954A external-priority patent/GB9119954D0/en
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of ATE175236T1 publication Critical patent/ATE175236T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
AT92301721T 1991-02-28 1992-02-28 Antithrombin-polypeptide ATE175236T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919104260A GB9104260D0 (en) 1991-02-28 1991-02-28 Anti-thrombin polypeptides
GB919119954A GB9119954D0 (en) 1991-09-18 1991-09-18 Antithrombin polypeptides

Publications (1)

Publication Number Publication Date
ATE175236T1 true ATE175236T1 (de) 1999-01-15

Family

ID=26298509

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92301721T ATE175236T1 (de) 1991-02-28 1992-02-28 Antithrombin-polypeptide

Country Status (23)

Country Link
US (2) US5356875A (de)
EP (1) EP0501821B1 (de)
JP (1) JPH05247090A (de)
KR (1) KR100218818B1 (de)
CN (1) CN1044479C (de)
AT (1) ATE175236T1 (de)
AU (1) AU643876B2 (de)
CA (1) CA2061920A1 (de)
CZ (1) CZ283458B6 (de)
DE (1) DE69228015T2 (de)
DK (1) DK0501821T3 (de)
ES (1) ES2129426T3 (de)
FI (1) FI920861A (de)
GR (1) GR3029364T3 (de)
HU (1) HU215580B (de)
IE (1) IE920622A1 (de)
IL (1) IL101062A0 (de)
MX (1) MX9200795A (de)
MY (1) MY110327A (de)
NO (1) NO300138B1 (de)
NZ (1) NZ241715A (de)
TW (1) TW214556B (de)
YU (1) YU19792A (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1266561B1 (it) * 1993-07-22 1997-01-09 Mini Ricerca Scient Tecnolog Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione
CN1064968C (zh) * 1996-07-10 2001-04-25 中国人民解放军第一军医大学 重组蛋白提取纯化方法
KR20000070338A (ko) * 1997-01-20 2000-11-25 나가시마 카쭈시게, 노미야마 아키히코 펩티드의 안정화 방법 및 당해 방법을 이용한 펩티드 함유 동결건조 의약조성물
US6077825A (en) * 1997-03-13 2000-06-20 Auburn University Antithrombin protein and DNA sequences from black fly
JP2000080046A (ja) * 1998-09-03 2000-03-21 Dai Ichi Seiyaku Co Ltd 多臓器障害の予防・治療剤
CN102876654A (zh) * 2012-10-19 2013-01-16 广东海洋大学 一种桑蚕丝素固定化凝血酶的制备方法
CN104193807B (zh) * 2014-09-28 2016-06-15 广州贝奥吉因生物科技有限公司 凝血酶抑制多肽及其制备方法、应用
CN104193809B (zh) * 2014-09-28 2016-08-17 顾玉奎 一种凝血酶抑制及其制备方法、应用
CN105646702B (zh) * 2016-04-13 2019-03-01 中国科学院昆明动物研究所 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用
CN108059672B (zh) * 2016-11-08 2021-06-11 中国科学院昆明动物研究所 森林山蛭抗血栓肽Sylvestin及其基因和应用
CN110468174A (zh) * 2019-08-21 2019-11-19 北京中医药大学 一种水蛭活性寡肽的制备方法
CN111454352B (zh) * 2020-03-05 2021-07-23 中国科学院昆明动物研究所 一种活性蛋白hmei-a、活性蛋白hmei-a的编码基因及应用
CN112114069B (zh) * 2020-09-18 2023-05-16 江苏艾迪药业股份有限公司 凝血酶的亲和色谱柱、制备方法及应用
CN112480210B (zh) * 2020-11-25 2021-09-17 广东海洋大学 一种抗凝血活性肽及其用途
KR102354461B1 (ko) * 2021-02-19 2022-01-20 김건언 덕트 일체형 조명등기구
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
EP0347376B1 (de) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
IT1250689B (it) * 1991-07-22 1995-04-21 Marco Gerna Analoghi dell'irudina e procedimento per la loro preparazione

Also Published As

Publication number Publication date
CS58492A3 (en) 1992-09-16
HU9200620D0 (en) 1992-05-28
US5439820A (en) 1995-08-08
AU643876B2 (en) 1993-11-25
KR920016468A (ko) 1992-09-24
NO920777D0 (no) 1992-02-27
YU19792A (sh) 1994-06-10
JPH05247090A (ja) 1993-09-24
MX9200795A (es) 1992-08-01
CN1044479C (zh) 1999-08-04
IL101062A0 (en) 1992-11-15
EP0501821A2 (de) 1992-09-02
NO920777L (no) 1992-08-31
CA2061920A1 (en) 1992-08-29
MY110327A (en) 1998-04-30
IE920622A1 (en) 1992-09-09
TW214556B (de) 1993-10-11
DK0501821T3 (da) 1999-08-30
FI920861A0 (fi) 1992-02-26
CN1066272A (zh) 1992-11-18
HUT64592A (en) 1994-01-28
NO300138B1 (no) 1997-04-14
GR3029364T3 (en) 1999-05-28
DE69228015T2 (de) 1999-06-02
EP0501821A3 (en) 1993-03-03
KR100218818B1 (ko) 1999-10-01
NZ241715A (en) 1993-07-27
US5356875A (en) 1994-10-18
FI920861A (fi) 1992-08-29
DE69228015D1 (de) 1999-02-11
CZ283458B6 (cs) 1998-04-15
AU1122192A (en) 1992-09-03
EP0501821B1 (de) 1998-12-30
ES2129426T3 (es) 1999-06-16
HU215580B (hu) 1999-01-28

Similar Documents

Publication Publication Date Title
DE69228015D1 (de) Antithrombin-Polypeptide
WO1996004378A3 (en) Chimeric proteins and muteins of tissue factor pathway inhibitors tfpi and tfpi-2
EP1484339A3 (de) Kallikreinhemmende "Kunitz-Domäne"Proteine dafür kodierende Nukleinsäure
BR0109494A (pt) Produção de fatores recombinantes de coagulação do sangue em linhas celulares humanas
CA2102208A1 (en) Binding domains in notch and delta proteins
DK0739355T3 (da) Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf
DE3588254D1 (de) Gag-Antigen und dessen Verwendung zum Nachweis von LAV-Infektion, sowie in immunogenen Zusammensetzungen
DK0662827T3 (da) Terapeutiske og diagnostiske fremgangsmåder og sammensætninger baseret på Notch-proteiner og nucleinsyrer
ATE173478T1 (de) Varianten des pankreatischen rinder- trypsininhibitors, deren herstellung und verwendung
DE69433742D1 (de) Bmp-10 zusammensetzungen
HUT68021A (en) Improved activating process of recombinant proteins
WO2001005810A3 (de) CYCLISCHE PEPTIDDERIVATE ALS INHIBITOREN DES INTEGRINS αvβ¿6?
KR950702579A (ko) 트롬빈 억제제(thrombin inhibitors)
NO892266D0 (no) Amblyommin, et nytt virkemiddel for antikoagulasjonsterapien.
DK0769056T3 (da) Ikke-splejsende verianter af gp350/220
ATE338770T1 (de) Mit bh4 fusionierte polypeptide
Sarmientos et al. Anti-thrombin polypeptides and pharmaceutical compositions thereof
KR19980020377A (ko) 거머린(Guamerin)에서 유도된 단백질분해효소 억제활성을 지닌 펩타이드
Tani et al. Academy of Dental Materials
DE4011375A1 (de) Hirudinpolyvinyllactamkonjugate

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee