YU19792A - Anti-trombin polipeptidi - Google Patents
Anti-trombin polipeptidiInfo
- Publication number
- YU19792A YU19792A YU19792A YU19792A YU19792A YU 19792 A YU19792 A YU 19792A YU 19792 A YU19792 A YU 19792A YU 19792 A YU19792 A YU 19792A YU 19792 A YU19792 A YU 19792A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- polypeptides
- thrombin
- preparation
- hirudinaria manillensis
- recombinant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Ovaj pronalazak se odnosi na anti-trombin polipeptide koji su izolovani iz pijavice Hirudinaria manillensis i na postupak za njihovu izradu. Polipeptidi pronalaska mogu da se modifikuju pomoću amino kiselinskog proširenja na oba ili na svakom kraju, i mogu da se podvrgnu naknadnoj translacionoj modifikaciji. Anti-trombin polipeptidi mogu da se izrade izolujući ih iz tkiva ili izlučevina pijavice Hirudinaria manillensis ali oni isto tako mogu da se sintetizuju pomoću postupaka rekombinantne DNK. Prema ovom poslednjem vidu, pronalazak daje DNK sekvence, ekspresione vektore i sojeve ćelije domaćina za rekombinantnu iz-radu polipeptida. Anti-trombin polipeptidi pronalaska nalaze korisnu primenu u lečenju venske tromboze, okluzije vaskularnog odliva i trombinom izazvanu rasejanu intravaskularnu koagulaciju.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919104260A GB9104260D0 (en) | 1991-02-28 | 1991-02-28 | Anti-thrombin polypeptides |
GB919119954A GB9119954D0 (en) | 1991-09-18 | 1991-09-18 | Antithrombin polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
YU19792A true YU19792A (sh) | 1994-06-10 |
Family
ID=26298509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU19792A YU19792A (sh) | 1991-02-28 | 1992-02-26 | Anti-trombin polipeptidi |
Country Status (23)
Country | Link |
---|---|
US (2) | US5356875A (sh) |
EP (1) | EP0501821B1 (sh) |
JP (1) | JPH05247090A (sh) |
KR (1) | KR100218818B1 (sh) |
CN (1) | CN1044479C (sh) |
AT (1) | ATE175236T1 (sh) |
AU (1) | AU643876B2 (sh) |
CA (1) | CA2061920A1 (sh) |
CZ (1) | CZ283458B6 (sh) |
DE (1) | DE69228015T2 (sh) |
DK (1) | DK0501821T3 (sh) |
ES (1) | ES2129426T3 (sh) |
FI (1) | FI920861A (sh) |
GR (1) | GR3029364T3 (sh) |
HU (1) | HU215580B (sh) |
IE (1) | IE920622A1 (sh) |
IL (1) | IL101062A0 (sh) |
MX (1) | MX9200795A (sh) |
MY (1) | MY110327A (sh) |
NO (1) | NO300138B1 (sh) |
NZ (1) | NZ241715A (sh) |
TW (1) | TW214556B (sh) |
YU (1) | YU19792A (sh) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1266561B1 (it) * | 1993-07-22 | 1997-01-09 | Mini Ricerca Scient Tecnolog | Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione |
CN1064968C (zh) * | 1996-07-10 | 2001-04-25 | 中国人民解放军第一军医大学 | 重组蛋白提取纯化方法 |
KR20000070338A (ko) | 1997-01-20 | 2000-11-25 | 나가시마 카쭈시게, 노미야마 아키히코 | 펩티드의 안정화 방법 및 당해 방법을 이용한 펩티드 함유 동결건조 의약조성물 |
US6077825A (en) * | 1997-03-13 | 2000-06-20 | Auburn University | Antithrombin protein and DNA sequences from black fly |
JP2000080046A (ja) * | 1998-09-03 | 2000-03-21 | Dai Ichi Seiyaku Co Ltd | 多臓器障害の予防・治療剤 |
CN102876654A (zh) * | 2012-10-19 | 2013-01-16 | 广东海洋大学 | 一种桑蚕丝素固定化凝血酶的制备方法 |
CN104193809B (zh) * | 2014-09-28 | 2016-08-17 | 顾玉奎 | 一种凝血酶抑制及其制备方法、应用 |
CN104193807B (zh) * | 2014-09-28 | 2016-06-15 | 广州贝奥吉因生物科技有限公司 | 凝血酶抑制多肽及其制备方法、应用 |
CN105646702B (zh) * | 2016-04-13 | 2019-03-01 | 中国科学院昆明动物研究所 | 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用 |
CN108059672B (zh) * | 2016-11-08 | 2021-06-11 | 中国科学院昆明动物研究所 | 森林山蛭抗血栓肽Sylvestin及其基因和应用 |
CN110468174A (zh) * | 2019-08-21 | 2019-11-19 | 北京中医药大学 | 一种水蛭活性寡肽的制备方法 |
CN111454352B (zh) * | 2020-03-05 | 2021-07-23 | 中国科学院昆明动物研究所 | 一种活性蛋白hmei-a、活性蛋白hmei-a的编码基因及应用 |
CN112114069B (zh) * | 2020-09-18 | 2023-05-16 | 江苏艾迪药业股份有限公司 | 凝血酶的亲和色谱柱、制备方法及应用 |
CN112480210B (zh) * | 2020-11-25 | 2021-09-17 | 广东海洋大学 | 一种抗凝血活性肽及其用途 |
KR102354461B1 (ko) * | 2021-02-19 | 2022-01-20 | 김건언 | 덕트 일체형 조명등기구 |
CN115572329B (zh) * | 2021-06-21 | 2024-02-06 | 王大勇 | 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2052062T3 (es) * | 1988-06-11 | 1994-07-01 | Ciba Geigy Ag | Nuevos polipeptidos con actividad anticoagulante. |
US5268296A (en) * | 1988-06-11 | 1993-12-07 | Ciba-Geigy Corporation | DNA vector and recombinant host cell for production of hirullin P6 and P18 |
GB8826428D0 (en) * | 1988-11-11 | 1988-12-14 | Biopharm Ltd | Antithrombin |
IT1250689B (it) * | 1991-07-22 | 1995-04-21 | Marco Gerna | Analoghi dell'irudina e procedimento per la loro preparazione |
-
1992
- 1992-02-24 IL IL101062A patent/IL101062A0/xx unknown
- 1992-02-25 HU HU9200620A patent/HU215580B/hu not_active IP Right Cessation
- 1992-02-25 AU AU11221/92A patent/AU643876B2/en not_active Ceased
- 1992-02-25 NZ NZ241715A patent/NZ241715A/en unknown
- 1992-02-25 TW TW081101387A patent/TW214556B/zh active
- 1992-02-25 MX MX9200795A patent/MX9200795A/es not_active IP Right Cessation
- 1992-02-26 KR KR1019920002964A patent/KR100218818B1/ko not_active IP Right Cessation
- 1992-02-26 FI FI920861A patent/FI920861A/fi unknown
- 1992-02-26 US US07/842,089 patent/US5356875A/en not_active Expired - Fee Related
- 1992-02-26 CA CA002061920A patent/CA2061920A1/en not_active Abandoned
- 1992-02-26 YU YU19792A patent/YU19792A/sh unknown
- 1992-02-27 IE IE062292A patent/IE920622A1/en not_active Application Discontinuation
- 1992-02-27 NO NO920777A patent/NO300138B1/no unknown
- 1992-02-27 JP JP4075594A patent/JPH05247090A/ja active Pending
- 1992-02-27 CZ CS92584A patent/CZ283458B6/cs not_active IP Right Cessation
- 1992-02-27 CN CN92101143A patent/CN1044479C/zh not_active Expired - Fee Related
- 1992-02-27 MY MYPI92000321A patent/MY110327A/en unknown
- 1992-02-28 AT AT92301721T patent/ATE175236T1/de not_active IP Right Cessation
- 1992-02-28 DE DE69228015T patent/DE69228015T2/de not_active Expired - Fee Related
- 1992-02-28 ES ES92301721T patent/ES2129426T3/es not_active Expired - Lifetime
- 1992-02-28 EP EP92301721A patent/EP0501821B1/en not_active Expired - Lifetime
- 1992-02-28 DK DK92301721T patent/DK0501821T3/da active
-
1994
- 1994-06-23 US US08/264,485 patent/US5439820A/en not_active Expired - Fee Related
-
1999
- 1999-02-10 GR GR990400451T patent/GR3029364T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH05247090A (ja) | 1993-09-24 |
AU643876B2 (en) | 1993-11-25 |
AU1122192A (en) | 1992-09-03 |
CZ283458B6 (cs) | 1998-04-15 |
IE920622A1 (en) | 1992-09-09 |
CS58492A3 (en) | 1992-09-16 |
GR3029364T3 (en) | 1999-05-28 |
ES2129426T3 (es) | 1999-06-16 |
KR920016468A (ko) | 1992-09-24 |
MX9200795A (es) | 1992-08-01 |
ATE175236T1 (de) | 1999-01-15 |
MY110327A (en) | 1998-04-30 |
TW214556B (sh) | 1993-10-11 |
CN1044479C (zh) | 1999-08-04 |
HU9200620D0 (en) | 1992-05-28 |
HU215580B (hu) | 1999-01-28 |
NO920777L (no) | 1992-08-31 |
DK0501821T3 (da) | 1999-08-30 |
EP0501821A2 (en) | 1992-09-02 |
DE69228015T2 (de) | 1999-06-02 |
HUT64592A (en) | 1994-01-28 |
NO920777D0 (no) | 1992-02-27 |
EP0501821B1 (en) | 1998-12-30 |
EP0501821A3 (en) | 1993-03-03 |
US5439820A (en) | 1995-08-08 |
CN1066272A (zh) | 1992-11-18 |
NZ241715A (en) | 1993-07-27 |
DE69228015D1 (de) | 1999-02-11 |
FI920861A0 (fi) | 1992-02-26 |
US5356875A (en) | 1994-10-18 |
CA2061920A1 (en) | 1992-08-29 |
IL101062A0 (en) | 1992-11-15 |
FI920861A (fi) | 1992-08-29 |
KR100218818B1 (ko) | 1999-10-01 |
NO300138B1 (no) | 1997-04-14 |
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