ES2052062T3 - Nuevos polipeptidos con actividad anticoagulante. - Google Patents

Nuevos polipeptidos con actividad anticoagulante.

Info

Publication number
ES2052062T3
ES2052062T3 ES89810414T ES89810414T ES2052062T3 ES 2052062 T3 ES2052062 T3 ES 2052062T3 ES 89810414 T ES89810414 T ES 89810414T ES 89810414 T ES89810414 T ES 89810414T ES 2052062 T3 ES2052062 T3 ES 2052062T3
Authority
ES
Spain
Prior art keywords
new polypeptides
anticoagulant activity
activity
new
mamillensis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89810414T
Other languages
English (en)
Inventor
Reinhard Dr Maschler
Verena Steiner
Markus Gerhard Dr Grutter
Fritz Raschdorf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCP Gen Pharma AG
Novartis AG
Original Assignee
Ciba Geigy AG
UCP Gen Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888813876A external-priority patent/GB8813876D0/en
Application filed by Ciba Geigy AG, UCP Gen Pharma AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2052062T3 publication Critical patent/ES2052062T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

NUEVOS POLIPEPTIDOS LLAMADOS HIRULINAS, TIENEN UNA FUERTE ACTIVIDAD ANTITROMBOS Y PUEDEN POR TANTO SER USADOS PARA LA TERAPIA Y PROFILAXIS DE TROMBOSIS. DICHOS COMPUESTOS SON AISLADOS DE HIRUDINARIA MAMILLENSIS O SON PRODUCIDOS POR SINTESIS DE PEPTIDOS CONVENCIONALES O POR TECNICAS DE ADN RECOMBINANTE.
ES89810414T 1988-06-11 1989-06-02 Nuevos polipeptidos con actividad anticoagulante. Expired - Lifetime ES2052062T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888813876A GB8813876D0 (en) 1988-06-11 1988-06-11 Novel polypeptides with anticoagulant activity
GB888818123A GB8818123D0 (en) 1988-06-11 1988-07-29 Novel polypeptides with anticoagulant activity

Publications (1)

Publication Number Publication Date
ES2052062T3 true ES2052062T3 (es) 1994-07-01

Family

ID=26294006

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89810414T Expired - Lifetime ES2052062T3 (es) 1988-06-11 1989-06-02 Nuevos polipeptidos con actividad anticoagulante.

Country Status (10)

Country Link
US (1) US5114922A (es)
EP (1) EP0347376B1 (es)
JP (1) JPH02117697A (es)
AU (1) AU625375B2 (es)
CA (1) CA1339106C (es)
DE (1) DE58907266T2 (es)
DK (1) DK283889A (es)
ES (1) ES2052062T3 (es)
IE (1) IE61809B1 (es)
PT (1) PT90798B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63424B1 (en) * 1987-04-09 1995-04-19 Delta Biotechnology Ltd Yeast vector
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
ZA907743B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Radiolabeled anticoagulant peptides
AU641215B2 (en) * 1990-02-13 1993-09-16 Merrell Dow Pharmaceuticals Inc. Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
HUT63180A (en) * 1990-07-24 1993-07-28 Merrell Dow Pharma Process for producing anticoagulant peptides
GB9022040D0 (en) * 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
ATE176500T1 (de) * 1990-11-08 1999-02-15 Japan Energy Corp Sekretionsvektor, diesen enthaltene transformierte mikroorganismen und herstellung von produkten durch obigen mikroorganismus
IL101062A0 (en) * 1991-02-28 1992-11-15 Erba Carlo Spa Anti-thrombin polypeptides and their preparation
US6719975B1 (en) * 1991-06-27 2004-04-13 Farmitalia Carlo Erba S.R.L. Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
US5783421A (en) 1993-04-09 1998-07-21 Bio-Technology General Corp. DNA encoding novel polypeptide having Factor Xa inhibitory activity
DK0696198T3 (da) * 1993-04-09 2001-08-06 Bio Technology General Corp Nyt polypeptid, der har inhiberende virkning mod faktor Xa
ES2199963T3 (es) * 1993-06-11 2004-03-01 Merrell Pharmaceuticals Inc. Peptidos trifuncionales antitrombina y antiplaquetarios.
CN1113389A (zh) * 1993-08-04 1995-12-13 西巴-盖尔基股份公司 高分子量的脱硫水蛭素
RU2112528C1 (ru) * 1994-12-23 1998-06-10 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН СПОСОБ ПОЛУЧЕНИЯ ФЕРМЕНТА ДЕСТАБИЛАЗЫ, ОБЛАДАЮЩЕГО ФИБРИНОЛИТИЧЕСКОЙ, ТРОМБОЛИТИЧЕСКОЙ, ЭНДО- И ЭКЗО- ε(γ GLY)-LYS-ИЗОПЕПТИДАЗНОЙ И АМИДОЛИТИЧЕСКОЙ АКТИВНОСТЬЮ
GB9509271D0 (en) * 1995-05-05 1995-06-28 Biopharm Res & Dev Ltd Blood clot stabilisation inhibitors
CN102914612B (zh) * 2011-08-06 2015-10-21 河北以岭医药研究院有限公司 一种菲牛蛭药材指纹图谱的测定方法
CN105646702B (zh) * 2016-04-13 2019-03-01 中国科学院昆明动物研究所 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
CN86101096A (zh) * 1985-04-26 1986-10-22 株式会社岛津制作所 印字绘图器
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
NO170430C (no) * 1986-09-18 1992-10-14 Pennsylvania Hospital Fremgangsmaate for fremstilling av et protein som har antikoagulerende og anti-metastatiske egenskaper
FR2630638B1 (fr) * 1988-05-02 1997-08-08 Inst Nat Sante Rech Med Implant oculaire et son procede de preparation

Also Published As

Publication number Publication date
DE58907266D1 (de) 1994-04-28
US5114922A (en) 1992-05-19
PT90798A (pt) 1989-12-29
DK283889D0 (da) 1989-06-09
EP0347376A3 (en) 1990-07-04
EP0347376B1 (en) 1994-03-23
DE58907266T2 (de) 1994-09-29
AU625375B2 (en) 1992-07-09
JPH02117697A (ja) 1990-05-02
IE61809B1 (en) 1994-11-30
PT90798B (pt) 1994-10-31
AU3630189A (en) 1989-12-14
IE891856L (en) 1989-12-11
CA1339106C (en) 1997-07-29
EP0347376A2 (en) 1989-12-20
DK283889A (da) 1989-12-12

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